For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SPSRSSKPSRFRSSAALLAGTAVLAGAACSTMLQGNAVSVFDDPFKVAGMPATDGPTGLRPDAESPARDV TGTDGGDIDNLAASAVSDIEDYWATAYEDAFDERFKPVAELISWDANGFDGEFCGDTTYGLVNAGYCYAD RTIGWDRGELLPSLQRAHGDIGVVMVLAHEYGHAVSRLSGLSGRDTPTLVAEQQADCFSGAYMRWVAEDS SQRFSLSTGEGLNNVLAGVISFRDPLLNEGDPDAGYDEHGSAFERVSAFQFGFTDGPSACSGIDLDEIGQ RRGDLPVLLPEDQTGELPVTEDSARSIVDAMEILFEPQNPPALSFEPADADNCADARPSPPASFCPATNT IVVDLPALEEMGTQADPDDGTALAAGDNTAYSVLVSRYMLAIQHERGGVALNSAEAALRTACLTGVATVK MSEEVTTPDGDTIALTAGDVDEAVSGMLTNGLAASDVNGESVPSGFSRIDAFRVGVLGDADRCFTRFP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2346 | - | - | 100% (489) | LpqM |
| M. gilvum PYR-GCK | Mflv_3788 | - | 4e-09 | 25.73% (241) | protein of unknown function, zinc metallopeptidase putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0427 | lpqM | 1e-132 | 50.31% (483) | lipoprotein peptidase LpqM |
| M. tuberculosis H37Rv | Rv0419 | lpqM | 1e-132 | 50.31% (483) | lipoprotein peptidase LpqM |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1470c | - | 1e-124 | 47.02% (487) | lipoprotein peptidase LpqM |
| M. marinum M | MMAR_0728 | lpqM | 1e-127 | 48.95% (474) | lipoprotein peptidase LpqM |
| M. avium 104 | MAV_4736 | - | 1e-132 | 49.27% (477) | LpqM protein |
| M. smegmatis MC2 155 | MSMEG_4913 | - | 0.0 | 68.06% (479) | LpqM protein |
| M. thermoresistible (build 8) | TH_1205 | - | 0.0 | 65.64% (486) | LpqM protein |
| M. ulcerans Agy99 | MUL_3589 | lpqM | 1e-125 | 48.31% (474) | lipoprotein peptidase LpqM |
| M. vanbaalenii PYR-1 | Mvan_4299 | - | 0.0 | 81.80% (489) | LpqM |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2346|M.gilvum_PYR-GCK ---------MSPSRSSKPSRFRSSAALLAGTAVLAGAA-CSTMLQGNAVS
Mvan_4299|M.vanbaalenii_PYR-1 ---------MSPSRRPG-TRIGVAAAVCA---VLAATA-CSTTLQGNAVS
MSMEG_4913|M.smegmatis_MC2_155 ---------MS--------RRHLLGAVIATCVVVPLAA-CSTIVEGSAVS
TH_1205|M.thermoresistible__bu ---------MTRRRR--LAAFSTTPALLAVLVVVLLVSGCARVVRGSAVS
MAB_1470c|M.abscessus_ATCC_199 ---------MSIPLR----WFHTSTTILA-CCVLGLAG-CANTVDGTPVS
Mb0427|M.bovis_AF2122/97 MHGRGRYRPLVRCVRPRRVAASVRTPIACLAAVVVIAG-CTTVVDGRALS
Rv0419|M.tuberculosis_H37Rv MHGRGRYRPLVRCVRPRRVAASVRTPIACLAAVVVIAG-CTTVVDGRALS
MMAR_0728|M.marinum_M MDNRGRKWLGVRRSRHGGLIASLWAATAFLTALLVVAG-CTTIVDGRALS
MUL_3589|M.ulcerans_Agy99 MDNRGRKWLGVRRSRHSGLIASLWAATAFLTALLVVAG-CTTIADGRALS
MAV_4736|M.avium_104 ---------------------------MSAAAVLLVAG-CSTFVEGRALS
:: .. *: * .:*
Mflv_2346|M.gilvum_PYR-GCK VFDDPFKVAGMPATDGPTGLRPDAESPARDVTGTDGGDIDNLAASAVSDI
Mvan_4299|M.vanbaalenii_PYR-1 VFDDPFRVAGMPATDGPTGVRPNAEPPARDVEGTDGGAIDELAASAISDI
MSMEG_4913|M.smegmatis_MC2_155 VFADPFSVAGMPATDGPSGLRPDAAAPTREVTDSDGGKIDELAASAVSDI
TH_1205|M.thermoresistible__bu VFADPFRVAGMPAVDGPSGLRPDADAPTRTVRATDGGPIDQLAASAVSDV
MAB_1470c|M.abscessus_ATCC_199 QLGNAYQIAGLPVVDGPSGLRPHPTSADRAVRGTDSGQMDRLAVNAIADI
Mb0427|M.bovis_AF2122/97 ILNDPFRVGGLPATNGPSGARPDAPAASGTVINTNNGAIDKLSLLSVNDI
Rv0419|M.tuberculosis_H37Rv ILNDPFRVGGLPATNGPSGARPDAPAASGTVINTNNGAIDKLSLLSVNDI
MMAR_0728|M.marinum_M ILNDPFRVGGLPATNGPSGPRPDGPPPTGTVINTNNGPIDKLSLLSVNDI
MUL_3589|M.ulcerans_Agy99 ILNDPFRVGGLPATNGPSGPRPDGPPPTGTVINTNNGPIDKLSLLSVNDI
MAV_4736|M.avium_104 MLNDPFLVGGLPATNGPSGIRSNAPAPTGKVLNTDNGSIDSLSLLSINDI
: :.: :.*:*..:**:* *.. .. * ::.* :* *: :: *:
Mflv_2346|M.gilvum_PYR-GCK EDYWATAYEDAFDERFKPVAELISWDANG-FDGEFCGDTTYGLVNAGYCY
Mvan_4299|M.vanbaalenii_PYR-1 EDYWAVAYEETFDEKFRPVAELISWDANG-FDGEFCGEDTYGLINAGYCY
MSMEG_4913|M.smegmatis_MC2_155 EEFWSATYGEVFEGDFTPVRELISWDSES-FDGEFCGLNTFALVNAAYCK
TH_1205|M.thermoresistible__bu EDYWDTAYLDTFGERFTPVRGLVSWDAAE-LFEVFCSMDTHGLENAAFCF
MAB_1470c|M.abscessus_ATCC_199 EDFWQEAYPKTFWATFHPVQSLMSWDSTGPNTGEFCGNPTTGFDNAGYCI
Mb0427|M.bovis_AF2122/97 EDYWMAVYSESLKGTFRPVGKLVSYDSNDPSSPIVCHIDTYQLVNAFFSS
Rv0419|M.tuberculosis_H37Rv EDYWMAVYSESLKGTFRPVGKLVSYDSNDPSSPIVCHIDTYQLVNAFFSS
MMAR_0728|M.marinum_M QDYWKANY-EPLQGTFRPVSKLVSYDSNDPNSPIVCHNDTYELVNAFFTS
MUL_3589|M.ulcerans_Agy99 QDYWKANY-EPLQGTFRPVSKLVSYDSNDPNSPIVCHNDTYELVNAFFTS
MAV_4736|M.avium_104 EDYWRSVYGQSLKGKFVPISKIVSYNSTDPSSPIVCHNDTYQLVNAFYTS
:::* * . : * *: ::*::: .* * : ** :
Mflv_2346|M.gilvum_PYR-GCK ADRTIGWDRGELLPSLQRAHGDIGVVMVLAHEYGHAVSRLSGLSGRDTPT
Mvan_4299|M.vanbaalenii_PYR-1 PDRTIGWDRGELLPGLQRAHGDMGVVMVLAHEYGHAISRLAGLTKKDTPT
MSMEG_4913|M.smegmatis_MC2_155 PDRTIGWDRGVLLPSLRKQNGDMGVVMVLAHEYGHAIQQQAKLVRRNTPT
TH_1205|M.thermoresistible__bu PERTIGWDRGQMLPRLRRANGDMAVVMVLAHEYGHWVSRQAGLTSRRSPI
MAB_1470c|M.abscessus_ATCC_199 NQNALGWDRGALLPKLVRMFGTMAVPMTLAHEYGHAVAHQSEMVDSRTQT
Mb0427|M.bovis_AF2122/97 RCNLIAWDRGVFMAVAQEYFGDMSVNGVLAHEFGHALQVMANLVTRKDPT
Rv0419|M.tuberculosis_H37Rv RCNLIAWDRGVFMAVAQEYFGDMSVNGVLAHEFGHALQVMANLVTRKDPT
MMAR_0728|M.marinum_M RCNMIAWDRGVFMPVAQEYFGEISVTGVLAHEFGHALQVMAKLVTRRDPT
MUL_3589|M.ulcerans_Agy99 RCNMIAWDRGVFMPVAQEYFGEISVTGVLAHEFGHALQVMAKLVTRRDPT
MAV_4736|M.avium_104 RCNLIAWDRGVFMPVAQKYFGDMSVTGVLAHEFGHALQQMAALVTKRDAT
. :.**** ::. . * :.* .****:** : : :
Mflv_2346|M.gilvum_PYR-GCK LVAEQQADCFSGAYMRWVAEDSSQRFSLSTGEGLNNVLAGVISFRDPLLN
Mvan_4299|M.vanbaalenii_PYR-1 LVAEQQADCFGGAYMRWVAEDSSARFTLSTGEGLNNVLAGVISFRDPLLA
MSMEG_4913|M.smegmatis_MC2_155 LVSEQQADCLAGTYMRWVAEGNSPRFTLGTGDGLNSLLAAVIAFRDPLLT
TH_1205|M.thermoresistible__bu LVAEQQADCFAGTYLRWVAEGNSRRFTLSTADGLNDVLAAVVAVRDPVLT
MAB_1470c|M.abscessus_ATCC_199 LVGEQMADCLAGTYLRWVAQNNSPRFTLSTGDGLNKVIAALIAFRDDPIE
Mb0427|M.bovis_AF2122/97 IVREQQADCFAGVYLWWVAEGKSTRFTLSTADGLDHVLAGIITTRDPVME
Rv0419|M.tuberculosis_H37Rv IVREQQADCFAGVYLWWVAEGKSTRFTLSTADGLDHVLAGIITTRDPVME
MMAR_0728|M.marinum_M IVREQQADCFAGVYLYWVAEGKSPRFRLSTADGLDHVLAGIITTRDPVMD
MUL_3589|M.ulcerans_Agy99 IVREQQADCFAGVYLYWVAEGKSPRFRLSTADGLDHVFAGIITTRDPVMD
MAV_4736|M.avium_104 IVREQQADCFAGVYLFWVADGKSPRFTLSTADGLDHVLAGIITTRDPVMD
:* ** ***:.*.*: ***:..* ** *.*.:**: ::*.::: ** :
Mflv_2346|M.gilvum_PYR-GCK EGDPDAGYDEHGSAFERVSAFQFGFTDGPSACSGIDLDEIGQRRGDLPVL
Mvan_4299|M.vanbaalenii_PYR-1 ENDPDVGFDEHGTAFERLSAFQFGFTDGPSACAAIDPAEIDQRRGELPVL
MSMEG_4913|M.smegmatis_MC2_155 ESDMYLGVDEHGSAFERVSAFQFGFTDGAAACKAIDVKEISQRRGDLPVL
TH_1205|M.thermoresistible__bu EGDWRAGLNEHGSAFERLSAFQFGFTNGPSACAAIDMPEIKQRRGELPVL
MAB_1470c|M.abscessus_ATCC_199 IGDI---VDSHGSAFERVSAFQHGFIDGAAECTRIDMAEITKRRGGLPVS
Mb0427|M.bovis_AF2122/97 ADAEND--DEHGSALDRVSAFQLGFINGTPACAAIDEDEVERRRGDLPTT
Rv0419|M.tuberculosis_H37Rv ADAEND--DEHGSALDRVSAFQLGFINGTPACAAIDEDEVERRRGDLPTA
MMAR_0728|M.marinum_M TDEQND--DEHGSALDRVSAFQMGFLSGTPACAAINESEIVRRRGDLPTG
MUL_3589|M.ulcerans_Agy99 TDEQND--DEHGSALDRVSAFQMGLLSGTPACAAINESEIVRRRGDLPTG
MAV_4736|M.avium_104 SETAND--DAHGSALDRISAFQMGFLNGASACASINRKEIEQRRGDLPYA
: **:*::*:**** *: .*.. * *: *: :*** **
Mflv_2346|M.gilvum_PYR-GCK LPED-----QTGELPVTEDSARSIVDAMEILFEPQ--NPPALSFEPADAD
Mvan_4299|M.vanbaalenii_PYR-1 LPED-----QTGELPVTEDSTRSIIDAMGILFSPK--NPPALSFDADEAE
MSMEG_4913|M.smegmatis_MC2_155 LPED-----QTGELPITEESVRAMVDALNVVFKPK--NPPRLSFAARDAD
TH_1205|M.thermoresistible__bu LPEN-----QTGELPVTERSVRTLLDALTIVFRPA--APPRLTLAAAEAE
MAB_1470c|M.abscessus_ATCC_199 PPSG-----VSTQIPISVDTLRTLMTVLKSVYPTNGTTAPRLTVSGAACD
Mb0427|M.bovis_AF2122/97 LRVDASGNPETGEVGINEETLSTLMELMGKIFSPK--NPPTLSYQPAG--
Rv0419|M.tuberculosis_H37Rv LRVDASGNPETGEVGINEETLSTLMELMGKIFSPK--NPPTLSYQPAG--
MMAR_0728|M.marinum_M LRVDSSGNPETGEVPINQDTLTTLMELLGKIFSPT--DPPTLSYQQAG--
MUL_3589|M.ulcerans_Agy99 LRVDSSGNSETGEVPINQDTLTTLMELLGKIFSPT--DPPTLSYQQAG--
MAV_4736|M.avium_104 LRVDTSGRPETGEVPINQDTLSTLMELLGKIFAPA--NPPALSYQPAT--
. : :: :. : ::: : :: . .* *:
Mflv_2346|M.gilvum_PYR-GCK NCADARPSPPASFCPATNTIVVDLPALEEMGTQADPDDGTALAAGDNTAY
Mvan_4299|M.vanbaalenii_PYR-1 SCADARPSPPASFCPATNTIVVDLPALEEMGAQADPQDGGSLATGDNMAY
MSMEG_4913|M.smegmatis_MC2_155 DCPDARPSPPTSYCPATNTIVVDLDELETVGFKPVDGQVGALALGDNSAY
TH_1205|M.thermoresistible__bu SCPDARPSPPASYCPATNVIAVDLDGLAALGAQSDTTDG--LASGDNTAY
MAB_1470c|M.abscessus_ATCC_199 EPGRRVASPPAIYCPISNTVALDLRRLTDL-AQPTHDQG--QITGDFTAF
Mb0427|M.bovis_AF2122/97 -CPDAKPSPPAAYCPATNTIVVDLPALARMGKVASAAEHS-LPQGDDTSL
Rv0419|M.tuberculosis_H37Rv -CPDAKPSPPAAYCPATNTIVVDLPALARMGKVASAAEHS-LPQGDDTSL
MMAR_0728|M.marinum_M -CPDAKPSPPASYCPATNTITVDLPALAAIGKVADSKQHS-LPQGDDTAL
MUL_3589|M.ulcerans_Agy99 -CPDAKPSPPASYCPATNTITVDLPALAAIGKVADSKQHS-LPQGDDTAL
MAV_4736|M.avium_104 -CPDAKPSPPASYCPATNTIAVDLPKLAALGRVADENEHT-LPQGDDTAL
.***: :** :*.:.:** * : . : ** :
Mflv_2346|M.gilvum_PYR-GCK SVLVSRYMLAIQHERGGVALNSAEAALRTACLTGVATVKMSEEVT-TPDG
Mvan_4299|M.vanbaalenii_PYR-1 SVLVSRYMLAIQQEHGGAALDTAEAALRTACLTGVATVKMTEDVT-TPDG
MSMEG_4913|M.smegmatis_MC2_155 SLLISRYMVARQHERG-LVLDNAQAALRTACLTGVATAKLSQPVT-TPDG
TH_1205|M.thermoresistible__bu SVLASRFVLALQREHGGVALNDAKAALRTACLTGVATTKLSAGVV-TSDG
MAB_1470c|M.abscessus_ATCC_199 SVVISRYALAVENQHG-LPLDNGQSALRAACLTGVASAALAKPTTPTQEP
Mb0427|M.bovis_AF2122/97 SIVMSRYALAVQHERG-LPMQSPWTALRTACLTGVAHRKMAVPID-LPSG
Rv0419|M.tuberculosis_H37Rv SIVMSRYALAVQHERG-LPMQSPWTALRTACLTGVAHRKMAVPID-LPSG
MMAR_0728|M.marinum_M SIVMSRYALSVQHQRD-LPMQSPWTALRTACLTGVVHREMAEPIE-LPSG
MUL_3589|M.ulcerans_Agy99 SIVMSRYALSVQHQRD-LPMQSPWTALRTACLTGVVHREMAEPIE-LPSG
MAV_4736|M.avium_104 SVVMSRYALAVQHERG-LAMQSPWTALRTACLTGVVHRRMAEPIE-LPSH
*:: **: :: :.::. :: :***:******. :: .
Mflv_2346|M.gilvum_PYR-GCK DTIALTAGDVDEAVSGMLTNGLAASDVNGESVPSGFSRIDAFRVGVLGDA
Mvan_4299|M.vanbaalenii_PYR-1 DTIALTAGDIDEAVSGILTNGLVASDVNGASVPSGFSRIDAFRLGVLSDT
MSMEG_4913|M.smegmatis_MC2_155 NTIVLTAGDVDEAVSGILTTGLVAGDVNGDSVPSGFSRIDAFRVGILGDE
TH_1205|M.thermoresistible__bu TSISLTAGDLDEAVSGMLTNGLVASDVHGETVPSGFSRIDAYRLGVLGDA
MAB_1470c|M.abscessus_ATCC_199 NPVVLSAGDLDEAVSGLLTNGMVASDVNGVTIPAGFSRIDAFRDGVAGTT
Mb0427|M.bovis_AF2122/97 QQLVLTAGDLDEAVSGLLTNRMVASDADGVSVPAGFTRIAAFRAGVGGDM
Rv0419|M.tuberculosis_H37Rv QQLVLTAGDLDEAVSGLLTNRMVASDADGVSVPAGFTRIAAFRAGVGGDM
MMAR_0728|M.marinum_M QQLVLTAGDLDEAVSGLLTNRMVASDADGISVPAGFTRIAAFRAGVSGDM
MUL_3589|M.ulcerans_Agy99 QQLVLTAGDLDEAVSGLLTNRMVASDADGISVPAGFTRIATFRAGVSGDM
MAV_4736|M.avium_104 NQLLLTAGDLDEAVAGLLTNHLVASDADGTSVPAGFTRIAAFRGGVTGNA
: *:***:****:*:**. :.*.*..* ::*:**:** ::* *: .
Mflv_2346|M.gilvum_PYR-GCK DRCFTRFP-
Mvan_4299|M.vanbaalenii_PYR-1 ERCFKRFP-
MSMEG_4913|M.smegmatis_MC2_155 ARCLKRFS-
TH_1205|M.thermoresistible__bu SRCYQRFG-
MAB_1470c|M.abscessus_ATCC_199 DRCLTRYG-
Mb0427|M.bovis_AF2122/97 DACYARYPG
Rv0419|M.tuberculosis_H37Rv DACYARYPG
MMAR_0728|M.marinum_M EACYSRYPG
MUL_3589|M.ulcerans_Agy99 EACYSRYPG
MAV_4736|M.avium_104 DACYSRYPG
* *: