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TTSPRTTPAVLERIARELPDQPAVVTAQRTLTYFGLRSEVLHAAAAMIDLGIEPGDRVAIWSPNTWHWVV ASLAIHHAGGVLVPLNTRYTASEAEDILARTGAPLLFASGAFLGADKAASVDRDSLPALRHIVRIPVDTD DGTWDEYIARGAKEEALAAVGARAAAVTADDVSDILFTSGTTGRSKGVRCAQRQSLDASAAWAACGQLTR DDRYLCINPFFHNFGYKAGILACLQTGATLYPELTFDPGETMQAVQEHRITVLPGPPTIYQTLLDHPRRS EFDLSSLRFAVTGAATIPVVLIERMQSELDIDIVLTAYGLTEAAGFGTMCRADDDAVTVATTSGRPIADF ELRIGESGEVLLRGPNVMLGYLDDPEATAAAIDGDGWLHTGDVGELDPAGNLKITDRLKDMYICGGFNVY PAEIEQVLARLDGVAEAAVIGVPDDRLGEVGKAFVVTLPGAELDEKTVIDHAREHLANFKTPRSVEFLDA LPRNPGGKVVKPLLRQRSERA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1480 | - | - | 100% (512) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_2525 | - | e-116 | 47.96% (490) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4867 | - | 6e-79 | 36.40% (522) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3591 | fadD3 | 0.0 | 75.90% (502) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv3561 | fadD3 | 0.0 | 76.10% (502) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 2e-48 | 31.01% (503) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_0596c | - | 0.0 | 63.71% (507) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_5050 | fadD3 | 0.0 | 75.79% (508) | fatty-acid-CoA ligase FadD3 |
| M. avium 104 | MAV_0600 | fadD | 0.0 | 77.06% (510) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_4772 | - | 1e-109 | 46.04% (493) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2068 | fadD3 | 0.0 | 78.68% (516) | PROBABLE FATTY-ACID-CoA LIGASE FADD3 (FATTY-ACID-CoA |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 0.0 | 75.59% (508) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_5286 | - | 0.0 | 85.90% (525) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1480|M.gilvum_PYR-GCK --------------------------MTTSPRTTPAVLERIARELPDQPA
Mvan_5286|M.vanbaalenii_PYR-1 ------------------------------MRTTPAVLDRIARELPDHPA
TH_2068|M.thermoresistible__bu ------------------------------MRTIPAVLDRAAERLPDHDA
MMAR_5050|M.marinum_M --------------------------MTSDPRTVPTALDRLVRRLPNHDA
MUL_4126|M.ulcerans_Agy99 --------------------------MTSDPRTVPTALDRLVRRLPNHDA
MAV_0600|M.avium_104 --------------------------MTTDPRTVPAALDRLARRLPDHDA
Mb3591|M.bovis_AF2122/97 --------------------------MINDLRTVPAALDRLVRQLPDHTA
Rv3561|M.tuberculosis_H37Rv --------------------------MINDLRTVPAALDRLVRQLPDHTA
MAB_0596c|M.abscessus_ATCC_199 ----------------------MESAQQTPGLTIPAALDQAAARFGERDA
MSMEG_4772|M.smegmatis_MC2_155 -------------------------MTHPSWQTIPEMVLSAADRFGDAEA
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
: . :
Mflv_1480|M.gilvum_PYR-GCK VVT------------------AQRTLTYFGLRSEVLHAAAAMIDLGIEPG
Mvan_5286|M.vanbaalenii_PYR-1 VVTTAGGAGNPAVAGESGNPAAARTLTYAELRAEVRQAAAALIDLGIEPG
TH_2068|M.thermoresistible__bu LVTAATGG------------AEARRFSYAELRAEVRRAAAAMIAAGIAPG
MMAR_5050|M.marinum_M LVT------------------DERSFTVSELHDEVYRAAAALIELGVKPA
MUL_4126|M.ulcerans_Agy99 LVT------------------DERSFTVSELNDEVYRAAAALIELGVKPA
MAV_0600|M.avium_104 LIT------------------EDRSFTAAALRDEVHRAAAALIELGVRAG
Mb3591|M.bovis_AF2122/97 LIA------------------EDRRFTSTELRDAVYGAAAALIALGVEPA
Rv3561|M.tuberculosis_H37Rv LIA------------------EDRRFTSTELRDAVYGAAAALIALGVEPA
MAB_0596c|M.abscessus_ATCC_199 LYA------------------DGSWLSFSELRARARRFAAALIALGVEHG
MSMEG_4772|M.smegmatis_MC2_155 VVDHGDNPAG---------AAGPLRLTFVELADRVRRAAGAFLAHGIGRG
MLBr_02546|M.leprae_Br4923 LPAMPARRSP----HRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGG
: :: * . * .:: *: .
Mflv_1480|M.gilvum_PYR-GCK DRVAIWSPNTWHWVVASLAIHHAGGVLVPLNTRYTASEAEDILARTGAPL
Mvan_5286|M.vanbaalenii_PYR-1 DRVAIWSPNTWHWVVACLAIHHAGGVLVPLNTRYTASEAEDILVRTAAPL
TH_2068|M.thermoresistible__bu DRVALWAPNTWHWVVACLATHYAGAVMVPLNTRYTASEAADVLARTGAPL
MMAR_5050|M.marinum_M ARVGIWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPV
MUL_4126|M.ulcerans_Agy99 ARVGIWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPV
MAV_0600|M.avium_104 DRVAIWSPNTWHWVVACLAIHHAGAAMVPLNTRYTAAEAGDILARVGAPV
Mb3591|M.bovis_AF2122/97 DRVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAPV
Rv3561|M.tuberculosis_H37Rv DRVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAPV
MAB_0596c|M.abscessus_ATCC_199 QRLAIWSPNSWHWPIACLGGQYAGAAVVPMNTRYTVDEATDILQRSHARV
MSMEG_4772|M.smegmatis_MC2_155 DRVAIWAPNSAEWMIAAFGALTAGGVVVPVNTRFKAEEAADVIRRSGAKV
MLBr_02546|M.leprae_Br4923 DGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKV
:.: : * : :* . .*. :: :*:.:. : :: * * :
Mflv_1480|M.gilvum_PYR-GCK LFASGAFLGADKAASVDRDSLPALRHIVRIPVDTDD---GTWDEYIARGA
Mvan_5286|M.vanbaalenii_PYR-1 LFASGEFLGADKAASVDRDAVPALRHVVRIPIEKSD---GTWDEFMSRGA
TH_2068|M.thermoresistible__bu LVAAGEFLGADKTADLDRDALPALRRIVRIPVDKPD---GTWDEFIAGGS
MMAR_5050|M.marinum_M LFAMGHFLGSDRVAGLDRKALPALRHIVRIPIEEPD---GTWDEFIETGT
MUL_4126|M.ulcerans_Agy99 LFAMGHFLGSDRVAGLDRKALPALRHIVRIPIEEPD---GTWDEFIETGT
MAV_0600|M.avium_104 LFGMGRFLGHDRLADLDRAALPALRHIVRIPIETDDPVPGSWDEFIAHGT
Mb3591|M.bovis_AF2122/97 LFAAGLFLGADRAAGLDRAALPALRHVVRVPVEADD---GTWDEFIATGA
Rv3561|M.tuberculosis_H37Rv LFAAGLFLGADRAAGLDRAALPALRHVVRVPVEADD---GTWDEFIATGA
MAB_0596c|M.abscessus_ATCC_199 LVSVGKFLGTDRIEQLDTSSLPDLRHIVRVAVEDGD--ESGWDAFVAHGD
MSMEG_4772|M.smegmatis_MC2_155 VLRQQGFLGQD-------FEVPAGVPAIEIKS-----------DFLASGE
MLBr_02546|M.leprae_Br4923 IIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPPGS-TDETLAELIARSS
:. : : : .
Mflv_1480|M.gilvum_PYR-GCK KE-EALAAVGARAAAVTADDVSDILFTSGTTGRSKGVRCAQRQSLDASAA
Mvan_5286|M.vanbaalenii_PYR-1 N----LDAVDERVAAVTGDDVSDILFTSGTTGRSKGVRCAHRQSLDASAA
TH_2068|M.thermoresistible__bu MSGAALAEVDARAAAVRPDDVSDILFTSGTTGRSKGALCAHRQSLDASAA
MMAR_5050|M.marinum_M ----DTGAVAARAAAVSPDDVSDILFTSGTTGRSKGVLCAHRQSLSASAS
MUL_4126|M.ulcerans_Agy99 ----DTGAVTARAAAVSPDDVSDILFTSGTTGRSKGVLCAHRQSLSASAS
MAV_0600|M.avium_104 ----DLGAVAERAAAVTSDDVSDILFTSGTTGRSKGVLCAHRQSLSASAS
Mb3591|M.bovis_AF2122/97 G---ALDAVAARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASAS
Rv3561|M.tuberculosis_H37Rv G---ALDAVAARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASAS
MAB_0596c|M.abscessus_ATCC_199 G--VSDGDIDTRKAAVSSEDISDILFTSGTTGRSKGVLCMHRQPLAASLA
MSMEG_4772|M.smegmatis_MC2_155 P---------AVVGGLRGTDIADIVYTSGTTGRPKGVMMNHLQTLRLYAE
MLBr_02546|M.leprae_Br4923 S----------APAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGG
. : *: ****** .**. .*
Mflv_1480|M.gilvum_PYR-GCK WAACGQLTRDDRYLCINPFFHNFGYKAGILACLQTGATLYPELTFDPGET
Mvan_5286|M.vanbaalenii_PYR-1 WAACGQVTSDDRYLCINPFFHNFGYKAGILACLQTGATLFPELTFDPENA
TH_2068|M.thermoresistible__bu WAECGRLSSDDRYLCINPFFHNFGYKAGILACIQTGATLYPQLTFDPEQA
MMAR_5050|M.marinum_M WAANGKITADDRYLCINPFFHNFGYKAGILACLQTGATLFPHLTFDPLRT
MUL_4126|M.ulcerans_Agy99 WAANGKITADDRHLCINPFFHNFGYKAGILACLQTGATLFPHLTFDPLRT
MAV_0600|M.avium_104 WAANGKITSDDRYLCINPFFHNFGYKAGILACLQTGATLIPHLTFDPLRA
Mb3591|M.bovis_AF2122/97 WAANGKITSDDRYLCINPFFHNFGYKAGILACLQTGATLIPHVTFDPLHA
Rv3561|M.tuberculosis_H37Rv WAANGKITSDDRYLCINPFFHNFGYKAGILACLQTGATLIPHVTFDPLHA
MAB_0596c|M.abscessus_ATCC_199 WATYGEFTENDRYLCVNPFFHNFGYKAGILACLQTGAALMPQLTFDPEKA
MSMEG_4772|M.smegmatis_MC2_155 WCDLADLREGDRYLIVNPFFHTFGYKAGCIASLIRGATVLPVAVFDVDAI
MLBr_02546|M.leprae_Br4923 ILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLG-STLVLRRRFKPATV
. : * *:** :** . :* : ::: *.
Mflv_1480|M.gilvum_PYR-GCK MQAVQEHRITVLPGPPTIYQTLLDHPR--RSEFDLSSLRFAVTGAATIPV
Mvan_5286|M.vanbaalenii_PYR-1 MRAVQEHGITVLPGPPTIYQTLLDHPK--RGDYDLSSLRFAVTGAATIPV
TH_2068|M.thermoresistible__bu MRAVAEHRITVLPGPPTIYQTILDHPK--RGEYDLSSLRFAVTGAAVVPV
MMAR_5050|M.marinum_M LQAIERHRITVLPGPPTIYQTLLDHPA--RDDYDLSSLRFAVTGAATVPV
MUL_4126|M.ulcerans_Agy99 LQAIERHRITVLPGPPTIYQTLLDHPA--RDDYDLSSLRFAVTGAATVPV
MAV_0600|M.avium_104 LQAIEQHRITVLPGPPTIYQTLLDHPA--RRDYDLSSLRFAVTGAATVPV
Mb3591|M.bovis_AF2122/97 LRAIERHRITVLPGPPTIYQSLLDHPA--RKDFDLSSLRFAVTGAATVPV
Rv3561|M.tuberculosis_H37Rv LRAIERHRITVLPGPPTIYQSLLDHPA--RKDFDLSSLRFAVTGAATVPV
MAB_0596c|M.abscessus_ATCC_199 MAAVQEHKITVLPGAPTIFQMLLDHPA--RKNYDLTSLRYSVTGAAVVPV
MSMEG_4772|M.smegmatis_MC2_155 VELIATERVTMLPGPPTLYHSLLGVP----DKAKLATLRAGVTGAADIPV
MLBr_02546|M.leprae_Br4923 LEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGA
: : . * : *.: :*. . .*::** ....: : .
Mflv_1480|M.gilvum_PYR-GCK VLIERMQSELDIDIVLTAYGLTEAAGFGTMCRADDDAVTVATTSGRPIAD
Mvan_5286|M.vanbaalenii_PYR-1 VLIERMQSELDIDIVLTAYGLTEAAGFGTMCRADDDAVTVATTSGRPIAD
TH_2068|M.thermoresistible__bu VLIERMQSELDIDIVLTAYGLTEASGFGTMCRPEDDAVTVATTCGRPIAG
MMAR_5050|M.marinum_M VLVERMQSELDIDIVLTAYGLTEANGMGTMCRADDDALTVATTCGRPFAD
MUL_4126|M.ulcerans_Agy99 VLVERMQSELDIDIVLTAYGLTEANGMGTMCRADDDALTVATTCGRPFAD
MAV_0600|M.avium_104 VLVERMQSELDIDIVLTAYGLTEANGMGTMCRADDDAVTVATTCGRPFAD
Mb3591|M.bovis_AF2122/97 VLVERMQSELDIDIVLTAYGLTEANGMGTMCRPEDDAVTVATTCGRPFAD
Rv3561|M.tuberculosis_H37Rv VLVERMQSELDIDIVLTAYGLTEANGMGTMCRPEDDAVTVATTCGRPFAD
MAB_0596c|M.abscessus_ATCC_199 VLIERMQSELDFDLVLTAYGLTETQGFATICRSDDDAVTVATTCGRPMLG
MSMEG_4772|M.smegmatis_MC2_155 ELIRRIHEELPFETVATGYGLTEAG-TATLSRPGDSFTDIATTVGTACDG
MLBr_02546|M.leprae_Br4923 ELATRALEELGP-VIYNMYGSTEIA-FATIAGPKD-LQINSATVGPVVKG
* * .** : . ** ** .*:. . * ::* * .
Mflv_1480|M.gilvum_PYR-GCK FELRIGE------SGEVLLRGPN--VMLG---YLDDPEATAAAIDGDGWL
Mvan_5286|M.vanbaalenii_PYR-1 FELRIGD------QSEVLLRGPN--VMLG---YLDDPEATAAAIDADGWL
TH_2068|M.thermoresistible__bu FELRIDNPAE-DGTGEVLLRGPN--VMLG---YLDDPEATAAAIDADGWL
MMAR_5050|M.marinum_M FELRIGP-----DTGEVLLRGPN--VMLG---YLDDPRATAAAIDADGWL
MUL_4126|M.ulcerans_Agy99 FELRIGP-----DTGEVLLRGPN--VMLG---YLDDPRATAAAIDADGWL
MAV_0600|M.avium_104 FELRID------DSGEVLLRGPN--VMLG---YLDDPDATAAAIDADGWL
Mb3591|M.bovis_AF2122/97 FELRIA------DDGEVLLRGPN--VMVG---YLDDTEATAAAIDADGWL
Rv3561|M.tuberculosis_H37Rv FELRIA------DDGEVLLRGPN--VMVG---YLDDTEATAAAIDADGWL
MAB_0596c|M.abscessus_ATCC_199 YELRIDGAEKPGDEGEVLLRSAN--VMKG---YLDDPKATAEAIDDDGWL
MSMEG_4772|M.smegmatis_MC2_155 VEVNLAD------DGEVLVRGYS--VMQG---YLDDPAATAEAIDADGWL
MLBr_02546|M.leprae_Br4923 VKVKILD-----DSGKEVPRGQVGRIFVGNAFPFEGYTGGGGKQIIDGLL
::.: .: : *. :: * ::. . . ** *
Mflv_1480|M.gilvum_PYR-GCK HTGDVGELDPAGNLKITDRLKDMYICGGFNVYPAEIEQVLARLDGVAEAA
Mvan_5286|M.vanbaalenii_PYR-1 HTGDVGELDDAGNLKITDRLKDMYICGGFNVYPAEIEQVLARLDGVAEAA
TH_2068|M.thermoresistible__bu HTGDVGKVDERGNLTITDRLKDMYICGGFNVYPAEVEQVLARLDGVAEAA
MMAR_5050|M.marinum_M HTGDIGVLDEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVADVA
MUL_4126|M.ulcerans_Agy99 HTGDIGVLDEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVADVA
MAV_0600|M.avium_104 HTGDIGVLDEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARMEGVADAA
Mb3591|M.bovis_AF2122/97 HTGDIGAVDQAGNLRINDRLKDMYICGGFNVYPAEVEQVLARMDGVADAA
Rv3561|M.tuberculosis_H37Rv HTGDIGAVDQAGNLRITDRLKDMYICGGFNVYPAEVEQVLARMDGVADAA
MAB_0596c|M.abscessus_ATCC_199 HTGDIGKLDARGNLTITDRLKDMYICGGFNVYPAEIEQVLMRLDGVADVA
MSMEG_4772|M.smegmatis_MC2_155 HTGDLGEFTESGRLRIIGRKKDMFIVGGFNAYPAEIEGFLLEHPDVAQVA
MLBr_02546|M.leprae_Br4923 SSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEAT
:**:* . . * * .* .:* : ** *.:***:* .: *.:.:
Mflv_1480|M.gilvum_PYR-GCK VIGVPDDRLGEVGKAFVVTLPGAE-----LDEKTVIDHAREHLANFKTPR
Mvan_5286|M.vanbaalenii_PYR-1 VIGVPDERLGEVGKAFVVRLPSAE-----LDEKTVIDYAREHLANFKTPR
TH_2068|M.thermoresistible__bu VIGVPDQRLGEVGKAFVVRRPGAT-----LDEQAVIAYCKQHLANFKVPR
MMAR_5050|M.marinum_M VIGIPDHRLGEVGRAFIVARPGFN-----LDEKSVIDYTREHLANFKAPR
MUL_4126|M.ulcerans_Agy99 VIGIPDHRLGEVGRAFIVARPGFN-----LDEKSVIDYTREHLANFKAPR
MAV_0600|M.avium_104 VIGVPDERLGEVGRAFVVPRPGAQ-----LDEQSVIAYTRDHLANFKAPR
Mb3591|M.bovis_AF2122/97 VIGVPDQRLGEVGRAFVVARPGTG-----LDEASVIAYTREHLANFKTPR
Rv3561|M.tuberculosis_H37Rv VIGVPDQRLGEVGRAFVVARPGTG-----LDEASVIAYTREHLANFKTPR
MAB_0596c|M.abscessus_ATCC_199 VIGVPDARLGEVGKAYIVLKPGAT-----LNADSVIEYSAKHVANFKKPR
MSMEG_4772|M.smegmatis_MC2_155 VIGVDDDRMGQVGKAFVVLREPLDGTRQCVTAEDLIAWSRERMAGYKVPR
MLBr_02546|M.leprae_Br4923 AIGVDDKEWGARLRAFVVKKQDAT-----IDEDAIKAYVRDHLARYKVPR
.**: * . * :*::* : : .::* :* **
Mflv_1480|M.gilvum_PYR-GCK SVEFLDALPRNPGGKVVKPLLRQRSERA--------
Mvan_5286|M.vanbaalenii_PYR-1 TVEFLDALPRNPGGKVVKPLLRQHSERA--------
TH_2068|M.thermoresistible__bu SVEFLDALPRNPGGKVVKPLLRERA-----------
MMAR_5050|M.marinum_M SVRFVDTLPRNAGGKVVKPQLRELA-----------
MUL_4126|M.ulcerans_Agy99 SVRFVDTLPRNAGGKVVKPQLRELA-----------
MAV_0600|M.avium_104 SVRFVDALPRNSGGKVVKPQLRELD-----------
Mb3591|M.bovis_AF2122/97 SVRFVDVLPRNAAGKVSKPQLRELG-----------
Rv3561|M.tuberculosis_H37Rv SVRFVDVLPRNAAGKVSKPQLRELG-----------
MAB_0596c|M.abscessus_ATCC_199 FVDFLDELPRNLGGKVVKPTLRAMHGEQRRAQKESS
MSMEG_4772|M.smegmatis_MC2_155 YVEFLEELPLNATGKVMKDHLKAREALSKR------
MLBr_02546|M.leprae_Br4923 EVIFLEELPRNPTGKVLKRELRDFEVH---------
* *:: ** * *** * *: