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VSATRAVHQPWPGLIEAYRDRLPIEDSWTPITLREGGTPLLPAPRLSEYTGCTVHLKVEGLNPTGSFKDR GMTMAVTEAVSRGQQAVLCASTGNTSASAAAYAARAGITCAVLVPQGKIAMGKLAQAVMHGAKIIQIDGN FDDCLELARKLTADFPTVSLVNSVNPFRIEGQKTAAFEIVDALGDAPDIHALPVGNAGNITAYWKGYTEY HRDGLASRLPRMLGTQAAGAAPLVLGEPVSDPETIATAIRIGSPASWSSAVEAQQQSDGRFLAATDEEIL AAYHLVARAEGVFVEPASAASIAGLLKAIEEGWVAKGSTVVCTVTGNGLKDPDTALKGMPAVIPVPVDPV AVVAKLGLV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2299 | - | - | 100% (359) | threonine synthase |
| M. gilvum PYR-GCK | Mflv_3634 | - | 4e-21 | 32.11% (299) | threonine dehydratase |
| M. gilvum PYR-GCK | Mflv_3599 | - | 2e-12 | 24.93% (337) | tryptophan synthase subunit beta |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1327 | thrC | 1e-180 | 87.25% (353) | threonine synthase |
| M. tuberculosis H37Rv | Rv1295 | thrC | 1e-180 | 87.25% (353) | threonine synthase |
| M. leprae Br4923 | MLBr_01130 | thrC | 0.0 | 88.35% (352) | threonine synthase |
| M. abscessus ATCC 19977 | MAB_1436 | - | 1e-171 | 82.95% (352) | threonine synthase |
| M. marinum M | MMAR_4102 | thrC | 0.0 | 89.24% (353) | threonine synthase ThrC |
| M. avium 104 | MAV_1510 | thrC | 0.0 | 86.63% (359) | threonine synthase |
| M. smegmatis MC2 155 | MSMEG_4956 | thrC | 0.0 | 88.24% (357) | threonine synthase |
| M. thermoresistible (build 8) | TH_2003 | thrC | 1e-180 | 87.39% (357) | PROBABLE THREONINE SYNTHASE THRC |
| M. ulcerans Agy99 | MUL_3969 | thrC | 0.0 | 88.67% (353) | threonine synthase |
| M. vanbaalenii PYR-1 | Mvan_4347 | - | 0.0 | 96.94% (359) | threonine synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1327|M.bovis_AF2122/97 MTVPPTATHQPWPGVIAAYRDRLPVGDDWTPVTLLEGGTPLIAATNLSKQ
Rv1295|M.tuberculosis_H37Rv MTVPPTATHQPWPGVIAAYRDRLPVGDDWTPVTLLEGGTPLIAATNLSKQ
MLBr_01130|M.leprae_Br4923 MSGQQTTTHQPWPGVIAAYRDRLPVGDDWTPVTLLEGGTPLIAAPRLSEQ
MMAR_4102|M.marinum_M MSASPTAVHKPWPGLIAAYRDRLPVADDWAPVTLLEGGTPLIAAPRLSKQ
MUL_3969|M.ulcerans_Agy99 MSASPTAVHKPWPGLIAAYRDRLPVADDWAPVTLLEGGTPLIAAPRLSKQ
MAV_1510|M.avium_104 MSAQRTAVHQPWPGLIEAYRDRLPVGDDWTPVTLLEGGTPLIPARRLSEK
Mflv_2299|M.gilvum_PYR-GCK -MSATRAVHQPWPGLIEAYRDRLPIEDSWTPITLREGGTPLLPAPRLSEY
Mvan_4347|M.vanbaalenii_PYR-1 -MSTARAVHQPWPGLIEAYRDRLPIEDSWTTITLREGGTPLLPAPRLSEY
TH_2003|M.thermoresistible__bu LSAADTPVHRAWPGLIEAYRSRLPVGPGWTPITLHEGGTPLVPAPRLSEL
MSMEG_4956|M.smegmatis_MC2_155 MSAAKAAVHQPWPGLIEAYRDRLPIGDDWTTVTLLEGGTPLIHAKRISEL
MAB_1436|M.abscessus_ATCC_1997 -----MTVHTPWPGLIAAYRDRLPIGENWQPVTLREGGTPLLPAARLSEL
..* .***:* ***.***: .* .:** ******: * .:*:
Mb1327|M.bovis_AF2122/97 TGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTSASA
Rv1295|M.tuberculosis_H37Rv TGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTSASA
MLBr_01130|M.leprae_Br4923 TGCTIHLKVEGLNPTGSFKDRGMTMAVTDALARGQRAVLCASTGNTSASA
MMAR_4102|M.marinum_M TGCTIHLKVEGLNPTGSFKDRGMTMAVTDALARGQQAVLCASTGNTSASA
MUL_3969|M.ulcerans_Agy99 TGCTIHLKVEGLNPTGSFKDRGMTMAVTDALARGQQAVLCASTGNTSASA
MAV_1510|M.avium_104 TGCTVHLKVEGLNPTGSFKDRGMTMAVTDALARGQQAVLCASTGNTSASA
Mflv_2299|M.gilvum_PYR-GCK TGCTVHLKVEGLNPTGSFKDRGMTMAVTEAVSRGQQAVLCASTGNTSASA
Mvan_4347|M.vanbaalenii_PYR-1 TGCTVHLKVEGLNPTGSFKDRGMTMAVTEAVSRGQQAVLCASTGNTSASA
TH_2003|M.thermoresistible__bu LGCTVYLKVEGLNPTGSFKDRGMTVAVTEAVARGQKAVLCASTGNTSASA
MSMEG_4956|M.smegmatis_MC2_155 TGCTVHLKVEGLNPTGSFKDRGMTVAVTESLARGQQAVLCASTGNTSASA
MAB_1436|M.abscessus_ATCC_1997 TGCTVHLKVEGLNPTGSFKDRGMTMAVTDALARGQRAVLCASTGNTSASA
***::******************:***:::::**:**************
Mb1327|M.bovis_AF2122/97 AAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELAR
Rv1295|M.tuberculosis_H37Rv AAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELAR
MLBr_01130|M.leprae_Br4923 AAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELAR
MMAR_4102|M.marinum_M AAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELAR
MUL_3969|M.ulcerans_Agy99 AAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELAR
MAV_1510|M.avium_104 AAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELAR
Mflv_2299|M.gilvum_PYR-GCK AAYAARAGITCAVLVPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELAR
Mvan_4347|M.vanbaalenii_PYR-1 AAYAARAGITCAVLVPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELAR
TH_2003|M.thermoresistible__bu AAYAARAGITCAVLVPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELAR
MSMEG_4956|M.smegmatis_MC2_155 AAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQVDGNFDDCLELAR
MAB_1436|M.abscessus_ATCC_1997 AAYAAKAGITCAVLIPQGKIAMGKLAQAVIHGARIIQVDGNFDDCLELAR
*****:********:**************:***:***:************
Mb1327|M.bovis_AF2122/97 KMAADFPTISLVNSVNPVRIEGQKTAAFEIVDVLGTAPDVHALPVGNAGN
Rv1295|M.tuberculosis_H37Rv KMAADFPTISLVNSVNPVRIEGQKTAAFEIVDVLGTAPDVHALPVGNAGN
MLBr_01130|M.leprae_Br4923 KMAADFPMISLVNSVNPVRIEGQKTAVFEIVDALGTAPHVHALPVGNAGN
MMAR_4102|M.marinum_M KMAADFPTISLVNSVNPVRIEGQKTAAFEIVDALGVAPDVHALPVGNAGN
MUL_3969|M.ulcerans_Agy99 KMAADFPTISLVNSVNPVRIEGQKTAAFEIVDALGVAPDVHALPVGNAGN
MAV_1510|M.avium_104 KMAADFPTISLVNSVNPVRIEGQKTAAFEIVDVLGAAPDVHALPVGNAGN
Mflv_2299|M.gilvum_PYR-GCK KLTADFPTVSLVNSVNPFRIEGQKTAAFEIVDALGDAPDIHALPVGNAGN
Mvan_4347|M.vanbaalenii_PYR-1 KLTSDFPTVSLVNSVNPFRIEGQKTAAFEIVDALGDAPDVHSLPVGNAGN
TH_2003|M.thermoresistible__bu KLTADFPTISLVNSVNKYRIEGQKTAAFEIVDVLGTAPDVHALPVGNAGN
MSMEG_4956|M.smegmatis_MC2_155 KLTADFPTIALVNSVNPYRIEGQKTAAFEIVDALGTAPDVHALPVGNAGN
MAB_1436|M.abscessus_ATCC_1997 KTTADYPTIALVNSVNPVRIEGQKTAAFEIVDALGTAPDIHALPVGNAGN
* ::*:* ::****** ********.*****.** **.:*:********
Mb1327|M.bovis_AF2122/97 ITAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPLVLGEPVSHPETIATAI
Rv1295|M.tuberculosis_H37Rv ITAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPLVLGEPVSHPETIATAI
MLBr_01130|M.leprae_Br4923 ITAYWKGYTEYHADGLIDRLPRMLGTQAAGAAPLVLGEPVSHPETIATAI
MMAR_4102|M.marinum_M ITAYWKGYTEYHRDGIIEKLPRMLGTQAAGAAPLVLGEPVNHPETIATAI
MUL_3969|M.ulcerans_Agy99 ITAYWKGYTEYHRDGIIEKLPRMLGTQAAGAAPLVLGEPVNHPETIATAI
MAV_1510|M.avium_104 ITAYWKGYTEYHHEGLIEKLPRMLGTQAAGAAPLVHGEPVKNPETIATAI
Mflv_2299|M.gilvum_PYR-GCK ITAYWKGYTEYHRDGLASRLPRMLGTQAAGAAPLVLGEPVSDPETIATAI
Mvan_4347|M.vanbaalenii_PYR-1 ITAYWKGYTEYHRDGLAARLPRMLGTQAAGAAPLVLGEPVSDPETIATAI
TH_2003|M.thermoresistible__bu ITAYWKGYTEYHRDGLTDRLPRMLGTQAAGAAPLVHGAPVRDPETIATAI
MSMEG_4956|M.smegmatis_MC2_155 ITAYWKGYSEYHRDGVSDRLPRMLGTQAAGAAPLVTGAPVKDPETIATAI
MAB_1436|M.abscessus_ATCC_1997 ITAYWRGYNEYHRDGLSDRLPKMLGAQAAGAAPLVNGAPVANPETIATAI
*****:**.*** *: :**:***:********* * ** .********
Mb1327|M.bovis_AF2122/97 RIGSPASWTSAVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASA
Rv1295|M.tuberculosis_H37Rv RIGSPASWTSAVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASA
MLBr_01130|M.leprae_Br4923 RIGSPASWTSAVEAQQQSKGRFLAATDEEILAAYHLVARAEGVFVEPASA
MMAR_4102|M.marinum_M RIGSPASWTSAVEAQQQSKGRFLAATDEEILAAYHLVARAEGVFVEPASA
MUL_3969|M.ulcerans_Agy99 RIGSPASWTSAVEAQQQSKGRFLAATDGEILAAYHLVARAEGVFVEPASA
MAV_1510|M.avium_104 RIGAPASWTAAVDAQQQSHGRFLAATDDEILAAYHLVAESEGVFVEPASA
Mflv_2299|M.gilvum_PYR-GCK RIGSPASWSSAVEAQQQSDGRFLAATDEEILAAYHLVARAEGVFVEPASA
Mvan_4347|M.vanbaalenii_PYR-1 RIGSPASWSSAVEAQQQSGGRFVAATDEEILAAYHLVARAEGVFVEPASA
TH_2003|M.thermoresistible__bu RIGSPASWSSAVEARDQSGGRFLAATDEEILAAYHQVASAEGVFVEPASA
MSMEG_4956|M.smegmatis_MC2_155 RIGSPASWNSAVEAQQQSDGRFLAATDEEILAAYHLVARTEGVFVEPASA
MAB_1436|M.abscessus_ATCC_1997 RIGSPASWSGAVAAQQESGGKFLAVTDEEILNAYRLVASSEGVFVEPASA
***:****..** *:::* *:*:*.:* *** **: ** **********
Mb1327|M.bovis_AF2122/97 ASIAGLLKAIDDGWVARGSTVVCTVTGNGLKDPDTALKDMPSVSPVPVDP
Rv1295|M.tuberculosis_H37Rv ASIAGLLKAIDDGWVARGSTVVCTVTGNGLKDPDTALKDMPSVSPVPVDP
MLBr_01130|M.leprae_Br4923 ASIAGLLKAIDGGWVARGSTVVCTITGNGLKDPDTALKDMPSVSPVPVDA
MMAR_4102|M.marinum_M ASIAGLLKAIDDGWVARGSTVVCTVTGNGLKDPDTALKDMPKVSPVPVDP
MUL_3969|M.ulcerans_Agy99 ASIAGLLKAIDDGWVARGSTVVCTVTGNGLKDPDTALKDMPKVSPVPVDP
MAV_1510|M.avium_104 ASIAGLLKAVEDGWVARGSTVVCTVTGNGLKDPDTALRDMPTVTPLPVDP
Mflv_2299|M.gilvum_PYR-GCK ASIAGLLKAIEEGWVAKGSTVVCTVTGNGLKDPDTALKGMPAVIPVPVDP
Mvan_4347|M.vanbaalenii_PYR-1 ASIAGLLKSIEDGWVAKGSTVVCTVTGNGLKDPDTALKGMPAVIPVPVDP
TH_2003|M.thermoresistible__bu ASIAGLFKAVEDGWVARGSTVVCTVTGNGLKDPDTALRDMPTVTPVPVDP
MSMEG_4956|M.smegmatis_MC2_155 ASIAGLLKSVEDGWVKRGSTVVCTVTGNGLKDPDTALKGMPQVTPVPVDP
MAB_1436|M.abscessus_ATCC_1997 ASIAGLLKSVADGWVAKGSTVVCTVTGNGLKDPDNALSGMPEVTPIPVQA
******:*:: *** :*******:*********.** .** * *:**:.
Mb1327|M.bovis_AF2122/97 VAVVEKLGLA
Rv1295|M.tuberculosis_H37Rv VAVVEKLGLA
MLBr_01130|M.leprae_Br4923 VAVVEQLGLV
MMAR_4102|M.marinum_M VAVVEKLGLA
MUL_3969|M.ulcerans_Agy99 IAVVEKLGLA
MAV_1510|M.avium_104 VLVVEKLGLA
Mflv_2299|M.gilvum_PYR-GCK VAVVAKLGLV
Mvan_4347|M.vanbaalenii_PYR-1 VAVVAKLGLV
TH_2003|M.thermoresistible__bu VAVVEQLGLD
MSMEG_4956|M.smegmatis_MC2_155 SAVVAELGLS
MAB_1436|M.abscessus_ATCC_1997 SAVAEALELA
*. * *