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VSSQETQWLAHDSPTDRELVRVVRELSDLLDRLDDAETSWADGIAAVDPQYRASARNIVHYWGIRQTDLR DLQRRLADFGLSSLGRSEAHVESTLRLVRSAAQAMLQGDWRPPEPAVVGARESRELLRHRCVDLLGPAPS GRETRIMVTLPSEAATDAALVRGLVDRGMNVARINCAHDDPQAWRAMAGHVRAASADAGRACAIAMDLAG PKLRTGPIRPGPRVVKLHPKRDALGRVLAPAEALLLAEPAARSVAEHGVTAVPVPADWLARRRPGETITL YDTRGAKRRLVVGDAHDGAAGRVATVDKTTYLTSGTTLRVDGAHDAAEVGEVPEVEQFLTLRPGDRLRLT RDCSPVPTDSADGPVIGCTLPELFDNARVGDRIYFDDGKIGGEIVTVNPDALEVRVERAAESGSKLRAAK GINVPDARLPISALTDKDLSDLTTVVDIADLVQLSFVQEPADVLRLHDALDGLGGDHVGVVLKIETASAF QNLPQLLLTAMRRPRTGVMIARGDLAVEVGYERLAELQEEILWLCEAAHLPVIWATQVLDQLAKSGLPSR AEVSDAAMGERAECVMLNKGPHIGEAVTVLDDILCRMAEHHYKKNALLPRLRSWGPDVESDG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0632 | - | - | 100% (622) | pyruvate kinase |
| M. vanbaalenii PYR-1 | Mvan_2824 | - | 6e-26 | 33.63% (223) | pyruvate kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1643 | pykA | 6e-28 | 33.06% (242) | pyruvate kinase |
| M. gilvum PYR-GCK | Mflv_0262 | - | 0.0 | 67.20% (625) | pyruvate kinase |
| M. tuberculosis H37Rv | Rv1617 | pykA | 3e-28 | 33.47% (242) | pyruvate kinase |
| M. leprae Br4923 | MLBr_01277 | pykA | 3e-30 | 34.30% (242) | pyruvate kinase |
| M. abscessus ATCC 19977 | MAB_2639c | - | 2e-27 | 32.64% (242) | pyruvate kinase |
| M. marinum M | MMAR_2420 | pykA | 3e-28 | 31.80% (305) | pyruvate kinase PykA |
| M. avium 104 | MAV_3170 | pyk | 2e-29 | 32.73% (278) | pyruvate kinase |
| M. smegmatis MC2 155 | MSMEG_0154 | pyk | 4e-29 | 33.61% (244) | pyruvate kinase |
| M. thermoresistible (build 8) | TH_1097 | pykA | 5e-27 | 33.06% (242) | Probable pyruvate kinase pykA |
| M. ulcerans Agy99 | MUL_1598 | pykA | 2e-28 | 31.80% (305) | pyruvate kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01277|M.leprae_Br4923 --------------------------------------------------
MAV_3170|M.avium_104 --------------------------------------------------
Mb1643|M.bovis_AF2122/97 --------------------------------------------------
Rv1617|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2420|M.marinum_M --------------------------------------------------
MUL_1598|M.ulcerans_Agy99 --------------------------------------------------
MAB_2639c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1097|M.thermoresistible__bu --------------------------------------------------
MSMEG_0154|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0632|M.vanbaalenii_PYR-1 MSSQETQWLAHDSPTDR---ELVRVVRELSDLLDRLDDAETSWADGIAAV
Mflv_0262|M.gilvum_PYR-GCK MTTQRSDARAHDDGADGRIGDLAGLAEELDSLLDNLAAGEAAWADALAAV
MLBr_01277|M.leprae_Br4923 --------------------------------------------------
MAV_3170|M.avium_104 --------------------------------------------------
Mb1643|M.bovis_AF2122/97 --------------------------------------------------
Rv1617|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2420|M.marinum_M --------------------------------------------------
MUL_1598|M.ulcerans_Agy99 --------------------------------------------------
MAB_2639c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1097|M.thermoresistible__bu --------------------------------------------------
MSMEG_0154|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0632|M.vanbaalenii_PYR-1 DPQYRASARNIVHYWGIRQTDLRDLQRRLADFGLSSLGRSEAHVESTLRL
Mflv_0262|M.gilvum_PYR-GCK PASRRASARNMAHYWSLRQTDLRDLQRRLADHGLSSLGRSEAHVEATLQR
MLBr_01277|M.leprae_Br4923 ------------------------------------------MTRRGKIV
MAV_3170|M.avium_104 --------------------------------------------------
Mb1643|M.bovis_AF2122/97 ------------------------------------------MTRRGKIV
Rv1617|M.tuberculosis_H37Rv ------------------------------------------MTRRGKIV
MMAR_2420|M.marinum_M ------------------------------------------MTRRGKIV
MUL_1598|M.ulcerans_Agy99 ------------------------------------------MTRRGKIV
MAB_2639c|M.abscessus_ATCC_199 ------------------------------------------MTRRGKIV
TH_1097|M.thermoresistible__bu --------------------------------------------------
MSMEG_0154|M.smegmatis_MC2_155 -----------------------------------------MANRRAKIV
Mvan_0632|M.vanbaalenii_PYR-1 VRSAAQAMLQGDWRPPEPAVVGARESRELLRHRCVDLLGPAPSGRETRIM
Mflv_0262|M.gilvum_PYR-GCK VRAAARAMAGEGFGDPAPAGLSPSAGRELLQRRTVELLGAAPRDRETRIM
MLBr_01277|M.leprae_Br4923 CTLG-PATQSDELIRALVEAGMDVARMNFSHGDYSDHKAVYDRVRVASDA
MAV_3170|M.avium_104 --------------MALVEAGMDVARLNFSHGDYADHKAAYERVRVASDA
Mb1643|M.bovis_AF2122/97 CTLG-PATQRDDLVRALVEAGMDVARMNFSHGDYDDHKVAYERVRVASDA
Rv1617|M.tuberculosis_H37Rv CTLG-PATQRDDLVRALVEAGMDVARMNFSHGDYDDHKVAYERVRVASDA
MMAR_2420|M.marinum_M CTLG-PATQQDDLVKELVEAGMDVARMNFSHGDYPDHEAAYERVRAASDA
MUL_1598|M.ulcerans_Agy99 CTLG-PATQQDDLVKELVEAGMDVARMNFSHGDYADHEAAYERVRAASDA
MAB_2639c|M.abscessus_ATCC_199 CTLG-PATGSAELVRALVEAGMDVARLNFSHGEHADHEQNYRWVRKASDE
TH_1097|M.thermoresistible__bu ---------------------MDVARLNFSHGTHADHERYYKLVRAASDL
MSMEG_0154|M.smegmatis_MC2_155 CTLG-PATATSSVLTELVDAGMDVARLNFSHSTHAEHSALYGMVREIAAQ
Mvan_0632|M.vanbaalenii_PYR-1 VTLPSEAATDAALVRGLVDRGMNVARINCAHDDPQAWRAMAGHVRAASAD
Mflv_0262|M.gilvum_PYR-GCK VTLPTEAATDPDVARNLLERGMDVARINCAHDDASAWRAMAHHVRTAAAA
*:***:* :*. ** :
MLBr_01277|M.leprae_Br4923 TGRAVGVLADLQGPKIRLGRFATG-------STYWADGETVRITVADCHG
MAV_3170|M.avium_104 TGRAVGVLADLQGPKIRLGRFATG-------PTYWADGETVRITVADCEG
Mb1643|M.bovis_AF2122/97 TGRAVGVLADLQGPKIRLGRFASG-------ATHWAEGETVRITVGACEG
Rv1617|M.tuberculosis_H37Rv TGRAVGVLADLQGPKIRLGRFASG-------ATHWAEGETVRITVGACEG
MMAR_2420|M.marinum_M TGRAVGVLADLQGPKIRLGRFADG-------PTYWADGDTVRITVEECEG
MUL_1598|M.ulcerans_Agy99 TGRAVGVLADLQGPKIRLGRFADG-------PTYWADGDTVRITVEECEG
MAB_2639c|M.abscessus_ATCC_199 SGRAVGVLADLQGPKIRLGRFATG-------SAHWATGEQVRITVEDVVG
TH_1097|M.thermoresistible__bu TGRAVGILADLQGPKIRLGRFADG-------STYWATGETVRITVDDIQG
MSMEG_0154|M.smegmatis_MC2_155 RGRVVGVLADLQGPKIRLGCFADG-------PVVWATGEHVTITTEDCPG
Mvan_0632|M.vanbaalenii_PYR-1 AGRACAIAMDLAGPKLRTGPIRPGPRVVKLHPKRDALGRVLAPAEALLLA
Mflv_0262|M.gilvum_PYR-GCK IDRPCLIAMDLGGPKLRTGPIRPGPRVVKMKPRRDGWGRVSALAEALLIA
.* : ** ***:* * : * . . * : .
MLBr_01277|M.leprae_Br4923 SHDRVSTTYKNLARDAVVGDRVLVDDGKVGLVVSAIDGDD---VVCTVTE
MAV_3170|M.avium_104 SHDRVSTTYKQLAQDAAVGDRVLVDDGKVGLVVDGIEGDD---VICTVVE
Mb1643|M.bovis_AF2122/97 SHDRVSTTYKRLAQDAVAGDRVLVDDGKVALVVDAVEGDD---VVCTVVE
Rv1617|M.tuberculosis_H37Rv SHDRVSTTYKRLAQDAVAGDRVLVDDGKVALVVDAVEGDD---VVCTVVE
MMAR_2420|M.marinum_M CRDRVSTTYKRLAQDAVAGDRVLVDDGKVGLIVDHIDGND---VVCTVVE
MUL_1598|M.ulcerans_Agy99 CRDRVSTTYKRLAQDAVAGDRVLVDDGKVGLIVDHIDGND---VVCTVVE
MAB_2639c|M.abscessus_ATCC_199 TPDRVSTTYKQLAADAAVGDRLLVDDGKVGLTVEAIEGDD---VVCRVTE
TH_1097|M.thermoresistible__bu THDRVSTTYKNLAADAARGDRLLVDDGKVALVVTAVEGDD---VVCEVVE
MSMEG_0154|M.smegmatis_MC2_155 DHDRVSTTYAGLSQDVRAGDRLLVDDGRVDLRVVAVDGPD---IRCEVVD
Mvan_0632|M.vanbaalenii_PYR-1 EPAARSVAEHGVTAVPVPADWLARRRPGETITLYDTRGAKRRLVVGDAHD
Mflv_0262|M.gilvum_PYR-GCK QEAPE--PSTGRPLLPVPGDWLARRRAGDEITVRDTRGAARRLVVGGTAD
. . .* : : : * : . :
MLBr_01277|M.leprae_Br4923 G--GPVSNNKGMSLPGMHVSAPALSDKDIEDLTFALNLGADLVALS--FV
MAV_3170|M.avium_104 G--GPVSNNKGISLPGMNVSAPALSDKDIEDLTFALELGVDLVALS--FV
Mb1643|M.bovis_AF2122/97 G--GPVSDNKGISLPGMNVTAPALSEKDIEDLTFALNLGVDMVALS--FV
Rv1617|M.tuberculosis_H37Rv G--GPVSDNKGISLPGMNVTAPALSEKDIEDLTFALNLGVDMVALS--FV
MMAR_2420|M.marinum_M G--GPVSNNKGISLPGMNVSAPALSEKDIDDLTFALNLGVDMVALS--FV
MUL_1598|M.ulcerans_Agy99 G--GPVSNNKGISLPGMNVSAPALSEKDIDDLTFALNLGVDMVALS--FV
MAB_2639c|M.abscessus_ATCC_199 G--GPVSNNKGLSLPGMNVSVPALSEKDIADLEFALRLGVDLIALS--FV
TH_1097|M.thermoresistible__bu G--GPVSNNKGLSLPGMNVSVPALTEKDVEDLEFAIRLGVDMVALS--FV
MSMEG_0154|M.smegmatis_MC2_155 G--GPVSDHKGISLPNIPVSVPPLSDKDIEDLKFALELGADMIAMS--FV
Mvan_0632|M.vanbaalenii_PYR-1 GAAGRVATVDKTTYLTSGTTLRVDGAHDAAEVGEVPEVEQFLTLRPGDRL
Mflv_0262|M.gilvum_PYR-GCK G--GRIVTATKTTYLSTGAALHADGRRDSAALGTVPDLEQSVLLRPGDQL
* * : : .: :* : . : : . :
MLBr_01277|M.leprae_Br4923 RSPSDVELVHKAMDRVGRR-VPVIAKLEKPEAVDNLEAIVLAFDAIMVAR
MAV_3170|M.avium_104 RSPSDVELVHEVMDRVGRR-VPVIAKLEKPEAVDNLEAIVLAFDAIMVAR
Mb1643|M.bovis_AF2122/97 RSPADVELVHEVMDRIGRR-VPVIAKLDKPEAIDNLEAIVLAFDAVMVAR
Rv1617|M.tuberculosis_H37Rv RSPADVELVHEVMDRIGRR-VPVIAKLEKPEAIDNLEAIVLAFDAVMVAR
MMAR_2420|M.marinum_M RSPSDVELVHEVMDRIGRR-VPVIAKLEKPEAIDNLEAIVLAFDAVMVAR
MUL_1598|M.ulcerans_Agy99 RSPSDVELVHEVMDRIGRR-VPVIAKLEKPEAIDNLEAIVLAFDAVMVAR
MAB_2639c|M.abscessus_ATCC_199 RSPSDVELVHAVMDRVGRR-VPVIAKLEKPEAVANLEAIVLAFDAIMVAR
TH_1097|M.thermoresistible__bu RSPADVELVHEVMDRVGRR-VPVIAKLEKPEAIDNLEAIVLAFDGVMVAR
MSMEG_0154|M.smegmatis_MC2_155 RAPEEVELAHKIMDEVGRR-VPVIAKLEKPEAVSDLPAIVEAFDGLMVAR
Mvan_0632|M.vanbaalenii_PYR-1 RLTRDCSPVPTDSADGPVIGCTLPELFDNARVGDRIYFDDGKIGGEIVTV
Mflv_0262|M.gilvum_PYR-GCK RVTRDCSPAAPDADGIPRIGCTLPEVFDNARAGDRIFFDDGKISGVVVAA
* . : . . .: :::... : :.. :*:
MLBr_01277|M.leprae_Br4923 GDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAE
MAV_3170|M.avium_104 GDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAE
Mb1643|M.bovis_AF2122/97 GDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAE
Rv1617|M.tuberculosis_H37Rv GDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAE
MMAR_2420|M.marinum_M GDLGVELPLEEVPLVQKRAIQIARENAKPVIVATQMLDSMIENSRPTRAE
MUL_1598|M.ulcerans_Agy99 GDLGVELPLEEVPLVQKRAIQIARENAKPVIVATQMLDSMIENSRPTRAE
MAB_2639c|M.abscessus_ATCC_199 GDLGVELPLEDVPIVQKRAIQIARENARPVIVATQMLESMIENSRPTRAE
TH_1097|M.thermoresistible__bu GDLGVELPLEEVPLVQKRAIQTARENAKPVIVATQMLESMIENSRPTRAE
MSMEG_0154|M.smegmatis_MC2_155 GDLGVEMPLEQIPLVQRRAIALCRQAAKPVIVATQMLDSMVSDRRPTRAE
Mvan_0632|M.vanbaalenii_PYR-1 NPDALEVRVERAAESGSKLRAAKGINVPDARLPISALTDKDLSDLTTVVD
Mflv_0262|M.gilvum_PYR-GCK TPDALDVRIARAAETGSKLREAKGINVPDTHLPISALTGKDLADLATVVE
.::: : . : . . :. . * . .* .:
MLBr_01277|M.leprae_Br4923 ASDVANAVLDGADALMLSEETSVGKYPLAAVKTMSRIVCAVEENS-TAAP
MAV_3170|M.avium_104 ASDVANAVLDGADAVMLSGETSVGKYPLAAVRTMARIICAVEDNS-TAAP
Mb1643|M.bovis_AF2122/97 ASDVANAVLDGADALMLSGETSVGKYPLAAVRTMSRIICAVEENS-TAAP
Rv1617|M.tuberculosis_H37Rv ASDVANAVLDGADALMLSGETSVGKYPLAAVRTMSRIICAVEENS-TAAP
MMAR_2420|M.marinum_M ASDVANAVLDGADALMLSGETSVGKYPLAAVRTMSRIVCAVEENS-TAAP
MUL_1598|M.ulcerans_Agy99 ASDVANAVLDGADALMLSGETSVGKYPLAAVRTMSRIVCAVEENS-TAAP
MAB_2639c|M.abscessus_ATCC_199 ASDVANAVLDGADAVMLSGETSVGKYPLEAVRTMARIVSAVESHS-VSAP
TH_1097|M.thermoresistible__bu ASDVANAVLDGTDAVMLSGETSVGKYPLEAVRTMASIVAAVEENS-TAAP
MSMEG_0154|M.smegmatis_MC2_155 VSDVANAVFDRADAVMLSAETSVGADPAHAVATMARIVVAAESGSGRGET
Mvan_0632|M.vanbaalenii_PYR-1 IADLVQLSFVQEPADVLRLHDALDGLGGDHVGVVLKIETASAFQN-LPQL
Mflv_0262|M.gilvum_PYR-GCK VADIVQLSFVQSPADVGALYDALEQFGDDGIGVVLKIETRRAFEN-LPRL
:*:.: : * : :: : .: * .
MLBr_01277|M.leprae_Br4923 PLTHVPRTKRG-------VISYAARDIGERLDAKALVAFTQSGDTVRRLA
MAV_3170|M.avium_104 PLTHVPRTKRG-------VISYAARDIGERLDAKALVAFTQSGDTVKRLA
Mb1643|M.bovis_AF2122/97 PLTHIPRTKRG-------VISYAARDIGERLDAKALVAFTQSGDTVRRLA
Rv1617|M.tuberculosis_H37Rv PLTHIPRTKRG-------VISYAARDIGERLDAKALVAFTQSGDTVRRLA
MMAR_2420|M.marinum_M PLTHVPRTKRG-------VISYAARDIGERLDAKALVAFTQSGDTVRRLA
MUL_1598|M.ulcerans_Agy99 PLTHVPRTKRG-------VISYAARDIGERLDAKALVAFTQSGDTVRRLA
MAB_2639c|M.abscessus_ATCC_199 PLTHVPRTKRG-------VISYAARDIGERLNAKALVAFTQSGDTVRRLA
TH_1097|M.thermoresistible__bu PLTHLPRTKRG-------VISYAARDIGERLDAKALVAFTQSGDTVRRLA
MSMEG_0154|M.smegmatis_MC2_155 PESALVEAVNGTDAVFGDAIAVAACEVGRRLGAAALCCFTRTGDTALRLA
Mvan_0632|M.vanbaalenii_PYR-1 LLTAMRRPRTG--------VMIARGDLAVEVGYERLAELQEEILWLCEAA
Mflv_0262|M.gilvum_PYR-GCK LFAAMRRPRVG--------VMIARGDLAVEVGYERLAELQEEILWLCESA
: : .. * : * ::. .:. * : . . *
MLBr_01277|M.leprae_Br4923 RLHTPLPLLAFTAWPEVRSQLAMTWGTETFLVPKMLSTDGMIRQVDKSLL
MAV_3170|M.avium_104 RLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVPMMTSTDGMIRQVDKSLL
Mb1643|M.bovis_AF2122/97 RLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVPKMQSTDGMIRQVDKSLL
Rv1617|M.tuberculosis_H37Rv RLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVPKMQSTDGMIRQVDKSLL
MMAR_2420|M.marinum_M RLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVPEMDSTDGMIRQVDKSLL
MUL_1598|M.ulcerans_Agy99 RLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVPEMDSTDGMIRQVDKSLL
MAB_2639c|M.abscessus_ATCC_199 RLHTPLPVLAFTPLPEVRSQLALTWGTETFIVPVMETTDGMIQQVDTALL
TH_1097|M.thermoresistible__bu RLHTPLPLLAFTSLPEIRSQLALTWGTETFIVPHIQTTDGMIRQVDQSLL
MSMEG_0154|M.smegmatis_MC2_155 RQRSPLPLLAFAHDDEVRGRLTFSWGVESAVLAPTELAESMPGEVSRALL
Mvan_0632|M.vanbaalenii_PYR-1 H----LPVIWATQVLDQLAKSGLPSRAEVSDAAMGERAECVMLNKGPHIG
Mflv_0262|M.gilvum_PYR-GCK H----LPVIWATQVLESLAKSGLPSRAEVSDAAMGARAECVMLNKGPHIG
: **:: : : .: :. .* . :: : : . :
MLBr_01277|M.leprae_Br4923 ELGRYKRGDLVVIVAGTPPGTVGSTNLIHVHRIGEDDV-
MAV_3170|M.avium_104 ELGRYRRGDLVVIVAGAPPGTVGSTNLIHVHRIGEDDV-
Mb1643|M.bovis_AF2122/97 ELARYKRGDLVVIVAGAPPGTVGSTNLIHVHRIGEDDV-
Rv1617|M.tuberculosis_H37Rv ELARYKRGDLVVIVAGAPPGTVGSTNLIHVHRIGEDDV-
MMAR_2420|M.marinum_M ELGRYKRGDLVVIVAGAPPGTVGSTNLIHVHRIGEDDV-
MUL_1598|M.ulcerans_Agy99 ELGRYKRGDLVVIVAGAPPGTVGSTNLIHVHRIGEDDV-
MAB_2639c|M.abscessus_ATCC_199 EMERYQRGDLVVIVAGAPPGTVGSTNLIHVHRIGEDDH-
TH_1097|M.thermoresistible__bu QLGRYKRGDLVVIVAGAPPGTVGSTNMIHVHRIGEDDHF
MSMEG_0154|M.smegmatis_MC2_155 SMGACHPGDVVVVVSGSRSGVAGYTDSVRVLRVE-----
Mvan_0632|M.vanbaalenii_PYR-1 EAVTVLDDILCRMAEHHYKKNALLPRLRSWGPDVESDG-
Mflv_0262|M.gilvum_PYR-GCK DAVTVLDDILCRMTEHHRKKSALMRRLRSWHPQSGDDG-
. . : :. .