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VEIEADITSGLPSVNLVGLPDTALQESRDRVRAAITNCGSSWPMSRLTLALSPATLRKVGSVYDLALASA VLSAHTKAAWARLEKTVLLGELALDGRVRPVTGVLPAVLAAKREGWPSVVVPVDNLAEASLIDGIDVWGV RTLGELQSWLKGKAELHGRVSAPTRGPEPAPDLADVVGQFQARHAVEVAAAGAHHLMLTGPPGTGKTMLA QRLPGLLPQLSHEEALEVTAIHSVAGLLSGDTPLITVPPFVAPHHTSSVASLVGGGTGLARPGAVSRAHR GVLFLDEFAEMGARALEALRTPLEDGEIRLARRDGVACYPARFQLVLAANPCPCAPPNPVDCICSAQARL RYRGKLSGPLVDRVDLRVELHPISAGAFTPEAAESSADVRARVAAARGAAEERWRPYGIRTNAEVAGPLL RRKFRLSKNTMAPLRIALDRGAVSIRGADRCLRVAWTLADLAGRTSPTVEDVTQALSFRQGGGM
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2509 | - | - | 100% (484) | Mg-chelatase subunits D/I family protein, ComM subfamily protein |
| M. smegmatis MC2 155 | MSMEG_2615 | - | 4e-06 | 24.02% (254) | chelatase |
| M. smegmatis MC2 155 | MSMEG_3582 | lon | 2e-05 | 27.21% (147) | ATP-dependent protease La |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2921c | - | 0.0 | 78.01% (482) | hypothetical protein Mb2921c |
| M. gilvum PYR-GCK | Mflv_4139 | - | 0.0 | 75.37% (479) | Mg chelatase, subunit ChlI |
| M. tuberculosis H37Rv | Rv2897c | - | 0.0 | 78.01% (482) | hypothetical protein Rv2897c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3213c | - | 0.0 | 72.03% (479) | putative magnesium chelatase |
| M. marinum M | MMAR_1813 | - | 0.0 | 76.35% (482) | hypothetical protein MMAR_1813 |
| M. avium 104 | MAV_3751 | - | 0.0 | 77.39% (482) | Mg-chelatase subunits D/I family protein, ComM subfamily |
| M. thermoresistible (build 8) | TH_0842 | - | 0.0 | 78.40% (426) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_2111 | - | 4e-05 | 25.23% (214) | magnesium chelatase |
| M. vanbaalenii PYR-1 | Mvan_2203 | - | 0.0 | 74.95% (483) | Mg chelatase, subunit ChlI |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2509|M.smegmatis_MC2_155 --------------------------------MEIEADITSGLPSVNLVG
TH_0842|M.thermoresistible__bu --------------------------------------------------
Mb2921c|M.bovis_AF2122/97 --------------MALGRAFSVAVRGLDGEIVEIEADITSGLPGVHLVG
Rv2897c|M.tuberculosis_H37Rv --------------MALGRAFSVAVRGLDGEIVEIEADITSGLPGVHLVG
MMAR_1813|M.marinum_M --------------MALGRAFSVAVCGLDGEIVEIEADISSGLPGVHLVG
MAV_3751|M.avium_104 --------------MALGRAFSVAVRGVDGQIVEIEADITSGLPGVHLVG
Mflv_4139|M.gilvum_PYR-GCK --------------MALGRAFSVAVRGVDGEIVEIEADISNGLPGVHLVG
Mvan_2203|M.vanbaalenii_PYR-1 -------------MTALGRAFSVAVRGVEGEIVEIEADISSGLPGVYLVG
MAB_3213c|M.abscessus_ATCC_199 --------------MALGRAYSVAVKAVTGQTVEIEADISAGLPGVHLVG
MUL_2111|M.ulcerans_Agy99 MKAYPFSAIVGHGPMRLALLLCAVRPEIGGVLIRGEKGTAKSTAVRGLAA
MSMEG_2509|M.smegmatis_MC2_155 LPDTALQESRDRVRAAITNCGSSWPMSRLTLA---------LSPATLRKV
TH_0842|M.thermoresistible__bu -------------------------------------------------M
Mb2921c|M.bovis_AF2122/97 LPDAALQESRDRVRAAVTNCGNSWPMARLTLA---------LSPATLPKM
Rv2897c|M.tuberculosis_H37Rv LPDAALQESRDRVRAAVTNCGNSWPMARLTLA---------LSPATLPKM
MMAR_1813|M.marinum_M LPDAALQESRDRVRAAVTNCGNSWPMARLTLA---------LSPATLPKM
MAV_3751|M.avium_104 LPDAALQESRDRVRAAVSNCTNNWPQARLTLA---------LSPATLPKM
Mflv_4139|M.gilvum_PYR-GCK LGDAALRESRDRVRAAITNCKFDWPQARLTLA---------LSPATLPKT
Mvan_2203|M.vanbaalenii_PYR-1 LADAALRESRDRVRAAISNCDFEWPMTRLTLA---------LSPATLPKM
MAB_3213c|M.abscessus_ATCC_199 LPDAALQESRDRVRAAITNCGFTWPASRLTLA---------LSPATLPKM
MUL_2111|M.ulcerans_Agy99 LLSAATGSSGPGLVEMPLGATEDRVVGSLDLQRVLRDGEHAFAPGLLARA
MSMEG_2509|M.smegmatis_MC2_155 G--------------SVYDLALASAVLS----AHTKAAWARLEKTVLLGE
TH_0842|M.thermoresistible__bu G--------------SVYDIALAAAVLA----AQGPDPRPRLEKTVLLGE
Mb2921c|M.bovis_AF2122/97 G--------------SVYDIALAAAVLS----AQQKKPWERLENTLLLGE
Rv2897c|M.tuberculosis_H37Rv G--------------SVYDIALAAAVLS----AQQKKPWERLENTLLLGE
MMAR_1813|M.marinum_M G--------------SVYDIALAAAVLS----AQRKKPWQRLEKTLLLGE
MAV_3751|M.avium_104 G--------------SVYDIALASAVLS----AQRKNPWHRLDKTVLLGE
Mflv_4139|M.gilvum_PYR-GCK G--------------SLYDIALAAAVLS----AQTKKTWPRLDKSVLLGE
Mvan_2203|M.vanbaalenii_PYR-1 G--------------SVYDVALAAAVLS----AHGKTSWPRLEKTVLLGE
MAB_3213c|M.abscessus_ATCC_199 G--------------SVYDLALATAVLS----ANKAIPPDRLEKTLLLGE
MUL_2111|M.ulcerans_Agy99 HGGVLYVDEVNLLHDHLVDILLDAAAMGRVHVERDGISHSHEARFVLIGT
: *: * :*.:. . . : . :*:*
MSMEG_2509|M.smegmatis_MC2_155 LALD-GRVRPVTG---VLPAVLAAKREGWPSVVVPVDNLAEASLIDGIDV
TH_0842|M.thermoresistible__bu LALD-GRVRPVKG---VLPAVLAAKREGWPAVVVPIGNLAEASLIEGIDV
Mb2921c|M.bovis_AF2122/97 LSLD-GRVRPVRG---VLPAVLAAKRDGWPAVVVPADNLPEASLVDGIDV
Rv2897c|M.tuberculosis_H37Rv LSLD-GRVRPVRG---VLPAVLAAKRDGWPAVVVPADNLPEASLVDGIDV
MMAR_1813|M.marinum_M LSLD-GRVRAVRG---VLPAVLAAKRDGWPAVVVPADNLAEASLVDGIDV
MAV_3751|M.avium_104 LSLD-GRVRPVRG---VLPAVLAAKRDGWPAVVVPADNLAEASLVDGIDV
Mflv_4139|M.gilvum_PYR-GCK LALD-GRVRPVHG---VLPAVLAAVHQGWPAVVVPVENLAEASLVDDIDV
Mvan_2203|M.vanbaalenii_PYR-1 LALD-GRVRPVKG---VLPAVLAAQRQGWPTVVVPVENLAEASLVDGIEV
MAB_3213c|M.abscessus_ATCC_199 LALD-GRVRPVRG---VLPAVLAAKRDGWPTVVVPQANLGEAGLVEGIEV
MUL_2111|M.ulcerans_Agy99 MNPEEGELRPQLLDRFGLTVDVHASRDVDVRVEVIRQRMAFEADPDAFCE
: : *.:*. *.. : * :: * * .: . : :
MSMEG_2509|M.smegmatis_MC2_155 WGVRTLGELQSWLKGKAELHGRVSAPTRGPEPAPDLADVVGQFQARHAVE
TH_0842|M.thermoresistible__bu WGVATLTELQAWLAGKGGLAGRITASASAPEPVADLADVVGQTQARYAVE
Mb2921c|M.bovis_AF2122/97 RGVRTLGQLQSWLRGSTGLAGRITTADTTPESAADLADVVGQSQARFAVE
Rv2897c|M.tuberculosis_H37Rv RGVRTLGQLQSWLRGSTGLAGRITTADTTPESAADLADVVGQSQARFAVE
MMAR_1813|M.marinum_M WGVRTLGQLQGWLTGAAGLDSPSGPAATSEGTSADLADVLGQSQARFAVE
MAV_3751|M.avium_104 WGVRTLGQLQDWLSGTGALDGRIEPDTTAPEPTADLVDVVGQTQARFAVE
Mflv_4139|M.gilvum_PYR-GCK WGVRSLGQLQSWLEGRGDLAPRVDSPLRGPEVSADLADVVGQTQARYAVE
Mvan_2203|M.vanbaalenii_PYR-1 WGVGSLRQLQSWLAGKGDLHARVERREQAPDRVVDLSDVVGQTQARYAVE
MAB_3213c|M.abscessus_ATCC_199 LGVRTLRQLTAWLCADGELDPVSQSEYRHVTEAPDMADVVGHADARFAVE
MUL_2111|M.ulcerans_Agy99 RYVGPDAELARRIAEARDIVDTVVLPDHELRRIAALCAAFDVDGMRADLV
* . :* : : : ... * :
MSMEG_2509|M.smegmatis_MC2_155 VAAAGAHHLMLTGPPGTGKTMLAQRLPGLLPQLSHEEALEVTAIHS----
TH_0842|M.thermoresistible__bu VAAAGAHHLMLTGPPGIGKTMLAQRLPGLLPPLSEEEALEVTAIHS----
Mb2921c|M.bovis_AF2122/97 VAAAGAHHLMLTGPPGVGKTMLAQRLPGLLPSLSGSESLEVTAIHS----
Rv2897c|M.tuberculosis_H37Rv VAAAGAHHLMLTGPPGVGKTMLAQRLPGLLPSLSGSESLEVTAIHS----
MMAR_1813|M.marinum_M VAAAGAHHLMLTGPPGVGKTMLAQRLPGLLPPLSRGESLEVTAIHS----
MAV_3751|M.avium_104 LAAAGAHHLMLTGPPGVGKTMLAQRLPGLLPPLTESESLEVTAIHS----
Mflv_4139|M.gilvum_PYR-GCK VAAAGGHNLLMTGPPGVGKTMLAQRLPGLLPPLSHKDALEVTAIHS----
Mvan_2203|M.vanbaalenii_PYR-1 VAAAGGHNLMMTGPPGVGKTMLAQRLPGLLPPLTHTESLEVTAIHS----
MAB_3213c|M.abscessus_ATCC_199 LAAAGAHHLMLTGPPGIGKTMLAQRLPGLLPPLRHEEALEVTAVHS----
MUL_2111|M.ulcerans_Agy99 LARTATAHAAWRGAPAVEEQDVRVAAELALPHRRRRDPFDDHGIDRDQLD
:* :. : *.*. : : ** :.:: .:.
MSMEG_2509|M.smegmatis_MC2_155 --------------------------------VAGLLSGDTPLITVPPFV
TH_0842|M.thermoresistible__bu --------------------------------VAGLLSDTTPLITRPPFV
Mb2921c|M.bovis_AF2122/97 --------------------------------VAGLLSGDTPLITRPPFV
Rv2897c|M.tuberculosis_H37Rv --------------------------------VAGLLSGDTPLITRPPFV
MMAR_1813|M.marinum_M --------------------------------VAGLLSGDTPLITRPPFV
MAV_3751|M.avium_104 --------------------------------VAGLLSGDTPLITRPPFV
Mflv_4139|M.gilvum_PYR-GCK --------------------------------VAGLLSGDTPLITRPPFV
Mvan_2203|M.vanbaalenii_PYR-1 --------------------------------VAGLLTGDTPLITRPPFV
MAB_3213c|M.abscessus_ATCC_199 --------------------------------VAGLLTARRPLITEPPFV
MUL_2111|M.ulcerans_Agy99 EALARAGAESQGSPEPEPDPPGGGQSAGQDCPPQQQNSNSRPQQAPKPSA
: * : * .
MSMEG_2509|M.smegmatis_MC2_155 APHHTSSVASLVGGGTGLARPGAVSRAHRG---VLFLDEFAEMG--ARAL
TH_0842|M.thermoresistible__bu APHHTSSVAALVGGGSGLARPGAVSRAHRG---VLFLDECAEIG--ARAL
Mb2921c|M.bovis_AF2122/97 APHHSSSVAALVGGGSGMARPGAVSRAHRG---VLFLDECAEIS--LSAL
Rv2897c|M.tuberculosis_H37Rv APHHSSSVAALVGGGSGMARPGAVSRAHRG---VLFLDECAEIS--LSAL
MMAR_1813|M.marinum_M APHHSSSVVALVGGGTGMARPGAVSRAHRG---VLFLDECAEIS--VSAM
MAV_3751|M.avium_104 APHHSSSVAALVGGGSGMARPGAVSRAHRG---VLFLDECAEIR--LSAL
Mflv_4139|M.gilvum_PYR-GCK APHHTSSVVALVGGGSGMARPGALSRAHRG---VLFLDEFPEIN--SGAL
Mvan_2203|M.vanbaalenii_PYR-1 APHHTSSVAALVGGGTGLARPGAVSRAHRG---VLFLDEFAEIN--SAAL
MAB_3213c|M.abscessus_ATCC_199 APHHTSSVAALVGGGSGTAKPGAVSMAHRG---VLFLDECAELS--TPAL
MUL_2111|M.ulcerans_Agy99 GPSKVFRTRALVVPGVGEGAPGRRSRARNGSGSVVAAADGSDSNSGARGL
.* : . :** * * . ** * *:.* *: : .: .:
MSMEG_2509|M.smegmatis_MC2_155 EALRTPLEDGE--------------IRLARRDGVACYPARFQLVLAANPC
TH_0842|M.thermoresistible__bu EALRTPLEDGE--------------IRLARRDGVVRYPARFQLVLAANPC
Mb2921c|M.bovis_AF2122/97 EALRTPLEDGE--------------IRLARRDGVACYPARFQLVLAANPC
Rv2897c|M.tuberculosis_H37Rv EALRTPLEDGE--------------IRLARRDGVACYPARFQLVLAANPC
MMAR_1813|M.marinum_M EALRTPLEDGE--------------IRLARRDGVACYPARFQLVLAANPC
MAV_3751|M.avium_104 EALRTPLEDGE--------------IRLARRDGVACYPARFQLVLAANLC
Mflv_4139|M.gilvum_PYR-GCK EALRTPLEDGE--------------IRLARRDGVARYQCRIQLVLAANLC
Mvan_2203|M.vanbaalenii_PYR-1 EALRTPLEDGV--------------IRLARSDGVACYQCRIQLVLAANLC
MAB_3213c|M.abscessus_ATCC_199 EALRTPLEDGE--------------IRLARRDGVVTYPARFQLVLAANPC
MUL_2111|M.ulcerans_Agy99 HLFATLLSAAENATGSGPLRPQGADIRRAVREGREGNLVIFVVDASGSMA
. : * *. . ** * :* : : :.. .
MSMEG_2509|M.smegmatis_MC2_155 PCAPPNPVDCICSAQARLRYRG--KLSGPLVDRVDLRVELHPISAGAFTP
TH_0842|M.thermoresistible__bu PCAPANPRDCTCPALVKRRYLG--KLSGPLLDRVDLRVELHPVPAGVYTT
Mb2921c|M.bovis_AF2122/97 PCAPADPQDCICAAATKRRYLG--KLSGPLLDRVDLRVQMHRLRAGAFSA
Rv2897c|M.tuberculosis_H37Rv PCAPADPQDCICAAATKRRYLG--KLSGPLLDRVDLRVQMHRLRAGAFSA
MMAR_1813|M.marinum_M PCAPADPQDCICAAAVKRRYLG--KLSGPLLDRVDLRVQMHPVRAGAFSA
MAV_3751|M.avium_104 PCAPADPQDCVCAAVAKRRYLG--KLSGPLLDRVDLRVQMHPVRAGAFGG
Mflv_4139|M.gilvum_PYR-GCK PCAPPDPRDCVCGAAERRRYRT--KLSGPLVDRVDLRVEMHAAREGTFTD
Mvan_2203|M.vanbaalenii_PYR-1 PCAPPDPRDCQCGVAERRRYRS--KLSGPLVDRVDLRVEMHASRAGTFND
MAB_3213c|M.abscessus_ATCC_199 PCAPANPRDCTCPAQLRRRYLG--KLSGPLLDRVDLRVKMHQVSQTALN-
MUL_2111|M.ulcerans_Agy99 ARDRMAAVSGATMSLLRDAYQRRDKVAVITFRQHEAKILLSPTSSAHIAS
. . . : * *:: . : : :: :
MSMEG_2509|M.smegmatis_MC2_155 ------EAAESSADVRARVAAARGAAEERWRPYGIR--TNAEVAGPLLRR
TH_0842|M.thermoresistible__bu ------EEGEDTARVRERVAAARRAAEHRWRPYGIR--TNAEISGALLRR
Mb2921c|M.bovis_AF2122/97 ------ADGESTSQVRQRVALAREAAAQRWRPHGFR--TNAEVSGPLLRR
Rv2897c|M.tuberculosis_H37Rv ------ADGESTSQVRQRVALAREAAAQRWRPHGFR--TNAEVSGPLLRR
MMAR_1813|M.marinum_M ------VAGESTSQVRDRVAQARNAAAQRWQPHGFR--TNAEVSGPLLRR
MAV_3751|M.avium_104 ------GDGESTAQVRRRVAQARQAAAQRWLPYGFR--TNAEVSGPLLRR
Mflv_4139|M.gilvum_PYR-GCK ------EEGESTALVRERVWAAREAAAERWRPYGFT--TNAEVSGALLRR
Mvan_2203|M.vanbaalenii_PYR-1 ------EEGESTDVVRQRVWAARQAAAERWRPHGVA--TNAEVSGSLLRR
MAB_3213c|M.abscessus_ATCC_199 ------DAAEGTAVVRERVLLARERASRRWADYGFR--VNADAPGPLLRR
MUL_2111|M.ulcerans_Agy99 RRLARFDTGGKTPLAEGLLAARELVIREKVRDRARRPLVVVLTDGRATAG
. : .. : . .: . . . *
MSMEG_2509|M.smegmatis_MC2_155 KFRLSKNTMAPLRIALDRGAVSIRGADR---CLRVAWTLADLAGRTSPTV
TH_0842|M.thermoresistible__bu DFRLGKQVMDSLTRALDRGLLSIRGFDR---CLRVAWTLADLNGRASPDR
Mb2921c|M.bovis_AF2122/97 KFRPSSAAMLPLRTALDRGLLSIRGVDR---TLRVAWSLADLAGRTSPGI
Rv2897c|M.tuberculosis_H37Rv KFRPSSAAMLPLRTALDRGLLSIRGVDR---TLRVAWSLADLAGRTSPGI
MMAR_1813|M.marinum_M EFRLGNSAMVPLRTALDRGLLSIRGVDR---TLRVAWSLADLAGRAAPGL
MAV_3751|M.avium_104 KFRLGSAAMDPLQKALDRGLLSIRGLDR---TLRVAWSVADLAGRTSPGP
Mflv_4139|M.gilvum_PYR-GCK RFRLGTEAMKPLRTAVDRGRLSIRGRDR---TVRVAWSLCDLAGRVSPSK
Mvan_2203|M.vanbaalenii_PYR-1 RFWPSTQVMKPLRRAVDRGTLSIRGMDR---TLRVAWTLCDLAGRTTPDA
MAB_3213c|M.abscessus_ATCC_199 EFRPSRAVMEPLRNAMERGLISVRALDR---CLRVAWTLADLGGRDLPAA
MUL_2111|M.ulcerans_Agy99 PDPLGRSRIAAARLVAEGATAVVVDCETSYVRLGLAQQLARHLGAPAVRL
. : . . : . : : : :* :. *
MSMEG_2509|M.smegmatis_MC2_155 EDVTQALSFRQGGGM-
TH_0842|M.thermoresistible__bu DDVSTALTFRQSGGIR
Mb2921c|M.bovis_AF2122/97 DEVAAALSFRQTGARR
Rv2897c|M.tuberculosis_H37Rv DEVAAALSFRQTGARR
MMAR_1813|M.marinum_M DEVSTALSFRQPGACR
MAV_3751|M.avium_104 EEVATALSFRQAGAQR
Mflv_4139|M.gilvum_PYR-GCK EDVTAAMSFRGLGEA-
Mvan_2203|M.vanbaalenii_PYR-1 DDVATAMSFRQVEGQ-
MAB_3213c|M.abscessus_ATCC_199 EDVKLALTFRDKR---
MUL_2111|M.ulcerans_Agy99 EQLHADYLAQAIRSVA
::: :