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MDSEARSGGRSGADGSDTRDDLNYPKVVLVTGACRFLGGYLTARLAQNPLINHVIAVDAIAPSKDLLRRM GRAEFVRADIRNPFIAKVIRNGDVDTVVHAAAASYAPRSGGRATLKELNVMGAIQLFAACQKAPSVRRVI LKSTSEVYGSSSRDPVLFSESSSRRRPPGEGFARDSIDIEGYARGLGRRRPDIAVTILRLANMIGPAMDT ALSRYLAGPVVPTIIGHDPRLQLLHEQDALGVLERATMAGKAGTFNVGASGVIMMSQAIRRSGRLALPVP RSVLVAVDSLWRATRNTELDREQLDYLSYGRVMDTTRMRTELGYTPKWTTAEAFDDYVRGRGLTPIVDPD WIRSVENRAVAAAQRWGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0840 | - | - | 100% (368) | NAD-dependent epimerase/dehydratase |
| M. vanbaalenii PYR-1 | Mvan_5808 | - | 2e-13 | 25.23% (325) | NAD-dependent epimerase/dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0513 | galE2 | 1e-162 | 79.56% (362) | UDP-glucose 4-epimerase |
| M. gilvum PYR-GCK | Mflv_0072 | - | 0.0 | 91.03% (368) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv0501 | galE2 | 1e-162 | 79.56% (362) | UDP-glucose 4-epimerase |
| M. leprae Br4923 | MLBr_02428 | - | 1e-153 | 76.97% (356) | putative glucose epimerase/dehydratase |
| M. abscessus ATCC 19977 | MAB_4003c | - | 1e-155 | 75.65% (345) | putative UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_0829 | galE2 | 1e-164 | 79.18% (365) | UDP-glucose 4-epimerase GalE2 |
| M. avium 104 | MAV_4649 | - | 1e-164 | 79.50% (361) | NAD dependent epimerase/dehydratase family protein |
| M. smegmatis MC2 155 | MSMEG_0946 | - | 1e-172 | 87.43% (342) | NAD dependent epimerase/dehydratase family protein |
| M. thermoresistible (build 8) | TH_0954 | galE1 | 1e-165 | 79.78% (356) | POSSIBLE UDP-GLUCOSE 4-EPIMERASE GALE2 (GALACTOWALDENASE) |
| M. ulcerans Agy99 | MUL_4573 | galE2 | 1e-163 | 78.90% (365) | UDP-glucose 4-epimerase GalE2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0840|M.vanbaalenii_PYR-1 MDSEARSGGRSGADGSDTRDDLNYPKVVLVTGACRFLGGYLTARLAQNPL
Mflv_0072|M.gilvum_PYR-GCK MDSEGRSG--TGPEGSDAREGLDYPKVVLVTGACRFLGGYLTARLAQNPL
MSMEG_0946|M.smegmatis_MC2_155 --------------------------MVLVTGACRFLGGYLTARLAQNPS
TH_0954|M.thermoresistible__bu VDA---------ADGTGTGDAAQQPKVVLVTGACRFLGGYLTARLAQNPA
Mb0513|M.bovis_AF2122/97 MSSSNGRGG-AGGVGGSS-EHPQYPKVVLVTGACRFLGGYLTARLAQNPL
Rv0501|M.tuberculosis_H37Rv MSSSNGRGG-AGGVGGSS-EHPQYPKVVLVTGACRFLGGYLTARLAQNPL
MMAR_0829|M.marinum_M MNSSNGQGGGAGGIGGGG-DSVHHPKVVLVTGACRFLGGYLTARLAQNPL
MUL_4573|M.ulcerans_Agy99 MNSSNGQGGGAGGIGGGG-DSVHHPKVVLVTGACRFLGGYLTARLAQNPL
MLBr_02428|M.leprae_Br4923 MDSSSGQDG--GGTGG----VVPYPKVVLVTGACRFLGGYLTARLAQNPL
MAV_4649|M.avium_104 MDPSNGHNSGPDDTAG---NTVHYPKIVLVTGACRFLGGYLTARLAQNPM
MAB_4003c|M.abscessus_ATCC_199 MSAGE--------------SNLHYPRVVLVTGASRFLGGYLAARLVQNPM
:******.*******:***.***
Mvan_0840|M.vanbaalenii_PYR-1 INHVIAVDAIAPSKDLLRRMGRAEFVRADIRNPFIAKVIRNGDVDTVVHA
Mflv_0072|M.gilvum_PYR-GCK INHVIAVDAVAPSKDLLRRMGRAEFVRADIRNPFIAKVIRNGEVDTVVHA
MSMEG_0946|M.smegmatis_MC2_155 IDHVIAVDAITPSKDLLRRMGRAEFVRADIRNPFIAKVIRNGNVDTVVHA
TH_0954|M.thermoresistible__bu IDHVIAVDVATPSKDMLRRMGRAEFIRADIRNPFIAKVIRNGNVDTVVHA
Mb0513|M.bovis_AF2122/97 INRVIAVDAIAPSKDMLRRMGRAEFVRADIRNPFIAKVIRNGEVDTVVHA
Rv0501|M.tuberculosis_H37Rv INRVIAVDAIAPSKDMLRRMGRAEFVRADIRNPFIAKVIRNGEVDTVVHA
MMAR_0829|M.marinum_M ISSVIAVDAIAPSKDMLRRMGRAEFVRADIRNPFIAKVIRNGDVDTVVHA
MUL_4573|M.ulcerans_Agy99 ISSVIAVDAIAPSKDMLRRMGRAEFVRADIRNPFIAKVIRNGDVDTVVHA
MLBr_02428|M.leprae_Br4923 INAVIAVDAIAPSKDMLRRMGHAEFVRADIRNPFIAKVIRNGEVDTVVHA
MAV_4649|M.avium_104 IKGVIAVDAIAPSKDMLRRMGRAEFVRADIRNPFIAKVIRNGDVDTVVHA
MAB_4003c|M.abscessus_ATCC_199 INRVIAVDAVAPSKDLLRRMGRAEFVRADIRNPFIAKVIRNGEVDTVVHT
*. *****. :****:*****:***:****************:******:
Mvan_0840|M.vanbaalenii_PYR-1 AAASYAPRSGGRATLKELNVMGAIQLFAACQKAPSVRRVILKSTSEVYGS
Mflv_0072|M.gilvum_PYR-GCK AAASYAPRAGGRATLKEINVMGAIQLFAACQKAPSVRRVILKSTSEVYGS
MSMEG_0946|M.smegmatis_MC2_155 AAASYAPRSGGRATLKELNVMGAIQLFAACQKTPSVRRVILKSTSEVYGS
TH_0954|M.thermoresistible__bu AAASYARGSGARATQKEFNVMGAIQLFAACQKAPSVRRVVLKSTSDVYGA
Mb0513|M.bovis_AF2122/97 AAASYAPRSGGSAALKELNVMGAMQLFAACQKAPSVRRVVLKSTSEVYGS
Rv0501|M.tuberculosis_H37Rv AAASYAPRSGGSAALKELNVMGAMQLFAACQKAPSVRRVVLKSTSEVYGS
MMAR_0829|M.marinum_M AAASYAPRSGGSAALKELNVMGAMQLFAACQKAPSVRRVVLKSTSEVYGS
MUL_4573|M.ulcerans_Agy99 AAASYAPRSGGSAALKELNVMGAMQLFAACQKAPSVRRVVLKSTSEVYGS
MLBr_02428|M.leprae_Br4923 DAASYAPRSCGSAALKELNVMGAMQLFAACQKAPTVRRVVLKSTSAVYGS
MAV_4649|M.avium_104 AAASYAPRSGGTAALKEINVMGAMQLFAACQKAPSVRRVVLKSTSEVYGS
MAB_4003c|M.abscessus_ATCC_199 ASASYSPRSGGRAALKELNVMGAMQLFAACQKAPTVQRVVVKSTAQVYGA
:***: : . *: **:*****:********:*:*:**::***: ***:
Mvan_0840|M.vanbaalenii_PYR-1 SSRDPVLFSESSSRRRPPGEGFARDSIDIEGYARGLGRRRPDIAVTILRL
Mflv_0072|M.gilvum_PYR-GCK SSRDPVLFSESSSRRRPPGEGFARDSIDIEGYARGMGRRRPDIAVTILRL
MSMEG_0946|M.smegmatis_MC2_155 SSRDPVMFTEESSARRPPRDGFARDSIDIEGYARGLARRRPDIAVTILRL
TH_0954|M.thermoresistible__bu HPRDPVVFSEECDARKPPGDGFARDSIDIEGYARGLARRRPDIAVTILRL
Mb0513|M.bovis_AF2122/97 SPHDPVMFTEDSSSRRPFSQGFPKDSLDIEGYVRALGRRRPDIAVTILRL
Rv0501|M.tuberculosis_H37Rv SPHDPVMFTEDSSSRRPFSQGFPKDSLDIEGYVRALGRRRPDIAVTILRL
MMAR_0829|M.marinum_M SPHDPVVFTEDSSSRRPFREGFAKDSLDIEGYARGLGRRRPDIAVTILRL
MUL_4573|M.ulcerans_Agy99 SPHDPVVFTEDSSSRRPFREGFAKDSLDIEGYARGLGRRRPDIAVTILRL
MLBr_02428|M.leprae_Br4923 GSRDPVMFTEDSSSWRSFREGFAKDSLDIEGYARGLGRRRSDIAVTILRL
MAV_4649|M.avium_104 SAHDPVMFTEDSTSRRPFRAGFAKDSLDIEAYARGLGRRRPDIAVTILRL
MAB_4003c|M.abscessus_ATCC_199 SARDPVMFTEEMSARRPPADGFARDSIDIESYARGLGRRRPDVAVTILRL
.:***:*:*. :. **.:**:***.*.*.:.***.*:*******
Mvan_0840|M.vanbaalenii_PYR-1 ANMIGPAMDTALSRYLAGPVVPTIIGHDPRLQLLHEQDALGVLERATMAG
Mflv_0072|M.gilvum_PYR-GCK ANMIGPATDTALSRYLAGPVVPTVIGHDPRLQLLHEQDALGALERATMAG
MSMEG_0946|M.smegmatis_MC2_155 ANMIGPAMDTALSRYLAGPVVPCVVGHDARLQLLHEQDALGALEHATVAG
TH_0954|M.thermoresistible__bu ANLIGPAINSPLTRFLARPVVTTVLGRDPRLQLLHEQDALGALEHATLSG
Mb0513|M.bovis_AF2122/97 ANMIGPAMDTTLSRYLAGPLVPTIFGRDARLQLLHEQDALGALERAAMAG
Rv0501|M.tuberculosis_H37Rv ANMIGPAMDTTLSRYLAGPLVPTIFGRDARLQLLHEQDALGALERAAMAG
MMAR_0829|M.marinum_M ANMIGPAMDTTLSRYLAGPGVPTMFGRDARLQLLHEQDALGALERAALSG
MUL_4573|M.ulcerans_Agy99 ANMIGPAMDTTLSRYLAGPGVPTMFGRDARLQLLHEQDALGALERAALSG
MLBr_02428|M.leprae_Br4923 ADMIGPAMDTTLSRYLAGPLVPTMCGRDARLQLLHEQDALGALECAAMTG
MAV_4649|M.avium_104 ANMIGPAMDTTLSRYLAGPLVPTILGRDARLQLLHEQDALGALERAAMAG
MAB_4003c|M.abscessus_ATCC_199 ANLIGPGMDTALARYLAGPVVPTMLGRDARLQLLHEQDALGALERATMAG
*::***. ::.*:*:** * *. : *:*.************.** *:::*
Mvan_0840|M.vanbaalenii_PYR-1 KAGTFNVGASGVIMMSQAIRRSGRLALPVPRSVLVAVDSLWRATRNTELD
Mflv_0072|M.gilvum_PYR-GCK RSGAFNIGASGIITMSQAIRRAGRLALPVPRSALVAVDSLWRATRNTELD
MSMEG_0946|M.smegmatis_MC2_155 KAGTFNIGADGIIMMSQALRRSGRIRLPVPRSALAAVDSLNRATRYSEVD
TH_0954|M.thermoresistible__bu KPGTFNIAAPGIIMMSQAIRRAGRIALPVPRSALSVVDSVVRATRSTELD
Mb0513|M.bovis_AF2122/97 KAGTFNIGADGILMLSQAIRRAGRIPVPVPGFGVWALDSLRRANHYTELN
Rv0501|M.tuberculosis_H37Rv KAGTFNIGADGILMLSQAIRRAGRIPVPVPGFGVWALDSLRRANHYTELN
MMAR_0829|M.marinum_M KGGTYNIGADGIIMLSQAIRRAGRIPLPVPGFGVWALDSLRRANRYTEIN
MUL_4573|M.ulcerans_Agy99 KGGTYNIGADGIIMLSQAIRRAGRIPLPVPGFGVWALDSLRRVNRYTEIN
MLBr_02428|M.leprae_Br4923 KAGTFNIGASGIMMLSQAIRRAGRIAVPIPSFGVWALDLLRWVNRYTEIT
MAV_4649|M.avium_104 KAGTFNIGADGIIMLSQAIRRAGRIPLPVPGFGVWALDSLRRANRYNEIS
MAB_4003c|M.abscessus_ATCC_199 KAGTFNIAADGMMMMSQAVRRSGQLGIPVPSFAVAAIASFTKGTRYTELS
: *::*:.* *:: :***:**:*:: :*:* : .: . .: .*:
Mvan_0840|M.vanbaalenii_PYR-1 REQLDYLSYGRVMDTTRMRTELGYTPKWTTAEAFDDYVRGRGLTPIVDPD
Mflv_0072|M.gilvum_PYR-GCK REQLDYLSYGRVMDTSRMRNELGYSPKWTTAEAFDDYVRGRGLTPIIDPR
MSMEG_0946|M.smegmatis_MC2_155 REQLNYLSYGRVMDTTRMRRDLGYSPKWTTGEAFDDYVRGRGLTPIIDPR
TH_0954|M.thermoresistible__bu REQLNYLSYGRVMDTTRMREDLGYSPKWTTVEAFDDYVRGRGLTPIVDPR
Mb0513|M.bovis_AF2122/97 REQFAYLSYGRVMDTTRMRVELGYQPKWTTVEAFDDYFRGRGLTPIIDPH
Rv0501|M.tuberculosis_H37Rv REQFAYLSYGRVMDTTRMRVELGYQPKWTTVEAFDDYFRGRGLTPIIDPH
MMAR_0829|M.marinum_M REQFAYLSYGRVMDTTRMRSELGYQPKWSTAEAFDDYVRGRGLTPIIDPH
MUL_4573|M.ulcerans_Agy99 REQFAYLSYGRVMDTTRMRSELGYQPKWSTAEAFDDYVRGRGLTPIIDPH
MLBr_02428|M.leprae_Br4923 RDQFEYLSYGRVMDTTRMGSELGYHPKWTTAGAFDDYVRGRGLTPIIDLH
MAV_4649|M.avium_104 RDQFDYLSYGRVMDTSRMRSELGYQPKWTTAEAFDDYVRGRGLTPIIDPD
MAB_4003c|M.abscessus_ATCC_199 SEQRDWLAYGRAMDNTRMKTELGYQPKWTTIGAFGDYVRGRGITPVIEPE
:* :*:***.**.:** :*** ***:* **.**.****:**:::
Mvan_0840|M.vanbaalenii_PYR-1 WIRSVENRAVAAAQRWGR----------
Mflv_0072|M.gilvum_PYR-GCK WIHAVENRAVAAAQRWGR----------
MSMEG_0946|M.smegmatis_MC2_155 WVGSLESRAVALAQRWGR----------
TH_0954|M.thermoresistible__bu WVRSMESRAVAVAQRWGR----------
Mb0513|M.bovis_AF2122/97 RVRSWEGRAVGLAQRWGSRNPIPWSGLR
Rv0501|M.tuberculosis_H37Rv RVRSWEGRAVGLAQRWGSRNPIPWSGLR
MMAR_0829|M.marinum_M RVRSWEGRAIAVAQRWGSRNPIPWGGVR
MUL_4573|M.ulcerans_Agy99 RVRSWEGRAIAVAQRWGSRNPIPWGGVR
MLBr_02428|M.leprae_Br4923 RVRYFEGRAIALAQRWSSRN--------
MAV_4649|M.avium_104 RVRSLESRAIALAQRWGSRNPIPWGGVR
MAB_4003c|M.abscessus_ATCC_199 WVRSLGDRAVAFAQKISS----------
: .**:. **: .