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VTVADPPVTMRQVIADAAETLAAAGVGSPRVDAELLAAHVAGTDRGLVAFVEPDAAFLSRYRDLTARRAA RVPLQHLTGTAAFGPVVVDVGPGVFIPRPETESLLEWALAQPLSGSARIVDLCTGSGALALALAQGFPGA TVFAVDDSDDALVYTRRNTAGTAVHVVRADVTDAGLLTELDRSVDLLVSNPPYIPDAAELEPEVAEHDPA HALYGGADGMAVIEHLAGVAARLLRPGGRCAVEHDDSTSQATVEVFVRAGGFTEVTARHDLTGRPRFVTA VRNGERVAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2308 | - | - | 100% (289) | HemK family modification methylase |
| M. gilvum PYR-GCK | Mflv_1039 | - | 2e-14 | 30.43% (184) | putative methylase |
| M. gilvum PYR-GCK | Mflv_3729 | - | 1e-07 | 36.84% (133) | Fmu (Sun) domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1332 | hemK | 4e-90 | 62.06% (282) | hypothetical protein Mb1332 |
| M. tuberculosis H37Rv | Rv1300 | hemK | 3e-90 | 62.06% (282) | hypothetical protein Rv1300 |
| M. leprae Br4923 | MLBr_01135 | - | 8e-84 | 57.14% (280) | putative protoporphyrinogen oxidase |
| M. abscessus ATCC 19977 | MAB_1443 | - | 4e-87 | 60.07% (273) | modification methylase HemK |
| M. marinum M | MMAR_4097 | hemK | 1e-88 | 60.87% (276) | modification methylase HemK |
| M. avium 104 | MAV_1517 | - | 2e-87 | 59.04% (293) | modification methylase, HemK family protein |
| M. smegmatis MC2 155 | MSMEG_4949 | - | 2e-99 | 67.15% (274) | modification methylase, HemK family protein |
| M. thermoresistible (build 8) | TH_1566 | hemK | 6e-87 | 60.70% (285) | PROBABLE HEMK PROTEIN HOMOLOG HEMK |
| M. ulcerans Agy99 | MUL_3964 | hemK | 3e-88 | 59.78% (276) | modification methylase HemK |
| M. vanbaalenii PYR-1 | Mvan_4338 | - | 1e-111 | 73.90% (272) | HemK family modification methylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1332|M.bovis_AF2122/97 MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSARCDAEQL
Rv1300|M.tuberculosis_H37Rv MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSARCDAEQL
MLBr_01135|M.leprae_Br4923 -------------------MMIRLRRAIDSAVTQLEEAGIGSARCDAEQL
MMAR_4097|M.marinum_M --------------------MTSLRHAIDSAAALLAEAGIDSARGDAEWL
MUL_3964|M.ulcerans_Agy99 --------------------MTSLRHAIDSAAALLAEAGIDSARGDAEWL
MAV_1517|M.avium_104 --------------MSSGTIRLSLRRAIDDATATLAEAGIASARWDAEQL
Mflv_2308|M.gilvum_PYR-GCK --------------MTVADPPVTMRQVIADAAETLAAAGVGSPRVDAELL
Mvan_4338|M.vanbaalenii_PYR-1 --------------------------MIDDAAAVLAAAGVGSPRVDAELL
MSMEG_4949|M.smegmatis_MC2_155 --------------------MTRLRTAIEAATATLAAAGVATPRIDAELL
TH_1566|M.thermoresistible__bu --------------------MTGLRQVIDAAARELTAAGVNSPRADALEL
MAB_1443|M.abscessus_ATCC_1997 --------------------MSRLRELLAEAAESLSRAGVSSPQVDAEEL
: *. * **: :.: ** *
Mb1332|M.bovis_AF2122/97 AAHLAGTDRGRLPLFEPPGD-EFFGRYRDIVTARARRVPLQHLIGTVSFG
Rv1300|M.tuberculosis_H37Rv AAHLAGTDRGRLPLFEPPGD-EFFGRYRDIVTARARRVPLQHLIGTVSFG
MLBr_01135|M.leprae_Br4923 AAHLAGTDRGRLALLDTPGE-EFFRRYSDAVAARSRRVPLQHLIGTVSFG
MMAR_4097|M.marinum_M AAHLTGTDRGLLYLPGEPLDTDALGQYRDMVTARSRRVPLQHLIGTVQFG
MUL_3964|M.ulcerans_Agy99 AAHLTGTDRGLLYLPDDPLDSDALGQYQDMVTARSRRVPLQHLIGTVQFG
MAV_1517|M.avium_104 AAHLAGVDRGRLGLLESPGQ-EFFQRYRDAVLARARRVPLQHLLGTAAFG
Mflv_2308|M.gilvum_PYR-GCK AAHVAGTDRGLVAFVE-PD-AAFLSRYRDLTARRAARVPLQHLTGTAAFG
Mvan_4338|M.vanbaalenii_PYR-1 AAHVTGTERGRVAFVQ-PD-DAFAARYRELVTARAERVPLQHLTGTAAFG
MSMEG_4949|M.smegmatis_MC2_155 AAHSLGVDRGRLMFVDDPD-PEALAAFEHLVAARAKRIPLQHLVGTAAFG
TH_1566|M.thermoresistible__bu AAHAAGVDRGRLLLLDGPDDASFLARYRELVAARARRVPLQHLTGSAAFG
MAB_1443|M.abscessus_ATCC_1997 AAHLLGVSRTQLRFTEAAA--DFPGRYRDLVAQRARRIPLQHLVGSAAFG
*** *..* : : . : . . *: *:***** *:. **
Mb1332|M.bovis_AF2122/97 PVVLHVGPGVFVPRPETEAILAWATAQSLP---ARPLIVDACTGSGALAV
Rv1300|M.tuberculosis_H37Rv PVVLHVGPGVFVPRPETEAILAWATAQSLP---ARPLIVDACTGSGALAV
MLBr_01135|M.leprae_Br4923 PVVLHVGPDVFIPRPETEAILAWVMAQRLP---ERPVIVDACTGSGALAV
MMAR_4097|M.marinum_M PVELQVGPGVFVPRPETEAVLEWAGAQQLS---EYPVIVDLCTGSGALAI
MUL_3964|M.ulcerans_Agy99 PVELQVGPGVFVPRPETEAVLEWAGAQQLS---EDPVIVDLCTGSGALAV
MAV_1517|M.avium_104 PVLLHVGPGVFVPRPETEALLEWATAQQLP---PRPVIVDLCTGSGALAV
Mflv_2308|M.gilvum_PYR-GCK PVVVDVGPGVFIPRPETESLLEWALAQPLS---GSARIVDLCTGSGALAL
Mvan_4338|M.vanbaalenii_PYR-1 PVTVQVGPGVFVPRPETESVLEWAVAQPLP---ARPRIVDLCTGSGALAL
MSMEG_4949|M.smegmatis_MC2_155 PLTLEVGPGVFIPRPETESLLEWAVAQQLP---RDAVIVDLCTGTGALAL
TH_1566|M.thermoresistible__bu PVTLSVGPGVFIPRPETEALLDWAVRHALPDLGPRPVIADLCTGSGALAL
MAB_1443|M.abscessus_ATCC_1997 PIEVRVGPGVFIPRPETESLYAWAAGQLAP----HATVVELCAGSAALAI
*: : ***.**:******:: *. : . . :.: *:*:.***:
Mb1332|M.bovis_AF2122/97 ALAQHRANLGLKARIIGIDDSDCALDYARRNAAGTPVELVRADVT----T
Rv1300|M.tuberculosis_H37Rv ALAQHRANLGLKARIIGIDDSDCALDYARRNAAGTPVELVRADVT----T
MLBr_01135|M.leprae_Br4923 ALAHHRP----AARVIGIDDSDSALDYARRNAEGTAVECVRADVT----T
MMAR_4097|M.marinum_M ALADRWP----AARILGVDDSGAALEYAQRNSVGTKVELVRADVT----T
MUL_3964|M.ulcerans_Agy99 ALANRWP----TARILGVDDSAAALEYAHRNSVGTKVELVRADVT----T
MAV_1517|M.avium_104 ALAHHRAGRGLPARIVGVDNSDAALEYARRNAAGTTVELVRADVIELARV
Mflv_2308|M.gilvum_PYR-GCK ALAQGFP----GATVFAVDDSDDALVYTRRNTAGTAVHVVRADVT----D
Mvan_4338|M.vanbaalenii_PYR-1 ALAVAFP----AAQVTAVDDSEAALDYARGNVADSSVQLVRADVT----A
MSMEG_4949|M.smegmatis_MC2_155 ALAQHRP----QARVIAVEDSPAALEYARCNAAGTSVEVLAADVT----A
TH_1566|M.thermoresistible__bu ALHHHRP----DARIIAVDISDAALEYARRNTAGTGIEVLRTDVT----A
MAB_1443|M.abscessus_ATCC_1997 ALAQHEP----TARVTAIEVDVDALIYTRRNAEGTGVEVVQADVT----S
** . * : .:: . ** *:: * .: :. : :**
Mb1332|M.bovis_AF2122/97 PCLLPELDGQVDLMVSNPPYIPD-----AAVLEPEVAQHDPHHALFGGPD
Rv1300|M.tuberculosis_H37Rv PRLLPELDGQVDLMVSNPPYIPD-----AAVLEPEVAQHDPHHALFGGPD
MLBr_01135|M.leprae_Br4923 PALLPELDGCVDLFVANPPYVPDDPV-VQSILEPEVTQYDPRHAVFGGPD
MMAR_4097|M.marinum_M PGLMPELDGQVDLVVTNPPYIPD-----GAVLEPEVAQHDPHRALFGGPN
MUL_3964|M.ulcerans_Agy99 PGLMPELDGQVDLVVTNPPYIPD-----GAVLEPEVAQHDPHRALFGGPN
MAV_1517|M.avium_104 PGSAPDLDGRVDLVVANPPYVPD-----GAVLEPEVAQHDPHHAVFGGPD
Mflv_2308|M.gilvum_PYR-GCK AGLLTELDRSVDLLVSNPPYIPDA-----AELEPEVAEHDPAHALYGGAD
Mvan_4338|M.vanbaalenii_PYR-1 PGLLADLDGSVDLLVANPPYIPAG-----ALLEPEVAQYDPAHALFGGAD
MSMEG_4949|M.smegmatis_MC2_155 PDLLPELDGAVDLVVSNPPYIPEG-----AELDPEVADHDPAHALFGGPD
TH_1566|M.thermoresistible__bu PELLAGLAGQVDLIVANPPYIPAPSVPAESGLEPEVARHDPPDALFGGPD
MAB_1443|M.abscessus_ATCC_1997 PDLLTELNGAVDLIVANPPYIPQD-----TELEPEVARHDPPQALFAGAD
. . * ***.*:****:* : *:***: :** *::.*.:
Mb1332|M.bovis_AF2122/97 GMTVISAVVGLAGRWLRPGGLFAVEHDDTTSSSTVDLVSSTKLFVDVQAR
Rv1300|M.tuberculosis_H37Rv GMTVISAVVGLAGRWLRPGGLFAVEHDDTTSSSTVDLVSSTKLFVDVQAR
MLBr_01135|M.leprae_Br4923 GMALTADIVGLAGRWLRPGGLFAVEHDDSTSVPTLDLVYRTDLFDDVLTH
MMAR_4097|M.marinum_M GMAVIPHVVRLAGRWLRPGGRFAVEHDDTTARQTVECIESEGVFEDIVAR
MUL_3964|M.ulcerans_Agy99 GMAVIPHVVRLAGRWLRPGGRFAVEHDDTTARQTVKCIESAGVFEDIVAR
MAV_1517|M.avium_104 GLAVIAPVVELAGRWLRPGGLIGIEHDDTTSHQTVELFDRTGLFDDVRAH
Mflv_2308|M.gilvum_PYR-GCK GMAVIEHLAGVAARLLRPGGRCAVEHDDSTSQATVEVFVRAGGFTEVTAR
Mvan_4338|M.vanbaalenii_PYR-1 GMSVIGPIVDAAARLLRPGGRCAVEHDDTTSEQTVAAFTRDGGFVDVTAR
MSMEG_4949|M.smegmatis_MC2_155 GMAVIRPIVALAARWLRDGGKCAVEHDDTTSARTVEAFTHDGNFTDVTAR
TH_1566|M.thermoresistible__bu GMAVITAIVDRAGVLLRPGGRCAIEHDDTTSAETVTAFTGTGRFVDVVAR
MAB_1443|M.abscessus_ATCC_1997 GLAIIAPIVIAAGRLLAPGGAIGIEHDDSKGGRTRELFTACDFFDEVVQR
*::: :. *. * ** .:****:.. * . * :: :
Mb1332|M.bovis_AF2122/97 KDLAGRPRFVTAMRWGHLPLAGENGAIDPRQRRCRAKR
Rv1300|M.tuberculosis_H37Rv KDLAGRPRFVTAMRWGHLPLAGENGAIDPRQRRCRAKR
MLBr_01135|M.leprae_Br4923 RDLAGRPRFVTARRRESWSA------------------
MMAR_4097|M.marinum_M QDLAGRPRFVTAVKRLVR--------------------
MUL_3964|M.ulcerans_Agy99 QDLAGRPRFVTAVKRLVR--------------------
MAV_1517|M.avium_104 RDLTGRPRFVTARRRSGADVSRRDDAERSDEEERR---
Mflv_2308|M.gilvum_PYR-GCK HDLTGRPRFVTAVRNGERVAR-----------------
Mvan_4338|M.vanbaalenii_PYR-1 HDLAGRPRFVTAVRAG----------------------
MSMEG_4949|M.smegmatis_MC2_155 HDLTGRPRFVTATRIARS--------------------
TH_1566|M.thermoresistible__bu RDLAGRPRFVTATRLGRGHQDSGHQEGLTR--------
MAB_1443|M.abscessus_ATCC_1997 HDLTGRPRFVTARRKIAAS-------------------
:**:******** :