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TVFSGAGISAESGVPTFRDVETGLWAKVDPYEISSADGWRAHPDRVWAWYLWRHHMMSAVGPNNAHRAVA AWEDYADVHVVTQNVDNLHERAGSRRVYHVHGSLFDFHCDTCRSAYRGPVPDMPEPVESVDPPVCEACGG LIRPDVVWFGEALPDDAWERSVEAVAGADLVVVVGTSSVVYPAAGLPEMALANGTPVIEVNPEPTPLSSS ATVTLREKASTALPGLLQRLPALLT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2134 | - | - | 100% (236) | NAD-dependent deacetylase |
| M. gilvum PYR-GCK | Mflv_2641 | - | 1e-25 | 32.58% (264) | silent information regulator protein Sir2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1182c | - | 5e-97 | 66.81% (235) | NAD-dependent deacetylase |
| M. tuberculosis H37Rv | Rv1151c | - | 5e-97 | 66.81% (235) | NAD-dependent deacetylase |
| M. leprae Br4923 | MLBr_01511 | - | 1e-96 | 66.81% (235) | NAD-dependent deacetylase |
| M. abscessus ATCC 19977 | MAB_3441c | - | 2e-69 | 53.25% (231) | NAD-dependent deacetylase (regulatory protein Sir2 homolog) |
| M. marinum M | MMAR_4302 | - | 1e-94 | 66.81% (235) | transcriptional regulatory protein |
| M. avium 104 | MAV_1289 | - | 1e-95 | 67.81% (233) | NAD-dependent deacetylase |
| M. smegmatis MC2 155 | MSMEG_5175 | - | 1e-106 | 75.74% (235) | NAD-dependent deacetylase |
| M. thermoresistible (build 8) | TH_2199 | - | 8e-23 | 31.84% (267) | NAD-dependent deacetylase 1 |
| M. ulcerans Agy99 | MUL_0992 | - | 4e-95 | 67.23% (235) | NAD-dependent deacetylase |
| M. vanbaalenii PYR-1 | Mvan_4570 | - | 1e-124 | 87.66% (235) | NAD-dependent deacetylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2134|M.gilvum_PYR-GCK -----------------MTVFSGAGISAESGVPTFRDVETGLWAKVDPYE
Mvan_4570|M.vanbaalenii_PYR-1 -----------------MTVFSGAGMSAESGVPTFRDVETGLWAKVDPYE
MSMEG_5175|M.smegmatis_MC2_155 ---------------MQVTVLSGAGISAESGVPTFRDAETGLWAQVDPYE
Mb1182c|M.bovis_AF2122/97 ---------------MRVAVLSGAGISAESGVPTFRDDKNGLWARFDPYE
Rv1151c|M.tuberculosis_H37Rv ---------------MRVAVLSGAGISAESGVPTFRDDKNGLWARFDPYE
MMAR_4302|M.marinum_M ---------------MRVTVLSGAGISAESGVPTFRDDKNGLWARFDPYE
MUL_0992|M.ulcerans_Agy99 ---------------MRVTVLSGAGISAESGVPTFRDDKNGLWARFDPYE
MAV_1289|M.avium_104 -------------------MLSGAGISAESGVPTFRDDKNGLWARFDPYE
MLBr_01511|M.leprae_Br4923 ---------------MRVVVLSGAGISAESDVPTFRDDKNGLWARFDPYQ
MAB_3441c|M.abscessus_ATCC_199 MTEVPDELIAAASKARSVTVLTGAGMSAESGLPTFRDAQTGLWSKYDPMT
TH_2199|M.thermoresistible__bu ---VDAPELIAALRGRRLAVLTGAGISTDSGIPDYRGPDSPPSNPMTIQQ
:::***:*::*.:* :*. ..
Mflv_2134|M.gilvum_PYR-GCK ISSADGWRAHPDRVWAWYLWRHHMMSAVGPNNAHRAVAAWEDYADVH-VV
Mvan_4570|M.vanbaalenii_PYR-1 ISSADGWRAHPDRVWAWYLWRHHMMSAVAPNNAHRAVAAWEDYADVH-VV
MSMEG_5175|M.smegmatis_MC2_155 ISSTDGWQRNPEKVWAWYLWRHYMMARVAPNEAHRTVAAWEDHLDVR-VV
Mb1182c|M.bovis_AF2122/97 LSSTQGWLRNPERVWGWYLWRHYLVANVEPNDGHRAIAAWQDHAEVS-VI
Rv1151c|M.tuberculosis_H37Rv LSSTQGWLRNPERVWGWYLWRHYLVANVEPNDGHRAIAAWQDHAEVS-VI
MMAR_4302|M.marinum_M LSSTQGWERNPERVWGWYLWRHYLVADVAPNPGHQAIAEWQDHAEVS-VV
MUL_0992|M.ulcerans_Agy99 LSSTQGWERNPERVWGWYLWRHYLVADVAPNPGHQAIAEWQDHAEVS-VV
MAV_1289|M.avium_104 LSSTQGWRDNPQRVWGWYLWRHYLVADVAPNAGHRAIAAWQDHAEVS-VI
MLBr_01511|M.leprae_Br4923 LSSTQGWQRNPERVWGWYLWRHYLVANVKPNDGHRAIAAWQEQIEVS-VI
MAB_3441c|M.abscessus_ATCC_199 LATPESWQEDPGLVWAWYQNRRIQLLAVQPNDGHRALAQWGSHRDIR-IV
TH_2199|M.thermoresistible__bu FTSDPAFR---QRYWARNHIGWRHMDQTLPNAGHRALAALEAAGVVTGLI
::: .: *. : . ** .*:::* : ::
Mflv_2134|M.gilvum_PYR-GCK TQNVDNLHERAGSRRVYHVHGSLFDFHCDTCRSAYR----GPVPDMPEPV
Mvan_4570|M.vanbaalenii_PYR-1 TQNVDNLHERAGSSRVYHVHGSLFEFHCDRCRSTFP----DKVPDMPEPA
MSMEG_5175|M.smegmatis_MC2_155 TQNIDDLHERAGSTNVYHLHGSLFEFRCDACGSAFE----GNLPEMPEPV
Mb1182c|M.bovis_AF2122/97 TQNVDDLHERAGSGAVHHLHGSLFEFRCARCGVPYT----DALPEMPEPA
Rv1151c|M.tuberculosis_H37Rv TQNVDDLHERAGSGAVHHLHGSLFEFRCARCGVPYT----DALPEMPEPA
MMAR_4302|M.marinum_M TQNVDDLHERAGSTPVHHLHGSLFEFRCARCNKPYT----DSLPQMPEPA
MUL_0992|M.ulcerans_Agy99 TQNVDDLHERAGSTPVHHLHGSLFEFRCARCNKPYT----DSLPQMPEPA
MAV_1289|M.avium_104 TQNVDDLHERAGSRPVHHLHGSLFEFRCARCAKPYT----GELPAMAEPA
MLBr_01511|M.leprae_Br4923 TQNVDDLHERAGSTPVHHLHGSLFKFHCARCNVAYT----GALPDMPEPV
MAB_3441c|M.abscessus_ATCC_199 TQNVDDLHERAGSSNVTHVHGSLLKSHCDTCRSDFE----ATVSAP--EA
TH_2199|M.thermoresistible__bu TQNVDRLHTKAGSRTVIELHGSYDRVICLDCRHTMSRAALAELLEAANPG
***:* ** :*** * .:*** * * :
Mflv_2134|M.gilvum_PYR-GCK ESVDPPVCE------------------------ACGGLIRPDVVWFGEAL
Mvan_4570|M.vanbaalenii_PYR-1 ESVAPPSCG------------------------ECGGLIRPNVVWFGEPL
MSMEG_5175|M.smegmatis_MC2_155 ETIDPPVC-------------------------PCSGLIRPSVVWFGEPL
Mb1182c|M.bovis_AF2122/97 IEVEPPVC-------------------------DCGGLIRPDIVWFGEPL
Rv1151c|M.tuberculosis_H37Rv IEVEPPVC-------------------------DCGGLIRPDIVWFGEPL
MMAR_4302|M.marinum_M LEVEPPVC-------------------------GCGGLIRPDIVWFGEPL
MUL_0992|M.ulcerans_Agy99 LEVEPPVC-------------------------GCGGLIRPDIVWFGEPL
MAV_1289|M.avium_104 LEVQPPVC-------------------------GCGGLIRPDIVWFGEQL
MLBr_01511|M.leprae_Br4923 LEVDPPVC-------------------------YCGGLIRPAIVWFGEPL
MAB_3441c|M.abscessus_ATCC_199 ERVAPPEC-------------------------GCGGKVRPSIVWFGEML
TH_2199|M.thermoresistible__bu FLERPEAVGGIAVAPDADAVVAETGSFRVIDCPRCAGMLKPDIVYFGENV
* *.* ::* :*:*** :
Mflv_2134|M.gilvum_PYR-GCK PDDAWERSVEAVAGADLVVVVGTSSVVYPAAGLPEMALANGTPVIEVNPE
Mvan_4570|M.vanbaalenii_PYR-1 PDDAWQRSVDAVVNADLVVVVGTSSVVYPAAGLPELAIAHGTPVIEVNPE
MSMEG_5175|M.smegmatis_MC2_155 PDAAWNRSVLAVSSADVVIVVGTSSIVYPAAGLPEAALAAGKPVIEVNPE
Mb1182c|M.bovis_AF2122/97 PEEPWRSAVEATGSADVMVVVGTSAIVYPAAGLPDLALARGTAVIEVNPE
Rv1151c|M.tuberculosis_H37Rv PEEPWRSAVEATGSADVMVVVGTSAIVYPAAGLPDLALARGTAVIEVNPE
MMAR_4302|M.marinum_M PEGPWHCAVEATEAADVMVVVGTSAIVYPAAGLPELALARGKIVIEVNPE
MUL_0992|M.ulcerans_Agy99 PEGPWHCAVEATEAADVVVVVGTSAIVYPAAGLPELALARGKIVIEVNPE
MAV_1289|M.avium_104 PDEPWRRAVEATESADVVVVVGTSAIVYPAAGLAELALSRGAAVVEVNPE
MLBr_01511|M.leprae_Br4923 PDEPWRRAVEATETTDVMVVVGTSAIVYPAAGLPELALSRGAVVIEVNPE
MAB_3441c|M.abscessus_ATCC_199 PEVEFGHAVAHSQNCDLMLLIGTSGIVYPAAGLPQLALSRGATVVEINPQ
TH_2199|M.thermoresistible__bu PKQRVLKALCMVDQADALLVAGSSLTVFSGFRFVRHAASLGLPIAIINRG
*. :: * ::: *:* *:.. : * : * : :*
Mflv_2134|M.gilvum_PYR-GCK PTPLSSSATVTLREKASTALPGLLQRLPALLT----
Mvan_4570|M.vanbaalenii_PYR-1 PTPLTASATVSLRETAATALPGLLQRLPALLG----
MSMEG_5175|M.smegmatis_MC2_155 RTPLSDSATVSLRETASEALPTLLQRLPELLNRSA-
Mb1182c|M.bovis_AF2122/97 PTPLSGSATISIRESASQALPGLLERLPALLK----
Rv1151c|M.tuberculosis_H37Rv PTPLSGSATISIRESASQALPGLLERLPALLK----
MMAR_4302|M.marinum_M PTPLSRSATLCVRESASQALPGLLERLPALLRD---
MUL_0992|M.ulcerans_Agy99 PTPLSRSATLCVRESASQALPGLLERLPALLRD---
MAV_1289|M.avium_104 VTPLSASATLSIRETASQALPGLLQRLPALLN----
MLBr_01511|M.leprae_Br4923 PTPLTKNATISIRETASQALPGLLQRLPALLK----
MAB_3441c|M.abscessus_ATCC_199 ETDLSDRADLVWRSTAATALPALLQALAPF------
TH_2199|M.thermoresistible__bu PTRGDELATVKVDAGCSEMLALLSCELGVLTTAERS
* * : .: *. * * :