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RDLVRHKPIGAILLGVALLAGCTAERQAEPSPTAPPPASTTPAAPAAGTARVTVEVDADLAGAPFDAPRE AMVPQGWTLSVWARTPRPRLAAWTPDGDLLVSVPSAGRVLRFEPRGDGPPDESVLLDGLDEPHGLAFDGS TLYVAESDQVDAYRYAAGAATEPRTVAGGLPDDRSPDLRGAYAHALKSVAVGPDGAVYFSIGSTGNISAQ DRSADPPRATVMRVPPGGGRAEPFATGVRNGTGLAVAPDGAVWTANNGRDNVAYPEPGPSYGQVIPEYVN DNPPEQIARLTPGRELGWPYCNNVDGPADLPFVRDVQTNPDGALLDCAALPPVEQSMGAHSAPLGLSFVD GELPAPFQRGALVGVHGSWNRQPPRAPEVSFYPWQDGTLGGQQTLVGGFQTDDGTRWGRPVAAVVGPDGA VYITDDAADAIYRLAPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0146 | - | - | 100% (438) | SMP-30/gluconolaconase/LRE-like region |
| M. vanbaalenii PYR-1 | Mvan_4964 | - | 1e-07 | 28.57% (175) | SMP-30/gluconolaconase/LRE domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_0697 | - | 0.0 | 79.82% (441) | SMP-30/gluconolaconase/LRE-like region |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0305 | - | 1e-05 | 27.18% (195) | hypothetical protein MMAR_0305 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_0214 | - | 1e-166 | 68.84% (430) | L-sorbosone dehydrogenase |
| M. thermoresistible (build 8) | TH_2267 | - | 3e-13 | 25.17% (433) | oxidoreductase |
| M. ulcerans Agy99 | MUL_4817 | - | 3e-05 | 26.15% (195) | hypothetical protein MUL_4817 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0146|M.vanbaalenii_PYR-1 ----------------------------MRDLVRHKPIGAILLGVALLAG
Mflv_0697|M.gilvum_PYR-GCK ----------------------------MRESVRHNRIGVLVLGCALLAG
MSMEG_0214|M.smegmatis_MC2_155 ----------------------------MRAWPGIS--AVVVTASVVLAG
MMAR_0305|M.marinum_M MVRAVIPVTRRLQHAGRYPVTRAPNVAEGWTLTRLTAPSRLFGANGLRTG
MUL_4817|M.ulcerans_Agy99 MVRAVIPVTRRLQHAGHYPVTRAPNVAEGWTLTRLTAPSRLFGANGLRTG
TH_2267|M.thermoresistible__bu -------------------------VAVGRIRRTTVRAAVALMCLALLAA
. . : :.
Mvan_0146|M.vanbaalenii_PYR-1 CTAER---QAEPSPTAPPP-ASTTPAAPAAGTARVTVEVDADLAG-----
Mflv_0697|M.gilvum_PYR-GCK CSGEQSSPSSTPTPTAAPSSSSTSTTQPVAGTQTVTVEVAPDLGD-----
MSMEG_0214|M.smegmatis_MC2_155 CGTEPQTTEPTAQPSRSSSQTTAEHPAGAAELTPVTVEVPEGLDD-----
MMAR_0305|M.marinum_M PDGRVYIAQVTGSQISALDLSTGRLDTVCPKGGAIIAPDDLAFDQDGNLY
MUL_4817|M.ulcerans_Agy99 PDGRVYIAQVTGSQISALDLSTGRLDTVCPKGGAIIAPDDLAFDQDGNLY
TH_2267|M.thermoresistible__bu ACDGEAVPAPPAPPEQPPAQTGESGARDVVTDLGVPWGIAFLPDG-----
. : :
Mvan_0146|M.vanbaalenii_PYR-1 --APFDAPREAMVPQGWTLSVWARTPRPRLAAWTPDGDLLVSVPSAGRVL
Mflv_0697|M.gilvum_PYR-GCK --SPFDEPRQAVVPKGWTLSVWARTSRPRLMAWAPDGALLVSVPSTGQVL
MSMEG_0214|M.smegmatis_MC2_155 --APLDQPRQALVPDGWTLEVVARVPKARMAAWAPDGALLVSVPSTGEVL
MMAR_0305|M.marinum_M ATEVMDGRVSVRAPDGHTRVLRDDIPSANGITFHQGRLFVGECRDGGRLL
MUL_4817|M.ulcerans_Agy99 ATEVMDGRVSVRAPDGHTRVLRDDIPSANGITFHQGRLFVGECRDGGRLL
TH_2267|M.thermoresistible__bu -SALIAERDSGMIKQLSEPGVVRDVGAVEGVAARGEGGLLGLATAGDTVF
: . . : . : :: . ::
Mvan_0146|M.vanbaalenii_PYR-1 RFEPRGDGPPDESVLLDGLDEPHGLAFDG------STLYVAESDQVDAYR
Mflv_0697|M.gilvum_PYR-GCK SFRPRGDGPPEESVLLDDLDEPHGLAFDG------PTLYVAQSDQVDGYD
MSMEG_0214|M.smegmatis_MC2_155 KVLP------TQSTLLDGLDQPHGLFFAG------PTLYVAESDQIDAYD
MMAR_0305|M.marinum_M ELDLNGG---APRVLARNLPSPNAMEVGPDGLLYFPVMGANEIWRIDPDG
MUL_4817|M.ulcerans_Agy99 ELDLNGG---APRVLARNLPSPNAMEVGPDGLLYFPVMGANEIWRIDPDG
TH_2267|M.thermoresistible__bu AYHT-----------------------------------TATDNRVVRMD
. ::
Mvan_0146|M.vanbaalenii_PYR-1 YAAGAATEPRTVAGGLPDDRSPDLRGAYAHALKSVAVGP---DGAVYFSI
Mflv_0697|M.gilvum_PYR-GCK YAGGAATNPRVVAGGLPDDRSPDLRGAYSHVLKSVAVGP---DGAVYFSI
MSMEG_0214|M.smegmatis_MC2_155 YADGAAVNRRTVIDGLPDAKSPDLRGAYAHALKSVVVGD---DGAVYFSI
MMAR_0305|M.marinum_M GVPQCVAGDLGVPDAVKFDPHGHLVSTQVHSGEVLRINPRTGDRTVLAAL
MUL_4817|M.ulcerans_Agy99 GVPQCVAGDLRVPDAVKFDPHGHLVSTQVHSGEVLRINPRTGDRTVLAAL
TH_2267|M.thermoresistible__bu FDGQALGPPAPILTGIP-------TGGSRHDGGRIAFGP---DGRLYVAT
. : .: . * : .. * : :
Mvan_0146|M.vanbaalenii_PYR-1 GSTGN---ISAQDRSADPPRATVMRVPPGGGRAEPFATGVRNGTGLAVAP
Mflv_0697|M.gilvum_PYR-GCK GSTGN---ISADDRDATPPRATIMRVPPGGGPAEPFATGVRNGTGLAVAP
MSMEG_0214|M.smegmatis_MC2_155 GSTGN---ISAEDRTADPPRATIMRVPPGGGPAEPFATGVRNGTGLAFAP
MMAR_0305|M.marinum_M HPGLDNLTFVGERLFVSSFTGEITEILGTGETRTTLPGGLTWPLGLAVDA
MUL_4817|M.ulcerans_Agy99 HPGLDNLTFVGERLFVSSFTGEITEILGTGETRTTLPGGLTWPLGLAVAA
TH_2267|M.thermoresistible__bu GEIGD----PPLAQDRSSLAGKILRINPDGSIPADNPD-----------P
: . . : .: * . .
Mvan_0146|M.vanbaalenii_PYR-1 DGAVWTANNGRDNVAYPEPGPSYGQVIPEYVNDNPPEQIARLTPG-----
Mflv_0697|M.gilvum_PYR-GCK DGAVWIANNGRDNIAFPDPEPSYGEVLPDYVDDNPPEQIARLTPG-----
MSMEG_0214|M.smegmatis_MC2_155 DGSLWTAVNNRDNVADPD-----GRVVQSYVDDHPPESVARLTPG-----
MMAR_0305|M.marinum_M DGDLYIADGTYFYVLLADGTLRVGGMLFSAGYPGFLRGVAALGSGEFAVT
MUL_4817|M.ulcerans_Agy99 DGDLYIADGTYFYVLLADGTLRVGGMLFSAGYPGFLRGVAALGSGEFAVT
TH_2267|M.thermoresistible__bu QSPVWSFGHRNVQGLAWDPG---GRLWATEYGADTWDELNLIEPG-----
:. :: : * : : : .*
Mvan_0146|M.vanbaalenii_PYR-1 ---RELG--WPYCNNVDGPAD-LPFVRDVQTNPDGALLDCAALP------
Mflv_0697|M.gilvum_PYR-GCK ---RELG--WPYCNNVGAPAD-LPFVRDVQTNPDGELLDCAALP------
MSMEG_0214|M.smegmatis_MC2_155 ---RELG--WPYCN-PDGPPP-AKLIRDLQTNPDGAEMDCAALP------
MMAR_0305|M.marinum_M TSNGEVARYRPWASESEVVATGLDQLYGVAVAGSGALFVAERGAGRVLSV
MUL_4817|M.ulcerans_Agy99 TSNGEVARYRPWASETEVLATGLDQLYGVAVAGSGALFVAERGAGRVLSV
TH_2267|M.thermoresistible__bu ---GNYG--WPVAEGRQEMPG--------MIDP-----------------
: . * .. .
Mvan_0146|M.vanbaalenii_PYR-1 ---PVEQSMGAHSAPLGLSFVDG----ELPAPFQRGALVGVHGSWNRQPP
Mflv_0697|M.gilvum_PYR-GCK ---PVEQSMGAHSAPLGLSFTDG----VLPEPYASGALVGVHGSWNRQPP
MSMEG_0214|M.smegmatis_MC2_155 ---PIEQTLGAHSAPLGMSFAE------LPQPFGQGALVGVHGSWNRDAP
MMAR_0305|M.marinum_M RPDGVEVMASGLSDPVGVAVTADGRCVVTEADAGRVRTLGDTGTLLDGLQ
MUL_4817|M.ulcerans_Agy99 RPDGVEVMASGLSDPVGVAVTADGRCVVTEADAGRVRTLGDTGTLLDGLQ
TH_2267|M.thermoresistible__bu ----VLQWRPAEASPSGLAFWDG-----------ALWIANLRGQRLLEVP
: . : * *::. . *
Mvan_0146|M.vanbaalenii_PYR-1 RAPEVSFYPWQDGTLGGQQTLVGGFQTDDGTR----WGRPVAAVV-----
Mflv_0697|M.gilvum_PYR-GCK RAPEVSFYPWRDGGLGDQQTLVGGFQADDGSR----WGRPVAATT-----
MSMEG_0214|M.smegmatis_MC2_155 RAPEVSFFAWRDGTLGPQQTLVGGFQDDDGQR----WGRPVAAVT-----
MMAR_0305|M.marinum_M CPQGVAICDRQVYVIDSGAKQLVAVDLGSRTRHTIAWDLPVGAPAGVTPK
MUL_4817|M.ulcerans_Agy99 CPQGVAICDRQVYVIDSGAKQLVAVDLGSRTRHTIAWDLPVGAPAGVTPN
TH_2267|M.thermoresistible__bu VRADGELGEPVSRFVGEYGRLRTVVAAPDGSL----WFTTSNRDG-----
: :. . . * .
Mvan_0146|M.vanbaalenii_PYR-1 --------------------GPDGAVYITDDAADAIYRLAPG-
Mflv_0697|M.gilvum_PYR-GCK --------------------GPDGSVYITDDAADAIYRLTPPA
MSMEG_0214|M.smegmatis_MC2_155 --------------------GPDGAVYITDDFAGAVYRLAPPP
MMAR_0305|M.marinum_M PLRGMPPFSGPQGPFAAITAGPDATLYISADADGSVLALRRES
MUL_4817|M.ulcerans_Agy99 PLRGMPPFSGPEGPFAAITPGPDATLYISADADGSVLALRRES
TH_2267|M.thermoresistible__bu -------------------------RGVPRSGDDRILRYRR--
:. . . :