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MSTRRDLPQSPYLAAVAGRKPSRVPVWFMRQAGRSLPEYRALRRQHSMLAACFEPEVACEVTMQPIRRYH VDAAILFSDIVVPLRAAGVDLDIVADVGPVIAAPVRTVADVDAIKPIDPQSIAPVLDAVELLVAELGDTP LIGFAGAPFTLASYLVEGGPSRHHARTKAMMLAEPATWHALMTKLTDLTIEFLLGQIRAGVDAIQVFDSW AGMLSLADYRQYALPHSARVFATLAEHGVPMTHFGVGTAELLGAMSEAVKPGTAKVVGVDWRTALADAAA RVQPGTALQGNLDPVVLLAGWPAVERAARAVVDDGRRAVDAGAAGYVFNLGHGVLPQTDPGVLTDLVSLV HSL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2038 | hemE | - | 100% (353) | uroporphyrinogen decarboxylase HemE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2697c | hemE | 1e-175 | 85.71% (357) | uroporphyrinogen decarboxylase |
| M. gilvum PYR-GCK | Mflv_3919 | hemE | 1e-151 | 74.29% (354) | uroporphyrinogen decarboxylase |
| M. tuberculosis H37Rv | Rv2678c | hemE | 1e-175 | 85.71% (357) | uroporphyrinogen decarboxylase |
| M. leprae Br4923 | MLBr_01043 | hemE | 1e-168 | 80.95% (357) | uroporphyrinogen decarboxylase |
| M. abscessus ATCC 19977 | MAB_2986c | - | 1e-142 | 71.79% (351) | uroporphyrinogen decarboxylase (HemE) |
| M. avium 104 | MAV_3573 | hemE | 1e-165 | 80.06% (351) | uroporphyrinogen decarboxylase |
| M. smegmatis MC2 155 | MSMEG_2780 | hemE | 1e-159 | 76.49% (353) | uroporphyrinogen decarboxylase |
| M. thermoresistible (build 8) | TH_2206 | hemE | 1e-161 | 78.53% (354) | PROBABLE UROPORPHYRINOGEN DECARBOXYLASE HEME |
| M. ulcerans Agy99 | MUL_3312 | hemE | 0.0 | 99.72% (353) | uroporphyrinogen decarboxylase |
| M. vanbaalenii PYR-1 | Mvan_2481 | hemE | 1e-157 | 77.40% (354) | uroporphyrinogen decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2986c|M.abscessus_ATCC_199 MDGSAPGRHAPAGAPCEAVMAAWAVMTGLNEDSATAAQTTSKTRRDLPLS
MSMEG_2780|M.smegmatis_MC2_155 ----------------------------------------MNTRRELPES
MMAR_2038|M.marinum_M ----------------------------------------MSTRRDLPQS
MUL_3312|M.ulcerans_Agy99 ----------------------------------------MSTRRDLPQS
Mb2697c|M.bovis_AF2122/97 ----------------------------------------MSTRRDLPQS
Rv2678c|M.tuberculosis_H37Rv ----------------------------------------MSTRRDLPQS
MLBr_01043|M.leprae_Br4923 ----------------------------------------MSTRRELLES
MAV_3573|M.avium_104 ------------------------------------MNSSARTRRDLPES
Mflv_3919|M.gilvum_PYR-GCK ----------------------------------------MNTRRELPES
Mvan_2481|M.vanbaalenii_PYR-1 ----------------------------------------MNTRRELPES
TH_2206|M.thermoresistible__bu --------------VSSDAPGDYPTCWKSARLATRETMVAMNNRRELPES
.**:* *
MAB_2986c|M.abscessus_ATCC_199 PYLVAAAGGVPSHPPVWFMRQAGRSLPEYRAVRADHAMLDACFNPELVCE
MSMEG_2780|M.smegmatis_MC2_155 PYLAAASGRSPHRVPVWFMRQAGRSLPEYRELRAQHRMLQACFDAELVCE
MMAR_2038|M.marinum_M PYLAAVAGRKPSRVPVWFMRQAGRSLPEYRALRRQHSMLAACFEPEVACE
MUL_3312|M.ulcerans_Agy99 PYLAAVAGRKPSRVPVWFMRQAGRSLPEYRALRRQHSMLAACFEPEVACE
Mb2697c|M.bovis_AF2122/97 PYLAAVTGRKPSRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPDVACE
Rv2678c|M.tuberculosis_H37Rv PYLAAVTGRKPSRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPDVACE
MLBr_01043|M.leprae_Br4923 PYLAAVSGRKPCRVPVWFMRQAGRSLPEYRALRERYSMLAACFEPEVACE
MAV_3573|M.avium_104 PYLAAVNGRKPHRVPVWFMRQAGRSLPEYRALRAQHDMLSACFDAELVCE
Mflv_3919|M.gilvum_PYR-GCK PYLAAAAGRKPHRVPVWMMRQAGRSLPEYRELRAKNTMMQACFDADLITE
Mvan_2481|M.vanbaalenii_PYR-1 PYLAAVAGRKPLRVPVWMMRQAGRSLPEYRALRAKNTMMQACFDADLITE
TH_2206|M.thermoresistible__bu PYLAAAAGRKPSRVPVWFMRQAGRSLPEYRALRAQNTMMQACFDADLVTE
***.*. * * : ***:************ :* *: ***:.:: *
MAB_2986c|M.abscessus_ATCC_199 ITLQPIRRHRVDAAILFSDIVVPLKAAGIDLDIVPDVGPVIANPVRTTAD
MSMEG_2780|M.smegmatis_MC2_155 ITMQPVRRHKVDAAILFSDIVVPLKAAGIGLDIVPDVGPVIDNPIRTLGD
MMAR_2038|M.marinum_M VTMQPIRRYHVDAAILFSDIVVPLRAAGVDLDIVADVGPVIAAPVRTVAD
MUL_3312|M.ulcerans_Agy99 VTMQPIRRYHVDAAILFSDIVVPLRAAGVDLDIVADVGPVIAAPVRTVAD
Mb2697c|M.bovis_AF2122/97 ITLQPIRRYDVDAAILFSDIVVPLRAAGVDLDIVADVGPVIADPVRTAAD
Rv2678c|M.tuberculosis_H37Rv ITLQPIRRYDVDAAILFSDIVVPLRAAGVDLDIVADVGPVIADPVRTAAD
MLBr_01043|M.leprae_Br4923 ITLQPLRRYDVDAAILFSDIVVPLCAAGIDLDIVPDVGPVIGDPVRTATD
MAV_3573|M.avium_104 ITLQPVRRHDVDAAILFSDIVVPLLGAGIDLDIVAGVGPVIASPVRTAAD
Mflv_3919|M.gilvum_PYR-GCK ITLQPVRRHGVDAAILFSDIVVPLRAAGIDLDIVPDVGPVIAHPIRTAAD
Mvan_2481|M.vanbaalenii_PYR-1 ITLQPVRRHGVDAAILFSDIVVPLRAAGIDLDIVPDVGPVIAQPVRTADD
TH_2206|M.thermoresistible__bu ITLQPVRRHGVDAAILFSDIVVPLRAAGVDLDIVADVGPVIAEPVRTAAD
:*:**:**: ************** .**:.****..***** *:** *
MAB_2986c|M.abscessus_ATCC_199 VAALPRLEPGQVEAVSAAVRLLVGELGATPLIGFAGAPFTLASYLVEGGP
MSMEG_2780|M.smegmatis_MC2_155 VQAMPALESPQVAPVAEAVRLLTAELGDVPLIGFAGAPFTLASYLVEGGP
MMAR_2038|M.marinum_M VDAIKPIDPQSIAPVLDAVELLVAELGDTPLIGFAGAPFTLASYLVEGGP
MUL_3312|M.ulcerans_Agy99 VDAIKPIDSQSIAPVLDAVELLVAELGDTPLIGFAGAPFTLASYLVEGGP
Mb2697c|M.bovis_AF2122/97 VAAMKPLDPQAIQPVLVAASLLVAELGDVPLIGFAGAPFTLASYLVEGGP
Rv2678c|M.tuberculosis_H37Rv VAAMKPLDPQAIQPVLVAASLLVAELGDVPLIGFAGAPFTLASYLVEGGP
MLBr_01043|M.leprae_Br4923 IHAMKPLEPQAIQPIFQAISLLVAALGDVPLIGFAGAPFTLASYLVEGGP
MAV_3573|M.avium_104 VAAMKPLERQRVQPIADAVRLLVSALGEVPLIGFAGAPFTLASYLIEGGP
Mflv_3919|M.gilvum_PYR-GCK VATVSPLRRETVAPVATAIGQLTAALGDVALIGFAGAPFTLASYLIEGGP
Mvan_2481|M.vanbaalenii_PYR-1 VAAIRPLEPSRVDPVATAIGRLVGELGDVPLIGFAGAPFTLASYLVEGGP
TH_2206|M.thermoresistible__bu VAALRPLEREQVAPVSQAVTQLVGELGETVLIGFAGAPFTLASYLVEGGP
: :: : : .: * *.. ** . ***************:****
MAB_2986c|M.abscessus_ATCC_199 SRHHQRTKALLLGDPQTWHALMTALTDITIAFLRAQLDAGVDALQLFDSW
MSMEG_2780|M.smegmatis_MC2_155 SRHHERTKAMMLGESSTWHALMTALTDLTIAFLQAQVDAGVDALQVFDSW
MMAR_2038|M.marinum_M SRHHARTKAMMLAEPATWHALMTKLTDLTIEFLLGQIRAGVDAIQVFDSW
MUL_3312|M.ulcerans_Agy99 SRHHARTKAMMLAEPATWHALMTKLTDLTIEFLLGQIRAGVDAIQVFDSW
Mb2697c|M.bovis_AF2122/97 SRHHAHVKAMMLAEPASWHALMAKLTDLTIAFLVGQIDAGVDAIQVFDSW
Rv2678c|M.tuberculosis_H37Rv SRHHAHVKAMMLAEPASWHALMAKLTDLTIAFLVGQIDAGVDAIQVFDSW
MLBr_01043|M.leprae_Br4923 SRNHPRTKAMMLAEPASWHTLMDKLTDLTLGFLLGQIDAGVDAIQVFDSW
MAV_3573|M.avium_104 SRHHARTKAMMLADPESWHTLMEKLTDITVGFLRVQLDAGVDAVQVFDSW
Mflv_3919|M.gilvum_PYR-GCK SRNHERTKAMMLGETETWNALMAALTDVTIEFLRVQLDAGVDAIQVFDSW
Mvan_2481|M.vanbaalenii_PYR-1 SRNHERTKAMMLGETATWHALMTALTDITIAFLRAQVDAGVDAIQVFDSW
TH_2206|M.thermoresistible__bu SRHHAHTKAMMFGEPDTWHALMTKLTDITIEFLRVQVDAGVDALQLFDSW
**:* :.**:::.:. :*::** ***:*: ** *: *****:*:****
MAB_2986c|M.abscessus_ATCC_199 AGALSLADYRAAVLPHSTRIFQEFAGVGVPMTHFGVGTAELLGAMGEAGA
MSMEG_2780|M.smegmatis_MC2_155 AGTLSLTDYREYVLPHSSRVFATMAAAGVPMTHFGVGTAELLGAMSEALA
MMAR_2038|M.marinum_M AGMLSLADYRQYALPHSARVFATLAEHGVPMTHFGVGTAELLGAMSEAV-
MUL_3312|M.ulcerans_Agy99 AGMLSLADYRQYALPHSARVFATLAEHGVPMTHFGVGTAELLGAMSEAV-
Mb2697c|M.bovis_AF2122/97 AGALSPIDYRQYVLPHSARVFAALGEHGVPMTHFGVGTAELLGAMSEAVT
Rv2678c|M.tuberculosis_H37Rv AGALSPIDYRQYVLPHSARVFAALGEHGVPMTHFGVGTAELLGAMSEAVT
MLBr_01043|M.leprae_Br4923 AGTLSLSDYRQYVLPHSARIFATVAEHGVPMTHFGVGTADLLGAMSAAVR
MAV_3573|M.avium_104 AGALSLANYRSYVQPHSARVFAALADYGVPMTHFGVGTAELLGAMSAAL-
Mflv_3919|M.gilvum_PYR-GCK AGTLSLADYRAYVLPHSARVFEALAGYGVPMTHFGVGTAELLGAMSEAVS
Mvan_2481|M.vanbaalenii_PYR-1 AGTLSLADYRTYVLPHSARVFASLAGAGVPMTHFGVGTAELLGAMSEAVT
TH_2206|M.thermoresistible__bu AGTLSLADYREYVLPHSTRVFTTLADAGVPMTHFGVGTAELLGAMSEAVS
** ** :** . ***:*:* .. ************:*****. *
MAB_2986c|M.abscessus_ATCC_199 T--------VVGVDWRTPLNVAASRVGSGKALQGNLDPAVLLAGWPVVES
MSMEG_2780|M.smegmatis_MC2_155 PG----AARVVGVDWRTSLADAAARVLPGAALQGNLDPVVLLAGWPVVEK
MMAR_2038|M.marinum_M ---KPGTAKVVGVDWRTALADAAARVQPGTALQGNLDPVVLLAGWPAVER
MUL_3312|M.ulcerans_Agy99 ---KPGTAKVVGVDWRTALADAAARVQPGTALQGNLDPVVLLAGWPAVER
Mb2697c|M.bovis_AF2122/97 AGERPGRGGVVGVDWRTPLTDAAARVVPGTALQGNLDPAVVLAGWPAVER
Rv2678c|M.tuberculosis_H37Rv AGERPGRGAVVGVDWRTPLTDAAARVVPGTALQGNLDPAVVLAGWPAVER
MLBr_01043|M.leprae_Br4923 SGEKPGHQAVVGVDWRTSLTDAAARVEPCTALQGNLDPVVLLAGWPAVER
MAV_3573|M.avium_104 ---KPAPATVVGVDWRTALADAATRVMPGTALQGNLDPVVLLAGWPVVET
Mflv_3919|M.gilvum_PYR-GCK ---GHGVPAVVGVDWRTSLTDAAARVRPGCALQGNLDPVVLLAGWPVVER
Mvan_2481|M.vanbaalenii_PYR-1 ---GHGVPAMVGVDWRTSLTDAAARVRPGTALQGNLDPVVLLAGWPVVER
TH_2206|M.thermoresistible__bu ---GHGTPAVVGVDWRTALADAATRVRPGTALQGNLDPVALLAGWPVAER
:*******.* **:** . ********..:*****..*
MAB_2986c|M.abscessus_ATCC_199 EVRRIVAEGRQAVADGAAGHIFNLGHGVLPDTDPAVLTDAAALVHSL
MSMEG_2780|M.smegmatis_MC2_155 AVRRVVEDGRAAVAAGAAGHIFNLGHGVLPATDPGIITDAVELVHSL
MMAR_2038|M.marinum_M AARAVVDDGRRAVDAGAAGYVFNLGHGVLPQTDPGVLTDLVSLVHSL
MUL_3312|M.ulcerans_Agy99 AARAVVDDGRRAVDAGAAGYVFNLGHGVLPQTDPGVLTDLVSLVHSL
Mb2697c|M.bovis_AF2122/97 AARAVVDDGRRAVDAGAAGHIFNLGHGVLPESDPAVLADLVSLVHSL
Rv2678c|M.tuberculosis_H37Rv AARAVVDDGRRAVDAGAAGHIFNLGHGVLPESDPAVLADLVSLVHSL
MLBr_01043|M.leprae_Br4923 VARTVVDDGRRAVVAGAAGHVFNLGHGVLPETDPGVLSELVSFIHSL
MAV_3573|M.avium_104 AARAVVDDGRRAVDAGAAGHVFNLGHGVLPETDPGVLTELVSLVHSL
Mflv_3919|M.gilvum_PYR-GCK AVRAVVEDGRRAVDAGATGHVFNLGHGVLPATDPAIITDAVALVHQL
Mvan_2481|M.vanbaalenii_PYR-1 AVRAVVEDGRRAVDAGAVGHVFNLGHGVLPATDPAVITDTVALVHEL
TH_2206|M.thermoresistible__bu AVRAVVEDGRRAVDAGAAGHIFNLGHGVLPSTDPGVITEVVALVHSL
.* :* :** ** **.*::********* :**.:::: . ::*.*