For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
STRPVRIGNASGFYGDRLTAMRSLIDGGDIDVITGDYLAELTMLILWKARQKDPETGYARTFLTQFADVV TDCADRGIKIVVNAGGLNPAGMAGQVRRIAAAAGVDMKVAHVEGDDLMPNLRFLQDSGIAFEHLDTGIPL ADSDRSPISANAYLGGWGIAAALRGGADVVITGRVTDAALVVGVGAWWHNWQPTDYDALAGAVAAGHIIE CGPQATGGNYSQLDEITDRRYPGSPIAELASDGGFAITKHPGTGGLLSVGTVTAQLLYEVASPAYANPDV VAHFDTMAVTQDGPDRVLVTGTVGSPPPPTLKVAMNAIGGYRNTMTMVLTGLNIEDKAAWAADELFEILG GKDTFDDVDVQLLRYDRPDPTSLPEATAHLRITVKDRELAKVDRAFSNAVVELAVAGYPGFHTTTPPGSA SEFGVYWPTLVPATTVEHTVMHADGTREVIPHPVRTEPAGPEPTVDTICAPVDFGRTLRRPLGNVVAARS GDKGGNANVGVWTDTPERWDWLHAHLSVGRLRELIPEAGGLPIRRYAFPNLKALNFVIVGYLGEGVASCT RTDPQAKGLGEYLRALHTDIPERFVK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0342 | - | - | 100% (587) | hypothetical protein Mvan_0342 |
| M. vanbaalenii PYR-1 | Mvan_4846 | - | e-168 | 52.75% (582) | hypothetical protein Mvan_4846 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1001c | - | 1e-167 | 53.18% (581) | hypothetical protein Mb1001c |
| M. gilvum PYR-GCK | Mflv_4598 | - | 0.0 | 59.49% (590) | hypothetical protein Mflv_4598 |
| M. tuberculosis H37Rv | Rv0976c | - | 1e-167 | 53.18% (581) | hypothetical protein Rv0976c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2060 | - | 0.0 | 60.21% (583) | hypothetical protein MAB_2060 |
| M. marinum M | MMAR_4531 | - | 1e-168 | 53.18% (581) | hypothetical protein MMAR_4531 |
| M. avium 104 | MAV_1092 | - | 1e-168 | 53.16% (585) | hypothetical protein MAV_1092 |
| M. smegmatis MC2 155 | MSMEG_0337 | - | 0.0 | 71.79% (585) | hypothetical protein MSMEG_0337 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4703 | - | 1e-167 | 53.18% (581) | hypothetical protein MUL_4703 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1001c|M.bovis_AF2122/97 -------------MRIGNCSGFYGDRLSAMREMLTGGE----LDYLTGDY
Rv0976c|M.tuberculosis_H37Rv -------------MRIGNCSGFYGDRLSAMREMLTGGE----LDYLTGDY
MMAR_4531|M.marinum_M MASRSDASG---AVRIANCSGFYGDRLSAMREMLTGGE----VDYLTGDY
MUL_4703|M.ulcerans_Agy99 MASRSDASG---AVRIANCSGFYGDRLSAMREMLTGGE----VDYLTGDY
MAV_1092|M.avium_104 MASRPGPPGDPGAVRIANCSGFYGDRLSAMREMLTGGE----VDYLTGDY
Mvan_0342|M.vanbaalenii_PYR-1 MSTRP--------VRIGNASGFYGDRLTAMRSLIDGGD----IDVITGDY
MSMEG_0337|M.smegmatis_MC2_155 -MSRA--------VRIGNVSGFYGDRHSAMRDLVATAD----VDVITGDY
Mflv_4598|M.gilvum_PYR-GCK -MRDP--------VRIGNCSGFYGDRIAAAREMVEGGTGEQSIDVLCGDY
MAB_2060|M.abscessus_ATCC_1997 -MSVP--------VRIGNCSGFYGDRIAAAREMVEGGP----IDVLCGDY
:**.* ******* :* *.:: . :* : ***
Mb1001c|M.bovis_AF2122/97 LAELTMLILGRDRMKNPDRGYAKTFLAQLEDCLGLAHDRGVRIVTNAGGL
Rv0976c|M.tuberculosis_H37Rv LAELTMLILGRDRMKNPDRGYAKTFLAQLEDCLGLAHDRGVRIVTNAGGL
MMAR_4531|M.marinum_M LAELTMLILGRDRMKNPERGYAKTFLAQLEDCLGLAHERGVRIVANAGGL
MUL_4703|M.ulcerans_Agy99 LAELTMLILGRDRMKNPERGYAKTFLAQLEDCLGLAHDRGVRIVANAGGL
MAV_1092|M.avium_104 LAELTMLILGRDRMKHPERGYAKTFLTQLEDCLGEARDRGVRIVANAGGL
Mvan_0342|M.vanbaalenii_PYR-1 LAELTMLILWKARQKDPETGYARTFLTQFADVVTDCADRGIKIVVNAGGL
MSMEG_0337|M.smegmatis_MC2_155 LAELTMLILWKSRKKNPETGYAHTFLTQFREVAAECARRGIKVVVNAGGL
Mflv_4598|M.gilvum_PYR-GCK LAELTMLILAKAQAKDPAGGYARTFLTQMEQVLGTCSDRGIKIVANAGGL
MAB_2060|M.abscessus_ATCC_1997 LAELTMLILAKAQAKDPSGGYARTFLTQMEQVLGTCLDHGIKVVANAGGL
********* : : *.* ***:***:*: : . :*:::*.*****
Mb1001c|M.bovis_AF2122/97 NPAGLANAVRALAARLGIPAQVAHVEGDDLQPRA--------------AE
Rv0976c|M.tuberculosis_H37Rv NPAGLANAVRALAARLGIPAQVAHVEGDDLQPRA--------------AE
MMAR_4531|M.marinum_M NPAGLADAIRALTERLGIGARIAHVEGDDLAPRA--------------AE
MUL_4703|M.ulcerans_Agy99 NPAGLADAIRALAECLGIGARIAHVEGDDLAPRA--------------AE
MAV_1092|M.avium_104 NPAGLADAIRDLAARLRLDVRVAHVEGDDLLARA--------------AE
Mvan_0342|M.vanbaalenii_PYR-1 NPAGMAGQVRRIAAAAGVDMKVAHVEGDDLMPNLRFLQDSGIAFEHLDTG
MSMEG_0337|M.smegmatis_MC2_155 NPAGMAGRVRELLAELGVDLTVAHVEGDDLMPRLPQLLERGHEFANIDTG
Mflv_4598|M.gilvum_PYR-GCK NPAGLAVRLRELADRLGITVRIAHIEGDDLRGNL--------------SA
MAB_2060|M.abscessus_ATCC_1997 NPAGLAAALRELSARLGLTARVAHVEGDDLRGDL--------------HA
****:* :* : : :**:*****
Mb1001c|M.bovis_AF2122/97 LGLG----TPLTANAYLGAWGIVDCFERGADVVVTGRVTDASVVVGAAAA
Rv0976c|M.tuberculosis_H37Rv LGLG----TPLTANAYLGAWGIVDCFERGADVVVTGRVTDASVVVGAAAA
MMAR_4531|M.marinum_M LGLG----TPLTANAYLGAWGIVDCLNSGADVVVTGRVTDASVIVGSAAA
MUL_4703|M.ulcerans_Agy99 LGLG----TSLTANAYLGAWGIVDCLNSGADVVVTGRVTDASVIVGSAAA
MAV_1092|M.avium_104 LGLG----SPLTANAYLGAWGIVDCLGDGANVVVTGRVTDASVIVGAAAA
Mvan_0342|M.vanbaalenii_PYR-1 IPLADSDRSPISANAYLGGWGIAAALRGGADVVITGRVTDAALVVGVGAW
MSMEG_0337|M.smegmatis_MC2_155 IPLRDKDVEPVSANAYLGGWGIASALARGADVVVTGRVTDAALVVGAGAW
Mflv_4598|M.gilvum_PYR-GCK ITPAVGEVKPVSANAYLGGWGIAEALGAGADVVVTGRVTDASLVVGPAAW
MAB_2060|M.abscessus_ATCC_1997 ITPPVGDIKPVSANAYLGAWGITEALRSGADVVVTGRVTDASLVVGPAAW
: .::******.***. .: **:**:*******:::** .*
Mb1001c|M.bovis_AF2122/97 HFGWGRTDYHRLAGAVVAGHVIECGVQATGGNYAFFTEIGDLTHAGFPLA
Rv0976c|M.tuberculosis_H37Rv HFGWGRTDYHRLAGAVVAGHVIECGVQATGGNYAFFTEIGDLTHAGFPLA
MMAR_4531|M.marinum_M HFGWGRTDYNQLAGAVVAGHVIECGVQATGGNYAFFTEVPDLTYAGFPLA
MUL_4703|M.ulcerans_Agy99 HFGWGRTDYNQLAGAVVAGHVIECGVQATGGNYAFFTEVPDLTYAGFPLA
MAV_1092|M.avium_104 HFGWERSDYDRLAGAVVAGHVIECGVQATGGNYSFFTEVPDLTHAGFPLA
Mvan_0342|M.vanbaalenii_PYR-1 WHNWQPTDYDALAGAVAAGHIIECGPQATGGNYSQLDEITDRRYPGSPIA
MSMEG_0337|M.smegmatis_MC2_155 WHGWSRDDYDALAGAVAAGHIIECGPQATGGNYSQIHEVTDRRYPGSPIA
Mflv_4598|M.gilvum_PYR-GCK WHGWERTDWDRLAGAVVAGHVIECGPQATGGNYAFLDEITDRRYPGFPIA
MAB_2060|M.abscessus_ATCC_1997 WHAWAPADWDRLAGAVVAGHVIECGPQATGGNYAFLDEITDRRYPGFPIA
. * *:. *****.***:**** *******: : *: * :.* *:*
Mb1001c|M.bovis_AF2122/97 EIAADGSSVITKHHGTGGLVSVDTITAQLLYEITGARYANPDVTARMDSV
Rv0976c|M.tuberculosis_H37Rv EIAADGSSVITKHHGTGGLVSVDTITAQLLYEITGARYANPDVTARMDSV
MMAR_4531|M.marinum_M EVSADGTSVITKHPGTGGLVSPDTVTAQLLYEISGARYANPDVTARMDTI
MUL_4703|M.ulcerans_Agy99 EVSADGTSVITKHPGTGGLVSPDTVTAQLLYEISGARYANPDVTARMDTI
MAV_1092|M.avium_104 EVHADGSSVITKHPGTGGLVSVDTVTAQLLYEITGARYANPDVTARMDTV
Mvan_0342|M.vanbaalenii_PYR-1 ELASDGGFAITKHPGTGGLLSVGTVTAQLLYEVASPAYANPDVVAHFDTM
MSMEG_0337|M.smegmatis_MC2_155 ELEHDGSFVITKPTDSGGVVTPGTVTAQLLYEVGAPAYVNPDVVAHFDTC
Mflv_4598|M.gilvum_PYR-GCK EVAADGSSVITKHADTGGLVSVGTVTAQLLYEIAEPAYLGPDVVTHFDTI
MAB_2060|M.abscessus_ATCC_1997 EVAEDGSSVITKHPGTGGLVSVGTVTAQLLYETAEPAYLGPDVVAHFDTI
*: ** .*** .:**::: .*:******* . * .***.:::*:
Mb1001c|M.bovis_AF2122/97 ELSPDGPDRVRISGVIGEPPPPTYKVSLNSIGGFRNAMTFVLTGLDIDAK
Rv0976c|M.tuberculosis_H37Rv ELSPDGPDRVRISGVIGEPPPPTYKVSLNSIGGFRNAMTFVLTGLDIDAK
MMAR_4531|M.marinum_M QLSSDGPDRVRISGVIGEAPPPTLKVSLNSIGGFRNAMTFVLTGLNIEAK
MUL_4703|M.ulcerans_Agy99 QLSSDGPDRVRIGGVIGEAPPQTLKVSLNSIGGFRNAMTFVLTGLNIEAK
MAV_1092|M.avium_104 ELSSDGPDRVRISGVRGEPPPPTYKVSLNSIGGFRNSMTFVLTGLDIEAK
Mvan_0342|M.vanbaalenii_PYR-1 AVTQDGPDRVLVTGTVGSPPPPTLKVAMNAIGGYRNTMTMVLTGLNIEDK
MSMEG_0337|M.smegmatis_MC2_155 SITQAGENRVRVSGTVGTPPPPTLKVAMNYIGGFRNTMTMALTGLDIEEK
Mflv_4598|M.gilvum_PYR-GCK SLAQQAEHRVAITGVTGSPPPETLKVALNEVGGYRNTMTMVLTGLDLEAK
MAB_2060|M.abscessus_ATCC_1997 RLAQQGEHRVAISGTKGSPPPDTLKVALNEVGGFRNTMTMVLTGLDIGAK
:: . .** : *. * .** * **::* :**:**:**:.****:: *
Mb1001c|M.bovis_AF2122/97 ADLVRRQLEAALTVKP--AELQWTLARTDHPDADTEETASALLTCVARDP
Rv0976c|M.tuberculosis_H37Rv ADLVRRQLEAALTVKP--AELQWTLARTDHPDADTEETASALLTCVARDP
MMAR_4531|M.marinum_M AELVQRQLEATLTVKP--AELEWTLARTDHVDADTEEAASALLHCVVRDP
MUL_4703|M.ulcerans_Agy99 AELVQRQLEATLTVKP--AELEWTLARTDHVDADTEEAASALLHCVVRDP
MAV_1092|M.avium_104 AELVRRQLQSALAVKP--AELQWSLARTDHLDADTEEAASALLHCVVRDP
Mvan_0342|M.vanbaalenii_PYR-1 AAWAADELFEILGGKDTFDDVDVQLLRYDRPDPTSLPEATAHLRITVKDR
MSMEG_0337|M.smegmatis_MC2_155 AKWAVEELMTILGGQERFDHVDIQLLRYDTPDPVSMEQATAHLRVTVKDR
Mflv_4598|M.gilvum_PYR-GCK AAFAQQQLFDILGGRGSFAEVDVRFLRFDTPDAPTNDQACAHLRITVKDT
MAB_2060|M.abscessus_ATCC_1997 AAFAEQQLFDVLGGRDAFDEVDVRLLRFDVSDAPTNEQACAHLRVTVKDA
* . :* * : .:: : * * *. : * * * ..:*
Mb1001c|M.bovis_AF2122/97 DPANVGRQFSSAAVELALASYPGFTATAPPGDGQVYGVFTPGYVDAGKVA
Rv0976c|M.tuberculosis_H37Rv DPANVGRQFSSAAVELALASYPGFTATAPPGDGQVYGVFTPGYVDAGKVA
MMAR_4531|M.marinum_M DPANVGRKFSSAAVELALASYPGFTSTAPPGDGQVYGVFVPGYVDAKLVP
MUL_4703|M.ulcerans_Agy99 DPANVGRKFSSAAVELALASYPGFTSTAPPGDGQVYGVFVPGYVDAKLVP
MAV_1092|M.avium_104 DPANVGRQFSSAAVELALASYPGFHVTAPPGDGQVYGVFTAGYVDADKVP
Mvan_0342|M.vanbaalenii_PYR-1 ELAKVDRAFSNAVVELAVAGYPGFHTTTPPGSASEFGVYWPTLVPATTVE
MSMEG_0337|M.smegmatis_MC2_155 DRAKVDRAFSNAVIELYVAGYAGFYTTTPPSSASEFGVYWPTLIPASEVA
Mflv_4598|M.gilvum_PYR-GCK DPRKVGRAFSSAIMEIALAGYAGFHTTTPPTSESVFGVYRPATVPRSSVT
MAB_2060|M.abscessus_ATCC_1997 DPRKVGRAFSGGVMEIALAGFAGFHTTTPPSSETAFGVYRPAYVARSALT
: :*.* **.. :*: :*.:.** *:** . :**: . : :
Mb1001c|M.bovis_AF2122/97 HIAVHADGTRTEIPCATETLELAPAHPPALP-DPLPAGPTRRVPLGLIAG
Rv0976c|M.tuberculosis_H37Rv HIAVHADGTRTEIPCATETLELAPAHPPALP-DPLPAGPTRRVPLGLIAG
MMAR_4531|M.marinum_M HIAVHADGTRTDIPCATETLELESVDPPALP-DPLPTGPTRRVPLGLIAG
MUL_4703|M.ulcerans_Agy99 HIAVHADGTRTYIPCATETLELESVDPPALP-DPLPTGPTRRVPLGLIAG
MAV_1092|M.avium_104 HIAVHADGTRVDIPCATDTLELAPVDDPALP-EPLPDGPVRRAPLGTIAG
Mvan_0342|M.vanbaalenii_PYR-1 HTVMHADGTREVIPHPVRTEPAGPEPTVDTICAPVDFGRTLRRPLGNVVA
MSMEG_0337|M.smegmatis_MC2_155 HTVVHADGTRELIEHSTETAGLTAAQAPESP-APRDFGTTSRRPLGTIVA
Mflv_4598|M.gilvum_PYR-GCK QVVVLPNGERRRIADPP-TGSVPAAKVRGSAAAAPPTEPTCRAPLGAVLG
MAB_2060|M.abscessus_ATCC_1997 HVLVDADGTRHEIPDPP-TGAVPPARIAALAKLPVPSGPTRRAPLGSVLG
: : .:* * * . * . . . * *** : .
Mb1001c|M.bovis_AF2122/97 ARSGDKGGSANVGVWVRTDEQWRWLAHTLTVELLKELL-PETAGLVVTRH
Rv0976c|M.tuberculosis_H37Rv ARSGDKGGSANVGVWVRTDEQWRWLAHTLTVELLKELL-PETAGLVVTRH
MMAR_4531|M.marinum_M ARSGDKGGSANVGLWVRTDEQWRWLANTLTVELLKELL-PEAADLQVTRY
MUL_4703|M.ulcerans_Agy99 ARSGDKGGSANVGLWVRTDEQWRWLANTLTVELLKELL-PEAANLQVTRY
MAV_1092|M.avium_104 ARSGDKGGSANVGVWVRTDEQWRWLAHTLTVERLTELL-PEAAEFAVTRH
Mvan_0342|M.vanbaalenii_PYR-1 ARSGDKGGNANVGVWTDTPERWDWLHAHLSVGRLRELI-PEAGGLPIRRY
MSMEG_0337|M.smegmatis_MC2_155 ARSGDKGGNANVGVWTDTDERWEWLRSHLTEQRFAELV-PECRGLTIRRF
Mflv_4598|M.gilvum_PYR-GCK ARSGDKGGNANIGLWARDDAGYAWVREHLTVERLRGLLGPEAAQLRIERF
MAB_2060|M.abscessus_ATCC_1997 ARSGDKGGNANLGLWARDDPGYAWARDYLSVERLRTLLGPETAHLPMERF
********.**:*:*. : * *: : *: ** : : *.
Mb1001c|M.bovis_AF2122/97 VLPNLRALNFVIEAILGQGVAYQARFDPQAKGLGEWLRSRHVEIPETLL-
Rv0976c|M.tuberculosis_H37Rv VLPNLRALNFVIEAILGQGVAYQARFDPQAKGLGEWLRSRHVEIPETLL-
MMAR_4531|M.marinum_M ALPNLRALNFVIEGILGQGVAYQARFDPQAKGLGEWLRSRHLDIPESLL-
MUL_4703|M.ulcerans_Agy99 ALPNLRALNFVIEGILGQGVAYQARFDPQAKGLGEWLRSRHLDIPESLL-
MAV_1092|M.avium_104 LLPNLRAVNFVIDGILGQGVAYQARFDPQAKGLGEWLRGRYLDIPESLL-
Mvan_0342|M.vanbaalenii_PYR-1 AFPNLKALNFVIVGYLGEGVASCTRTDPQAKGLGEYLRALHTDIPERFVK
MSMEG_0337|M.smegmatis_MC2_155 EFPNLKALNFVVAGFLGDGVASCTRPDAQAKSFGEYLRAVHTDVPDALI-
Mflv_4598|M.gilvum_PYR-GCK ELPNLRALNVVVHGLLGEGVASSTRPDAQAKGLCEYLRSRIVDIPQSLVG
MAB_2060|M.abscessus_ATCC_1997 ELPNLRALNVVVHGLLGDGVASSTRLDAQAKGLGEYVRSRMVDIPQSLLD
:***:*:*.*: . **:*** :* *.***.: *::*. ::*: ::
Mb1001c|M.bovis_AF2122/97 --
Rv0976c|M.tuberculosis_H37Rv --
MMAR_4531|M.marinum_M --
MUL_4703|M.ulcerans_Agy99 --
MAV_1092|M.avium_104 --
Mvan_0342|M.vanbaalenii_PYR-1 --
MSMEG_0337|M.smegmatis_MC2_155 --
Mflv_4598|M.gilvum_PYR-GCK AT
MAB_2060|M.abscessus_ATCC_1997 TH