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ALGRAFSVAVRGVDGEIVEIEADISNGLPGVHLVGLGDAALRESRDRVRAAITNCKFDWPQARLTLALSP ATLPKTGSLYDIALAAAVLSAQTKKTWPRLDKSVLLGELALDGRVRPVHGVLPAVLAAVHQGWPAVVVPV ENLAEASLVDDIDVWGVRSLGQLQSWLEGRGDLAPRVDSPLRGPEVSADLADVVGQTQARYAVEVAAAGG HNLLMTGPPGVGKTMLAQRLPGLLPPLSHKDALEVTAIHSVAGLLSGDTPLITRPPFVAPHHTSSVVALV GGGSGMARPGALSRAHRGVLFLDEFPEINSGALEALRTPLEDGEIRLARRDGVARYQCRIQLVLAANLCP CAPPDPRDCVCGAAERRRYRTKLSGPLVDRVDLRVEMHAAREGTFTDEEGESTALVRERVWAAREAAAER WRPYGFTTNAEVSGALLRRRFRLGTEAMKPLRTAVDRGRLSIRGRDRTVRVAWSLCDLAGRVSPSKEDVT AAMSFRGLGEA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4139 | - | - | 100% (502) | Mg chelatase, subunit ChlI |
| M. gilvum PYR-GCK | Mflv_3336 | - | 7e-10 | 31.29% (163) | ATP-dependent protease La |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2921c | - | 0.0 | 77.00% (500) | hypothetical protein Mb2921c |
| M. tuberculosis H37Rv | Rv2897c | - | 0.0 | 77.00% (500) | hypothetical protein Rv2897c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3213c | - | 0.0 | 67.61% (497) | putative magnesium chelatase |
| M. marinum M | MMAR_1813 | - | 0.0 | 76.00% (500) | hypothetical protein MMAR_1813 |
| M. avium 104 | MAV_3751 | - | 0.0 | 77.20% (500) | Mg-chelatase subunits D/I family protein, ComM subfamily |
| M. smegmatis MC2 155 | MSMEG_2509 | - | 0.0 | 75.37% (479) | Mg-chelatase subunits D/I family protein, ComM subfamily |
| M. thermoresistible (build 8) | TH_0842 | - | 1e-176 | 73.52% (423) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3003 | lon | 4e-05 | 30.46% (151) | Lon, ATP-dependent Lon protease |
| M. vanbaalenii PYR-1 | Mvan_2203 | - | 0.0 | 82.46% (496) | Mg chelatase, subunit ChlI |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4139|M.gilvum_PYR-GCK ----------------MALGRAFSVAVRGVDGEIVEIEADISNG------
Mvan_2203|M.vanbaalenii_PYR-1 ---------------MTALGRAFSVAVRGVEGEIVEIEADISSG------
MSMEG_2509|M.smegmatis_MC2_155 ----------------------------------MEIEADITSG------
TH_0842|M.thermoresistible__bu --------------------------------------------------
Mb2921c|M.bovis_AF2122/97 ----------------MALGRAFSVAVRGLDGEIVEIEADITSG------
Rv2897c|M.tuberculosis_H37Rv ----------------MALGRAFSVAVRGLDGEIVEIEADITSG------
MMAR_1813|M.marinum_M ----------------MALGRAFSVAVCGLDGEIVEIEADISSG------
MAV_3751|M.avium_104 ----------------MALGRAFSVAVRGVDGQIVEIEADITSG------
MAB_3213c|M.abscessus_ATCC_199 ----------------MALGRAYSVAVKAVTGQTVEIEADISAG------
MUL_3003|M.ulcerans_Agy99 MPQAISVPVLFVSDTIVLPGMVVPITLDDAAQAAIDAARASESGQLLIAS
Mflv_4139|M.gilvum_PYR-GCK -----------LPGVHLVG-LGDAALRESRDRVRAAITNCKFDWPQARLT
Mvan_2203|M.vanbaalenii_PYR-1 -----------LPGVYLVG-LADAALRESRDRVRAAISNCDFEWPMTRLT
MSMEG_2509|M.smegmatis_MC2_155 -----------LPSVNLVG-LPDTALQESRDRVRAAITNCGSSWPMSRLT
TH_0842|M.thermoresistible__bu --------------------------------------------------
Mb2921c|M.bovis_AF2122/97 -----------LPGVHLVG-LPDAALQESRDRVRAAVTNCGNSWPMARLT
Rv2897c|M.tuberculosis_H37Rv -----------LPGVHLVG-LPDAALQESRDRVRAAVTNCGNSWPMARLT
MMAR_1813|M.marinum_M -----------LPGVHLVG-LPDAALQESRDRVRAAVTNCGNSWPMARLT
MAV_3751|M.avium_104 -----------LPGVHLVG-LPDAALQESRDRVRAAVSNCTNNWPQARLT
MAB_3213c|M.abscessus_ATCC_199 -----------LPGVHLVG-LPDAALQESRDRVRAAITNCGFTWPASRLT
MUL_3003|M.ulcerans_Agy99 RLDDRYPTYGVLAKILQVGRIAGGGAAAVVRGERRAQIGAGASGPGAALW
Mflv_4139|M.gilvum_PYR-GCK LALSPATLP-------KTGSLYDIALAAAVLS------------------
Mvan_2203|M.vanbaalenii_PYR-1 LALSPATLP-------KMGSVYDVALAAAVLS------------------
MSMEG_2509|M.smegmatis_MC2_155 LALSPATLR-------KVGSVYDLALASAVLS------------------
TH_0842|M.thermoresistible__bu -----------------MGSVYDIALAAAVLA------------------
Mb2921c|M.bovis_AF2122/97 LALSPATLP-------KMGSVYDIALAAAVLS------------------
Rv2897c|M.tuberculosis_H37Rv LALSPATLP-------KMGSVYDIALAAAVLS------------------
MMAR_1813|M.marinum_M LALSPATLP-------KMGSVYDIALAAAVLS------------------
MAV_3751|M.avium_104 LALSPATLP-------KMGSVYDIALASAVLS------------------
MAB_3213c|M.abscessus_ATCC_199 LALSPATLP-------KMGSVYDLALATAVLS------------------
MUL_3003|M.ulcerans_Agy99 VEVTEIPEPEATEEAKSLAAEYKKLLVAMLQRREAWQIIDHVNSLTDPSA
.: *. *.: :
Mflv_4139|M.gilvum_PYR-GCK ----AQTKKTWPRLDKSVLLGELALDGRVR--------------------
Mvan_2203|M.vanbaalenii_PYR-1 ----AHGKTSWPRLEKTVLLGELALDGRVR--------------------
MSMEG_2509|M.smegmatis_MC2_155 ----AHTKAAWARLEKTVLLGELALDGRVR--------------------
TH_0842|M.thermoresistible__bu ----AQGPDPRPRLEKTVLLGELALDGRVR--------------------
Mb2921c|M.bovis_AF2122/97 ----AQQKKPWERLENTLLLGELSLDGRVR--------------------
Rv2897c|M.tuberculosis_H37Rv ----AQQKKPWERLENTLLLGELSLDGRVR--------------------
MMAR_1813|M.marinum_M ----AQRKKPWQRLEKTLLLGELSLDGRVR--------------------
MAV_3751|M.avium_104 ----AQRKNPWHRLDKTVLLGELSLDGRVR--------------------
MAB_3213c|M.abscessus_ATCC_199 ----ANKAIPPDRLEKTLLLGELALDGRVR--------------------
MUL_3003|M.ulcerans_Agy99 LADTAGYASYLADMQKRQLLETADVSQRLRLLIDWTGDHLAEVEVNDKIA
* ::: ** :. *:*
Mflv_4139|M.gilvum_PYR-GCK --------------PVHGVLPAVLAAVHQGWPAVVVPVEN----LAEASL
Mvan_2203|M.vanbaalenii_PYR-1 --------------PVKGVLPAVLAAQRQGWPTVVVPVEN----LAEASL
MSMEG_2509|M.smegmatis_MC2_155 --------------PVTGVLPAVLAAKREGWPSVVVPVDN----LAEASL
TH_0842|M.thermoresistible__bu --------------PVKGVLPAVLAAKREGWPAVVVPIGN----LAEASL
Mb2921c|M.bovis_AF2122/97 --------------PVRGVLPAVLAAKRDGWPAVVVPADN----LPEASL
Rv2897c|M.tuberculosis_H37Rv --------------PVRGVLPAVLAAKRDGWPAVVVPADN----LPEASL
MMAR_1813|M.marinum_M --------------AVRGVLPAVLAAKRDGWPAVVVPADN----LAEASL
MAV_3751|M.avium_104 --------------PVRGVLPAVLAAKRDGWPAVVVPADN----LAEASL
MAB_3213c|M.abscessus_ATCC_199 --------------PVRGVLPAVLAAKRDGWPTVVVPQAN----LGEAGL
MUL_3003|M.ulcerans_Agy99 DDMRAGMEKTQKEFLLRQQLAAIRKELGEGDPDGAGDPEDYRARIEAAEL
: *.*: :* * . : : * *
Mflv_4139|M.gilvum_PYR-GCK VDDIDVWGVRSLGQLQ-------------SWLEGRGDLAPRVDSPLRGPE
Mvan_2203|M.vanbaalenii_PYR-1 VDGIEVWGVGSLRQLQ-------------SWLAGKGDLHARVERREQAPD
MSMEG_2509|M.smegmatis_MC2_155 IDGIDVWGVRTLGELQ-------------SWLKGKAELHGRVSAPTRGPE
TH_0842|M.thermoresistible__bu IEGIDVWGVATLTELQ-------------AWLAGKGGLAGRITASASAPE
Mb2921c|M.bovis_AF2122/97 VDGIDVRGVRTLGQLQ-------------SWLRGSTGLAGRITTADTTPE
Rv2897c|M.tuberculosis_H37Rv VDGIDVRGVRTLGQLQ-------------SWLRGSTGLAGRITTADTTPE
MMAR_1813|M.marinum_M VDGIDVWGVRTLGQLQ-------------GWLTGAAGLDSPSGPAATSEG
MAV_3751|M.avium_104 VDGIDVWGVRTLGQLQ-------------DWLSGTGALDGRIEPDTTAPE
MAB_3213c|M.abscessus_ATCC_199 VEGIEVLGVRTLRQLT-------------AWLCADGELDPVSQSEYRHVT
MUL_3003|M.ulcerans_Agy99 PDKVREAALREVGKLERASDQSPDSGWIRTWLDTVLELPWNITTEDSVDL
: : .: : :* ** *
Mflv_4139|M.gilvum_PYR-GCK VSA---------DLADVVGQTQARYAVEVAAAG-----------GHNLLM
Mvan_2203|M.vanbaalenii_PYR-1 RVV---------DLSDVVGQTQARYAVEVAAAG-----------GHNLMM
MSMEG_2509|M.smegmatis_MC2_155 PAP---------DLADVVGQFQARHAVEVAAAG-----------AHHLML
TH_0842|M.thermoresistible__bu PVA---------DLADVVGQTQARYAVEVAAAG-----------AHHLML
Mb2921c|M.bovis_AF2122/97 SAA---------DLADVVGQSQARFAVEVAAAG-----------AHHLML
Rv2897c|M.tuberculosis_H37Rv SAA---------DLADVVGQSQARFAVEVAAAG-----------AHHLML
MMAR_1813|M.marinum_M TSA---------DLADVLGQSQARFAVEVAAAG-----------AHHLML
MAV_3751|M.avium_104 PTA---------DLVDVVGQTQARFAVELAAAG-----------AHHLML
MAB_3213c|M.abscessus_ATCC_199 EAP---------DMADVVGHADARFAVELAAAG-----------AHHLML
MUL_3003|M.ulcerans_Agy99 SAARETLDADHHGLDDVKDRIIEYLAVRARRAQRGLQVVGGRGSGAVMVL
.: ** .: **. * . :::
Mflv_4139|M.gilvum_PYR-GCK TGPPGVGKTMLAQRLPGLLPP---------LSHKDALEVTAIHSVAGLLS
Mvan_2203|M.vanbaalenii_PYR-1 TGPPGVGKTMLAQRLPGLLPP---------LTHTESLEVTAIHSVAGLLT
MSMEG_2509|M.smegmatis_MC2_155 TGPPGTGKTMLAQRLPGLLPQ---------LSHEEALEVTAIHSVAGLLS
TH_0842|M.thermoresistible__bu TGPPGIGKTMLAQRLPGLLPP---------LSEEEALEVTAIHSVAGLLS
Mb2921c|M.bovis_AF2122/97 TGPPGVGKTMLAQRLPGLLPS---------LSGSESLEVTAIHSVAGLLS
Rv2897c|M.tuberculosis_H37Rv TGPPGVGKTMLAQRLPGLLPS---------LSGSESLEVTAIHSVAGLLS
MMAR_1813|M.marinum_M TGPPGVGKTMLAQRLPGLLPP---------LSRGESLEVTAIHSVAGLLS
MAV_3751|M.avium_104 TGPPGVGKTMLAQRLPGLLPP---------LTESESLEVTAIHSVAGLLS
MAB_3213c|M.abscessus_ATCC_199 TGPPGIGKTMLAQRLPGLLPP---------LRHEEALEVTAVHSVAGLLT
MUL_3003|M.ulcerans_Agy99 AGPPGVGKTSLGESVARALGRRFVRVALGGVRDEAEIRGHRRTYVGALPG
:**** *** *.: :. * : :. *..*
Mflv_4139|M.gilvum_PYR-GCK GDTPLITRP----PFVAPHHTSSVVALVGGGSGMARPGALSRAHRG----
Mvan_2203|M.vanbaalenii_PYR-1 GDTPLITRP----PFVAPHHTSSVAALVGGGTGLARPGAVSRAHRG----
MSMEG_2509|M.smegmatis_MC2_155 GDTPLITVP----PFVAPHHTSSVASLVGGGTGLARPGAVSRAHRG----
TH_0842|M.thermoresistible__bu DTTPLITRP----PFVAPHHTSSVAALVGGGSGLARPGAVSRAHRG----
Mb2921c|M.bovis_AF2122/97 GDTPLITRP----PFVAPHHSSSVAALVGGGSGMARPGAVSRAHRG----
Rv2897c|M.tuberculosis_H37Rv GDTPLITRP----PFVAPHHSSSVAALVGGGSGMARPGAVSRAHRG----
MMAR_1813|M.marinum_M GDTPLITRP----PFVAPHHSSSVVALVGGGTGMARPGAVSRAHRG----
MAV_3751|M.avium_104 GDTPLITRP----PFVAPHHSSSVAALVGGGSGMARPGAVSRAHRG----
MAB_3213c|M.abscessus_ATCC_199 ARRPLITEP----PFVAPHHTSSVAALVGGGSGTAKPGAVSMAHRG----
MUL_3003|M.ulcerans_Agy99 RIVRAISEAGSMNPVVLLDEIDKVGSDYRGDPSAALLEVLDPAQNHTFRD
*: . *.* .. ..* : *... * .:. *:.
Mflv_4139|M.gilvum_PYR-GCK -----------VLFLDEFPEIN--------SGALEALRTPLEDGEIRLAR
Mvan_2203|M.vanbaalenii_PYR-1 -----------VLFLDEFAEIN--------SAALEALRTPLEDGVIRLAR
MSMEG_2509|M.smegmatis_MC2_155 -----------VLFLDEFAEMG--------ARALEALRTPLEDGEIRLAR
TH_0842|M.thermoresistible__bu -----------VLFLDECAEIG--------ARALEALRTPLEDGEIRLAR
Mb2921c|M.bovis_AF2122/97 -----------VLFLDECAEIS--------LSALEALRTPLEDGEIRLAR
Rv2897c|M.tuberculosis_H37Rv -----------VLFLDECAEIS--------LSALEALRTPLEDGEIRLAR
MMAR_1813|M.marinum_M -----------VLFLDECAEIS--------VSAMEALRTPLEDGEIRLAR
MAV_3751|M.avium_104 -----------VLFLDECAEIR--------LSALEALRTPLEDGEIRLAR
MAB_3213c|M.abscessus_ATCC_199 -----------VLFLDECAELS--------TPALEALRTPLEDGEIRLAR
MUL_3003|M.ulcerans_Agy99 HYLDLDLDLSDVVFLATANVIENIPSALLDRMELVEIDGYTEDDKVAIAR
*:** : : : **. : :**
Mflv_4139|M.gilvum_PYR-GCK RDGVARYQCRIQLVLAANLCPCAPPDPRDCVCGAAERRRYRTKLSGPLVD
Mvan_2203|M.vanbaalenii_PYR-1 SDGVACYQCRIQLVLAANLCPCAPPDPRDCQCGVAERRRYRSKLSGPLVD
MSMEG_2509|M.smegmatis_MC2_155 RDGVACYPARFQLVLAANPCPCAPPNPVDCICSAQARLRYRGKLSGPLVD
TH_0842|M.thermoresistible__bu RDGVVRYPARFQLVLAANPCPCAPANPRDCTCPALVKRRYLGKLSGPLLD
Mb2921c|M.bovis_AF2122/97 RDGVACYPARFQLVLAANPCPCAPADPQDCICAAATKRRYLGKLSGPLLD
Rv2897c|M.tuberculosis_H37Rv RDGVACYPARFQLVLAANPCPCAPADPQDCICAAATKRRYLGKLSGPLLD
MMAR_1813|M.marinum_M RDGVACYPARFQLVLAANPCPCAPADPQDCICAAAVKRRYLGKLSGPLLD
MAV_3751|M.avium_104 RDGVACYPARFQLVLAANLCPCAPADPQDCVCAAVAKRRYLGKLSGPLLD
MAB_3213c|M.abscessus_ATCC_199 RDGVVTYPARFQLVLAANPCPCAPANPRDCTCPAQLRRRYLGKLSGPLLD
MUL_3003|M.ulcerans_Agy99 DYLLPRQRDRAALSDDEVMITEAALRKIAADYTREPGVRQFERLLAKVLR
: * * . *. . * :* . ::
Mflv_4139|M.gilvum_PYR-GCK RVDLRVEMHA-------------AREGTFTDEEGESTALVRERVWAARE-
Mvan_2203|M.vanbaalenii_PYR-1 RVDLRVEMHA-------------SRAGTFNDEEGESTDVVRQRVWAARQ-
MSMEG_2509|M.smegmatis_MC2_155 RVDLRVELHP-------------ISAGAFTPEAAESSADVRARVAAARG-
TH_0842|M.thermoresistible__bu RVDLRVELHP-------------VPAGVYTTEEGEDTARVRERVAAARR-
Mb2921c|M.bovis_AF2122/97 RVDLRVQMHR-------------LRAGAFSAADGESTSQVRQRVALARE-
Rv2897c|M.tuberculosis_H37Rv RVDLRVQMHR-------------LRAGAFSAADGESTSQVRQRVALARE-
MMAR_1813|M.marinum_M RVDLRVQMHP-------------VRAGAFSAVAGESTSQVRDRVAQARN-
MAV_3751|M.avium_104 RVDLRVQMHP-------------VRAGAFGGGDGESTAQVRRRVAQARQ-
MAB_3213c|M.abscessus_ATCC_199 RVDLRVKMHQ-------------VSQTALN-DAAEGTAVVRERVLLARE-
MUL_3003|M.ulcerans_Agy99 KVTTKLAADPGPATIDEPDLVGYLGRPRFTPEAAERTAVPGVATGLAVTG
:* :: . .* : . *
Mflv_4139|M.gilvum_PYR-GCK --------AAAERWRPYGFTTNAEVSGALLRRRFRLGTEAMKPLRTAVDR
Mvan_2203|M.vanbaalenii_PYR-1 --------AAAERWRPHGVATNAEVSGSLLRRRFWPSTQVMKPLRRAVDR
MSMEG_2509|M.smegmatis_MC2_155 --------AAEERWRPYGIRTNAEVAGPLLRRKFRLSKNTMAPLRIALDR
TH_0842|M.thermoresistible__bu --------AAEHRWRPYGIRTNAEISGALLRRDFRLGKQVMDSLTRALDR
Mb2921c|M.bovis_AF2122/97 --------AAAQRWRPHGFRTNAEVSGPLLRRKFRPSSAAMLPLRTALDR
Rv2897c|M.tuberculosis_H37Rv --------AAAQRWRPHGFRTNAEVSGPLLRRKFRPSSAAMLPLRTALDR
MMAR_1813|M.marinum_M --------AAAQRWQPHGFRTNAEVSGPLLRREFRLGNSAMVPLRTALDR
MAV_3751|M.avium_104 --------AAAQRWLPYGFRTNAEVSGPLLRRKFRLGSAAMDPLQKALDR
MAB_3213c|M.abscessus_ATCC_199 --------RASRRWADYGFRVNADAPGPLLRREFRPSRAVMEPLRNAMER
MUL_3003|M.ulcerans_Agy99 LGGGVLYIEAGAAGPPRPGEGSLQLTGQLGDVMKESAQIALSYVRSHAGQ
* . : .* * . .: : :
Mflv_4139|M.gilvum_PYR-GCK GRLSIRGRDRTVRVAWSLCDLAGRVSPSKEDVTAAMSFRGLGEA------
Mvan_2203|M.vanbaalenii_PYR-1 GTLSIRGMDRTLRVAWTLCDLAGRTTPDADDVATAMSFRQVEGQ------
MSMEG_2509|M.smegmatis_MC2_155 GAVSIRGADRCLRVAWTLADLAGRTSPTVEDVTQALSFRQGGGM------
TH_0842|M.thermoresistible__bu GLLSIRGFDRCLRVAWTLADLNGRASPDRDDVSTALTFRQSGGIR-----
Mb2921c|M.bovis_AF2122/97 GLLSIRGVDRTLRVAWSLADLAGRTSPGIDEVAAALSFRQTGARR-----
Rv2897c|M.tuberculosis_H37Rv GLLSIRGVDRTLRVAWSLADLAGRTSPGIDEVAAALSFRQTGARR-----
MMAR_1813|M.marinum_M GLLSIRGVDRTLRVAWSLADLAGRAAPGLDEVSTALSFRQPGACR-----
MAV_3751|M.avium_104 GLLSIRGLDRTLRVAWSVADLAGRTSPGPEEVATALSFRQAGAQR-----
MAB_3213c|M.abscessus_ATCC_199 GLISVRALDRCLRVAWTLADLGGRDLPAAEDVKLALTFRDKR--------
MUL_3003|M.ulcerans_Agy99 FGVDPTTLDRSIHVHVPAGAVPKDGPSAGVTMVTALVSMATGRQVRADVG
:. ** ::* . : . : *:
Mflv_4139|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2203|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2509|M.smegmatis_MC2_155 --------------------------------------------------
TH_0842|M.thermoresistible__bu --------------------------------------------------
Mb2921c|M.bovis_AF2122/97 --------------------------------------------------
Rv2897c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1813|M.marinum_M --------------------------------------------------
MAV_3751|M.avium_104 --------------------------------------------------
MAB_3213c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_3003|M.ulcerans_Agy99 MTGEVTLNGRVLPIGGVKQKLLAAQRAGLSTVFIPARNEPDLDDVPAEVL
Mflv_4139|M.gilvum_PYR-GCK ------------------------------
Mvan_2203|M.vanbaalenii_PYR-1 ------------------------------
MSMEG_2509|M.smegmatis_MC2_155 ------------------------------
TH_0842|M.thermoresistible__bu ------------------------------
Mb2921c|M.bovis_AF2122/97 ------------------------------
Rv2897c|M.tuberculosis_H37Rv ------------------------------
MMAR_1813|M.marinum_M ------------------------------
MAV_3751|M.avium_104 ------------------------------
MAB_3213c|M.abscessus_ATCC_199 ------------------------------
MUL_3003|M.ulcerans_Agy99 GALVVKPMTDVAEIVAQALEPAAEAAGVAA