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TTTDAPGAIAAGPAVMQTPKVSICIPAHQAAAYLQPLLDSVLSQAYDDFEVVVIDNHSTDGTSDILARVD DPRVRVMRNPATLPFVENWNLLVSQSRGEFVKLVCADDLLKPGCLAVQASVLDNNPDVALVSVKCDFIDD NERLIVPARGLDGIEGQVTAEGVVRRIVRNGGNPIGAPVAGMFRRADFDRVGGFTADFPFLSDIHLWVRL LGCGDFYGIPATHASFRIRGGSMSGLTSARTQLAQSLDFEKSLARDPRWDLSQIDLFRGWMRCHEQTLRR MALFGLTKWRVARRDRGPVRAGPRAGTDLPSTVVADTLTVVICAYTTQRWDELCPAVESVLNQDFPVLGV VVVIDHCPELYRLARDRFGARGRVTVLESDGERGLSGARNTGVGAARGDVVAFLDDDAVAEPGWAHALMR HYRDPRVAAVGGYAAPVWPTGARPHWMPAEFDWVVGCSYTGQPTELAEVRNPLGCNMSIRRSVFDDIGGF RSEVGRVGNHPVGGEETELCLRIRGRQPDARVLYDPDAVVRHHVSCDRTTIRYFRRRCYHEGISKAVVTE IAGVGNPLLAERAYTTRTLPRGVLRELTAPRQGGFRRAGVMAFGLAATTAGYLRAKTQYRLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0211 | - | - | 100% (623) | glycosyl transferase family protein |
| M. vanbaalenii PYR-1 | Mvan_2677 | - | 5e-60 | 43.14% (299) | glycosyl transferase family protein |
| M. vanbaalenii PYR-1 | Mvan_2680 | - | 2e-13 | 29.55% (247) | glycosyl transferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1545 | - | 2e-18 | 30.84% (214) | hypothetical protein Mb1545 |
| M. gilvum PYR-GCK | Mflv_5057 | - | 3e-13 | 29.15% (223) | glycosyl transferase family protein |
| M. tuberculosis H37Rv | Rv1518 | - | 2e-18 | 30.84% (214) | hypothetical protein Rv1518 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3831c | - | 7e-12 | 28.71% (202) | putative glycosyltransferase |
| M. marinum M | MMAR_1024 | - | 4e-12 | 30.00% (210) | membrane glycosyl transferase |
| M. avium 104 | MAV_4475 | - | 3e-11 | 29.29% (198) | membrane sugar transferase |
| M. smegmatis MC2 155 | MSMEG_1426 | - | 1e-12 | 28.25% (223) | membrane sugar transferase |
| M. thermoresistible (build 8) | TH_1903 | - | 7e-13 | 30.52% (213) | PROBABLE MEMBRANE SUGAR TRANSFERASE |
| M. ulcerans Agy99 | MUL_0776 | - | 4e-12 | 29.52% (210) | membrane glycosyl transferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5057|M.gilvum_PYR-GCK ----------------------------------------MTGPRLPDGF
MSMEG_1426|M.smegmatis_MC2_155 ----------------------------------------MTGPRLPDGF
TH_1903|M.thermoresistible__bu ----------------------------------------MTGQRLPDGF
MMAR_1024|M.marinum_M ----------------------------------------MTQPRLPDGF
MUL_0776|M.ulcerans_Agy99 ----------------------------------------MTQPRLPDGF
MAV_4475|M.avium_104 --------------------------------------MTAPAPRLPDGF
MAB_3831c|M.abscessus_ATCC_199 ----------------------------MTTSDEQAQHAAPSQERLPDGF
Mb1545|M.bovis_AF2122/97 --------------------------------------------------
Rv1518|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_0211|M.vanbaalenii_PYR-1 MTTTDAPGAIAAGPAVMQTPKVSICIPAHQAAAYLQPLLDSVLSQAYDDF
Mflv_5057|M.gilvum_PYR-GCK AVQVDRRVRVLGEGAALLGGSPTRLLRLAPAAQTMLHGGRLEVHDAVSAQ
MSMEG_1426|M.smegmatis_MC2_155 AVQVDRRVKVLGEGAALLGGSPTRLLRLAPTAQNMLSGGRLEVHDAVSAQ
TH_1903|M.thermoresistible__bu AVQVDRRVKVLGEGAALLGGSPTRLLKLAPAARTMLAGGRLEVRDAVSAQ
MMAR_1024|M.marinum_M AVQVDRRVRVLGGGSALLGGSPTRLLRLAPAAQDMLCDGRLKVRDDISAE
MUL_0776|M.ulcerans_Agy99 AVQVDRRVRVLGGGSALLGGSPTRLLRLAPAAQDMLCDGRLKVRDDISAE
MAV_4475|M.avium_104 AVQVDRRVRVLGDGSALLGGSPTRLLKLAPAAQDLLCDGRLKVRDDVSAQ
MAB_3831c|M.abscessus_ATCC_199 AVQVDRRVRVLDEGSALLGGSPTRLLRLAPAARTLLSGGRLEVRDATSAQ
Mb1545|M.bovis_AF2122/97 --------MVPGDASSVVSVNPAKPL------------------------
Rv1518|M.tuberculosis_H37Rv --------MVPGDASSVVSVNPAKPL------------------------
Mvan_0211|M.vanbaalenii_PYR-1 EVVVIDNHSTDGTSDILARVDDPRVRVMRNPATLPFVENWNLLVSQSRGE
. . . : . .:
Mflv_5057|M.gilvum_PYR-GCK LARTLLDATVAHP-----RPLSGPSHRDVTVVIPVHNNATGLTRLVAALR
MSMEG_1426|M.smegmatis_MC2_155 LARTLLDATVAHP-----RPASGPSHLDVTVVVPVRDNASGLHRLMAALR
TH_1903|M.thermoresistible__bu LARTLLDATVAHP-----RPASGPSHRDVTVVIPVRDNAFGLHRLMRALR
MMAR_1024|M.marinum_M LARTLLDATVAHP-----RPASGPSHRDVTVVIPVRDNASGVRRLVASLR
MUL_0776|M.ulcerans_Agy99 LARTLLDATVAHP-----RPASGPSHRDVTVVISVRDNASGVRRLVASLR
MAV_4475|M.avium_104 LARTLLDATVAHP-----RPAGGPSHHDVTVVIPVRDNLSGVRRLVSSLR
MAB_3831c|M.abscessus_ATCC_199 LARTLLDATVAHP-----RPVGGPGYRDVTVVIPCRDNGFGLRRLLRALR
Mb1545|M.bovis_AF2122/97 ----------------------------ISVCIPMYNNGATIERCLRSIL
Rv1518|M.tuberculosis_H37Rv ----------------------------ISVCIPMYNNGATIERCLRSIL
Mvan_0211|M.vanbaalenii_PYR-1 FVKLVCADDLLKPGCLAVQASVLDNNPDVALVSVKCDFIDDNERLIVPAR
::: : * : .
Mflv_5057|M.gilvum_PYR-GCK G-------------LKVVIVDDGSSRPVNEA-------------------
MSMEG_1426|M.smegmatis_MC2_155 G-------------LRVIVVDDGSAIPVQPS-------------------
TH_1903|M.thermoresistible__bu G-------------LRVIIVDDGSAVPVDAA-------------------
MMAR_1024|M.marinum_M G-------------LRVIVVDDGSSSPVELE-------------------
MUL_0776|M.ulcerans_Agy99 G-------------LRVIVVDDGSSSPVELE-------------------
MAV_4475|M.avium_104 G-------------LRVVVVDDGSFPPIEPE-------------------
MAB_3831c|M.abscessus_ATCC_199 G-------------MRVIVVDDGSTIPIVES-------------------
Mb1545|M.bovis_AF2122/97 EQEGVE--------FEIVVVDDDSSDDCAAI-------------------
Rv1518|M.tuberculosis_H37Rv EQEGVE--------FEIVVVDDDSSDDCAAI-------------------
Mvan_0211|M.vanbaalenii_PYR-1 GLDGIEGQVTAEGVVRRIVRNGGNPIGAPVAGMFRRADFDRVGGFTADFP
.. :: :...
Mflv_5057|M.gilvum_PYR-GCK DFASAACDIRVLRHSRRKGPSAARN---------AGLAVCATDFVAFLDS
MSMEG_1426|M.smegmatis_MC2_155 DFSGMHCDVQVLRHTRSNGPAAARN---------TGLASCETDFVAFLDS
TH_1903|M.thermoresistible__bu EFTGLHCDVQVLRHPHSKGPAAARN---------TGLAACTTDFVAFLDS
MMAR_1024|M.marinum_M DFAGAHCDVEVLHHRRSKGPAAARN---------TGLAACTTEFVAFLDS
MUL_0776|M.ulcerans_Agy99 DFAGAHCDIEVLHHRRSKGPAAARN---------TGLAACTTEFVAFLDS
MAV_4475|M.avium_104 DFVGAHCDIEVLRHHRSKGPAAARN---------TGLAACRTDFVAFLDS
MAB_3831c|M.abscessus_ATCC_199 DLEGMHCHVEVVRHADSQGPAAARN---------TGLKLATTDFVAFLDS
Mb1545|M.bovis_AF2122/97 AATMLRPGDRLLRNEPRLGLNRNHN---------KCLEVARGGLIQFVHG
Rv1518|M.tuberculosis_H37Rv AATMLRPGDRLLRNEPRLGLNRNHN---------KCLEVARGGLIQFVHG
Mvan_0211|M.vanbaalenii_PYR-1 FLSDIHLWVRLLGCGDFYGIPATHASFRIRGGSMSGLTSARTQLAQSLDF
.:: * : * . : :.
Mflv_5057|M.gilvum_PYR-GCK DVVPRKG--WLEALLGHFCDPAVALVAPR-------IVAHEPSDNVVARY
MSMEG_1426|M.smegmatis_MC2_155 DVVPKRG--WLEALLGHFCDPAVALVAPR-------IVGLHNADNIVARY
TH_1903|M.thermoresistible__bu DVVPQRG--WLEALLGHFCDPAVALVAPR-------IVGLRKDDNLIARY
MMAR_1024|M.marinum_M DVAPRRG--WLEALLGHFCDPTVALVAPR-------IVGLAPSENLVARY
MUL_0776|M.ulcerans_Agy99 DVAPRRG--WLEALLGHFCDPTVALVAPR-------IVGLAPSENLVARY
MAV_4475|M.avium_104 DVAPRRG--WLEALLGHFCDPTVGLVAPR-------IVGLSHSENVVARY
MAB_3831c|M.abscessus_ATCC_199 DVVPRRG--WLEALLGHFSDPAVALVAPR-------IVGLVLSDNAIARY
Mb1545|M.bovis_AF2122/97 DDRLLPG--ALQTLSRRFEDPSVGMAFAPRRVESDDIKWQQRYGRVHTRF
Rv1518|M.tuberculosis_H37Rv DDRLLPG--ALQTLSRRFEDPSVGMAFAPRRVESDDIKWQQRYGRVHTRF
Mvan_0211|M.vanbaalenii_PYR-1 EKSLARDPRWDLSQIDLFRGWMRCHEQTLRR---MALFGLTKWRVARRDR
: . : * . . :
Mflv_5057|M.gilvum_PYR-GCK EAVRSSLDLGLREAPVIPFGTVS--YVPSAAIICRRSAILEIGGFDETLV
MSMEG_1426|M.smegmatis_MC2_155 ESVRSSLDLGVREAPVVPHGTVS--YVPSAAIICRRSALVEVGGFDETMH
TH_1903|M.thermoresistible__bu EAVRSSLDLGVREAPVVPYGPVS--YVPSAAIICRRKVLDEIGGFDEALR
MMAR_1024|M.marinum_M EAVRSSLDLGQREAPILPHSPVS--YVPSAAIICRCSAIRQVGGFDETMH
MUL_0776|M.ulcerans_Agy99 EAVRSSLDLGQREAPILPHSPVS--YVPSAAIICRCSAIRQVGGFDETMH
MAV_4475|M.avium_104 EAVHSSLDLGEREAPVLPHSTVS--YVPSAAIICRCSAIREIGGFDETLQ
MAB_3831c|M.abscessus_ATCC_199 EAVRSSLDLGLREAPVVPYGPVS--YVPSAAIVVRRSAINEIGGFDEALQ
Mb1545|M.bovis_AF2122/97 RKLRDRNHGPSLVLQMVLHGAKENWIGEPTAVMFRRQLALDAGGFRTDIY
Rv1518|M.tuberculosis_H37Rv RKLRDRNHGPSLVLQMVLHGAKENWIGEPTAVMFRRQLALDAGGFRTDIY
Mvan_0211|M.vanbaalenii_PYR-1 GPVRAGPRAGTDLPSTVVADTLTVVICAYTTQRWDELCPAVESVLNQDFP
:: : .. :: . : :
Mflv_5057|M.gilvum_PYR-GCK SG---EDVDLCWRLNE-SGARLRYEPIAMVG----------------HDH
MSMEG_1426|M.smegmatis_MC2_155 SG---EDVDLCWRLVE-SGARLRYEPIALVA----------------HDH
TH_1903|M.thermoresistible__bu SG---EDVDLCWRLVE-AGTRLRYEPIALVA----------------HDH
MMAR_1024|M.marinum_M SG---EDVDLCWRLIE-SGARLRYEPIALVG----------------HEH
MUL_0776|M.ulcerans_Agy99 SG---EDVDLCWRLIE-SGARLRYEPIALVG----------------HEH
MAV_4475|M.avium_104 SG---EDVDLCWRLIE-AGVRLRYEPIALVG----------------HDH
MAB_3831c|M.abscessus_ATCC_199 CG---EDVDLCWRLIE-AGSRLRYEPVSHVA----------------HDH
Mb1545|M.bovis_AF2122/97 QL---VDVDFWLRLMLRSAVCFVPHELSVRR----------------HTA
Rv1518|M.tuberculosis_H37Rv QL---VDVDFWLRLMLRSAVCFVPHELSVRR----------------HTA
Mvan_0211|M.vanbaalenii_PYR-1 VLGVVVVIDHCPELYRLARDRFGARGRVTVLESDGERGLSGARNTGVGAA
:* .* : : .
Mflv_5057|M.gilvum_PYR-GCK RTELRKWFARKSFYGGSAAPLTIRHPGKTAPLVISGWMLVVWMLVAVGSG
MSMEG_1426|M.smegmatis_MC2_155 RTNLRAWFHRKAFYGTSAAPLTVRHPGKTSPLVISGWTLMVWLMLGVGSF
TH_1903|M.thermoresistible__bu RTDIGEWLGRKAFYGSSAAPLTARHPDKTAPLLMSGWTLVLGVLVAMGSW
MMAR_1024|M.marinum_M RTQLRAWIARKAFYGGSAAPLSVRHPDKTAPLVISGWALTAWVLMSLGTR
MUL_0776|M.ulcerans_Agy99 RTQLRAWIARKAFYGGSAAPLSVRHPDKTAPLVISGWALTAWVLLSLGTR
MAV_4475|M.avium_104 RTELRDWLARKAFYGGSAAPLSVRHPDKTAPVVISGWALMTWILMAFGST
MAB_3831c|M.abscessus_ATCC_199 RLTLREWFARKAFYGKSAAPLSTRHPDKVAPMVISRWTLLVWILAAVGSG
Mb1545|M.bovis_AF2122/97 ATETTRVMATRRNVLDRQRILTWLIVDPLSPNRVRSAAALWWIP------
Rv1518|M.tuberculosis_H37Rv ATETTRVMATRRNVLDRQRILTWLIVDPLSPNSVRSAAALWWIP------
Mvan_0211|M.vanbaalenii_PYR-1 RGDVVAFLDDDAVAEPGWAHALMRHYRDPRVAAVGGYAAPVWPTGARPHW
: :
Mflv_5057|M.gilvum_PYR-GCK IGYAASVAVAAVTGRR-----------------IAKSLSTVQTEPMEVAV
MSMEG_1426|M.smegmatis_MC2_155 FGYLASLAAAVFAGTR-----------------IARALSVVETEPKEVAV
TH_1903|M.thermoresistible__bu VGYLAALVLAVITGRR-----------------VAKSLSTVGSEPVEVVA
MMAR_1024|M.marinum_M ATQLASLIIAVLTGRR-----------------IATALRSAQTSSWDVVV
MUL_0776|M.ulcerans_Agy99 ATQLASLIIAVLTGRR-----------------IATALRSAQTSSWDVVV
MAV_4475|M.avium_104 LSRLASLLLAVLTGRR-----------------IARAMRSAETSMTDVVT
MAB_3831c|M.abscessus_ATCC_199 MGYLAAVGMAALAAGR-----------------VARTLRGVDTPPRDVVR
Mb1545|M.bovis_AF2122/97 -AWLAMIVEVAVLGPQ-----------------RRTHLKALAPAPFREFA
Rv1518|M.tuberculosis_H37Rv -AWLAMIVEVAVLGPQ-----------------RRTHLKALAPAPFREFA
Mvan_0211|M.vanbaalenii_PYR-1 MPAEFDWVVGCSYTGQPTELAEVRNPLGCNMSIRRSVFDDIGGFRSEVGR
: :
Mflv_5057|M.gilvum_PYR-GCK VAAHGLWSAALQLAS----------------ALCRHYWPIALVASVLSKR
MSMEG_1426|M.smegmatis_MC2_155 VAAHGLWSSALQLCS----------------AICRHYWPIAMIAAVLFRR
TH_1903|M.thermoresistible__bu LAAQGLGSAARQLAG----------------AICRHYWPIALIAALLSPR
MMAR_1024|M.marinum_M VAARGLWSAALQLAS----------------AICRHYWPVTLIAVIVSRH
MUL_0776|M.ulcerans_Agy99 VAARGLWSAALQLAS----------------AICRHYWPVTLIAVIVSRH
MAV_4475|M.avium_104 VAGRGLWSAALQLAS----------------ALCRHYWPLALLAATMSRH
MAB_3831c|M.abscessus_ATCC_199 VAAQGVGGAALQIAS----------------ALCRHYWPLALFAAALSRR
Mb1545|M.bovis_AF2122/97 HARRQLPLAD----------------------------------------
Rv1518|M.tuberculosis_H37Rv HARRQLPMAD----------------------------------------
Mvan_0211|M.vanbaalenii_PYR-1 VGNHPVGGEETELCLRIRGRQPDARVLYDPDAVVRHHVSCDRTTIRYFRR
. : :
Mflv_5057|M.gilvum_PYR-GCK ----CRRVVVVAAVLDGVFDWVTRNGNADEDTKRVGILTYILLKRLDDIA
MSMEG_1426|M.smegmatis_MC2_155 ----ARHAVLVAAVVDGVVDWVTRRGNADDDTKPVGLLTHIVLKRLDDIA
TH_1903|M.thermoresistible__bu ----FRQVVVVAAVVDGVVDWLSRREHAGEDTKPVGLFAYLVLKRLDDLA
MMAR_1024|M.marinum_M ----CRRVVLVAAVIDGVVDWLRRREDPDGDSEPIGLLTYLLLKRIDDLA
MUL_0776|M.ulcerans_Agy99 ----CRRVVLVAAVIDGVVDWLRRREDPDGDSEPIGLLTYLLLKRIDDLA
MAV_4475|M.avium_104 ----FRRVVLVAAVMDGVVDWLRRRDAVGDDVEPIGLPTYLVLKRVDDLA
MAB_3831c|M.abscessus_ATCC_199 ----SRQVLVVAAIVDGVVDWMKRNDSSASPDDRIGLIEYVLLKRLDDIA
Mb1545|M.bovis_AF2122/97 --------------------------------------------------
Rv1518|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_0211|M.vanbaalenii_PYR-1 RCYHEGISKAVVTEIAGVGNPLLAERAYTTRTLPRGVLRELTAPRQGGFR
Mflv_5057|M.gilvum_PYR-GCK YGLGLWSGVVRERHAGALKPQIRA---
MSMEG_1426|M.smegmatis_MC2_155 YGTGLWTGVVRERHLGALKPQVRS---
TH_1903|M.thermoresistible__bu YGCGLWAGVLRERDLGALKPQIRI---
MMAR_1024|M.marinum_M YGLGLWYGVMRERNAGALKPQIRR---
MUL_0776|M.ulcerans_Agy99 YGLGLWYGVMRERNAGALKPQIRR---
MAV_4475|M.avium_104 YGLGLWWGVLRERNARALRPQIRS---
MAB_3831c|M.abscessus_ATCC_199 YGIGLWSGIVRERDLGALRPELRP---
Mb1545|M.bovis_AF2122/97 ---------------------------
Rv1518|M.tuberculosis_H37Rv ---------------------------
Mvan_0211|M.vanbaalenii_PYR-1 R-AGVMAFGLAATTAGYLRAKTQYRLS