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TVVLALRCANGLVLASDSQITDPGRGLTYPAQKLHTLGAHAAWGGSGSRAVLYDVEQVFSREPDSILEAK DIGHALQARILPILKHHYANFIAEVPGQETGGTPATYVLAAGYVGDAPFIIDIDPNGLIGHHEETGFQAV GSGAAMAQQAHALVTHFHMSQRDVDYGVVAALRVLDALDASSPSVGGPMDICRITPEGAHHLSEDEVADV RGHVRRWVQLEQKALDGLFD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2743 | - | - | 100% (231) | hypothetical protein Mflv_2743 |
| M. gilvum PYR-GCK | Mflv_3077 | - | 5e-09 | 25.00% (220) | 20S proteasome, A and B subunits |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2134c | prcB | 4e-07 | 25.11% (219) | proteasome (beta subunit) PrcB |
| M. tuberculosis H37Rv | Rv2110c | prcB | 4e-07 | 25.11% (219) | proteasome (beta subunit) PrcB |
| M. leprae Br4923 | MLBr_01322 | prcB | 6e-07 | 23.74% (219) | proteasome beta-type subunit 2 |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3085 | prcB | 9e-07 | 23.32% (223) | proteasome (beta subunit) PrcB |
| M. avium 104 | MAV_2404 | - | 6e-07 | 24.66% (223) | PcrB protein |
| M. smegmatis MC2 155 | MSMEG_3895 | - | 2e-06 | 24.57% (232) | proteasome beta subunit |
| M. thermoresistible (build 8) | TH_4264 | - | 8e-87 | 63.36% (232) | PUTATIVE hypothetical protein Mflv_2743 |
| M. ulcerans Agy99 | MUL_2331 | prcB | 6e-07 | 23.32% (223) | proteasome (beta subunit) PrcB |
| M. vanbaalenii PYR-1 | Mvan_3449 | - | 1e-07 | 23.56% (225) | 20S proteasome, A and B subunits |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2134c|M.bovis_AF2122/97 MTWPLPDRLSINSLSGT-----------PAVDLSSFTDFLRRQAPELLPA
Rv2110c|M.tuberculosis_H37Rv MTWPLPDRLSINSLSGT-----------PAVDLSSFTDFLRRQAPELLPA
MMAR_3085|M.marinum_M MTWPLPDRLSINSAISG-----------SAVDLSSFAEFLRRQAPELLPA
MUL_2331|M.ulcerans_Agy99 MTWPLPDRLSINSAISG-----------SAVDLSSFAEFLRRQAPELLPA
MAV_2404|M.avium_104 MTWQFPDRLSTNSALPGPAFSG-----QPAVDLSSFADFLRRQAPELLPA
MLBr_01322|M.leprae_Br4923 MTRSFPDRLPTNLAFPG----------ISVINQSSFVDLLRRQAPELLPV
MSMEG_3895|M.smegmatis_MC2_155 ------------------------------MDLSSFSELLSRQAPELLPV
Mvan_3449|M.vanbaalenii_PYR-1 MTWPNRDQPAFPSSSSGAFSALPQGVSHGGVNLSSFSDFLRHQAPHLLPG
Mflv_2743|M.gilvum_PYR-GCK --------------------------------------------------
TH_4264|M.thermoresistible__bu --------------------------------------------------
Mb2134c|M.bovis_AF2122/97 ---SISGG----APLAGGDAQLPHGTTIVALKYPGGVVMAGDRRSTQGNM
Rv2110c|M.tuberculosis_H37Rv ---SISGG----APLAGGDAQLPHGTTIVALKYPGGVVMAGDRRSTQGNM
MMAR_3085|M.marinum_M ---SIKHG----GGAVG--DQLPHATTIVALKYPGGVLIAGDRRSTQGNM
MUL_2331|M.ulcerans_Agy99 ---SIKHG----GGAVG--DQLPHATTIVALKYPGGVLIAGDRRSTQGNM
MAV_2404|M.avium_104 ---ALGGAQSGPASSSGGTGQLPHGTTIVALKYPGGVVLAGDRRSTQGNM
MLBr_01322|M.leprae_Br4923 ---SLGGG------QSGGGQQLSHGTTIVVLKYPGGVVIAGDRRSTQGNM
MSMEG_3895|M.smegmatis_MC2_155 NRVAYGTT-----PVG-PTDAVPHGTTIVALKYPGGVLIAGDRRSTQGNM
Mvan_3449|M.vanbaalenii_PYR-1 ---APGPG-----PTGLPTDAVPHGTTIVALKCPGGVVMAGDRRATQGNM
Mflv_2743|M.gilvum_PYR-GCK ------------------------MTVVLALRCANGLVLASDSQITDPGR
TH_4264|M.thermoresistible__bu ------------------------MTVVIALRCADGIVMGSDSQITDPGL
*.::.*: ..*:::..* : *: .
Mb2134c|M.bovis_AF2122/97 ISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLT
Rv2110c|M.tuberculosis_H37Rv ISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLT
MMAR_3085|M.marinum_M IAGRDVRKVYITDDYTATGIAGTAAIAVEFARLYAVELEHYEKLEGVPLT
MUL_2331|M.ulcerans_Agy99 IAGRDVRKVYITDDYTATGIAGTAAIAVEFARLYAVELEHYEKLEGVPLT
MAV_2404|M.avium_104 IAGRDVKKVYITDDYTATGIAGTAAIAVEFARLYAVELEHYEKLEGVPLT
MLBr_01322|M.leprae_Br4923 IAGRDVRKVYITDDYTATGIAGIAAVAVEFARLYAVELEHYEKLEGVPLT
MSMEG_3895|M.smegmatis_MC2_155 IAGRDVQKVYITDDYTATGIAGTAAIAVEFARLYAVELEHYEKLEGVPLT
Mvan_3449|M.vanbaalenii_PYR-1 IASRDVQKVYITDDYTVTGIAGTAAIAVEFARLYAVELEHYEKLEGVALT
Mflv_2743|M.gilvum_PYR-GCK GLTYPAQKLHTLGAHAAWGGSGSRAVLYDVEQVFSREPDSILEAKDIGHA
TH_4264|M.thermoresistible__bu GLTYQDQKLHPLGERAAWGGSGSRAALYDIEQTFAADAAAIVDADDVGRA
:*:: . :. * :* * :. : :: : . ..: :
Mb2134c|M.bovis_AF2122/97 FAGKINRLAIMVRGNLAAAMQG-LLALPLLAGYDIHASDPQSAGRIVSFD
Rv2110c|M.tuberculosis_H37Rv FAGKINRLAIMVRGNLAAAMQG-LLALPLLAGYDIHASDPQSAGRIVSFD
MMAR_3085|M.marinum_M FAGKVNRLAIMVRGNLAAAMQG-LVALPLLASYDIHASDPRSAGRIVSFD
MUL_2331|M.ulcerans_Agy99 FAGKVNRLAIMVRGNLAAAMQG-LVALPLLASYDIHASDPRSAGRIVSFD
MAV_2404|M.avium_104 FAGKVNRLAIMVRGNLAAAMQG-LVALPLLAGYDIDARDPEGAGRIVSFD
MLBr_01322|M.leprae_Br4923 FAGKVNRLAIMVRSNLTAAMQG-LLALPLLAGYDIHAPDPQSAGRIVSFD
MSMEG_3895|M.smegmatis_MC2_155 FRGKVNRLAIMVRGNLGAALQG-FVALPLLVGYDLDDPHPEGAGRIVSFD
Mvan_3449|M.vanbaalenii_PYR-1 FPGKVNRLATMVRGNLGAALQG-FVALPLLAGYDLDDPNPEAAGRIVSFD
Mflv_2743|M.gilvum_PYR-GCK LQARILPILKHHYANFIAEVPGQETGG-TPATYVLAAGYVGDAPFIIDID
TH_4264|M.thermoresistible__bu LQARVVPLLKHHYDHFIETVPAKDTGGATPATYVLAAGYSGDRPFIADID
: .:: : :: : . . . * : * .:*
Mb2134c|M.bovis_AF2122/97 AAGGWN-IEEEGYQAVGSGSLFAKSS---MKKLYSQVTDGDSGLRVAVEA
Rv2110c|M.tuberculosis_H37Rv AAGGWN-IEEEGYQAVGSGSLFAKSS---MKKLYSQVTDGDSGLRVAVEA
MMAR_3085|M.marinum_M AAGGWN-IEEEGYQAVGSGSIFAKSS---IKKLYAQVTDADSALRVAVEA
MUL_2331|M.ulcerans_Agy99 AAGGWN-IEEEGYQAVGSGSIFAKSS---IKKLYAQVTDADSALRVAVEA
MAV_2404|M.avium_104 AAGGWN-LEEEGYQSVGSGSIFAKSS---MKKLYSQVVDADSAVRVAIEA
MLBr_01322|M.leprae_Br4923 AAGGWN-IEEEGYQSVGSGSIFAKSS---IKKLYSQVSDADSALRVAIEA
MSMEG_3895|M.smegmatis_MC2_155 AAGGWN-IEEEGYQSVGSGSIFAKSS---MKKLYSQVSDADSALKVAVEA
Mvan_3449|M.vanbaalenii_PYR-1 AAGGWN-FEEEGYQSVGSGSIFAKSS---MKKLYSQVTDAESALRVAVEA
Mflv_2743|M.gilvum_PYR-GCK PNGLIGHHEETGFQAVGSGAAMAQQAHALVTHFHMSQRDVDYGVVAALRV
TH_4264|M.thermoresistible__bu PHGAVGRHEDTGFQAIGSGAPMAQLAHTMLANFRMSERGTDHGVLAVLRV
. * . *: *:*::***: :*: : : :: . . : .: ..:..
Mb2134c|M.bovis_AF2122/97 LYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIES
Rv2110c|M.tuberculosis_H37Rv LYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIES
MMAR_3085|M.marinum_M LYDAADDDSATGGPDLVRGIYPTAVTINADGAVDVPEVRIAELAREVIGS
MUL_2331|M.ulcerans_Agy99 LYDAADDDSATGGPDLVRGIYPTAVTINADGAVDVPEVRIAELAREVIGS
MAV_2404|M.avium_104 LYDAADDDSATGGPDLVRGIYPTAVTIGAEGALEVPESRIAELAREVIQS
MLBr_01322|M.leprae_Br4923 LYDAADDDSATGGPDLVRGIYPTAVTIGAEGAAEVTESRIAELAREIIES
MSMEG_3895|M.smegmatis_MC2_155 LYDAADDDSATGGPDLVRGIYPTAVTIGAEGAEEVPETRIAELAREVIES
Mvan_3449|M.vanbaalenii_PYR-1 LYDAADDDSATGGPDLVRGIFPTAVVIGADGAHEVPEAKISSLCREVVEN
Mflv_2743|M.gilvum_PYR-GCK LDALDASSPSVGGPMDICRITPEGAHHLSE--DEVADVRGHVRRWVQLEQ
TH_4264|M.thermoresistible__bu LDSLAVSAPSVGGPMDVCRITPERACHLTP--EDIEQARRDIERWKEREQ
* . .:.*** : * * . : :: : : .
Mb2134c|M.bovis_AF2122/97 RSGADTFGSD-------GGEK-
Rv2110c|M.tuberculosis_H37Rv RSGADTFGSD-------GGEK-
MMAR_3085|M.marinum_M RSRADTFGPD-------GGEK-
MUL_2331|M.ulcerans_Agy99 RSRADTFGPD-------GGEK-
MAV_2404|M.avium_104 RSRADTFGPDA-----AGGDK-
MLBr_01322|M.leprae_Br4923 RSRAYTLGSFG------GSEK-
MSMEG_3895|M.smegmatis_MC2_155 RSRTDTFGPDARRGIDARGDS-
Mvan_3449|M.vanbaalenii_PYR-1 RSRTETFGPDARP---TRGDEL
Mflv_2743|M.gilvum_PYR-GCK KALDGLFD--------------
TH_4264|M.thermoresistible__bu RVLDDLFD--------------
: :.