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KFLEAPPRFLFFTGKGGVGKTSIACAAAIHLAGSGKRVLLVSTDPASNVGQVLGLTIGNTITRVPAVDGL SALEIDPDQAAEAYRERIIGPVRGLLPAPELQSITEQLSGSCTTEIASFNEFTELLTDSDGPVKQFDHVL FDTAPTGHTIRLLQLPGSWTDFLDAGKGDASCLGPLSGLGKQRALYAGAVDALADPQRTRMVLVARAQRS ALTEIARTHGELAAIGLTHQHVVINGVLPACAGSGDPLAAAIYARERDAIATMPDELRALPLDQVDLKQV NIVGLEALTTLFEPDAVTPGTDREVDFAVADAPLAKLVDELATSEHGLIMCMGKGGVGKTTIAAAIAVAL ADRGHPVHLTTTDPAGHLTDMLHGTMENLHVSRIDPAEATRAYRDHVLATKGAALDDQGRVMLEEDLRSP CTEEVAVFQAFSRVIAESRRKFVVVDTAPTGHTLLLLDATGSYHREVARQLGDRHFTTPLMRLQDPDLTK VIIVTLAETTPVLEAAGLESDLERAQIHPWAWVVNNSTSAAHPTAPLLRHRAVAELPEIDKVRTRHADRL AVVPLLAAEPVGIRALEALTGSSKSAMQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1654 | - | - | 100% (589) | arsenite-activated ATPase ArsA |
| M. gilvum PYR-GCK | Mflv_1367 | - | 3e-11 | 28.73% (181) | anion-transporting ATPase |
| M. gilvum PYR-GCK | Mflv_1368 | - | 5e-10 | 27.04% (270) | anion-transporting ATPase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3705 | - | 9e-12 | 26.57% (286) | anion transporter ATPase |
| M. tuberculosis H37Rv | Rv3680 | - | 1e-11 | 26.57% (286) | anion transporter ATPase |
| M. leprae Br4923 | MLBr_00890 | - | 6e-18 | 30.35% (257) | putative membrane transport ATPase |
| M. abscessus ATCC 19977 | MAB_1982 | - | 1e-17 | 31.27% (259) | putative arsenite-transporting ATPase |
| M. marinum M | MMAR_3228 | - | 5e-11 | 27.69% (242) | hypothetical protein MMAR_3228 |
| M. avium 104 | MAV_0448 | - | 2e-12 | 25.07% (343) | anion-transporting ATPase |
| M. smegmatis MC2 155 | MSMEG_4250 | - | 9e-19 | 30.47% (256) | putative membrane transport ATPase |
| M. thermoresistible (build 8) | TH_1108 | - | 4e-13 | 28.45% (232) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4255 | - | 3e-10 | 30.82% (159) | anion transporter ATPase |
| M. vanbaalenii PYR-1 | Mvan_5095 | - | 0.0 | 82.14% (588) | arsenite-activated ATPase ArsA |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1654|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5095|M.vanbaalenii_PYR-1 MSKVEVFEPALCCATGVCGEDVDQQLVTFSADLDFVSGRGGDISRYNLAG
MSMEG_4250|M.smegmatis_MC2_155 --------------------------------------------------
TH_1108|M.thermoresistible__bu --------------------------------------------------
MLBr_00890|M.leprae_Br4923 --------------------------------------------------
MMAR_3228|M.marinum_M --------------------------------------------------
MAB_1982|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3705|M.bovis_AF2122/97 --------------------------------------------------
Rv3680|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4255|M.ulcerans_Agy99 --------------------------------------------------
MAV_0448|M.avium_104 --------------------------------------------------
Mflv_1654|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5095|M.vanbaalenii_PYR-1 EPRAFAENDTVRAFLHVAGSVGLPLVLVDGVTVMTGRYPDRSQLAAWAGI
MSMEG_4250|M.smegmatis_MC2_155 --------------------------------------------------
TH_1108|M.thermoresistible__bu --------------------------------------------------
MLBr_00890|M.leprae_Br4923 --------------------------------------------------
MMAR_3228|M.marinum_M --------------------------------------------------
MAB_1982|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3705|M.bovis_AF2122/97 --------------------------------------------------
Rv3680|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4255|M.ulcerans_Agy99 --------------------------------------------------
MAV_0448|M.avium_104 --------------------------------------------------
Mflv_1654|M.gilvum_PYR-GCK -----------------------------------------MKFLEAPPR
Mvan_5095|M.vanbaalenii_PYR-1 DTPDGKIPLDIEDTTAAGGGCCGSDSSGATQLLLESARPMTLRFLDAPPR
MSMEG_4250|M.smegmatis_MC2_155 -----------------------------------MPPIPPPESPSVPAR
TH_1108|M.thermoresistible__bu --------------------------------------------------
MLBr_00890|M.leprae_Br4923 --------------------------------------------MPASAQ
MMAR_3228|M.marinum_M --------------------------------------------------
MAB_1982|M.abscessus_ATCC_1997 --------------------------------MSRPGDAAPEVHAPPAAT
Mb3705|M.bovis_AF2122/97 ------------------------------MSVTPKTLDMGAILADTSNR
Rv3680|M.tuberculosis_H37Rv ------------------------------MSVTPKTLDMGAILADTSNR
MUL_4255|M.ulcerans_Agy99 ------------------------------MSSVPKTLDMAAILADTANR
MAV_0448|M.avium_104 ---------------------------------------MAAILADTTNR
Mflv_1654|M.gilvum_PYR-GCK FLFFTGKGGVGKTSIACAAAIHLAGSGKRVLLVSTDPASNVGQVLGLTIG
Mvan_5095|M.vanbaalenii_PYR-1 FLFFTGKGGVGKTSIACAAAIHLARNGKRVLLVSTDPASNVGQVFGLRVG
MSMEG_4250|M.smegmatis_MC2_155 ISLFVGKGGVGKSTLATATAVRDAQAGQRVLIVSTDQAHSTGDVLGIELA
TH_1108|M.thermoresistible__bu --------------------VREARAGQRVLVVSTDQAHSTGDVLGVPVT
MLBr_00890|M.leprae_Br4923 ISLFVGKGGVGKSTLAAATAVRDAGEGRRVLVVSTDQAHSLGDVLGVVVA
MMAR_3228|M.marinum_M --------------MAAATAVCDATAGQRVLVVSTDQAHSLGDVLGIAVA
MAB_1982|M.abscessus_ATCC_1997 IGLFVGKGGVGKSTLAGATAVRHARAGQRVLAVSTDQAHSLGDVFGVRVD
Mb3705|M.bovis_AF2122/97 VVVCCGAGGVGKTTTAAALALRAAEYGRTVVVLTIDPAKRLAQALGINDL
Rv3680|M.tuberculosis_H37Rv VVVCCGAGGVGKTTTAAALALRAAEYGRTVVVLTIDPAKRLAQALGINDL
MUL_4255|M.ulcerans_Agy99 VVVCCGAGGVGKTTTAAAIALRAAEYGRTVVVLTIDPAKRLAQALGVNDL
MAV_0448|M.avium_104 VVVCCGAGGVGKTTTAAAIALRAAEYGRNVCVLTIDPAKRLAQALGVNDL
: * *: * :: * * .:.:*:
Mflv_1654|M.gilvum_PYR-GCK ----NTITRVPAVDG----------LSALEIDPDQAAEAYRERIIGPVRG
Mvan_5095|M.vanbaalenii_PYR-1 ----NAITTVPAVEG----------LSALEIDPEQAAEAYRERIVAPVRG
MSMEG_4250|M.smegmatis_MC2_155 PTGERAPTRVLADMD-AGSDTGG-LLDALALDTLALLEARWVEVAETLSA
TH_1108|M.thermoresistible__bu PTGRREPTRVLADLE-ASAAVGGGSLDALALDTLELLAARWAEVAGPVAA
MLBr_00890|M.leprae_Br4923 PTGHGNPVRVLG----CDAEAGGGFLDALALDTLALLEARWCDVVDALDR
MMAR_3228|M.marinum_M PTGSGEPVRVFADLETGQVDTGGGFLDALALDTLALLEDRWRDVVDALNG
MAB_1982|M.abscessus_ATCC_1997 PSPGAHCVRVIEDPY-------GGELDVMALDTLGLLERRWGDIADTIAA
Mb3705|M.bovis_AF2122/97 GNTPQRVPLAPEVPG---------ELHAMMLDMRRTFDEMVMQYSGPERA
Rv3680|M.tuberculosis_H37Rv GNTPQRVPLAPEVPG---------ELHAMMLDMRRTFDEMVMQYSGPERA
MUL_4255|M.ulcerans_Agy99 GNVPQRVPLAPEVSG---------ELHAMMLDMRRTFDEMVIQYSGSERA
MAV_0448|M.avium_104 GNTPQRVPLAAEVPG---------ELHAMMLDMRRTFDEMVVQYSGPGRA
. * .: :* .
Mflv_1654|M.gilvum_PYR-GCK LLPAPELQSITEQLSGSCT--TEIASFNEFTELLTDSDGPVKQFDHVLFD
Mvan_5095|M.vanbaalenii_PYR-1 LLPDREVQSITEQLSGSCT--TEIASFNEFTELLTDSDALTGQFDHVLFD
MSMEG_4250|M.smegmatis_MC2_155 RFGESDLGSVAPEELSALPGIQEVLGLYEVGELAE-----SGQWDHVVVD
TH_1108|M.thermoresistible__bu RFPDSDLDILAPEELSALPGVQEVLGLHEVAELAA-----AGRWDHVVVD
MLBr_00890|M.leprae_Br4923 RFPESELGSIAPEELSALPGIQEMLGLYTVGEFAT-----AGRWDRIVVD
MMAR_3228|M.marinum_M RFPDSELGSIAPEELSALPGVQEVLGLHAVGELAA-----SGRWDRIVVD
MAB_1982|M.abscessus_ATCC_1997 QYPESDIGSLAPEELSALPGVQEMLGLHEVQQLAD-----TGEWDVVVVD
Mb3705|M.bovis_AF2122/97 QSILD--NQFYQTVATSLAGTQEYMAMEKLGQLLS-----QDRWDLIVVD
Rv3680|M.tuberculosis_H37Rv QSILD--NQFYQTVATSLAGTQEYMAMEKLGQLLS-----QDRWDLIVVD
MUL_4255|M.ulcerans_Agy99 QSILD--NQFYQTVATSLAGTQEYMAMEKLGQLLA-----QDRWDLVVVD
MAV_0448|M.avium_104 QAILD--NQFYQTVASSLAGTQEYMAMEKLGQLLA-----EDRWDLVVVD
. : . * .: . :: .:* ::.*
Mflv_1654|M.gilvum_PYR-GCK TAPTGHTIRLLQLPGSWTDFLDAGKGDASCLGPLSGLGKQRALYAGAVDA
Mvan_5095|M.vanbaalenii_PYR-1 TAPTGHTIRLLQLPGSWTDFLNEGKGDASCLGPLSGLDKQRAIYAEAVEA
MSMEG_4250|M.smegmatis_MC2_155 CASTADALRMLTLPETFGLYLER------------AWPRHRRLS-GTVDA
TH_1108|M.thermoresistible__bu CASTADALRMLTLPDTFNVYLER------------AWPRHRRLSTGIDDP
MLBr_00890|M.leprae_Br4923 CASTADVLRMLTLPSTVGLYVER------------AWPRHRRLSIAAGDA
MMAR_3228|M.marinum_M CASTADALRMLTLPATFSLYVER------------AWPRHRRLSLAIEDG
MAB_1982|M.abscessus_ATCC_1997 CASTADALRMLTLPGTFAMYLER------------AWPRHRRLG-GVGTP
Mb3705|M.bovis_AF2122/97 TPPSRNALDFLDAPKRLGSFMDS---------------RLWRLLLAPGRG
Rv3680|M.tuberculosis_H37Rv TPPSRNALDFLDAPKRLGSFMDS---------------RLWRLLLAPGRG
MUL_4255|M.ulcerans_Agy99 TPPSRNALDFLDAPKRLGSFMDS---------------RLWRLLLAPGRG
MAV_0448|M.avium_104 TPPSRNALDFLDAPKRLGSFMDS---------------RLWRLLLAPGRG
..: ..: :* * ::: : :
Mflv_1654|M.gilvum_PYR-GCK LADPQRTRMVLVARAQRSALTEIARTHGELAAIGLTHQHVVINGVLPACA
Mvan_5095|M.vanbaalenii_PYR-1 LADPLRTRLVLVARAQRSTLAEITRTHRELAAIGLTRQYVVINGVLASPA
MSMEG_4250|M.smegmatis_MC2_155 AT-------ATIVALMERIDAGLRRVGSLLTDGSRVSAHLVLT-------
TH_1108|M.thermoresistible__bu RS-------AAVVALVERLAAATERLSALLTDETLVSAHLVLT-------
MLBr_00890|M.leprae_Br4923 PS-------AAVVELLERISTSVERLGALLTDGSLVSAHLVLT-------
MMAR_3228|M.marinum_M RS-------AALVELLERTSASVDRLSTLLTDGSLVGAHLVLT-------
MAB_1982|M.abscessus_ATCC_1997 RA-------LILAELLERIAASADRLAVLLSDAERVGAHLVLT-------
Mb3705|M.bovis_AF2122/97 IG----------RLITGVMGLAMKALSTVLGSQMLADAAAFVQS------
Rv3680|M.tuberculosis_H37Rv IG----------RLITGVMGLAMKALSTVLGSQMLADAAAFVQS------
MUL_4255|M.ulcerans_Agy99 IG----------RLVTGVMGLAMKAMSTVLGSRMLGDAADFVQS------
MAV_0448|M.avium_104 IG----------RLVTGAMGLAMKAMSTILGSQMLADAAAFVQS------
* .:
Mflv_1654|M.gilvum_PYR-GCK GSGDPLAAAIYARERDAIATMPDELRALPLDQVDLKQVNIVGLEALTTLF
Mvan_5095|M.vanbaalenii_PYR-1 GNGDPLAAAIHTREQQAIAALPDELRGLPLDQVELKATNIVGVDALDSLF
MSMEG_4250|M.smegmatis_MC2_155 --PERVVAAEAARTLGSLALMGVEVAELLVNQILVQDD----SFEYHNLP
TH_1108|M.thermoresistible__bu --AERVVAAEAVRTLGSLALLGVRVPELIVNQILVQDD----SFEYQNLP
MLBr_00890|M.leprae_Br4923 --PERVVAAEAVRTLGSLALMGIRVEELIVNQVLVRNK----FYEYRSLL
MMAR_3228|M.marinum_M --PERVVAAEATRTLGSLALMGVRVEELLVNQVLVRDE----AYEYRSLP
MAB_1982|M.abscessus_ATCC_1997 --PERVVVAEAIRTVGALALMGVRIDQVIVNQVLIQDD----SYEYHNLP
Mb3705|M.bovis_AF2122/97 --LDATFGGFREKADRTYALLKRRGTQFVVVSAAEPDA------------
Rv3680|M.tuberculosis_H37Rv --LDATFGGFREKADRTYALLKRRGTQFVVVSAAEPDA------------
MUL_4255|M.ulcerans_Agy99 --LDATFGGFREKADRTYALLKRRGTQFVVVSAAEPDA------------
MAV_0448|M.avium_104 --LDATFGGFREKADRTYALLKRRGTQFVVVSAAEPDA------------
: . : : * : . . : .
Mflv_1654|M.gilvum_PYR-GCK EPDAVTPGTDREVDFAVADAPLAKLVDELATSEHGLIMCMGKGGVGKTTI
Mvan_5095|M.vanbaalenii_PYR-1 TSDARIPEGDDGTGLPVVDAPLSALIDELAEGDHGLIMCMGKGGVGKTTI
MSMEG_4250|M.smegmatis_MC2_155 AHPAFDWYTER---ISEQQAVLDELDATIGDVSLVLVPHLAGEPIGPKAL
TH_1108|M.thermoresistible__bu QHPAFDWYAER---IAEQRAVLDELEAAIGDVALVLVPHLPGEPIGPKAL
MLBr_00890|M.leprae_Br4923 DHPVFCWYTER---ICEQRAVLDNLDSTIGDVALVVIPYLSGEPIGPKAL
MMAR_3228|M.marinum_M DHPAFYWYAER---ISEQRAVLEELDATIGDVALVLVAHAAGEPIGPKAL
MAB_1982|M.abscessus_ATCC_1997 DHPAFDWYMQR---ITDQSAVLDEMGEAIGDVQMLLVPHLPREPIGPDAL
Mb3705|M.bovis_AF2122/97 -LREASFFVDR---LSQESMPLAGLVFNRTHPMLCALPIER-----AIDA
Rv3680|M.tuberculosis_H37Rv -LREASFFVDR---LSQESMPLAGLVFNRTHPMLCALPIER-----AIDA
MUL_4255|M.ulcerans_Agy99 -LREASFFVDR---LSEESMPLAGLVLNRTHPTLCGLPVER-----AIDA
MAV_0448|M.avium_104 -LREASFFVDR---LSQEGMPLAGLVLNRTHPPLCSLPAER-----AIDG
: : * : :
Mflv_1654|M.gilvum_PYR-GCK AAAIAVALADRGHPVHLTTTDPAGHLTDMLHGTMENLHVSRIDPAEATRA
Mvan_5095|M.vanbaalenii_PYR-1 AAAIAVALADRGHPVHLTTTDPAGHLSGTLHGTLPNLHVSSIDPVEATRA
MSMEG_4250|M.smegmatis_MC2_155 AELLEAARRRDGA-------PPPGPLKPIVD-------------------
TH_1108|M.thermoresistible__bu AELLDSARRRDGS-------PPPQPLRPVVD-------------------
MLBr_00890|M.leprae_Br4923 AELLDVAHRRRGP-------APMGPLRPIVD-------------------
MMAR_3228|M.marinum_M GGLLDGARRRRGS-------APPGPLRPIVD-------------------
MAB_1982|M.abscessus_ATCC_1997 GELAESVRRRDGA-------KPPAPLATVVE-------------------
Mb3705|M.bovis_AF2122/97 AETLDAETTDSDA---------TSLAAAVLR-------------------
Rv3680|M.tuberculosis_H37Rv AETLDAETTDSDA---------TSLAAAVLR-------------------
MUL_4255|M.ulcerans_Agy99 TETLDEEHADSET---------AALTAAVLR-------------------
MAV_0448|M.avium_104 TEMLEHD-GDPET---------TSLAAAVLR-------------------
:
Mflv_1654|M.gilvum_PYR-GCK YRDHVLATKGAALDDQGRVMLEEDLRSPCTEEVAVFQAFSRVIAESRRKF
Mvan_5095|M.vanbaalenii_PYR-1 YRDHVLATKGAALDEQGRSMLEEDLRSPCTEEVAVFQAFSRVISESRNKF
MSMEG_4250|M.smegmatis_MC2_155 ------RESGSGLEAVYR--------------------------------
TH_1108|M.thermoresistible__bu ------RESGSGLQAVYR--------------------------------
MLBr_00890|M.leprae_Br4923 ------LESGSGLESVYR--------------------------------
MMAR_3228|M.marinum_M ------LESGSGLGSVYR--------------------------------
MAB_1982|M.abscessus_ATCC_1997 ------HESGSGADTVYR--------------------------------
Mb3705|M.bovis_AF2122/97 -------IHAERGQTAKR--------------------------------
Rv3680|M.tuberculosis_H37Rv -------IHAERGQTAKR--------------------------------
MUL_4255|M.ulcerans_Agy99 -------IHPDRAQTAKR--------------------------------
MAV_0448|M.avium_104 -------IHADRAQTAKR--------------------------------
*
Mflv_1654|M.gilvum_PYR-GCK VVVDTAPTGHTLLLLDATGSYHREVARQLGDRHFTTPLMRLQDPDLT-KV
Mvan_5095|M.vanbaalenii_PYR-1 VVVDTAPTGHTLLLLDATGSYHREVARQLGNRHFTTPLMRLQDPELT-KV
MSMEG_4250|M.smegmatis_MC2_155 --------------------------------------MRLELPQVDSAA
TH_1108|M.thermoresistible__bu --------------------------------------LRLELPHVDPGA
MLBr_00890|M.leprae_Br4923 --------------------------------------LRLALPQLDFAA
MMAR_3228|M.marinum_M --------------------------------------LRLALPQLDPGS
MAB_1982|M.abscessus_ATCC_1997 --------------------------------------LRLELPQIDPAT
Mb3705|M.bovis_AF2122/97 --------------------------------------------EIRLLS
Rv3680|M.tuberculosis_H37Rv --------------------------------------------EIRLLS
MUL_4255|M.ulcerans_Agy99 --------------------------------------------EIRLLS
MAV_0448|M.avium_104 --------------------------------------------EIRLLS
.:
Mflv_1654|M.gilvum_PYR-GCK IIVTLAETTPVLEAAGLESDLERAQIHPWAWVVNNSTSAAHPTAPLLRHR
Mvan_5095|M.vanbaalenii_PYR-1 IVVTLAETTPVLEAAGLQSELERAQIQPWAWVVNNSLAAAHPTSPLLRQR
MSMEG_4250|M.smegmatis_MC2_155 LTLGRVDDDLIIGVGAMRRRVRLASVLRRCIVVDASLRGSQLTVRFRPNP
TH_1108|M.thermoresistible__bu LTLGRVDDDLIIGVGALRRRVRLASVLRRCLVLDAALRGNELTVRFRPNP
MLBr_00890|M.leprae_Br4923 LTLGRVDDDLIISAGGTRCRVRLASVLRRCMVLGAQLRGSELTVRFRPDP
MMAR_3228|M.marinum_M LTLGRADDDLIISAGGMRRRVRLASVLRRCIVLDARLSGGELTVRFRPDP
MAB_1982|M.abscessus_ATCC_1997 LSLGRVGDDLVIGANGMRRRVRLASVLRRCVVVDARLVGGELTIRFRADP
Mb3705|M.bovis_AF2122/97 RFTGANPTVPVVGVPSLPFDVSDLEALR---ALADQLTTVGNDAGRAAGR
Rv3680|M.tuberculosis_H37Rv RFTGANPTVPVVGVPSLPFDVSDLEALR---ALADQLTTVGNDAGRAAGR
MUL_4255|M.ulcerans_Agy99 RFTGANPHVPIIGVPSLPFDVSDLDALR---ALADQITAAGNGGGATPAR
MAV_0448|M.avium_104 RFTGANPHVPVIGVPSLPFDVSDLEALR---ALADQITSN-----RATAR
:: . . : . .:
Mflv_1654|M.gilvum_PYR-GCK AVAELPEIDKVRTRHADRLAVVPLLAAEPVGIRALEALTGSSKSAMQ
Mvan_5095|M.vanbaalenii_PYR-1 AVAELPQIDKVRTDYADRVAVIPLLACEPVGIPALEALAGSRTAAV-
MSMEG_4250|M.smegmatis_MC2_155 EVWPV------------------------------------------
TH_1108|M.thermoresistible__bu EVWPT------------------------------------------
MLBr_00890|M.leprae_Br4923 EVWPI------------------------------------------
MMAR_3228|M.marinum_M EVWPT------------------------------------------
MAB_1982|M.abscessus_ATCC_1997 EVWPT------------------------------------------
Mb3705|M.bovis_AF2122/97 -----------------------------------------------
Rv3680|M.tuberculosis_H37Rv -----------------------------------------------
MUL_4255|M.ulcerans_Agy99 -----------------------------------------------
MAV_0448|M.avium_104 -----------------------------------------------