For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
NTRRELPESPYLAAAAGRKPHRVPVWMMRQAGRSLPEYRELRAKNTMMQACFDADLITEITLQPVRRHGV DAAILFSDIVVPLRAAGIDLDIVPDVGPVIAHPIRTAADVATVSPLRRETVAPVATAIGQLTAALGDVAL IGFAGAPFTLASYLIEGGPSRNHERTKAMMLGETETWNALMAALTDVTIEFLRVQLDAGVDAIQVFDSWA GTLSLADYRAYVLPHSARVFEALAGYGVPMTHFGVGTAELLGAMSEAVSGHGVPAVVGVDWRTSLTDAAA RVRPGCALQGNLDPVVLLAGWPVVERAVRAVVEDGRRAVDAGATGHVFNLGHGVLPATDPAIITDAVALV HQL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3919 | hemE | - | 100% (354) | uroporphyrinogen decarboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2697c | hemE | 1e-149 | 73.67% (357) | uroporphyrinogen decarboxylase |
| M. tuberculosis H37Rv | Rv2678c | hemE | 1e-150 | 73.95% (357) | uroporphyrinogen decarboxylase |
| M. leprae Br4923 | MLBr_01043 | hemE | 1e-146 | 72.55% (357) | uroporphyrinogen decarboxylase |
| M. abscessus ATCC 19977 | MAB_2986c | - | 1e-140 | 70.45% (352) | uroporphyrinogen decarboxylase (HemE) |
| M. marinum M | MMAR_2038 | hemE | 1e-151 | 74.29% (354) | uroporphyrinogen decarboxylase HemE |
| M. avium 104 | MAV_3573 | hemE | 1e-155 | 77.05% (353) | uroporphyrinogen decarboxylase |
| M. smegmatis MC2 155 | MSMEG_2780 | hemE | 1e-160 | 79.66% (354) | uroporphyrinogen decarboxylase |
| M. thermoresistible (build 8) | TH_2206 | hemE | 1e-172 | 83.05% (354) | PROBABLE UROPORPHYRINOGEN DECARBOXYLASE HEME |
| M. ulcerans Agy99 | MUL_3312 | hemE | 1e-151 | 74.29% (354) | uroporphyrinogen decarboxylase |
| M. vanbaalenii PYR-1 | Mvan_2481 | hemE | 0.0 | 89.27% (354) | uroporphyrinogen decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2986c|M.abscessus_ATCC_199 MDGSAPGRHAPAGAPCEAVMAAWAVMTGLNEDSATAAQTTSKTRRDLPLS
MSMEG_2780|M.smegmatis_MC2_155 ----------------------------------------MNTRRELPES
Mflv_3919|M.gilvum_PYR-GCK ----------------------------------------MNTRRELPES
Mvan_2481|M.vanbaalenii_PYR-1 ----------------------------------------MNTRRELPES
TH_2206|M.thermoresistible__bu --------------VSSDAPGDYPTCWKSARLATRETMVAMNNRRELPES
Mb2697c|M.bovis_AF2122/97 ----------------------------------------MSTRRDLPQS
Rv2678c|M.tuberculosis_H37Rv ----------------------------------------MSTRRDLPQS
MLBr_01043|M.leprae_Br4923 ----------------------------------------MSTRRELLES
MMAR_2038|M.marinum_M ----------------------------------------MSTRRDLPQS
MUL_3312|M.ulcerans_Agy99 ----------------------------------------MSTRRDLPQS
MAV_3573|M.avium_104 ------------------------------------MNSSARTRRDLPES
.**:* *
MAB_2986c|M.abscessus_ATCC_199 PYLVAAAGGVPSHPPVWFMRQAGRSLPEYRAVRADHAMLDACFNPELVCE
MSMEG_2780|M.smegmatis_MC2_155 PYLAAASGRSPHRVPVWFMRQAGRSLPEYRELRAQHRMLQACFDAELVCE
Mflv_3919|M.gilvum_PYR-GCK PYLAAAAGRKPHRVPVWMMRQAGRSLPEYRELRAKNTMMQACFDADLITE
Mvan_2481|M.vanbaalenii_PYR-1 PYLAAVAGRKPLRVPVWMMRQAGRSLPEYRALRAKNTMMQACFDADLITE
TH_2206|M.thermoresistible__bu PYLAAAAGRKPSRVPVWFMRQAGRSLPEYRALRAQNTMMQACFDADLVTE
Mb2697c|M.bovis_AF2122/97 PYLAAVTGRKPSRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPDVACE
Rv2678c|M.tuberculosis_H37Rv PYLAAVTGRKPSRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPDVACE
MLBr_01043|M.leprae_Br4923 PYLAAVSGRKPCRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPEVACE
MMAR_2038|M.marinum_M PYLAAVAGRKPSRVPVWFMRQAGRSLPEYRALRRQHSMLAACFEPEVACE
MUL_3312|M.ulcerans_Agy99 PYLAAVAGRKPSRVPVWFMRQAGRSLPEYRALRRQHSMLAACFEPEVACE
MAV_3573|M.avium_104 PYLAAVNGRKPHRVPVWFMRQAGRSLPEYRALRAQHDMLSACFDAELVCE
***.*. * * : ***:************ :* *: ***:.:: *
MAB_2986c|M.abscessus_ATCC_199 ITLQPIRRHRVDAAILFSDIVVPLKAAGIDLDIVPDVGPVIANPVRTTAD
MSMEG_2780|M.smegmatis_MC2_155 ITMQPVRRHKVDAAILFSDIVVPLKAAGIGLDIVPDVGPVIDNPIRTLGD
Mflv_3919|M.gilvum_PYR-GCK ITLQPVRRHGVDAAILFSDIVVPLRAAGIDLDIVPDVGPVIAHPIRTAAD
Mvan_2481|M.vanbaalenii_PYR-1 ITLQPVRRHGVDAAILFSDIVVPLRAAGIDLDIVPDVGPVIAQPVRTADD
TH_2206|M.thermoresistible__bu ITLQPVRRHGVDAAILFSDIVVPLRAAGVDLDIVADVGPVIAEPVRTAAD
Mb2697c|M.bovis_AF2122/97 ITLQPIRRYDVDAAILFSDIVVPLRAAGVDLDIVADVGPVIADPVRTAAD
Rv2678c|M.tuberculosis_H37Rv ITLQPIRRYDVDAAILFSDIVVPLRAAGVDLDIVADVGPVIADPVRTAAD
MLBr_01043|M.leprae_Br4923 ITLQPLRRYDVDAAILFSDIVVPLCAAGIDLDIVPDVGPVIGDPVRTATD
MMAR_2038|M.marinum_M VTMQPIRRYHVDAAILFSDIVVPLRAAGVDLDIVADVGPVIAAPVRTVAD
MUL_3312|M.ulcerans_Agy99 VTMQPIRRYHVDAAILFSDIVVPLRAAGVDLDIVADVGPVIAAPVRTVAD
MAV_3573|M.avium_104 ITLQPVRRHDVDAAILFSDIVVPLLGAGIDLDIVAGVGPVIASPVRTAAD
:*:**:**: ************** .**:.****..***** *:** *
MAB_2986c|M.abscessus_ATCC_199 VAALPRLEPGQVEAVSAAVRLLVGELGATPLIGFAGAPFTLASYLVEGGP
MSMEG_2780|M.smegmatis_MC2_155 VQAMPALESPQVAPVAEAVRLLTAELGDVPLIGFAGAPFTLASYLVEGGP
Mflv_3919|M.gilvum_PYR-GCK VATVSPLRRETVAPVATAIGQLTAALGDVALIGFAGAPFTLASYLIEGGP
Mvan_2481|M.vanbaalenii_PYR-1 VAAIRPLEPSRVDPVATAIGRLVGELGDVPLIGFAGAPFTLASYLVEGGP
TH_2206|M.thermoresistible__bu VAALRPLEREQVAPVSQAVTQLVGELGETVLIGFAGAPFTLASYLVEGGP
Mb2697c|M.bovis_AF2122/97 VAAMKPLDPQAIQPVLVAASLLVAELGDVPLIGFAGAPFTLASYLVEGGP
Rv2678c|M.tuberculosis_H37Rv VAAMKPLDPQAIQPVLVAASLLVAELGDVPLIGFAGAPFTLASYLVEGGP
MLBr_01043|M.leprae_Br4923 IHAMKPLEPQAIQPIFQAISLLVAALGDVPLIGFAGAPFTLASYLVEGGP
MMAR_2038|M.marinum_M VDAIKPIDPQSIAPVLDAVELLVAELGDTPLIGFAGAPFTLASYLVEGGP
MUL_3312|M.ulcerans_Agy99 VDAIKPIDSQSIAPVLDAVELLVAELGDTPLIGFAGAPFTLASYLVEGGP
MAV_3573|M.avium_104 VAAMKPLERQRVQPIADAVRLLVSALGEVPLIGFAGAPFTLASYLIEGGP
: :: : : .: * *.. ** . ***************:****
MAB_2986c|M.abscessus_ATCC_199 SRHHQRTKALLLGDPQTWHALMTALTDITIAFLRAQLDAGVDALQLFDSW
MSMEG_2780|M.smegmatis_MC2_155 SRHHERTKAMMLGESSTWHALMTALTDLTIAFLQAQVDAGVDALQVFDSW
Mflv_3919|M.gilvum_PYR-GCK SRNHERTKAMMLGETETWNALMAALTDVTIEFLRVQLDAGVDAIQVFDSW
Mvan_2481|M.vanbaalenii_PYR-1 SRNHERTKAMMLGETATWHALMTALTDITIAFLRAQVDAGVDAIQVFDSW
TH_2206|M.thermoresistible__bu SRHHAHTKAMMFGEPDTWHALMTKLTDITIEFLRVQVDAGVDALQLFDSW
Mb2697c|M.bovis_AF2122/97 SRHHAHVKAMMLAEPASWHALMAKLTDLTIAFLVGQIDAGVDAIQVFDSW
Rv2678c|M.tuberculosis_H37Rv SRHHAHVKAMMLAEPASWHALMAKLTDLTIAFLVGQIDAGVDAIQVFDSW
MLBr_01043|M.leprae_Br4923 SRNHPRTKAMMLAEPASWHTLMDKLTDLTLGFLLGQIDAGVDAIQVFDSW
MMAR_2038|M.marinum_M SRHHARTKAMMLAEPATWHALMTKLTDLTIEFLLGQIRAGVDAIQVFDSW
MUL_3312|M.ulcerans_Agy99 SRHHARTKAMMLAEPATWHALMTKLTDLTIEFLLGQIRAGVDAIQVFDSW
MAV_3573|M.avium_104 SRHHARTKAMMLADPESWHTLMEKLTDITVGFLRVQLDAGVDAVQVFDSW
**:* :.**:::.:. :*::** ***:*: ** *: *****:*:****
MAB_2986c|M.abscessus_ATCC_199 AGALSLADYRAAVLPHSTRIFQEFAGVGVPMTHFGVGTAELLGAMGEAGA
MSMEG_2780|M.smegmatis_MC2_155 AGTLSLTDYREYVLPHSSRVFATMAAAGVPMTHFGVGTAELLGAMSEALA
Mflv_3919|M.gilvum_PYR-GCK AGTLSLADYRAYVLPHSARVFEALAGYGVPMTHFGVGTAELLGAMSEAVS
Mvan_2481|M.vanbaalenii_PYR-1 AGTLSLADYRTYVLPHSARVFASLAGAGVPMTHFGVGTAELLGAMSEAVT
TH_2206|M.thermoresistible__bu AGTLSLADYREYVLPHSTRVFTTLADAGVPMTHFGVGTAELLGAMSEAVS
Mb2697c|M.bovis_AF2122/97 AGALSPIDYRQYVLPHSARVFAALGEHGVPMTHFGVGTAELLGAMSEAVT
Rv2678c|M.tuberculosis_H37Rv AGALSPIDYRQYVLPHSARVFAALGEHGVPMTHFGVGTAELLGAMSEAVT
MLBr_01043|M.leprae_Br4923 AGTLSLSDYRQYVLPHSARIFATVAEHGVPMTHFGVGTADLLGAMSAAVR
MMAR_2038|M.marinum_M AGMLSLADYRQYALPHSARVFATLAEHGVPMTHFGVGTAELLGAMSEAV-
MUL_3312|M.ulcerans_Agy99 AGMLSLADYRQYALPHSARVFATLAEHGVPMTHFGVGTAELLGAMSEAV-
MAV_3573|M.avium_104 AGALSLANYRSYVQPHSARVFAALADYGVPMTHFGVGTAELLGAMSAAL-
** ** :** . ***:*:* .. ************:*****. *
MAB_2986c|M.abscessus_ATCC_199 T--------VVGVDWRTPLNVAASRVGSGKALQGNLDPAVLLAGWPVVES
MSMEG_2780|M.smegmatis_MC2_155 PG----AARVVGVDWRTSLADAAARVLPGAALQGNLDPVVLLAGWPVVEK
Mflv_3919|M.gilvum_PYR-GCK ---GHGVPAVVGVDWRTSLTDAAARVRPGCALQGNLDPVVLLAGWPVVER
Mvan_2481|M.vanbaalenii_PYR-1 ---GHGVPAMVGVDWRTSLTDAAARVRPGTALQGNLDPVVLLAGWPVVER
TH_2206|M.thermoresistible__bu ---GHGTPAVVGVDWRTALADAATRVRPGTALQGNLDPVALLAGWPVAER
Mb2697c|M.bovis_AF2122/97 AGERPGRGGVVGVDWRTPLTDAAARVVPGTALQGNLDPAVVLAGWPAVER
Rv2678c|M.tuberculosis_H37Rv AGERPGRGAVVGVDWRTPLTDAAARVVPGTALQGNLDPAVVLAGWPAVER
MLBr_01043|M.leprae_Br4923 SGEKPGHQAVVGVDWRTSLTDAAARVEPCTALQGNLDPVVLLAGWPAVER
MMAR_2038|M.marinum_M ---KPGTAKVVGVDWRTALADAAARVQPGTALQGNLDPVVLLAGWPAVER
MUL_3312|M.ulcerans_Agy99 ---KPGTAKVVGVDWRTALADAAARVQPGTALQGNLDPVVLLAGWPAVER
MAV_3573|M.avium_104 ---KPAPATVVGVDWRTALADAATRVMPGTALQGNLDPVVLLAGWPVVET
:*******.* **:** . ********..:*****..*
MAB_2986c|M.abscessus_ATCC_199 EVRRIVAEGRQAVADGAAGHIFNLGHGVLPDTDPAVLTDAAALVHSL
MSMEG_2780|M.smegmatis_MC2_155 AVRRVVEDGRAAVAAGAAGHIFNLGHGVLPATDPGIITDAVELVHSL
Mflv_3919|M.gilvum_PYR-GCK AVRAVVEDGRRAVDAGATGHVFNLGHGVLPATDPAIITDAVALVHQL
Mvan_2481|M.vanbaalenii_PYR-1 AVRAVVEDGRRAVDAGAVGHVFNLGHGVLPATDPAVITDTVALVHEL
TH_2206|M.thermoresistible__bu AVRAVVEDGRRAVDAGAAGHIFNLGHGVLPSTDPGVITEVVALVHSL
Mb2697c|M.bovis_AF2122/97 AARAVVDDGRRAVDAGAAGHIFNLGHGVLPESDPAVLADLVSLVHSL
Rv2678c|M.tuberculosis_H37Rv AARAVVDDGRRAVDAGAAGHIFNLGHGVLPESDPAVLADLVSLVHSL
MLBr_01043|M.leprae_Br4923 VARTVVDDGRRAVVAGAAGHVFNLGHGVLPETDPGVLSELVSFIHSL
MMAR_2038|M.marinum_M AARAVVDDGRRAVDAGAAGYVFNLGHGVLPQTDPGVLTDLVSLVHSL
MUL_3312|M.ulcerans_Agy99 AARAVVDDGRRAVDAGAAGYVFNLGHGVLPQTDPGVLTDLVSLVHSL
MAV_3573|M.avium_104 AARAVVDDGRRAVDAGAAGHVFNLGHGVLPETDPGVLTELVSLVHSL
.* :* :** ** **.*::********* :**.:::: . ::*.*