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GERVEPSALVGGDGHAVQHRLERCVAALRRMVDDGWFDDHDDTVGMEVELDLVDPLGRPRLINDAVLARL GRADMQRELGQFNVELNLAPRRLRGGVLRECESDLDGVFDRCRAAIEVLGVRLVAVGMLPTLSAEQLTAE HISHSPRYELLARRVRAARHRPFSVRILDGCEPVEFSTDSVAPDAATTSLQLHLRVPPDRFAAYYNAAQT IAGAQLAVAANAPYLVGSQVWQETRIPLLEQLLDTRRPKDIRRGAPARVSLGDRWIDDPVELFDETVRDF PPLFPTLEAEDPDVAVDAGRVPGLRELRLHNGTVWRWNRPVYDVQAGRPQLRIENRVLPSGPTAVDMIAN AAYYYGLVRAVADTDPAPWEQMPFAVAERDLHRGARDGLAAQLHWRGADHPADRLTREVLLPAAAAGLDA WGVDPDDRDRYLGVIEARVRSGRTGAAWQVETVRRLQDRGLDRIAALHEMTRRYVEHAHTGAPVHEWPVS *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1073 | - | - | 100% (491) | hypothetical protein Mvan_1073 |
| M. vanbaalenii PYR-1 | Mvan_5470 | - | e-112 | 45.65% (471) | hypothetical protein Mvan_5470 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3724 | - | 1e-113 | 44.79% (489) | hypothetical protein Mb3724 |
| M. gilvum PYR-GCK | Mflv_1325 | - | 1e-110 | 44.80% (471) | hypothetical protein Mflv_1325 |
| M. tuberculosis H37Rv | Rv3698 | - | 1e-113 | 44.99% (489) | hypothetical protein Rv3698 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0374c | - | 1e-116 | 44.69% (490) | hypothetical protein MAB_0374c |
| M. marinum M | MMAR_1559 | - | 0.0 | 73.12% (491) | hypothetical protein MMAR_1559 |
| M. avium 104 | MAV_0405 | - | 1e-115 | 44.69% (490) | CBS domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_6234 | - | 1e-108 | 42.54% (489) | CBS domain-containing protein |
| M. thermoresistible (build 8) | TH_1721 | - | 1e-110 | 43.18% (491) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1325|M.gilvum_PYR-GCK ---------------MGQDISAELKQSEFSRAHRREYRRKVQLCLDVFET
MSMEG_6234|M.smegmatis_MC2_155 -------------------MGEEVKRTEYTRAHRQEYRRKVQLCLDVFET
TH_1721|M.thermoresistible__bu -------------------VGEEVKGGDFSRAQRREYRRKVQLCLDVFET
Mb3724|M.bovis_AF2122/97 MRTISPFLRCRHETCCISNVGEEVTRTTYSREHQREYRRKVRLCLDVFET
Rv3698|M.tuberculosis_H37Rv MRTISPFLRCRHETCCISNVGEEVTRTTYSREHQREYRRKVRLCLDVFET
MAV_0405|M.avium_104 -------------------MGEEVKRATYDSAHRREFRRKVALCLDVFET
MAB_0374c|M.abscessus_ATCC_199 -------------------MGDEVARTQFTGEHRRAYRTKVQNCLDVFET
Mvan_1073|M.vanbaalenii_PYR-1 -------------------MGERVEPSALVGGDGHAVQHRLERCVAALRR
MMAR_1559|M.marinum_M -----------MCGREGRPVGDRIDASALVLGHGDDVRRRLTRSVAVLRQ
:. .: . : :: .: .:.
Mflv_1325|M.gilvum_PYR-GCK MLAQASFDFEKPLTGMEIECNLVDSAYQPAMNNSEVLDAIADPAYQTELG
MSMEG_6234|M.smegmatis_MC2_155 MLNQSSFEFERPLTGMEIECNLVDREYQPALRNHEVLKSIADPAYQTELG
TH_1721|M.thermoresistible__bu ILAQSTFETDRPLIGMEIECNLVDDDYQPAMTNREVLASIADPAYQTELG
Mb3724|M.bovis_AF2122/97 MLAQTRFEADRPLTGIEIECNLVDADYQPAMSNRYVLDAIADPAYQTELG
Rv3698|M.tuberculosis_H37Rv MLAQTRFEADRPLTGMEIECNLVDADYQPAMSNRYVLDAIADPAYQTELG
MAV_0405|M.avium_104 MLARSCFESEQPLTGMEIECNLVDADYQPAMSNRHVLDAIGDPAYQVELG
MAB_0374c|M.abscessus_ATCC_199 MLAESRFDFERPLTGLEIEFNLVDGNYQPAMTNTEVLASIADPAFQTELG
Mvan_1073|M.vanbaalenii_PYR-1 MVDDGWFDDHDDTVGMEVELDLVDPLGRPRLINDAVLARLGRADMQRELG
MMAR_1559|M.marinum_M MVEAGWFAGHEDTIGMEVELDLVDPLGRPRLVNDAVLQALDRTDMQHELG
:: * . *:*:* :*** :* : * ** : . * ***
Mflv_1325|M.gilvum_PYR-GCK AYNIEFNVPPRRLPGRAALDLEAEVRASLNAAESKAGTDG-SHIVMIGIL
MSMEG_6234|M.smegmatis_MC2_155 AYNIELNVPPRPLPGRSALELEDEVRASLNAAEAKAAAEG-THIVMIGIL
TH_1721|M.thermoresistible__bu AYNIEFNVPPRPLPGQAALELENDVRASLNVAESRANQSG-THIVMIGIL
Mb3724|M.bovis_AF2122/97 AYNIEFNVPPRPLPGRTCLELEDEVRASLNDAETKASCSG-AHIVMIGIL
Rv3698|M.tuberculosis_H37Rv AYNIEFNVPPRPLPGRTCLELEDEVRASLNDAETKASCSG-AHIVMIGIL
MAV_0405|M.avium_104 AYNIEFNVPPHALPGHTGLDLEAEVRASLNEAETKAGAAGGAHIVMIGIL
MAB_0374c|M.abscessus_ATCC_199 AYNIEMNVPPRALPGSAALELEEDVRASLNAAEQRAGERG-AHIVMIGIL
Mvan_1073|M.vanbaalenii_PYR-1 QFNVELNLAPRRLRGGVLRECESDLDGVFDRCRAAIEVLG-VRLVAVGML
MMAR_1559|M.marinum_M QFNVELNLPPHPLTGHVLRDSEQLLADVLDGSGARIESLG-TRLIAVGML
:*:*:*:.*: * * : * : :: . * ::: :*:*
Mflv_1325|M.gilvum_PYR-GCK PTLMPEHLTGHWMSESTRYQALNDSIFTARGEDIMIDIS-GPERLSLQTA
MSMEG_6234|M.smegmatis_MC2_155 PTLMPEHLSGSWMSDSTRYQALNDSIFTARGEDLVIDIS-GPERLSIQAA
TH_1721|M.thermoresistible__bu PTLMPEHLTSGWMSESTRYQALNDSIFTARGEDIVIDIE-GPERLTLQSA
Mb3724|M.bovis_AF2122/97 PTLMPEHLTDGWMSASARYAALNESIFKARGEDIPINIA-GPEPLSCHAG
Rv3698|M.tuberculosis_H37Rv PTLMPEHLTDGWMSASARYAALNESIFKARGEDIPINIA-GPEPLSCHAG
MAV_0405|M.avium_104 PTLMPEHLDHDWMSESTRYAALNDSIFTARGEDIPIDIS-GPEPLSWHTA
MAB_0374c|M.abscessus_ATCC_199 PTVMPENLDGAWMSPSSRYRALNDAVFSARGEDMQIDIA-GTERLSVRSP
Mvan_1073|M.vanbaalenii_PYR-1 PTLSAEQLTAEHISHSPRYELLARRVRAARHRPFSVRILDGCEPVEFSTD
MMAR_1559|M.marinum_M PTLSADHMTAERLSTNPRYELLSRRIRTARHRPFRVHISDAPEPVEFTTD
**: .::: :* ..** * : ** . : : * . * : :
Mflv_1325|M.gilvum_PYR-GCK SIAPESACTSMQLHLQVSPADFANNWNAAQVVAGPQLALGANSPYFFGHH
MSMEG_6234|M.smegmatis_MC2_155 SIAPESACTSMQLHQQVSPAEFAQYWNAAQVLAGPQLAVGSNSPFFFGHH
TH_1721|M.thermoresistible__bu TIAPESACTSMQLHLQVSPADFAPNWNAAQLLAAPQLALGANSPYFFGHQ
Mb3724|M.bovis_AF2122/97 SIAPESACTSVQLHLQLAPADFPANWNAAQVLAGRQLALGANSPYFFGHQ
Rv3698|M.tuberculosis_H37Rv SIAPESACTSVQLHLQLAPADFPANWNAAQVLAGPQLALGANSPYFFGHQ
MAV_0405|M.avium_104 TIAPESACTSTQLHLQVAAETFAANWNAAQTVAGPQLALGANSPFFFGHQ
MAB_0374c|M.abscessus_ATCC_199 SIAPESACTSIQLHLQVAPDDFAANWNAAQALAGPQLALAANSPFFFGKS
Mvan_1073|M.vanbaalenii_PYR-1 SVAPDAATTSLQLHLRVPPDRFAAYYNAAQTIAGAQLAVAANAPYLVGSQ
MMAR_1559|M.marinum_M SVAPEASATSLQLHLRAHRDRFAAYFNAAQLIAGAQVAVAANSPFLLGRH
::**::: ** *** : *. :**** :*. *:*:.:*:*::.*
Mflv_1325|M.gilvum_PYR-GCK LWAETRIELFAQATDTRPDELKTQGVRPRVWFGERWITSIFDLFEENVRY
MSMEG_6234|M.smegmatis_MC2_155 LWAETRIELFTQATDTRPDELKTQGVRPRVWFGERWITSIFDLFEENVRY
TH_1721|M.thermoresistible__bu LWEETRIELFTQATDTRPDELKAQGVRPRVWFGERWITSIFDLFEENVRY
Mb3724|M.bovis_AF2122/97 LWSETRIELFTQSTDARPEELKSRGVRPRVWFGERWITSVLDLFQENIRY
Rv3698|M.tuberculosis_H37Rv LWSETRIELFTQSTDARPEELKSRGVRPRVWFGERWITSVLDLFQENIRY
MAV_0405|M.avium_104 LWAETRIELFAQSTDTRPEELKTQGVRPRVWFGERWIDSVLDLFAENIRY
MAB_0374c|M.abscessus_ATCC_199 LWAETRIELFTQSTDTRPQELKVQGVRPRVWFGERWITSIFDLFEENVLY
Mvan_1073|M.vanbaalenii_PYR-1 VWQETRIPLLEQLLDTRRPKDIRRGAPARVSLGDRWIDDPVELFDETVRD
MMAR_1559|M.marinum_M AWQETRITLVEQLLDSRRPSEVKASAPARVRLGEGWISDPVDLFDHLVRE
* **** *. * *:* . .. .** :*: ** . .:** . :
Mflv_1325|M.gilvum_PYR-GCK FPSLLPELSDEDPAAELAAGRTPKLSELRLHNGTIYRWNRPVYDIVNERP
MSMEG_6234|M.smegmatis_MC2_155 FPSLLPEVSDEDPAAELAAGRTPKLSELRLHNGTIYRWNRPIYDVVNGMP
TH_1721|M.thermoresistible__bu FPSLLPELSDEDPAAELAAGRTPQLHELRLHNGTIYRWNRPVYDVVNGRP
Mb3724|M.bovis_AF2122/97 FPTLLPEVSDEDPLAELSAGRIPHLSELRLHNGTVYRWNRPVYDVVDGRP
Rv3698|M.tuberculosis_H37Rv FPTLLPEVSDEDPLAELSAGRIPHLSELRLHNGTVYRWNRPVYDVVDGRP
MAV_0405|M.avium_104 FGSLLPEVSDEDPVAELAAGRTPQLSELRLHNGTVYRWNRPVYDVAEGRP
MAB_0374c|M.abscessus_ATCC_199 FPSLLPEISDEDPVAELAAGRAPRLQELRLHNGTVYRWNRPIYDVVNGTP
Mvan_1073|M.vanbaalenii_PYR-1 FPPLFPTLEAEDPDVAVDAGRVPGLRELRLHNGTVWRWNRPVYDVQAGRP
MMAR_1559|M.marinum_M YPPLFPTLEAEDPDAALEAGQAPVLHELRLHNGTVWQWNRPVYDVQGGSP
: .*:* :. *** . : **: * * ********:::****:**: *
Mflv_1325|M.gilvum_PYR-GCK HLRVENRVLPAGPTVVDMMANAAFYYGVLRTLSEEDRPLWTKMSFAAAES
MSMEG_6234|M.smegmatis_MC2_155 HLRVENRVLPAGPTVIDMMANAAFYYGLLRTLSEEDRPIWTKMSFAAAQH
TH_1721|M.thermoresistible__bu HLRVENRVLPAGPTVLDMLANSAFYYGCLHMLSREDRPLWTRMSFGAAHH
Mb3724|M.bovis_AF2122/97 HLRLENRVLPAGPTVVDMLANHAFYYGALRGLSEADPPLWTQMNFAAAQA
Rv3698|M.tuberculosis_H37Rv HLRLENRVLPAGPTVVDMLANHAFYYGALRGLSEADPPLWTQMNFAAAQA
MAV_0405|M.avium_104 HLRLENRVLPAGPTVIDMLANSAFFYGMLRSLSEADDPLWERMDFAVAEA
MAB_0374c|M.abscessus_ATCC_199 HLRVENRVLPAGPSVIDVMANAAFYYGALRSLSEDDRPVWTKMTFSAAHD
Mvan_1073|M.vanbaalenii_PYR-1 QLRIENRVLPSGPTAVDMIANAAYYYGLVRAVADTDPAPWEQMPFAVAER
MMAR_1559|M.marinum_M QLRIENRVLPSGPTAVDMVANAAFYYGLVRAIADSDRTPWEQTPFAVAER
:**:******:**:.:*::** *::** :: :: * . * : *..*.
Mflv_1325|M.gilvum_PYR-GCK NFVAAAQHGMDARLYWPGEGEVTPDELILRRLLPMADEGLRRWEVAAEVR
MSMEG_6234|M.smegmatis_MC2_155 NFTAAAQHGMESRLYWPELGEVTPDELILRQLLPLAHEGLRRRGVAGEVC
TH_1721|M.thermoresistible__bu NFVEAARHGMHARLYWPGSGDVTPDELVLRELLPLAHEGLRQRGVAAAVR
Mb3724|M.bovis_AF2122/97 NFLAAARYGMDAQLDWPGLGEVTTRELVLGTLLPMAHEGLRRWGVDAEVR
Rv3698|M.tuberculosis_H37Rv NFLAAARYGMDAQLDWPGLGEVTTRELVLGTLLPMAHEGLRRWGVDAEVR
MAV_0405|M.avium_104 NFLTAARHGIDARLRWPGFGEVSARELVLDTLLPIADEGLRRWGVDAEVR
MAB_0374c|M.abscessus_ATCC_199 NFLSGARHGTSAKLYWPGVGEITADELTLRYLLPMAHEGLRRWGVAPQVR
Mvan_1073|M.vanbaalenii_PYR-1 DLHRGARDGLAAQLHWRG-ADHPADRLTREVLLPAAAAGLDAWGVDPDDR
MMAR_1559|M.marinum_M DLHRAARDGLAAQLSWQG-TDQPAAQLTRDVLLPAAASGLDAWGVDAHDR
:: .*: * ::* * : .. .* *** * ** *
Mflv_1325|M.gilvum_PYR-GCK DRYLGVIEGRAKTGRNGAVWQSEAVTALQGRGLSRPDALAEMLRLYCERM
MSMEG_6234|M.smegmatis_MC2_155 DRYLGVIEGRAKTGQTGAAWQVSTVQRIQESGRSRPEALAGMLREYVERM
TH_1721|M.thermoresistible__bu ERYLGVIEGRAKTGRNGARWQVATVEALQRRGLSRPDALAEMLRRYCQEM
Mb3724|M.bovis_AF2122/97 DRFLGVIGGRAQTGRNGARWQVATVAALQDGGLTRPAALAEMLRRYCEHM
Rv3698|M.tuberculosis_H37Rv DRFLGVIGGRAQTGRNGARWQVATVAALQDGGLTRPAALAEMLRRYCEHM
MAV_0405|M.avium_104 DRFLGVIDGRARAGRNGASWQVATVRALQDGGLSRRAALAEMLRRYCEHM
MAB_0374c|M.abscessus_ATCC_199 DRYLGVIEARAKSGINGAAWQTRTVSALERRGLNRKQALTEMLRKYCAHM
Mvan_1073|M.vanbaalenii_PYR-1 DRYLGVIEARVRSGRTGAAWQVETVRRLQDRGLDRIAALHEMTRRYVEHA
MMAR_1559|M.marinum_M DRYLGVIEARVRSGRTGAAWQTETVRHLEERGLERISALHEMTRRYVEHA
:*:**** .*.::* .** ** :* :: * * ** * * * .
Mflv_1325|M.gilvum_PYR-GCK HANEPVHTWDLPA
MSMEG_6234|M.smegmatis_MC2_155 HSNEPVHTWG---
TH_1721|M.thermoresistible__bu HSNEPVHTWAVPA
Mb3724|M.bovis_AF2122/97 HSNEPVHTWDT--
Rv3698|M.tuberculosis_H37Rv HSNEPVHTWDT--
MAV_0405|M.avium_104 HANEPVHTWE---
MAB_0374c|M.abscessus_ATCC_199 HSNEPVHTWELI-
Mvan_1073|M.vanbaalenii_PYR-1 HTGAPVHEWPVS-
MMAR_1559|M.marinum_M RSGAPVHEWPLS-
::. *** *