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GAGAWGTALAKVLADAGNSVTLWARRPELADAINRTHRNDNYLDATLPESIRATSDAADALTGACTVLFA VPSQTLRTNLEAWKSHVGADATLVNLAKGIELDTLLRMSQVIAQVTGADPGRIAVVTGPNLASEIGAGQP AATVVACTDSGRAVALQRALATGYFRPYTNADVIGAEIGGACKNVIALACGMAAGAGLGENTAAAIITRG LAEIMRLGIALGAKPATLAGLAGIGDLVATCTSPHSRNRSFGERLGKGGTMQAALDATGGHVAEGVTSCR SVLALAASYDVEMPLTEAVHGVCHKGLSVDEAIALLLGRTTKPE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4221 | gpsA | - | 100% (325) | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_5249 | - | 1e-59 | 39.68% (315) | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3006c | gpsA | 1e-135 | 76.38% (326) | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase |
| M. tuberculosis H37Rv | Rv2982c | gpsA | 1e-135 | 76.38% (326) | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase |
| M. leprae Br4923 | MLBr_01679 | gpsA | 1e-129 | 71.04% (335) | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3288c | - | 1e-132 | 72.70% (326) | glycerol-3-phosphate dehydrogenase, NAD-dependent |
| M. marinum M | MMAR_1732 | gpsA | 1e-135 | 75.15% (326) | glycerol-3-phosphate dehydrogenase |
| M. avium 104 | MAV_4577 | - | 4e-61 | 40.63% (315) | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2393 | gpsA | 1e-147 | 79.75% (326) | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase |
| M. thermoresistible (build 8) | TH_2048 | gpdA2 | 1e-142 | 79.81% (317) | PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE |
| M. ulcerans Agy99 | MUL_1975 | gpsA | 1e-134 | 74.85% (326) | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2141 | gpsA | 1e-165 | 89.54% (325) | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3006c|M.bovis_AF2122/97 ---MAGIAS----TVAVMGAGAWGTALAKVLADAGG---EVTLWARRAEV
Rv2982c|M.tuberculosis_H37Rv ---MAGIAS----TVAVMGAGAWGTALAKVLADAGG---EVTLWARRAEV
MMAR_1732|M.marinum_M ---MASTG-----TVTVMGAGAWGTALAKVLADAGG---EVQLWARRADV
MUL_1975|M.ulcerans_Agy99 ---MASTG-----TVTVMGAGAWGTALAKVLADAGG---EVKLWARRADV
MLBr_01679|M.leprae_Br4923 -MEMAGIVVRSESAVAVMGAGAWGTALAKVLIDAGGPEAGVVLWARRPDV
Mflv_4221|M.gilvum_PYR-GCK -----------------MGAGAWGTALAKVLADAGN---SVTLWARRPEL
Mvan_2141|M.vanbaalenii_PYR-1 -----------------MGAGAWGTALAKVLADAGN---SVTLWARRPEL
MSMEG_2393|M.smegmatis_MC2_155 ------------MEAAVMGCGAWGTALAKVLADAGN---PVTMWARRPEV
TH_2048|M.thermoresistible__bu --------------------------LAKVLADAGN---DVTLWARRPEV
MAB_3288c|M.abscessus_ATCC_199 MATDEPLAGRRPVKAAVMGAGSWGTALGKVLADAGH---DVRLWARRSEL
MAV_4577|M.avium_104 -----MAAQMREPKVVVLGGGSWGTTVASICARRGP----TLQWVRSRET
:..: * . *.* :
Mb3006c|M.bovis_AF2122/97 ADQINTTRYNPDYLP-GALLPPSIHATADAEEALGGASTVLLGVPAQTMR
Rv2982c|M.tuberculosis_H37Rv ADQINTTRYNPDYLP-GALLPPSIHATADAEEALGGASTVLLGVPAQTMR
MMAR_1732|M.marinum_M ANQINDSRYNPDYLP-GTLLPPGIRATADAAEALAGADTVLLGVPAQTMR
MUL_1975|M.ulcerans_Agy99 ANQINDSRYNPDYLP-GTLLPPGIRATADAAEALAGADTVLLGVPAQTMR
MLBr_01679|M.leprae_Br4923 AERINTTRCNRAYLP-GTLLPPGIRATADPADALRGASTVLLGVPAQRMR
Mflv_4221|M.gilvum_PYR-GCK ADAINRTHRNDNYL--DATLPESIRATSDAADALTGACTVLFAVPSQTLR
Mvan_2141|M.vanbaalenii_PYR-1 ADEINRTHRNSGYL--DAELPEAIRATSDAAEALAGACTVFLAVPSQTLR
MSMEG_2393|M.smegmatis_MC2_155 ADEINSEHRNSEYLG-DVVLPASIRATSDPEEALRGACTVMLAVPSQKLR
TH_2048|M.thermoresistible__bu AEEINETRRNTRYLG-DAELPKTIRATSDAAAALAGACTVLLAVPSQTMR
MAB_3288c|M.abscessus_ATCC_199 ADEINATHRNSVYLS-DVDLPASIVATGVAEEALQGAELVLLAVPSQSLR
MAV_4577|M.avium_104 ADDINENHRNSRYLGNDVVLSDTLRATTDFCEAANTADVVVMGVPSHGFR
*: ** : * ** .. *. : ** * * *.:.**:: :*
Mb3006c|M.bovis_AF2122/97 ANLERWAPLLPEGATLVSLAKGIELGTLMRMSQVIISVTGAEPAQVAVIS
Rv2982c|M.tuberculosis_H37Rv ANLERWAPLLPEGATLVSLAKGIELGTLMRMSQVIISVTGAEPPQVAVIS
MMAR_1732|M.marinum_M TNLEHWTTLIPRGATLVSLAKGIELGTLMRMSQVIVSVTGADPAQVAVIS
MUL_1975|M.ulcerans_Agy99 TNLEHWTTLIPRGATLVSLAKGIELGTLMRMSQVIVSVTGADPAQVAVIS
MLBr_01679|M.leprae_Br4923 ANLERWGGLVADGATLVSLAKGIELGTLMRMSQVIVSVTGVDPAQVAVLS
Mflv_4221|M.gilvum_PYR-GCK TNLEAWKSHVGADATLVNLAKGIELDTLLRMSQVIAQVTGADPGRIAVVT
Mvan_2141|M.vanbaalenii_PYR-1 ANLELWKDHLGSDTTLVNLAKGIELHTLMRMSQVIVQVTGADPGRVAVVS
MSMEG_2393|M.smegmatis_MC2_155 ANLDNWKHLIEDDVTLVSLAKGIELGTLMRMSQVIVQVTGADPSRVGVVS
TH_2048|M.thermoresistible__bu DNLTQWTGLIGPDVTLVSVAKGIELNTLMRMSQVVTQVTGADPSRVAVVT
MAB_3288c|M.abscessus_ATCC_199 ANLTPWADLIEPNSSVVSLAKGIEVGTLMRMSQVVTQVLGTDPSRVAVLT
MAV_4577|M.avium_104 GVLTELARELRPWVPVVSLVKGLEQGTNMRMSQIVEEVLPGHP--AGILA
* : .:*.:.**:* * :****:: .* .* .:::
Mb3006c|M.bovis_AF2122/97 GPNLASEIAECQPAATVVACSDSGRAVALQRALNSGYFRPYTNADVVGTE
Rv2982c|M.tuberculosis_H37Rv GPNLASEIAECQPAATVVACSDSGRAVALQRALNSGYFRPYTNADVVGTE
MMAR_1732|M.marinum_M GPNLASEIAECQPAATVVACSDSGRAVALQRALNSGYFRPYTNTDVVGTE
MUL_1975|M.ulcerans_Agy99 GPNLASEIAECQPAATVVACSDSGRAVALQRALNSGYFRPYTNTDVVGTE
MLBr_01679|M.leprae_Br4923 GPNLASEIAQCQPAATVIACSDLGRAVALQRMLSSGYFRPYTNSDVVGTE
Mflv_4221|M.gilvum_PYR-GCK GPNLASEIGAGQPAATVVACTDSGRAVALQRALATGYFRPYTNADVIGAE
Mvan_2141|M.vanbaalenii_PYR-1 GPNLASEIAQEQPAATVVACTDSGRAVALQRALSTGYFRPYTNADVIGAE
MSMEG_2393|M.smegmatis_MC2_155 GPNLASEIADEQPAATVIACSDSGRAVTLQRAMATGYFRPYTNPDVIGAE
TH_2048|M.thermoresistible__bu GPNLAGEIADEQPAAAVVACSDSGRAVALQRALSTGYFRPYTNSDVIGAE
MAB_3288c|M.abscessus_ATCC_199 GPNLASEIAAGQPAATVIGCTDSTRAVALQRAFSTRYFRPYTNSDVVGCE
MAV_4577|M.avium_104 GPNIAREVAEGYAAAAVLAMPDQHLATRLSGLFRTRRFRVYTTDDVVGAE
***:* *:. .**:*:. .* *. *. : : ** **. **:* *
Mb3006c|M.bovis_AF2122/97 IGGACKNIIALACGMAVGIGLGENTAAAIITRGLAEIIRLGTALGANGAT
Rv2982c|M.tuberculosis_H37Rv IGGACKNIIALACGMAVGIGLGENTAAAIITRGLAEIIRLGTALGANGAT
MMAR_1732|M.marinum_M IGGACKNVIALACGMAAGVGLGENTVATIITRGLAEIIRLGIALGAKGAT
MUL_1975|M.ulcerans_Agy99 IGGACKNVIALACGMAAGVGLGENTVATIITRGLAEIIRLGIALGAKGAT
MLBr_01679|M.leprae_Br4923 IGGVCKNVIALACGMAAGVGFGENTAATIITRGLAEIIRLGMALGAQVTT
Mflv_4221|M.gilvum_PYR-GCK IGGACKNVIALACGMAAGAGLGENTAAAIITRGLAEIMRLGIALGAKPAT
Mvan_2141|M.vanbaalenii_PYR-1 IGGACKNVIALACGMAAGVGLGENTAAAIITRGLAEIMRLGIALGAKPAT
MSMEG_2393|M.smegmatis_MC2_155 VGGACKNVIALACGMAVGVGLGENTVAALITRGLAEIMRLGIALGATPAT
TH_2048|M.thermoresistible__bu IGGACKNVIALACGMAAGVGLGENTAAAIITRGLAEIMRLGIALGAQPQT
MAB_3288c|M.abscessus_ATCC_199 VGGACKNVIALSCGMAAGVGLGENTIATIITRGLAEITRLGLALGASHTT
MAV_4577|M.avium_104 MAGALKNVFAIAVGMGYSLGIGENTRALVIARALREMTKLGVAMGGSPDT
:.*. **::*:: **. . *:**** * :*:*.* *: :** *:*. *
Mb3006c|M.bovis_AF2122/97 LAGLAGVGDLVATCTSPRSRNRSFGERLGRGETLQSAG--------KACH
Rv2982c|M.tuberculosis_H37Rv LAGLAGVGDLVATCTSPRSRNRSFGERLGRGETLQSAG--------KACH
MMAR_1732|M.marinum_M LAGLAGVGDLVATCTSSRSRNRSLGECLGRGEILQSALH------SKEGH
MUL_1975|M.ulcerans_Agy99 LAGLAGVGDLVATCTSSRSRNRSLGECLGRGEILQSALH------SKEGH
MLBr_01679|M.leprae_Br4923 LAGLAGVGDLVATCTSPHSRNRSLGERLGRGEIMQSILHGMDGSDGGDGY
Mflv_4221|M.gilvum_PYR-GCK LAGLAGIGDLVATCTSPHSRNRSFGERLGKGGTMQAALD------ATGGH
Mvan_2141|M.vanbaalenii_PYR-1 LAGLAGIGDLVATCMSPHSRNRSFGERLGKGGTMQAALD------AAGGH
MSMEG_2393|M.smegmatis_MC2_155 LAGLAGVGDLVATCTSPHSRNRTFGERLGKGGTMESALA------AAGGH
TH_2048|M.thermoresistible__bu LAGLAGVGDLIATCTSRHSRNRTFGERLGRGGSLESALA------AAGGH
MAB_3288c|M.abscessus_ATCC_199 LAGLAGVGDLVATCTSAHSRNRTFGMRLGNGETLQEARN------AAGGR
MAV_4577|M.avium_104 FPGLAGLGDLIVTCTSQRSRNRHVGEQLGAGKPIDEIIA-------SMNQ
:.****:***:.** * :**** .* ** * ::
Mb3006c|M.bovis_AF2122/97 VVEGVTSCESVLALASSYDVEMPLTDAVHRVCHKGLSVDEAITLLLGRRT
Rv2982c|M.tuberculosis_H37Rv VVEGVTSCESVLALASSYDVEMPLTDAVHRVCHKGLSVDEAITLLLGRRT
MMAR_1732|M.marinum_M VVEGVTSCESVLALASSYDVEMPLTDAVHRVCYKGLSVDDAIALLLGRST
MUL_1975|M.ulcerans_Agy99 VVEGVTSCESVLALASSYDVEMPLTDGVHRVCYKGLSVDDAIALLLGRST
MLBr_01679|M.leprae_Br4923 VVEGVTSCASVLALASSYDVEMPLTDAVHRVCHKGLSVEKAMALLLGRST
Mflv_4221|M.gilvum_PYR-GCK VAEGVTSCRSVLALAASYDVEMPLTEAVHGVCHKGLSVDEAIALLLGRTT
Mvan_2141|M.vanbaalenii_PYR-1 VAEGVTSCQSVLALASSYDVEMPLTDAVRRVCHKGLSVDDAVALLLGRTT
MSMEG_2393|M.smegmatis_MC2_155 VAEGVASCESVLALASSYGVEMPLTDAVHRVCHKGLSVHEAVALLLGRST
TH_2048|M.thermoresistible__bu VAEGVTSCQSVLALASSYGVEMPLTAAVHEVCHRGLSVEEAIIRLLGRTT
MAB_3288c|M.abscessus_ATCC_199 VAEGVTSCESILALASSYDVEMPLTEAVHGVCHRGLSVTDAVAQLLGRST
MAV_4577|M.avium_104 VAEGVKAASVIMEFANEFGLTMPIAREVDAVINHGSTVEQAYRGLIAEVP
*.*** :. :: :* .:.: **:: * * :* :* .* *:.. .
Mb3006c|M.bovis_AF2122/97 KPE------
Rv2982c|M.tuberculosis_H37Rv KPE------
MMAR_1732|M.marinum_M KPE------
MUL_1975|M.ulcerans_Agy99 KPE------
MLBr_01679|M.leprae_Br4923 KSE------
Mflv_4221|M.gilvum_PYR-GCK KPE------
Mvan_2141|M.vanbaalenii_PYR-1 KPE------
MSMEG_2393|M.smegmatis_MC2_155 KPE------
TH_2048|M.thermoresistible__bu KPE------
MAB_3288c|M.abscessus_ATCC_199 KPE------
MAV_4577|M.avium_104 GHEVHGSGF
*