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TIRVEKNGAVTTVIMDRPQARNAVDGPTALALHAAFDEFDKDDSASVAVLWGDHGTFCAGADLKAMGTAD SNPVHRTGPGPMGPTRMVLSKPVIAAISGYAVAGGLELALWCDLRIVEQDAVLGVFCRRWGVPLIDGGTV RLPRLIGHGRAMDLILTGRAVDADEAKSIGLANRVVPSGAARQEAEDLAAELAALPQQCLRSDRMSALNQ WGKSESDAMDVEFGSLSRVAAESLEGAARFSAGTGRHGAKT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5084 | - | - | 100% (252) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2036 | - | 6e-28 | 37.19% (199) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_1542 | - | 6e-27 | 37.63% (194) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0694 | echA5 | 1e-112 | 77.42% (248) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv0675 | echA5 | 1e-112 | 77.42% (248) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 2e-25 | 35.32% (201) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_3857c | - | 1e-106 | 75.40% (248) | enoyl-CoA hydratase |
| M. marinum M | MMAR_1004 | echA5 | 1e-115 | 79.92% (249) | enoyl-CoA hydratase, EchA5 |
| M. avium 104 | MAV_4497 | - | 1e-116 | 79.84% (248) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_1390 | - | 1e-111 | 77.42% (248) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_2627 | - | 1e-114 | 78.23% (248) | PUTATIVE enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_0756 | echA5 | 1e-114 | 79.12% (249) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_1272 | - | 1e-128 | 88.76% (249) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5084|M.gilvum_PYR-GCK -------------MTIRVEKNGAVTTVIMDRPQARNAVDGPTALALHAAF
Mvan_1272|M.vanbaalenii_PYR-1 MSGTAGRSEATRGESIRVEKSGAVTTVVMDRPQARNAVDGPTAMELHAAF
MSMEG_1390|M.smegmatis_MC2_155 -----------MSEPVRIERNGPVTTVIIDRPEARNAVNGPTAAALFAAF
TH_2627|M.thermoresistible__bu -----------MTKPVRIERDGPVTTVIIDRPEARNAVNGPTAAALYAAF
Mb0694|M.bovis_AF2122/97 -----------MSDLVRVERKGRVTTVILNRPASRNAVNGPTAAALCAAF
Rv0675|M.tuberculosis_H37Rv -----------MSDLVRVERKGRVTTVILNRPASRNAVNGPTAAALCAAF
MMAR_1004|M.marinum_M -----------MSDLVQVERNGPVTTVIINRPQARNAVNGPTAAALYSAF
MUL_0756|M.ulcerans_Agy99 -----------MSDLVQVERNGPVTTVIINRPQARNAVNGPTAAALYSAF
MAV_4497|M.avium_104 -----------MSDPVRIERNGPVTTVIINRPAARNAVNGPTAAALYAAF
MAB_3857c|M.abscessus_ATCC_199 -------MSEEMQPAVRVEKAGPVTTVILNRPHARNAVDGPTAAALLAAF
MLBr_02402|M.leprae_Br4923 ----------MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNEITNAA
: :: * : ::** : **::. : *
Mflv_5084|M.gilvum_PYR-GCK DEFDKDDSASVAVLWGDHGTFCAGADLKAMGTADSNPVHRTGPGPMGPTR
Mvan_1272|M.vanbaalenii_PYR-1 DEFDKDESASVAVLWGDNGTFCAGADLKAMGTENSNPVHRTGPGPMGPSR
MSMEG_1390|M.smegmatis_MC2_155 EEFDADDTASVAVLTGANGTFCAGADLKAFGTPEANQVHREGPGPMGPSR
TH_2627|M.thermoresistible__bu DEFDRDEDAAVAVLWGANGTFCAGADLKAFGTPEANPVHRSGPGPMGPTR
Mb0694|M.bovis_AF2122/97 EQFDRDDAASVAVLWGAGGTFCAGADLKAFGTPEANSVHRTGPGPMGPSR
Rv0675|M.tuberculosis_H37Rv EQFDRDDAASVAVLWGAGGTFCAGADLKAFGTPEANSVHRTGPGPMGPSR
MMAR_1004|M.marinum_M AEFDRDESASVAVLCGNGGTFCAGADLKAFGTAEANAVHRTGPGPMGPSR
MUL_0756|M.ulcerans_Agy99 AEFDRDESASVAVLCGNGGTFCAGADLKAFGTAEANAVHRTGPGPMGRSR
MAV_4497|M.avium_104 EEFDRDDSASVAVLWGEGGTFCAGADLKAFGTPEANAVHRSGPGPMGPTR
MAB_3857c|M.abscessus_ATCC_199 TEFDADPEASVAVLWGDNGTFCAGADLKAMGTDRGNELHPHGPGPMGPSR
MLBr_02402|M.leprae_Br4923 KELDIDPDVGAILITGSPKVFAAGADIKEMASLTFTDAFDADFFSAWGKL
::* * ... :: * .*.****:* :.: . . . . .
Mflv_5084|M.gilvum_PYR-GCK MVLSKPVIAAISGYAVAGGLELALWCDLRIVEQDAVLGVFCRRWGVPLID
Mvan_1272|M.vanbaalenii_PYR-1 MVLSKPVIAAVSGYAVAGGLELALWCDLRIVEQDAVMGVFCRRWGVPLID
MSMEG_1390|M.smegmatis_MC2_155 MDLSKPVIAAISGYAVAGGLELALWCDLRVVDEDATMGVFCRRWGVPLID
TH_2627|M.thermoresistible__bu MVLSKPVIAAVSGYAVAGGLELALWTDLRIVEQDAIMGVFCRRWGVPLID
Mb0694|M.bovis_AF2122/97 MMLSKPVIAAVSGYAVAGGLELALWCDLRVAEEDAVFGVFCRRWGVPLID
Rv0675|M.tuberculosis_H37Rv MMLSKPVIAAVSGYAVAGGLELALWCDLRVAEEDAVFGVFCRRWGVPLID
MMAR_1004|M.marinum_M MMLSKPVIAAVSGYAVAGGLELALWCDLRVAEQDAVFGVFCRRWGVPLID
MUL_0756|M.ulcerans_Agy99 MMLSKPVIAAVSGYAVAGGLELALWCDLRVAEQDSVFGVFCRRWGVPLID
MAV_4497|M.avium_104 MVLSKPVIAAVSGYAVAGGLELAIWCDLRVVEQDAVFGVFCRRWGVPLID
MAB_3857c|M.abscessus_ATCC_199 LRLSKPVIAAISGHAVAGGIELALWCDLRVVEEDAVLGVFCRRWGVPLID
MLBr_02402|M.leprae_Br4923 AAVRTPMIAAVAGYALGGGCELAMMCDLLIAADTAKFGQPEIKLGVLPGM
: .*:***::*:*:.** ***: ** :. : : :* : **
Mflv_5084|M.gilvum_PYR-GCK GGTVRLPRLIGHGRAMDLILTGRAVDADEAKSIGLANRVVPSGAARQEAE
Mvan_1272|M.vanbaalenii_PYR-1 GGTVRLPRLIGHSRAMDLILTGRAVDADEAYAIGLANRVVPKGEARQRAE
MSMEG_1390|M.smegmatis_MC2_155 GGTVRLPRLIGHSRAMDLILTGRAVDAAEAYAIGLANRVVPTGQARQAAE
TH_2627|M.thermoresistible__bu GGTVRLPRLIGESRAMDLILTGRPVDADEALAIGLANRVVPTGEARARAE
Mb0694|M.bovis_AF2122/97 GGTVRLPRLIGHSRAMDMILTGRGVPADEALAMGLANRVVPKGQARQAAE
Rv0675|M.tuberculosis_H37Rv GGTVRLPRLIGHSRAMDMILTGRGVPADEALAMGLANRVVPKGQARQAAE
MMAR_1004|M.marinum_M GGTVRLPRLIGHSRAMDMILTGRAVQADEALAIGLANRVVPNGQARQAAE
MUL_0756|M.ulcerans_Agy99 GGTVRLPRLIGHSRAMDMILTGRAVQADEALAIGLANRVVPNGQARQAAE
MAV_4497|M.avium_104 GGTVRLPRLIGHSRAMDMILTGRAVAADEAQAIGLANRVVPKGQSRRAAE
MAB_3857c|M.abscessus_ATCC_199 GGTIRLPRLIGHSRAMDLILTGRPVHANEALDIGLVNRVVARGQAREAAE
MLBr_02402|M.leprae_Br4923 GGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVLADDLLPEAK
**: **.* **..:***:***** : * ** **..*** . *:
Mflv_5084|M.gilvum_PYR-GCK DLAAELAALPQQCLRSDRMSALNQWG--KSESDAMDVEFGSLSRVAAESL
Mvan_1272|M.vanbaalenii_PYR-1 ELAAELAALPQQCMRSDRMSLLNQWG--MSEAEAMDVEFGSLSRVAAESL
MSMEG_1390|M.smegmatis_MC2_155 ELAADLARLPQQCMRADRLSALHQWG--ESENAAMDFEFASISRVKDEAM
TH_2627|M.thermoresistible__bu ELAAELARLPQQCLRADRMSVLQQWG--KREAEAMDFEFASISKVSHEAA
Mb0694|M.bovis_AF2122/97 ELAAQLAALPQQCLRSDRLSALHQWG--LPESAALDLEFASIARVAGEAL
Rv0675|M.tuberculosis_H37Rv ELAAQLAALPQQCLRSDRLSALHQWG--LPESAALDLEFASIARVAGEAL
MMAR_1004|M.marinum_M ELAAQLAALPQQCLRSDRLSALQQWG--LPESAALDLEFASISRVAAEAL
MUL_0756|M.ulcerans_Agy99 ELAAQLAALPQQCLRSDRLSALQQWG--LPESAALDLEFASISRVAAEAL
MAV_4497|M.avium_104 ELAAQLAALPQQCLRSDRLSALHQWG--ATESEALDFEFASISRVAAEAN
MAB_3857c|M.abscessus_ATCC_199 TLAAEIAAFPQQCVRADRDSAIAQWG--MAEEAALDNEFGSIERVATEAL
MLBr_02402|M.leprae_Br4923 AVATTISQMSRSATRMAKEAVNRSFESTLAEGLLHERRLFHSTFVTDDQS
:*: :: :.:.. * : : .: * : .: * :
Mflv_5084|M.gilvum_PYR-GCK EGAARFSAGTGRHGAKT---------
Mvan_1272|M.vanbaalenii_PYR-1 EGAVRFAEGAGRHGAPG---------
MSMEG_1390|M.smegmatis_MC2_155 HGAGRFAAGAGRHGANA---------
TH_2627|M.thermoresistible__bu AGASRFAAGAGRHGAPA---------
Mb0694|M.bovis_AF2122/97 EGARRFAAGAGRHGAPAPRAEQGDTL
Rv0675|M.tuberculosis_H37Rv EGARRFAAGAGRHGAPAPRAEQGDTL
MMAR_1004|M.marinum_M EGAGRFAAGAGRHGAQASHD------
MUL_0756|M.ulcerans_Agy99 EGAGRFAAGAGRHGAQASHD------
MAV_4497|M.avium_104 EGAGRFAAGAGRHGASAV--------
MAB_3857c|M.abscessus_ATCC_199 EGAGRFAAGEGRHGAGV---------
MLBr_02402|M.leprae_Br4923 EGMAAFIEKRAPQFTHR---------
* * . : :