For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VTASDTGKNPRYVWAWRLLRLDFTGVALGALFFCVSLTPSLLPRDWLFQGLIGGINAAIGYGIGVFLERM LRRFVLPNRLWWPLSPRLRKALKTVTVAVSVGACVLMVIPAAAWQRQVSGLMSMEGPSTTGYLRLLLVAA AVAALCIATSRLLLDVIKTVARLLIRRWRLSDEMALFFGTAVVVILVITLVNGVLMRGFFAGANQVFQPQ NATTREGVVQPEEREKSGSPDSFAAWDTLGYQGRNFVGTGPHAEELTRINGRPAEEPIRVYVGLQTADTD EARMAVLLSELERTGAFDREVLVIVPTTGTGWVNPIAARSLEMMYNGDSAIVASQYSYLPSWISFLGDQE KSMAAGRLLIDAVHGRWSTLPPERRPRLILYGESLGSMAGQAAFDWLPDISRMGFSSVLWVGPPNASPLW RAITIRRDPRTPEVEPRYDDGRTVRFSQGNDATQIAEDARSPWDEPRVLFLQHASDPIVWWSPDLLFTRP DWLSEPPGRDRTTAMRWYPIVTFWQVAADMTNASSVPGGHGHNYGDYILDGWAGVAPPDGWTRADTERIR VALEQTESEDGDF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1631 | - | - | 100% (573) | hypothetical protein Mflv_1631 |
| M. gilvum PYR-GCK | Mflv_2035 | - | e-115 | 41.94% (558) | hypothetical protein Mflv_2035 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1098c | - | 1e-111 | 41.52% (554) | hypothetical protein Mb1098c |
| M. tuberculosis H37Rv | Rv1069c | - | 1e-111 | 41.52% (554) | hypothetical protein Rv1069c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0708 | - | 0.0 | 58.87% (564) | hypothetical protein MAB_0708 |
| M. marinum M | MMAR_4397 | - | 1e-112 | 41.89% (561) | hypothetical protein MMAR_4397 |
| M. avium 104 | MAV_1193 | - | 1e-114 | 41.56% (551) | hypothetical protein MAV_1193 |
| M. smegmatis MC2 155 | MSMEG_5823 | - | 0.0 | 71.83% (568) | membrane-spanning protein |
| M. thermoresistible (build 8) | TH_0675 | - | 1e-112 | 41.08% (555) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0211 | - | 1e-101 | 41.37% (527) | hypothetical protein MUL_0211 |
| M. vanbaalenii PYR-1 | Mvan_5118 | - | 0.0 | 78.71% (573) | hypothetical protein Mvan_5118 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1098c|M.bovis_AF2122/97 MTEPAAATTTNASDEP----------ATGAEQAVDTAATPQTPEPQPIR-
Rv1069c|M.tuberculosis_H37Rv MTEPAAATTTNASDEP----------ATGAEQAVDTAATPQTPEPQPIR-
MMAR_4397|M.marinum_M MSDMDSATSTDASDEA----------APAADESVETSGSGETAAPKTTR-
MUL_0211|M.ulcerans_Agy99 MSDMDSATSTDASDEA----------APAADESVETSGSGETAAPKTTR-
MAV_1193|M.avium_104 MSEPGSATDTDTGDEPSQQQTAPDGTRTGAQTAVAEHPAPKAPAPGTPQP
TH_0675|M.thermoresistible__bu --------VTATPDKT------------AEHASEEVAPQEHKSEP-----
Mflv_1631|M.gilvum_PYR-GCK --------MTASDTG------------------------------KNPRY
Mvan_5118|M.vanbaalenii_PYR-1 --------MTASDTE------------------------------ERPAY
MSMEG_5823|M.smegmatis_MC2_155 ------MIEEHSHTL------------------------------RHPLL
MAB_0708|M.abscessus_ATCC_1997 MSETPGVPVTTSTVDPD---------DWIGRSWLAFQELEEHIEHRHPLV
:
Mb1098c|M.bovis_AF2122/97 -STWWIRHYTFTGTAMGLVFVWFSMTPSLLPRGPLFQGLVSGICGAFGYG
Rv1069c|M.tuberculosis_H37Rv -STWWIRHYTFTGTAMGLVFVWFSMTPSLLPRGPLFQGLVSGICGAFGYG
MMAR_4397|M.marinum_M -NAWWVRHYTFTGSAVGLIFLWFSMTPSLLPRGPLFQGLVSGISGAIGYG
MUL_0211|M.ulcerans_Agy99 -NAWWVRHYTFTGSAVGLIFLWFSMTPSLLPRGPLFQGLVSGISGAIGYG
MAV_1193|M.avium_104 EKPWWVRHYTFTGTTVGLVFIWFSLTPSLLPRGAIFQGLVSGISGAIGYG
TH_0675|M.thermoresistible__bu -GAWWTRHYTFFGTAVGLVFLWFSLTPSLLPRGPLFQGIVSGAAGAAGYG
Mflv_1631|M.gilvum_PYR-GCK VWAWRLLRLDFTGVALGALFFCVSLTPSLLPRDWLFQGLIGGINAAIGYG
Mvan_5118|M.vanbaalenii_PYR-1 LWAWRLLRLDFIGVAFGALFFCLSLTPSLLPRDWLFQGLIGGLNAAIGYG
MSMEG_5823|M.smegmatis_MC2_155 RWAWSLLRLDFAGVAVGALFFCLSLTPSLLPRDWLFAGLIGGVNAAIGYG
MAB_0708|M.abscessus_ATCC_1997 AWAWNLLRLDFCGIAFGALFFCLSLTPSLMPRTWLFQGLIGGATAAIGYG
.* : * * :.* :*. .*:****:** :* *::.* .* ***
Mb1098c|M.bovis_AF2122/97 LGVFAVWLVR--YMRSHNSSPPPP---RWAWPPLIAVGAVGMVGMAVQFH
Rv1069c|M.tuberculosis_H37Rv LGVFAVWLVR--YMRSHNSSPPPP---RWAWPPLIAVGAVGMVGMAVQFH
MMAR_4397|M.marinum_M LGVFAVWLVR--YMRSQDDSPPPP---RWVWPPLIAVGGVGIVLMAIWFH
MUL_0211|M.ulcerans_Agy99 LGVFAVWLVR--YMRSQDDSPPPP---RWVWPPLIAVGGVGIVLMAIWFH
MAV_1193|M.avium_104 LGVFAVWLYR--YLWAKPSSPPPP---RWAWKILIPVGAVGMVLMAIWFH
TH_0675|M.thermoresistible__bu IGVFGVWLVR--FMASRDSSPRAP---RWAWIALIVVGTVVQLLMINYFR
Mflv_1631|M.gilvum_PYR-GCK IGVFLERMLRRFVLPNRLWWPLSPRLRKALKTVTVAVSVGACVLMVIPAA
Mvan_5118|M.vanbaalenii_PYR-1 IGVFLAKILRRFVLANRRWWPPPPKVLYASKAVIVVVAASACVLMVIPAA
MSMEG_5823|M.smegmatis_MC2_155 LGVVLGKALYRFALRNRTWWPPPNWVLLWAKTLIVGGSIASCVLMLIPAA
MAB_0708|M.abscessus_ATCC_1997 IGVALSKLVLRFWLRHQKWWPLRDRVMITVKLGVVVLGAVCSLAMIVPAA
:** : : * : . : *
Mb1098c|M.bovis_AF2122/97 VWQDDVRDLMGVEHLRWYDYPLAAALSLVVLFTLVEIGQFIRWLFRFLVG
Rv1069c|M.tuberculosis_H37Rv VWQDDVRDLMGVEHLRWYDYPLAAALSLVVLFTLVEIGQFIRWLFRFLVG
MMAR_4397|M.marinum_M FWQDDVRDLMGVVHLKWYDYPLTAVVSLIVLFAFVEVGQFIRRLFSFLVR
MUL_0211|M.ulcerans_Agy99 FWQDDVRDLMGVVHLKWYDYPLTAVVSLIVLFAFVEVGQFIRRLFSFLVR
MAV_1193|M.avium_104 VWQDKVRDLMGVAHLKWYDYPVAGVLSLVVLFTCVEIGQFTRWLVSFLVG
TH_0675|M.thermoresistible__bu IWQDEVRDFMGVPRLTFWDHPLAGALSIAFLFTLVEIGKLIGRAVRFLNG
Mflv_1631|M.gilvum_PYR-GCK AWQRQVSGLMSMEGPSTTGYLRLLLVAAAVAALCIATSRLLLDVIKTVAR
Mvan_5118|M.vanbaalenii_PYR-1 AWQRQVSALMGMDGPSTTSYFRTLLLAAVVGGVCVATARVLLEFIKTLAR
MSMEG_5823|M.smegmatis_MC2_155 AWQRQVSALMGMEGPATPGYLRTAVLAAAVAGALIATARVLRDAVRQVAK
MAB_0708|M.abscessus_ATCC_1997 RWQRQIAALMDAQGPTTLEYSKAFLVSIAVGALFISVARILRDLVRLLAR
** .: :*. : :: . : .:. . :
Mb1098c|M.bovis_AF2122/97 QVDR--IAPFRVSAAIVVVLLVVLTITLLNGVVLKFAMNSMNSTFAAVNN
Rv1069c|M.tuberculosis_H37Rv QVDR--IAPFRVSAAIVVVLLVVLTITLLNGVVLKFAMNSMNSTFAAVNN
MMAR_4397|M.marinum_M QLDR--IAPFRLSATIVVVLLVTLTITVLNGVVLKFAMHSMNSTFASVND
MUL_0211|M.ulcerans_Agy99 QLDR--IAPFRLSATIVVVLLVTLTITVLNGVVLKFAMHSMNSTFASVND
MAV_1193|M.avium_104 RLDR--IAPFRLSATIVVALLVVLTITLLNGVVLKFAMRTMNNTFASANN
TH_0675|M.thermoresistible__bu QLRR--FAPPRVSAVVSVLLVVALIIAILNGIVVRWAMSTINSTFAAVNE
Mflv_1631|M.gilvum_PYR-GCK LLIRRWRLSDEMALFFGTAVVVILVITLVNGVLMRGFFAGANQVFQPQNA
Mvan_5118|M.vanbaalenii_PYR-1 VLIRRWRLSDEIALFVGTAVVVVLVITLVNGVLFRGFLAGANAVFQPQNA
MSMEG_5823|M.smegmatis_MC2_155 VLIRRLHLHREVAQFIGTVVVVVLVVTLVNGVLYRGFLLGASNVFRPQNS
MAB_0708|M.abscessus_ATCC_1997 FLIRRLRLSQEVSLLIGTAIVAVLAIMLFNGVLVRGFFAAANASFGPHND
: * .:: . . ::. * : :.**:: : : . * . *
Mb1098c|M.bovis_AF2122/97 EMNPDSAPPKTPLRSGGPGSLVSWESLGHQGRIFVHSGPTIADLTAFNGT
Rv1069c|M.tuberculosis_H37Rv EMNPDSAPPKTPLRSGGPGSLVSWESLGHQGRIFVHSGPTIADLTAFNGT
MMAR_4397|M.marinum_M ELDPNSAPPNTALRSGGPQSLVSWESLGHQGRVFVEGGPSRADLTAFNGS
MUL_0211|M.ulcerans_Agy99 ELDPNSAPPNTALRSGGPQSLVSWESLGHQGRVFVEGGPSRADLTAFNGS
MAV_1193|M.avium_104 EMSPDTAPPKTPLRSGGPESLVSWESLGHQGRVFIEGGPRVEQLTAFNGA
TH_0675|M.thermoresistible__bu EDDPAFPAPTTPLRSGGPGSLVSWESLGHQGRIFVAAGPTVEQLSEFNGA
Mflv_1631|M.gilvum_PYR-GCK TTREGVVQPEEREKSGSPDSFAAWDTLGYQGRNFVGTGPHAEELTRINGR
Mvan_5118|M.vanbaalenii_PYR-1 TTAEGVVQPALPEKSGSPDSFAQWDSLGFQGRSFVAGGLNADELARINGR
MSMEG_5823|M.smegmatis_MC2_155 TTREGVSQPTEPERSGSPESFAPWDTLGYQGRNFVATGPRADELEEVNGR
MAB_0708|M.abscessus_ATCC_1997 TTRAGVQQPLQPERSGSPASLSSWDSLGYEGRNFVSGGLHADVLAKVNGR
* :**.* *: *::**.:** *: * * .**
Mb1098c|M.bovis_AF2122/97 PAVEPIRTYAGLNSADGIMATAELAARELARTGGLRRAVVAVATSTGTGW
Rv1069c|M.tuberculosis_H37Rv PAVEPIRTYAGLNSADGIMATAELAARELARTGGLRRAVVAVATSTGTGW
MMAR_4397|M.marinum_M PATEPIRAYAGLNSANGIIATAELAARELQRTGGLQRAVVAVATTTGTGW
MUL_0211|M.ulcerans_Agy99 PATEPIRAYAGLNSANGIIATAELAARELQRTGGLQRAVVAVATTTGTGW
MAV_1193|M.avium_104 PATEPIRAYAGLNSADGITATAELAARELQRTGGLRRAVVAVATTTGTGW
TH_0675|M.thermoresistible__bu PAVEPIRAYAGLNSANGIRETAALAARELQRTGGLNRQVVAVATTTGTGW
Mflv_1631|M.gilvum_PYR-GCK PAEEPIRVYVGLQTADTDEARMAVLLSELERTGAFDREVLVIVPTTGTGW
Mvan_5118|M.vanbaalenii_PYR-1 PAKEPVRVYVGLQTADTDEGRMAVLLSELERTGAFDREVLVIAPTTGTGW
MSMEG_5823|M.smegmatis_MC2_155 PAREPIRVYVGLQSADTEEQRISLLLSELERTHAFDREVLVIVPTTGTGW
MAB_0708|M.abscessus_ATCC_1997 PAKEPIRVYAGLETADTAEERADILVRELERTKAFDRKVLVIVPTTGTGW
** **:*.*.**::*: : ** ** .: * *:.:..:*****
Mb1098c|M.bovis_AF2122/97 INEAEASALEYMYNGDTAIVSMQYSFLPSWLSFLVDKENARHAGEALFEA
Rv1069c|M.tuberculosis_H37Rv INEAEASALEYMYNGDTAIVSMQYSFLPSWLSFLVDKENARHAGEALFEA
MMAR_4397|M.marinum_M INEAEASALEYMYNGNTAIVSMQYSYLPSWLSFLVDKENARQAGQALFEA
MUL_0211|M.ulcerans_Agy99 INEAEASALEYMYNGNTAIVSMQYSYLPSWLSFLVDKENARQAGQALFEA
MAV_1193|M.avium_104 INEAEATALEYMYNGNTAIVSMQYSFLPSWLSFLVDKENARHAGQALFEA
TH_0675|M.thermoresistible__bu INEAEASALEYMFNGDTAIVSMQYSYLPSWLSFLVDKENARQAGQALFEA
Mflv_1631|M.gilvum_PYR-GCK VNPIAARSLEMMYNGDSAIVASQYSYLPSWISFLGDQEKSMAAGRLLIDA
Mvan_5118|M.vanbaalenii_PYR-1 INPIAARSIEMMYNGDTAIVGSQYSFLPSWISFLGDQEKSMKSGRSMIDA
MSMEG_5823|M.smegmatis_MC2_155 VNPVAARAIELMYNGDTATVGMQYSYLPSWISFLGDREISMHTGRLMIDA
MAB_0708|M.abscessus_ATCC_1997 VTPAAARGIELMYNGDTAIVATQYSFLPSWISFLADKKKALASGQLLVDT
:. * .:* *:**::* *. ***:****:*** *:: : :*. :.::
Mb1098c|M.bovis_AF2122/97 VDKLIRQLPESQRPKLVVFGESLGSFGGEAPFMNLNNILAR-TDGALFSG
Rv1069c|M.tuberculosis_H37Rv VDKLIRQLPESQRPKLVVFGESLGSFGGEAPFMNLNNILAR-TDGALFSG
MMAR_4397|M.marinum_M VDKLIRQMPEFQRPKLVVFGESLGSFGGEAPFMNLNNILAR-TDGALFSG
MUL_0211|M.ulcerans_Agy99 VDKLIRQMPEFQRPKLVVFGESLGSFGGEAPFMNLNNILAR-TDGALFSG
MAV_1193|M.avium_104 VDRLVRQLPEAQRPKLVVFGESLGSFGGEAPFMSLNNVLAR-TDGALFSG
TH_0675|M.thermoresistible__bu VDALIREMPEAERPRLVVFGESLGSFGGEAPFLALNNLVAR-TDGALFSG
Mflv_1631|M.gilvum_PYR-GCK VHGRWSTLPPERRPRLILYGESLGSMAGQAAFDWLPDISRMGFSSVLWVG
Mvan_5118|M.vanbaalenii_PYR-1 VHERWAKRPPDRRPRLLLYGESLGSMAGQGAFDWLPDIPRMGFSSVLWVG
MSMEG_5823|M.smegmatis_MC2_155 VQSRWEALPPDRRPKLVLYGESLGSMAGQGAFSWLPDIARKGFSSVLWVG
MAB_0708|M.abscessus_ATCC_1997 VQKRWAQQPEGHRPKLLIYGESLGSFAGQGAFGGLGDIRAAGVAGVLWTG
*. * .**:*:::******:.*:..* * :: ..*: *
Mb1098c|M.bovis_AF2122/97 PTFNNTVWNSLTANRDAGSPQWLPIYDDGRNVRFVAR---ARDLQRPDAP
Rv1069c|M.tuberculosis_H37Rv PTFNNTVWNSLTANRDAGSPQWLPIYDDGRNVRFVAR---ARDLQRPDAP
MMAR_4397|M.marinum_M PTFNNTVWTELTANRDPGSPEWLPIYDDGYNVRFIAR---ASDLQRPDAP
MUL_0211|M.ulcerans_Agy99 PTFNNTVWTELTANRDPGSPEWLPIYDDGYNVRFIAR---ASDLQRPDAP
MAV_1193|M.avium_104 PTFNNTIWTDLTSTRDAGSPEWLPIYNDGRNVRFVAR---AANLARPKDP
TH_0675|M.thermoresistible__bu PTFNNEIWAELTRTRDPGSPMWLPIYDRGANVRFVSR---PDDLNRPDAP
Mflv_1631|M.gilvum_PYR-GCK PPNASPLWRAITIRRDPRTPEVEPRYDDGRTVRFSQGNDATQIAEDARSP
Mvan_5118|M.vanbaalenii_PYR-1 PPNASPLWRGITARRDPGTPEVLPRYDNGRTVRFSQGNNAAQIAADTAAP
MSMEG_5823|M.smegmatis_MC2_155 PPNASPLWHGLTVRRDPGTPEVRPRYDNGRTVRFSEAADPAQIARDTAEP
MAB_0708|M.abscessus_ATCC_1997 PPNFSHIWNELVSKRDRGTLEALPVYDSGFTARFAIG---PDIDALAKPP
*. . :* :. ** : * *: * ..** . . *
Mb1098c|M.bovis_AF2122/97 WGRPRVVYLQHASDPIAWWTPRLLFREPDWLREQRGYDVLPQTRWIPVVT
Rv1069c|M.tuberculosis_H37Rv WGRPRVVYLQHASDPIAWWTPRLLFREPDWLREQRGYDVLPQTRWIPVVT
MMAR_4397|M.marinum_M WGKPRVVYLQHASDPIAWWTPDLLFSEPDWLREKRGYDVLPQTRWIPLVT
MUL_0211|M.ulcerans_Agy99 WGKPRVVYLQHASDPIAWWTPDLLFSEPDWLREKRGYDVLPQTRWIPLVT
MAV_1193|M.avium_104 WDHPRVVYLQHASDPIAWWTTDLLFARPDWLKERRGYDVLPETTWIPVVT
TH_0675|M.thermoresistible__bu WGEPRVVYLQHASDPIAWWSPDLLFAEPDWLKEPRGYDVSGRTQWIPVVT
Mflv_1631|M.gilvum_PYR-GCK WDEPRVLFLQHASDPIVWWSPDLLFTRPDWLSEPPGRDRTTAMRWYPIVT
Mvan_5118|M.vanbaalenii_PYR-1 WDGTRVLFLQHPSDPIVWLSQELLFTRPNWLSEPPGPDRTASMRWYPIIT
MSMEG_5823|M.smegmatis_MC2_155 WEGTRVLFLQHPSDPIVWWSTDLLFSRPDWLVEPPGGDRTASMRWYPIIT
MAB_0708|M.abscessus_ATCC_1997 WQNPKVLFVQHPSDPVTWWSTDLLFSEPDWLKEAPVGDRSAAMRWYPIVT
* .:*:::**.***:.* : *** .*:** * * * *::*
Mb1098c|M.bovis_AF2122/97 FVQVSADMAVATHVPDG-----------HGHRYVATVAD------GWAAV
Rv1069c|M.tuberculosis_H37Rv FVQVSADMAVATHVPDG-----------HGHRYVATVAD------GWAAV
MMAR_4397|M.marinum_M FLQVSADMAVAVDVPDG-----------HGHRYVSNVAN------GWAAV
MUL_0211|M.ulcerans_Agy99 FLQVSADMAVAVDVPDGMDTATSATSPTAGPRSCRRRAGPPRKPSGYDRC
MAV_1193|M.avium_104 FLQVSADMAVAQNVPDG-----------HGHHYVADVAD------AWAAV
TH_0675|M.thermoresistible__bu FLQVAADMAVATQVPDG-----------HGHRYVHTVAD------AWAAV
Mflv_1631|M.gilvum_PYR-GCK FWQVAADMTNASSVPGG-----------HGHNYGDYILD------GWAGV
Mvan_5118|M.vanbaalenii_PYR-1 FWQVAADMTNAVSVPPG-----------HGHNYNDFILD------GWAGV
MSMEG_5823|M.smegmatis_MC2_155 FWQVAADMTNASSVPAG-----------HGHNYGESVLD------GWAAV
MAB_0708|M.abscessus_ATCC_1997 FWQVAADLANAVGVPDG-----------HGHNYGISSVN------GWAAI
* **:**:: * ** * * . . .:
Mb1098c|M.bovis_AF2122/97 LSPPGWTQQKTERLQPLLHANAKPFGS----
Rv1069c|M.tuberculosis_H37Rv LSPPGWTQQKTERLQPLLHANAKPFGS----
MMAR_4397|M.marinum_M LSPPGWTPEKTERLRPLLRAN----------
MUL_0211|M.ulcerans_Agy99 CAPTSGCGVGRRSGRPSIVSR----------
MAV_1193|M.avium_104 LSPPGWTPDKTDRLRPLLHANG---------
TH_0675|M.thermoresistible__bu LQPPGWTHEKTERLRPLLHADAKPNEVSPTK
Mflv_1631|M.gilvum_PYR-GCK APPDGWTRADTERIRVALEQTESEDG-DF--
Mvan_5118|M.vanbaalenii_PYR-1 APPRGWTQEDTERIRLALEEAGSEGG-GY--
MSMEG_5823|M.smegmatis_MC2_155 APPDGWTPEDTERIRMALQKTAANDGPEY--
MAB_0708|M.abscessus_ATCC_1997 APPAGWTPQDTERIRKALVDTASLDGPDT--
* . : :