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MTVVLVDPRRPSLVPVEAIELLSGDVQYTEEMPIKVPWSLPAARPAHTGDPAEVLLSSDARHPAVVARVA AGERVIAAPAAQSGERLVDAVAMMDRLRTAGPWESQQTHDSLRRYLLEETYELFDAVHGGDLTELRDELG DVLLQVLFHARIAEEAPENGFGIDDVADALVRKLGNRVPAVLAGESISLEDQLAQWEQRKALERSTRRSS MDDIPTAQPALALAQKVLARAETAGVPVDLIPDAVTKVTVTADFDAENALRTAVLEFMADVRVAERAAGA ARRGADVAEELDDAPRGGITEDEWRAAWPREIAESASEPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1949 | - | - | 100% (320) | nucleoside triphosphate pyrophosphohydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1049 | - | 1e-123 | 70.16% (315) | nucleoside triphosphate pyrophosphohydrolase |
| M. tuberculosis H37Rv | Rv1021 | - | 1e-123 | 70.16% (315) | nucleoside triphosphate pyrophosphohydrolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1158 | - | 1e-105 | 61.68% (321) | nucleoside triphosphate pyrophosphohydrolase |
| M. marinum M | MMAR_4464 | - | 1e-120 | 69.97% (323) | hypothetical protein MMAR_4464 |
| M. avium 104 | MAV_1162 | - | 1e-123 | 69.78% (321) | nucleoside triphosphate pyrophosphohydrolase |
| M. smegmatis MC2 155 | MSMEG_5422 | - | 1e-130 | 72.98% (322) | nucleoside triphosphate pyrophosphohydrolase |
| M. thermoresistible (build 8) | TH_0915 | - | 1e-124 | 70.46% (325) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4633 | - | 1e-120 | 69.97% (323) | nucleoside triphosphate pyrophosphohydrolase |
| M. vanbaalenii PYR-1 | Mvan_4776 | - | 1e-150 | 84.47% (322) | nucleoside triphosphate pyrophosphohydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1949|M.gilvum_PYR-GCK MTVVLVDPRRPSLVPVEAIELLSGDVQYTEEMPIKVPWSLPAARPAHTG-
Mvan_4776|M.vanbaalenii_PYR-1 MTVVLVDPRRPSLIPIEAIELLTGDVQYTEEMPIKVPWSLPSARPCLAGS
Mb1049|M.bovis_AF2122/97 MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAG-
Rv1021|M.tuberculosis_H37Rv MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAG-
MMAR_4464|M.marinum_M MIVVLVDPRRPSLVPVEAIELLGGTVQYTEEMPIAVPWSLPDAHPVHVG-
MUL_4633|M.ulcerans_Agy99 MIVVLVDPRRPSLVPVEAIELLGGTVQYTEEMPIAVPWSLPDAYPVHVG-
MAV_1162|M.avium_104 MIVILCDPRRPSLVPVEAVEHLTGEVQYTEEMPIAVPWSLPAARPVHSGD
MSMEG_5422|M.smegmatis_MC2_155 MIVVLVDPRRPALVPVDAVEFLTGDVQYTEEMPVKVPWSLPSARPAYDGE
TH_0915|M.thermoresistible__bu MTVVLVDPRRPSLVPVEAVGLLAGDVQYTEEMPVKVPWSLPSARPWMADS
MAB_1158|M.abscessus_ATCC_1997 MTVILVDPRHPSMVPVEAVALLAGDLQYTEELPVRLAWSLSTARPVYIG-
* *:* ***:*:::*::*: * * :*****:*: :.***. * . .
Mflv_1949|M.gilvum_PYR-GCK --DPAEVLLSSDARHPAVVARVAAGERVIAAPAAQSGERLVDAVAMMDRL
Mvan_4776|M.vanbaalenii_PYR-1 DDEPAAVLLSSDPGHPSVAARIAAGERVICAPAPQPGERLVDAVAMMDKL
Mb1049|M.bovis_AF2122/97 --NDAPVLLSSDPNHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKL
Rv1021|M.tuberculosis_H37Rv --NDAPVLLSSDPNHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKL
MMAR_4464|M.marinum_M --EEAPVLLSSDPNHPAVVARLAAGARLIAAPDRRRGERLLDAVAMMDKL
MUL_4633|M.ulcerans_Agy99 --EEAPVLLSSDPNHPAVVARLAAGVRLIAAPDRRRGERLLDAVAMMDKL
MAV_1162|M.avium_104 PDDPAPVLLSSDRDHPAVTARLAAGARLISAPDAPRGERLVDAVAMMDKL
MSMEG_5422|M.smegmatis_MC2_155 D---APVLLSSDPEHPVVKARLAAGDRLIAAPEPQPGERLVDAVALMDKL
TH_0915|M.thermoresistible__bu DDDPAPVLLSSDPDHPAVQDRLAAGEQLIRAPEPYPGERLLDAVAMMDQL
MAB_1158|M.abscessus_ATCC_1997 --EDAPALLSSDPDHPEVRARVKAGAAVIAPPARQ-GEKLIDAVAVMDRL
* .***** ** * *: ** :* .* **:*:****:**:*
Mflv_1949|M.gilvum_PYR-GCK RTAGPWESQQTHDSLRRYLLEETYELFDAVHGGDLTELRDELGDVLLQVL
Mvan_4776|M.vanbaalenii_PYR-1 RTAGPWESQQTHDSLRRYLLEETYELFDAVHGGDLTELRDELGDVLLQVL
Mb1049|M.bovis_AF2122/97 RTAGPWESEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVL
Rv1021|M.tuberculosis_H37Rv RTAGPWESEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVL
MMAR_4464|M.marinum_M RTDGPWESEQTHDSLRRYLLEETYELLDAVHSGSVDQLREELGDLLLQVL
MUL_4633|M.ulcerans_Agy99 RTDGPWESEQTHDSLRRYLLEETYELLDAVHSGSVDQLREELGDLLLQVL
MAV_1162|M.avium_104 RTAGPWESEQTHESLRRFLLEETYELLDAVAGGNAEALRDELGDVLLQVL
MSMEG_5422|M.smegmatis_MC2_155 RTSGPWESEQTHDSLRRYLLEETYELFDAVRSGNADELREELGDVLLQVL
TH_0915|M.thermoresistible__bu RTSGPWESEQTHDSLRRYLLEETYELFDAVRSGNADELREELGDVLLQVL
MAB_1158|M.abscessus_ATCC_1997 RTNGPWESTQTHDSLRRYLLEETYELFDAVRTGDADELREELGDVLLQVL
** ***** ***:****:********:*** *. **:****:*****
Mflv_1949|M.gilvum_PYR-GCK FHARIAEEAPENGFGIDDVADALVRKLGNRVPAVLAG----ESISLEDQL
Mvan_4776|M.vanbaalenii_PYR-1 FHARIAEEAPHNSFDVDDVADALVRKLGNRVPAVLAG----ESISLEDQL
Mb1049|M.bovis_AF2122/97 FHARIAEDASQSPFTIDDVADTLMRKLGNRAPGVLAG----ESISLEDQL
Rv1021|M.tuberculosis_H37Rv FHARIAEDASQSPFTIDDVADTLMRKLGNRAPGVLAG----ESISLEDQL
MMAR_4464|M.marinum_M FHARIAEDAALLPFTIDDVADTLMRKLGNRAPGVLAG----ESISLQEQM
MUL_4633|M.ulcerans_Agy99 FHARIAEDAALLPFTIDDVADTLMRKLGNRAPGVLAG----ESISLQEQI
MAV_1162|M.avium_104 FHARIAEDAPQSAFTIDDVAAALIRKLGNRVPGVLAG----QTISLEEQL
MSMEG_5422|M.smegmatis_MC2_155 FHARIAEDAPHHPFSIDDVADALVRKLGNRVPAVLAG----ESISLDEQL
TH_0915|M.thermoresistible__bu FHARIAEDAPENPFSIDDVADALVRKLGNRVPAVLAG----EPVTLDEQL
MAB_1158|M.abscessus_ATCC_1997 FHARIAEDAPEHPFNIDDVAETLLSKLGNRIPVLLGAGGDSASISLEEQL
*******:*. * :**** :*: ***** * :*.. .::*::*:
Mflv_1949|M.gilvum_PYR-GCK AQWEQRKALERSTR--RSSMDDIPTAQPALALAQKVLARAETAGVPVDLI
Mvan_4776|M.vanbaalenii_PYR-1 AQWEQRKALERSTR--ESIMDDIPTAQPALALAQKVLARAETGGVPHDLI
Mb1049|M.bovis_AF2122/97 AQWEAAKASEKAR---KSVADDVHTGQPALALAQKVIQRAQKAGLPAHLI
Rv1021|M.tuberculosis_H37Rv AQWEAAKASEKAR---KSVADDVHTGQPALALAQKVIQRAQKAGLPAHLI
MMAR_4464|M.marinum_M AQWEEGKAAEKARNPRESVLDDVPTGQPALALAQKVIARVCNAGLPVQLI
MUL_4633|M.ulcerans_Agy99 AQWEEGKAAEKARNPRESVLDDVPTGQPALALAQKVIARVCNAGLPVQLI
MAV_1162|M.avium_104 AQWEERKAAEKPR---KSVMDDVHTGQPALALAQKVIGRAEKAGLPADLI
MSMEG_5422|M.smegmatis_MC2_155 AQWEERKAQEKKVKARASSMDDVPTGQPALALAQKVLARVSQAGLPAELI
TH_0915|M.thermoresistible__bu AQWEERKALERRSKRNRSCLDDVPTGQPALALAQKVIERVTQAGLPADLI
MAB_1158|M.abscessus_ATCC_1997 AQWEERKAEEKKDR--DSCLDGISSSQPALALTQKVLGRVTAAGLPAELI
**** ** *: * *.: :.******:***: *. .*:* .**
Mflv_1949|M.gilvum_PYR-GCK PDAVTKVTVTADFDAENALRTAVLEFMADVRVAERAAGAARRGADVAEEL
Mvan_4776|M.vanbaalenii_PYR-1 PAAITSVAVSADIDAENALRSAVLEFMADVRDAERAATAARRGADVAEEL
Mb1049|M.bovis_AF2122/97 PDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQL
Rv1021|M.tuberculosis_H37Rv PDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQL
MMAR_4464|M.marinum_M PAEITSIAVSADTDAENCLRAAVLDFSDNVRRAERAIVAARRGDAVAEEL
MUL_4633|M.ulcerans_Agy99 PAEITSIAVSADIDAENCLRAAVLDFSDNVRRAERAIVAARRGDAVAEEL
MAV_1162|M.avium_104 PPQVTSIAISADVDAESALRTAVLDFVATVRGVERSIAAARRGTSVPDEF
MSMEG_5422|M.smegmatis_MC2_155 PASLTSVSVSADTDSENELRTAVLEFMDTVREVEAAVAAGRRGEDVPEEL
TH_0915|M.thermoresistible__bu PSTITSVAVSAGSDAEHVLRTHVLEFMDTVRRVEEAVAAVRRGEDVPEEL
MAB_1158|M.abscessus_ATCC_1997 PAQLLSVRIDPDGDAENQLRADALEFMDTVRRAEKDILRGRRGDDVASEL
* : .: : .. *:* **: .*:* :* .* *** *..::
Mflv_1949|M.gilvum_PYR-GCK DDAPRGGITEDEWRAAWPREIA----------------------------
Mvan_4776|M.vanbaalenii_PYR-1 DDAPHGVISADEWRAHWPGADE----------------------------
Mb1049|M.bovis_AF2122/97 DVTPLGVITEQEWLAHWPTAVN----------------------------
Rv1021|M.tuberculosis_H37Rv DVTPLGVITEQEWLAHWPTAVN----------------------------
MMAR_4464|M.marinum_M DMAPVGTITEQEWLVHWPSGSAGADVAPEPVVDEEPPQEPAEPEEQVEAP
MUL_4633|M.ulcerans_Agy99 DMAPVGTITEQEWLVHWPSGSAGADVAPEPVVDEEPPQEPAEPEEQVEAP
MAV_1162|M.avium_104 DIAPLGEISEQEWRQHWPAGDTDPEPAP----------------------
MSMEG_5422|M.smegmatis_MC2_155 DVAPLGVISEDEWRAYWP--------------------------------
TH_0915|M.thermoresistible__bu DVAPLDDITEEEWRTYWPTVSAAEAGTVAEVDAE----------------
MAB_1158|M.abscessus_ATCC_1997 DVSDLREVSTEEWRAHWRQAPADPAAATETDLTAE---------------
* : :: :** *
Mflv_1949|M.gilvum_PYR-GCK ----------ESASE------PA---------------
Mvan_4776|M.vanbaalenii_PYR-1 ----------PVAEE------PDAAEG-----------
Mb1049|M.bovis_AF2122/97 ----------DSRGG------SKKRKGMR---------
Rv1021|M.tuberculosis_H37Rv ----------DSRGG------SKKRKGMR---------
MMAR_4464|M.marinum_M AEGETPKESRESRGG------SKKRKGRR---------
MUL_4633|M.ulcerans_Agy99 AEGETPKESRESRGG------SKKRKGRR---------
MAV_1162|M.avium_104 -----AEQLTDDAGG------DEN--------------
MSMEG_5422|M.smegmatis_MC2_155 --------GAESSAS-----EAEPEE------------
TH_0915|M.thermoresistible__bu -----TVSGAESDAEPAHSGDGEPGDGEPGDGAAADEP
MAB_1158|M.abscessus_ATCC_1997 ------EQQPDVHDD------EEAADSGRPKSA-----