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TAHKALRSASQIARLVLEDGRVFTGTPFGAEGETLGEAVFSTGMSGYQETLTDPSYHRQIVVATAPQIGN TGWNHEDSESRGDKIWVAGYAVRDPSPRASNWRATGTLDDELKRQGIVGIAGIDTRAVVRHLRSRGSMKA GIFSGEQADASVDDLIARVRDQAAMLGADLAGEVSTDTDYEVDSEGPQRFTVAALDLGIKTNTPRNFAKR GVRSIVLPSSATFDHIAELKPDGVFLSNGPGDPATADHIVGVTREVLDAGIPLFGICFGNQILGRALGLS TYKMVFGHRGINIPVMDHTTGRVAITAQNHGFALEGEAGQTFDTPFGQAEVSHTCANDGVVEGVRLSNGR AFSVQYHPEAAAGPRDAEYLFDTFIDLMNEGKGESK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3744 | - | - | 100% (387) | carbamoyl phosphate synthase small subunit |
| M. gilvum PYR-GCK | Mflv_0813 | - | 3e-06 | 28.47% (144) | para-aminobenzoate synthase component II |
| M. gilvum PYR-GCK | Mflv_4903 | guaA | 5e-06 | 26.90% (171) | bifunctional GMP synthase/glutamine amidotransferase protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1418 | carA | 1e-175 | 82.35% (374) | carbamoyl phosphate synthase small subunit |
| M. tuberculosis H37Rv | Rv1383 | carA | 1e-176 | 82.62% (374) | carbamoyl phosphate synthase small subunit |
| M. leprae Br4923 | MLBr_00535 | carA | 1e-174 | 80.71% (368) | carbamoyl phosphate synthase small subunit |
| M. abscessus ATCC 19977 | MAB_2828c | - | 1e-170 | 78.88% (374) | carbamoyl-phosphate synthase, small chain (CarA) |
| M. marinum M | MMAR_2198 | carA | 1e-179 | 84.24% (368) | carbamoyl-phosphate synthase small chain CarA |
| M. avium 104 | MAV_3390 | carA | 0.0 | 85.25% (366) | carbamoyl phosphate synthase small subunit |
| M. smegmatis MC2 155 | MSMEG_3046 | carA | 1e-178 | 84.97% (366) | carbamoyl phosphate synthase small subunit |
| M. thermoresistible (build 8) | TH_0817 | carA | 1e-174 | 77.84% (379) | PROBABLE CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN CARA |
| M. ulcerans Agy99 | MUL_1783 | carA | 1e-179 | 84.24% (368) | carbamoyl phosphate synthase small subunit |
| M. vanbaalenii PYR-1 | Mvan_2663 | - | 0.0 | 87.53% (377) | carbamoyl phosphate synthase small subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3744|M.gilvum_PYR-GCK --MTAHKALRS--ASQIARLVLEDGRVFTGTPFGAEGETLGEAVFSTGMS
Mvan_2663|M.vanbaalenii_PYR-1 --MTTQKAL----------LVLEDGRIFTGTTFGAVGETLGEAVFSTAMS
Mb1418|M.bovis_AF2122/97 --MS------------KAVLVLEDGRVFTGRPFGATGQALGEAVFSTGMS
Rv1383|M.tuberculosis_H37Rv --MS------------KAVLVLEDGRVFTGRPFGATGQALGEAVFSTGMS
MLBr_00535|M.leprae_Br4923 --MS------------KALLVLEDGRVFTGMPFGAIGQTLGEAVFSTGMS
MAV_3390|M.avium_104 --MSG-----------KAQLVLEDGRVFTGTPFGAIGQTLGEAVFSTGMS
MMAR_2198|M.marinum_M --MS------------KALLVLEDGRVFTGMSFGAVGQTLGEAVFSTGMS
MUL_1783|M.ulcerans_Agy99 --MS------------KALLVLEDGRVFTGMSFGAVGQTLGEAVFSTGMS
MSMEG_3046|M.smegmatis_MC2_155 --MTR--NGKR--GGEKAVLVLEDGRVFTGVSFGAVGQTLGEAVFSTGMS
TH_0817|M.thermoresistible__bu MTMTASTQATT--AATRAVLVLEDGRVFTGVAFGAVGETLGEAVFTTGMS
MAB_2828c|M.abscessus_ATCC_199 --MTDEPRARRGFGRDKAVLVLEDGRVFTGKPFGAVGETLGEAVFCTAMS
*: *******:*** .*** *::****** *.**
Mflv_3744|M.gilvum_PYR-GCK GYQETLTDPSYHRQIVVATAPQIGNTGWNHEDSESRGDKIWVAGYAVRDP
Mvan_2663|M.vanbaalenii_PYR-1 GYQETLTDPSYHRQIVVATAPQIGNTGWNLDDSESRGDKIWVAGYAVRDP
Mb1418|M.bovis_AF2122/97 GYQETLTDPSYHRQIVVATAPQIGNTGWNGEDSESRGERIWVAGYAVRDP
Rv1383|M.tuberculosis_H37Rv GYQETLTDPSYHRQIVVATAPQIGNTGWNGEDSESRGERIWVAGYAVRDP
MLBr_00535|M.leprae_Br4923 GYQETLTDPSYHRQIVVATAPQIGNTGWNDQDGESRDDRIWVAGYAVRDP
MAV_3390|M.avium_104 GYQETLTDPSYHRQIVVATAPQIGNTGWNGEDAESRGDKIWVAGYAVRDP
MMAR_2198|M.marinum_M GYQETLTDPSYHRQIVVATAPQIGNTGWNDEDGESRGDKIWVAGYAVRDP
MUL_1783|M.ulcerans_Agy99 GYQETLTDPSYHRQIVVATAPQIGNTGWNDEDGESRGDKIWVAGYAVRDP
MSMEG_3046|M.smegmatis_MC2_155 GYQETLTDPSYYGQIVVATAPQIGNTGWNDEDGESRGDKIWVAGYAVRDP
TH_0817|M.thermoresistible__bu GYQEALTDPSFHRQIVIATAPHIGNTGWNDEDSESRGDKIWVAGYAVRDP
MAB_2828c|M.abscessus_ATCC_199 GYQETLTDPSYHRQIVVATAPQIGNTGWNDEDDESRGGKIWVAGYAVRDP
****:*****:: ***:****:******* :* ***. :***********
Mflv_3744|M.gilvum_PYR-GCK SPRASNWRATGTLDDELKRQGIVGIAGIDTRAVVRHLRSRGSMKAGIFSG
Mvan_2663|M.vanbaalenii_PYR-1 SPRASNWRATGTLDDELQRQSIVGIAGIDTRAVVRHLRSRGSMKAGVFSG
Mb1418|M.bovis_AF2122/97 SPRASNWRATGTLEDELIRQRIVGIAGIDTRGVVRHLRSRGSMKAGVFSD
Rv1383|M.tuberculosis_H37Rv SPRASNWRATGTLEDELIRQRIVGIAGIDTRAVVRHLRSRGSMKAGVFSD
MLBr_00535|M.leprae_Br4923 SPCASNWRATGTLEDELVRQRIVGIAGIDTRAVVRHLRRYGSMKAGVFSG
MAV_3390|M.avium_104 SPRVSNWRATGSLEDELIRQRIVGIARIDTRAVVRHLRTRGSMKAGVFSG
MMAR_2198|M.marinum_M SPRASNWRSSTTLEDELIRQRIVGIAGIDTRAVVRHLRSRGSMKAGVFSG
MUL_1783|M.ulcerans_Agy99 SPRASNWRSSTTLEDELIRQCIVGIAGIDTRAVVRHLRSRGSMKAGVFSG
MSMEG_3046|M.smegmatis_MC2_155 SPRASNWRATRTLDDELVAQGIVGIAGIDTRAVVRHLRTRGSMKAGVFSG
TH_0817|M.thermoresistible__bu SPRASNWRATRTLEEELVRQNIVGIAGIDTRAVVRHLRTRGTMKAGVFSG
MAB_2828c|M.abscessus_ATCC_199 SNRVSNWRASGTLDDALKAQHVVGIAGIDTRAVVRHLRTRGSMKAGIFSG
* .****:: :*:: * * :**** ****.****** *:****:**.
Mflv_3744|M.gilvum_PYR-GCK EQADASVD--DLIARVRDQAAMLGADLAGEVSTDTDYEVDSEGP---QRF
Mvan_2663|M.vanbaalenii_PYR-1 AAADAPVD--ELVARVRGQKPMLGADLAGEVSTDAGYVVEPEGS---QRF
Mb1418|M.bovis_AF2122/97 GALAEPA---DLIARVRAQQSMLGADLAGEVSTAEPYVVEPDGPPGVSRF
Rv1383|M.tuberculosis_H37Rv GALAEPA---DLIARVRAQQSMLGADLAGEVSTAEPYVVEPDGPPGVSRF
MLBr_00535|M.leprae_Br4923 KAMIEPLNIEALVQHVRTQQSMLGADLVGEASTLDAYVVEPKGK---ERF
MAV_3390|M.avium_104 DALADPD---ELVQRVRGQQSMLGADLAGEVSTPDAYIVEPEGP---PRF
MMAR_2198|M.marinum_M AALTAGTQVAELVERVAAQPPMLGADLAGEVSTPEAYIVEPEGP---QRF
MUL_1783|M.ulcerans_Agy99 AALTAGTQVAELVERVAAQPPMLGADLAGEVSTPEAYIVEPEGP---QRF
MSMEG_3046|M.smegmatis_MC2_155 DALADVD---ALLERVRNQPSMLGADLAGKVTTGQTYVVDPDGD---HRF
TH_0817|M.thermoresistible__bu PALADID---ELVTRVREQPSMLGANLSGEVTTPEPYVLEPEGP---HRF
MAB_2828c|M.abscessus_ATCC_199 TVADAPTD--FLLSRVNGQPAMLGADLAGEVSTASTYTVEPDGA---HRF
*: :* * .****:* *:.:* * ::..* **
Mflv_3744|M.gilvum_PYR-GCK TVAALDLGIKTNTPRNFAKRGVRSIVLPSSATFDHIAELKPDGVFLSNGP
Mvan_2663|M.vanbaalenii_PYR-1 TVAALDLGIKTNTPRNFARRGVRSVVLPSSATFAQIADLRPDGVFLSNGP
Mb1418|M.bovis_AF2122/97 TVAALDLGIKTNTPRNFARRGIRCHVLPASTTFEQIAELNPHGVFLSNGP
Rv1383|M.tuberculosis_H37Rv TVAALDLGIKTNTPRNFARRGIRCHVLPASTTFEQIAELNPHGVFLSNGP
MLBr_00535|M.leprae_Br4923 TVAALDLGIKTNTPRNFARRGIRSYVLPASATFNQIADIKPHGLFLSNGP
MAV_3390|M.avium_104 TVAALDLGIKTNTPRNFARRGIRSHVLPSSATFEQIADLRPDGVFLSNGP
MMAR_2198|M.marinum_M TVVALDLGIKTNTPRNFARRGVRSHVLPSSVTFDQIADIKPDGVFLSNGP
MUL_1783|M.ulcerans_Agy99 TVVALDLGIKTNTPRNFARRGVRSHVLPSSVTFDQIADIKPDGVFLSNGP
MSMEG_3046|M.smegmatis_MC2_155 TVAAVDLGIKTNTPRNFARRGVRTHVLPASATFDQIADFKPDGVFLSNGP
TH_0817|M.thermoresistible__bu VIAAIDLGIKTNTPRNFVQRGVRTHVMPAGTTFDELRDLKPDGVFLSNGP
MAB_2828c|M.abscessus_ATCC_199 TVAALDLGIKTNTPRNFARRGIRVQVVPASISPDELLALAPDGVFLSNGP
.:.*:************.:**:* *:*:. : .: : *.*:******
Mflv_3744|M.gilvum_PYR-GCK GDPATADHIVGVTREVLDAGIPLFGICFGNQILGRALGLSTYKMVFGHRG
Mvan_2663|M.vanbaalenii_PYR-1 GDPATADHIVAVTREVLGAGIPLFGICFGNQILGRALGLSTYKMVFGHRG
Mb1418|M.bovis_AF2122/97 GDPATADHVVALTREVLGAGIPLFGICFGNQILGRALGLSTYKMVFGHRG
Rv1383|M.tuberculosis_H37Rv GDPATADHVVALTREVLGAGIPLFGICFGNQILGRALGLSTYKMVFGHRG
MLBr_00535|M.leprae_Br4923 GDPATADHVVALTREVLNAGIPLFGICFGNQILGRALGLSTYKMVFGHRG
MAV_3390|M.avium_104 GDPATADHIVAVTREVLGAGIPLFGICFGNQILGRALGLSTYKMVFGHRG
MMAR_2198|M.marinum_M GDPATADHVVSLTREVLGAGIPLFGICFGNQILGRALGLSTYKMVFGHRG
MUL_1783|M.ulcerans_Agy99 GDPATADHVVSLTREVLGAGIPLFGICFGNQILGRALGLSTYKMVFGHRG
MSMEG_3046|M.smegmatis_MC2_155 GDPATADHIVEVTREVLGAGIPLFGICFGNQILGRALGRSTYKMVFGHRG
TH_0817|M.thermoresistible__bu GDPATADHVVAVTRSVLEAGIPLFGICFGNQILGRALGRSTYKMVFGHRG
MAB_2828c|M.abscessus_ATCC_199 GDPATADHVVSVTRAVLDRKIPLFGICFGNQLLGRALGRSTYKMTFGHRG
********:* :** ** ***********:****** *****.*****
Mflv_3744|M.gilvum_PYR-GCK INIPVMDHTTGRVAITAQNHGFALEGEAGQTFDTPFGQAEVSHTCANDGV
Mvan_2663|M.vanbaalenii_PYR-1 INIPVIDHATGRVAITAQNHGFALEGEAGQTFDTPFGDAEVSHTCANDGV
Mb1418|M.bovis_AF2122/97 INIPVVDHATGRVAVTAQNHGFALQGEAGQSFATPFGPAVVSHTCANDGV
Rv1383|M.tuberculosis_H37Rv INIPVVDHATGRVAVTAQNHGFALQGEAGQSFATPFGPAVVSHTCANDGV
MLBr_00535|M.leprae_Br4923 INIPVIDHATGRVAVTAQNHGFALEGEAGQSFDTPFGSAVVSHTCANDGV
MAV_3390|M.avium_104 INIPVIDHATGRVAVTAQNHGFALQGEAGQAFDTPFGAAVVSHTCANDGV
MMAR_2198|M.marinum_M INIPVIDHATGRVAVTAQNHGFALEGEAGQSFETPFGRAAVSHTCANDGV
MUL_1783|M.ulcerans_Agy99 INIPVIDHATGRVAVTAQNHGFALEGEAGQSFETPFGRAAVSHTCANDGV
MSMEG_3046|M.smegmatis_MC2_155 INIPVVDHITGRVAITAQNHGFALEGEAGEKFDTPFGTAEVSHTCANDGV
TH_0817|M.thermoresistible__bu HNVPVIDHRTGRVAITAQNHGFALEGEAGEVFDTPFGRAEISHTCANDGV
MAB_2828c|M.abscessus_ATCC_199 INIPVIDHSTGRVAITAQNHGFALEGEAGEQFDTPFGRAEVSHTCANDGT
*:**:** *****:*********:****: * **** * :********.
Mflv_3744|M.gilvum_PYR-GCK VEGVRLSNGRAFSVQYHPEAAAGPRDAEYLFDTFIDLMNEG---------
Mvan_2663|M.vanbaalenii_PYR-1 VEGVRLKSGRAFSVQYHPEAAAGPHDAEYLFDQFIELMA-----------
Mb1418|M.bovis_AF2122/97 VEGVKLVDGRAFSVQYHPEAAAGPHDAEYLFDQFVELMA-----------
Rv1383|M.tuberculosis_H37Rv VEGVKLVDGRAFSVQYHPEAAAGPHDAEYLFDQFVELMA-----------
MLBr_00535|M.leprae_Br4923 VEGVKLADGRAFSVQYHPEAAAGPHDAEYLFDSFVELMA-----------
MAV_3390|M.avium_104 VEGVKLADGRAFSVQYHPEAAAGPHDANYLFDQFIELME-----------
MMAR_2198|M.marinum_M VEGVRLVDGRAFSVQYHPEAAAGPHDAEYLFDQFVDLMA-----------
MUL_1783|M.ulcerans_Agy99 VEGVRLVDGRAFSVQYHPEAAAGPHDAEYLFDQFVDLMA-----------
MSMEG_3046|M.smegmatis_MC2_155 VEGVRLVNGKAFSVQYHPEAAGGPHDAEYLFDQFIDLMA-----------
TH_0817|M.thermoresistible__bu VEGVRLVSGRAFSVQYHPEAAAGPHDANNLFDQFIDVMASAASDRVCTPT
MAB_2828c|M.abscessus_ATCC_199 VEGIRLLDGSAFSVQYHPEAAAGPHDAEYLFDQFASALETN---------
***::* .* ***********.**:**: *** * . :
Mflv_3744|M.gilvum_PYR-GCK ------KGESK------
Mvan_2663|M.vanbaalenii_PYR-1 -------GENK------
Mb1418|M.bovis_AF2122/97 -------GEGR------
Rv1383|M.tuberculosis_H37Rv -------GEGR------
MLBr_00535|M.leprae_Br4923 -------AQR-------
MAV_3390|M.avium_104 -------GDR-------
MMAR_2198|M.marinum_M -------GDR-------
MUL_1783|M.ulcerans_Agy99 -------GDR-------
MSMEG_3046|M.smegmatis_MC2_155 -------GEHHS-----
TH_0817|M.thermoresistible__bu SGVSRTNGDSHGDGETR
MAB_2828c|M.abscessus_ATCC_199 -------SENRGNR---
.: