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EAPELVALLAGRRVAVLTGAGMSTDSGIPDYRGPDSPPSNPMTIRQFTSDPVFRRRYWARNHLGWRHMDD TQPNAGHRALAALERAGVVTGVITQNVDLLHTKAGSERVIDLHGTYARVICLQCHRTMSRASLADLLEAA NPGFSDRAAAVGGIAVAPDADAVVADTSSFRIVDCPSCGGMLKPDIVYFGENVPKERVDEAYSLVDGAEA LLVAGSSLTVYSGFRFVRHASAKGIPVAIINRGHTRGDDLATVKIDNGCSPMLALLADELPAAGATLTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2641 | - | - | 100% (280) | silent information regulator protein Sir2 |
| M. gilvum PYR-GCK | Mflv_2134 | - | 2e-25 | 32.58% (264) | NAD-dependent deacetylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1182c | - | 7e-25 | 33.58% (268) | NAD-dependent deacetylase |
| M. tuberculosis H37Rv | Rv1151c | - | 7e-25 | 33.58% (268) | NAD-dependent deacetylase |
| M. leprae Br4923 | MLBr_01511 | - | 3e-22 | 31.09% (267) | NAD-dependent deacetylase |
| M. abscessus ATCC 19977 | MAB_3441c | - | 6e-20 | 30.98% (255) | NAD-dependent deacetylase (regulatory protein Sir2 homolog) |
| M. marinum M | MMAR_3760 | - | 1e-130 | 80.29% (274) | Sir2-like regulatory protein |
| M. avium 104 | MAV_1735 | - | 1e-124 | 78.52% (270) | NAD-dependent deacetylase 1 |
| M. smegmatis MC2 155 | MSMEG_4620 | - | 1e-125 | 78.02% (273) | NAD-dependent deacetylase 1 |
| M. thermoresistible (build 8) | TH_2199 | - | 1e-126 | 79.34% (271) | NAD-dependent deacetylase 1 |
| M. ulcerans Agy99 | MUL_3706 | - | 1e-129 | 79.93% (274) | Sir2-like regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_3942 | - | 1e-137 | 87.13% (272) | silent information regulator protein Sir2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2641|M.gilvum_PYR-GCK ------MEAPELVALLAGRRVAVLTGAGMSTDSGIPDYRGPDS---PPSN
Mvan_3942|M.vanbaalenii_PYR-1 ------MEAPELVALLQGRRVAVLTGAGMSTDSGIPDYRGPDS---PPSN
MSMEG_4620|M.smegmatis_MC2_155 ------MDAPELVALLQGRRIVALTGAGMSTDSGIPDYRGPDS---PPSN
MMAR_3760|M.marinum_M MPTLKAVESPELVAALTGHRIAVLTGAGISTDSGIPDYRGPDS---PPSN
MUL_3706|M.ulcerans_Agy99 ------MESPELVAALTGHRIAVLTGAGISTDSGIPDYRGPDS---PPSN
MAV_1735|M.avium_104 -MTVGRAESPELVAVLAGRRIAVLTGAGISTDSGIPDYRGPES---PPSN
TH_2199|M.thermoresistible__bu ------VDAPELIAALRGRRLAVLTGAGISTDSGIPDYRGPDS---PPSN
Mb1182c|M.bovis_AF2122/97 ------------------MRVAVLSGAGISAESGVPTFRDDKNGLWARFD
Rv1151c|M.tuberculosis_H37Rv ------------------MRVAVLSGAGISAESGVPTFRDDKNGLWARFD
MLBr_01511|M.leprae_Br4923 ------------------MRVVVLSGAGISAESDVPTFRDDKNGLWARFD
MAB_3441c|M.abscessus_ATCC_199 ---MTEVPDELIAAASKARSVTVLTGAGMSAESGLPTFRDAQTGLWSKYD
:..*:***:*::*.:* :*. .. . :
Mflv_2641|M.gilvum_PYR-GCK PMTIRQFTSDPVFRRRYWARNHLGWRHMDDTQPNAGHRALAALERAGVVT
Mvan_3942|M.vanbaalenii_PYR-1 PMTIRQFTSDPVFRQRYWARNHLGWRHMDQTQPNAGHRALAALEHAGVVS
MSMEG_4620|M.smegmatis_MC2_155 PMTIQQFTSDPVFRQRYWARNHVGWRHMDETQPNAGHRALAAMEASGVVA
MMAR_3760|M.marinum_M PMTIRQFTSDPVFRQRYWARNHVGWRHMDDTAPNAGHRALAALERAGVVT
MUL_3706|M.ulcerans_Agy99 PMTIRQFTSDPVFRQRYWARNHVGWRHMDDTAPNAGHRALAALERAGVVT
MAV_1735|M.avium_104 PMTIRQFTGDPAFRQRYWARNHVGWRHMDDTLPNAGHRALAALEDAAVVT
TH_2199|M.thermoresistible__bu PMTIQQFTSDPAFRQRYWARNHIGWRHMDQTLPNAGHRALAALEAAGVVT
Mb1182c|M.bovis_AF2122/97 PYELSSTQGWLRNPERVWGWYLWRHYLVANVEPNDGHRAIAAWQDHAEVS
Rv1151c|M.tuberculosis_H37Rv PYELSSTQGWLRNPERVWGWYLWRHYLVANVEPNDGHRAIAAWQDHAEVS
MLBr_01511|M.leprae_Br4923 PYQLSSTQGWQRNPERVWGWYLWRHYLVANVKPNDGHRAIAAWQEQIEVS
MAB_3441c|M.abscessus_ATCC_199 PMTLATPESWQEDPGLVWAWYQNRRIQLLAVQPNDGHRALAQWGSHRDIR
* : . *. : . ** ****:* :
Mflv_2641|M.gilvum_PYR-GCK GVITQNVDLLHTKAGSERVIDLHGTYARVICL--QCHRTMSRASLADLLE
Mvan_3942|M.vanbaalenii_PYR-1 GVITQNVDLLHSKAGSKVVIDLHGTYARVICL--ECGHTMARATLAELLE
MSMEG_4620|M.smegmatis_MC2_155 GVITQNVDLLHTKAGSREVINLHGTYAQVVCLNPDCGHTMSRAALAVMLE
MMAR_3760|M.marinum_M GVITQNVDLLHTKAGSKNVVNLHGTYAQVTCLG--CGHTISRSTLAAELE
MUL_3706|M.ulcerans_Agy99 GVITQNVDLLHTKAGSKNVVNLHGTYAQVTCLG--CGHTISRSTLAAELE
MAV_1735|M.avium_104 GVITQNVDLLHTKAGSRNVIDLHGSYARVICLG--CGDTTSRAALAERLE
TH_2199|M.thermoresistible__bu GLITQNVDRLHTKAGSRTVIELHGSYDRVICLD--CRHTMSRAALAELLE
Mb1182c|M.bovis_AF2122/97 -VITQNVDDLHERAGSGAVHHLHGSLFEFRCARCGVPYTDALPEMPEPAI
Rv1151c|M.tuberculosis_H37Rv -VITQNVDDLHERAGSGAVHHLHGSLFEFRCARCGVPYTDALPEMPEPAI
MLBr_01511|M.leprae_Br4923 -VITQNVDDLHERAGSTPVHHLHGSLFKFHCARCNVAYTGALPDMPEPVL
MAB_3441c|M.abscessus_ATCC_199 -IVTQNVDDLHERAGSSNVTHVHGSLLKSHCDTCRSDFEATVSAP--EAE
::***** ** :*** * .:**: . * : .
Mflv_2641|M.gilvum_PYR-GCK AANPGFSDRAAAVGGIAVAPDADAVVADTSSFRIVDCPSCGGMLKPDIVY
Mvan_3942|M.vanbaalenii_PYR-1 QANPGFADGATQLGGIAVAPDADAVVADTASFQVVDCPRCGGMLKPDIVY
MSMEG_4620|M.smegmatis_MC2_155 EANPGFLARAESVGGIAVAPDADAMITDTASFVVVDCPMCGGMLKPDIVY
MMAR_3760|M.marinum_M SLNPGFIERAEAVGGLAVAPDADAVIADTESFRYIDCRCCGGMLKPDIVY
MUL_3706|M.ulcerans_Agy99 SLNPGFIERAEAVGGLAVAPDADAVIADTESFRYIDCRCCGGMLKPDIVY
MAV_1735|M.avium_104 ALNPGFIERTEAIGGLAVAPDADAVVAETASFRYVDCARCAGMLKPDIVY
TH_2199|M.thermoresistible__bu AANPGFLERPEAVGGIAVAPDADAVVAETGSFRVIDCPRCAGMLKPDIVY
Mb1182c|M.bovis_AF2122/97 EVEP-------------------------------PVCDCGGLIRPDIVW
Rv1151c|M.tuberculosis_H37Rv EVEP-------------------------------PVCDCGGLIRPDIVW
MLBr_01511|M.leprae_Br4923 EVDP-------------------------------PVCYCGGLIRPAIVW
MAB_3441c|M.abscessus_ATCC_199 RVAP-------------------------------PECGCGGKVRPSIVW
* *.* ::* **:
Mflv_2641|M.gilvum_PYR-GCK FGENVPKERVDEAYSLVDGAEALLVAGSSLTVYSGFRFVRHASAKGIPVA
Mvan_3942|M.vanbaalenii_PYR-1 FGESVPKERVAQAFSLVDGADALLVAGSSLTVYSGYRFVRHAAATGKPVA
MSMEG_4620|M.smegmatis_MC2_155 FGDSVPKTRVEQAYSLVDSADALLVAGSSLTVFSGYRFVRHAAARGIPVG
MMAR_3760|M.marinum_M FGESVPKERVDQAFSLVDQSDALLVAGSSLTVFSGYRFLRHAAARGIPVA
MUL_3706|M.ulcerans_Agy99 FGESVPKEPVDQAFSLVDQSDALLVAGSSLTVFSGYRFLRHAAARGIPVA
MAV_1735|M.avium_104 FGESVPKDVVAAAYRLIDESDTLLVAGSSLTVFSGYRFVRHAAARGIPIA
TH_2199|M.thermoresistible__bu FGENVPKQRVLKALCMVDQADALLVAGSSLTVFSGFRFVRHAASLGLPIA
Mb1182c|M.bovis_AF2122/97 FGEPLPEEPWRSAVEATGSADVMVVVGTSAIVYPAAGLPDLALARGTAVI
Rv1151c|M.tuberculosis_H37Rv FGEPLPEEPWRSAVEATGSADVMVVVGTSAIVYPAAGLPDLALARGTAVI
MLBr_01511|M.leprae_Br4923 FGEPLPDEPWRRAVEATETTDVMVVVGTSAIVYPAAGLPELALSRGAVVI
MAB_3441c|M.abscessus_ATCC_199 FGEMLPEVEFGHAVAHSQNCDLMLLIGTSGIVYPAAGLPQLALSRGATVV
**: :*. * : ::: *:* *:.. : * : * :
Mflv_2641|M.gilvum_PYR-GCK IINRGHTRGDDLATVKIDNGCSPMLALLADELPAAG------------AT
Mvan_3942|M.vanbaalenii_PYR-1 IINRGRTRGDDLADVKIDNGCSPMLALLADELPGLSDRDQIVGVYRRSAH
MSMEG_4620|M.smegmatis_MC2_155 IVNRGPTRGDDLAAVKVHSGCSEMLTLLAGELTRTYT-----------AS
MMAR_3760|M.marinum_M IINRGHTRGDDLADVKVDGGCSELLVLLASELAAAVYVE--------PIT
MUL_3706|M.ulcerans_Agy99 IINRGHTRGDDLADVKVDGGCSELLVLLASELAAAVYVE--------PIT
MAV_1735|M.avium_104 IVNRGDTRGDHLATVKVDGGCSELLALLADELS--------------PLP
TH_2199|M.thermoresistible__bu IINRGPTRGDELATVKVDAGCSEMLALLSCELG--------------VLT
Mb1182c|M.bovis_AF2122/97 EVNPEPTPLSGSATISIRESASQALPGLLERLPALLK-------------
Rv1151c|M.tuberculosis_H37Rv EVNPEPTPLSGSATISIRESASQALPGLLERLPALLK-------------
MLBr_01511|M.leprae_Br4923 EVNPEPTPLTKNATISIRETASQALPGLLQRLPALLK-------------
MAB_3441c|M.abscessus_ATCC_199 EINPQETDLSDRADLVWRSTAATALPALLQALAPF---------------
:* * * : .: * * *
Mflv_2641|M.gilvum_PYR-GCK LTR--
Mvan_3942|M.vanbaalenii_PYR-1 LSR--
MSMEG_4620|M.smegmatis_MC2_155 PG---
MMAR_3760|M.marinum_M VC---
MUL_3706|M.ulcerans_Agy99 VC---
MAV_1735|M.avium_104 TH---
TH_2199|M.thermoresistible__bu TAERS
Mb1182c|M.bovis_AF2122/97 -----
Rv1151c|M.tuberculosis_H37Rv -----
MLBr_01511|M.leprae_Br4923 -----
MAB_3441c|M.abscessus_ATCC_199 -----