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MEAVDLPVRPPLEPMLAKAQAKVPDDPGVWSYEPKWDGFRALVFRDGDDVVLLSRSGKDLGRYFPEVLDA VRDELAPHCVLDGEIVVPREIGGRMRLDWESLSQRIHPAESRITLLSEQTPAHFIGFDALALGDTPLMKE PFRTRREALIDAVTPKQWCHVTRTTEDPQLGTQWLDEFEGAGLDGVIAKRLDGPYLPGKREMVKVKHHRD ADCVAMGYRIHKSGEGIGSILLGLYRDDGELQMVGGAASFTAKARLKLLDDLEPLRIGDDLRDGEPSRWN SAADKRWIPVRPERVCEVAYDQMEGNTEHGRRFRHAVKFLRWRPDRDPQSCTFDQLDVPLHFDLYDVLER S
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1273 | ligC | - | 100% (351) | ATP-dependent DNA ligase |
| M. gilvum PYR-GCK | Mflv_1254 | ligC | e-101 | 53.02% (364) | ATP-dependent DNA ligase |
| M. gilvum PYR-GCK | Mflv_1828 | - | 5e-23 | 30.98% (326) | ATP-dependent DNA ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3758 | ligC | 1e-93 | 50.27% (366) | ATP-dependent DNA ligase |
| M. tuberculosis H37Rv | Rv3731 | ligC | 9e-94 | 50.27% (366) | ATP-dependent DNA ligase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0279c | ligC | 3e-91 | 51.57% (351) | ATP-dependent DNA ligase |
| M. marinum M | MMAR_5266 | ligC | 5e-96 | 52.35% (361) | ATP-dependent DNA ligase LigC |
| M. avium 104 | MAV_0360 | ligC | 8e-97 | 52.53% (356) | ATP-dependent DNA ligase |
| M. smegmatis MC2 155 | MSMEG_6302 | ligC | 1e-178 | 83.82% (346) | ATP-dependent DNA ligase |
| M. thermoresistible (build 8) | TH_3157 | - | 1e-175 | 80.63% (351) | PUTATIVE DNA ligase |
| M. ulcerans Agy99 | MUL_4340 | ligC | 2e-93 | 51.52% (361) | ATP-dependent DNA ligase |
| M. vanbaalenii PYR-1 | Mvan_5543 | ligC | 0.0 | 88.67% (353) | ATP-dependent DNA ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5266|M.marinum_M -------MDLPVMPPISPMLAKAVKTIPADA---SYEPKWDGFRSICFRD
MUL_4340|M.ulcerans_Agy99 -------MDLPVMPPISPMLAKAVKTIPADA---SYEPKWDGFRSICFRD
Mb3758|M.bovis_AF2122/97 -------MQLPVMPPVSPMLAKSVTAIPPDA---SYEPKWDGFRSICFRD
Rv3731|M.tuberculosis_H37Rv -------MQLPVMPPVSPMLAKSVTAIPPDA---SYEPKWDGFRSICFRD
MAV_0360|M.avium_104 ------------MPPVSPMLAKSVGAIPPAA---SYEPKWDGFRSICFRD
MAB_0279c|M.abscessus_ATCC_199 ------------------MLAKPVAKIPDGA---SYEPKWDGFRSIVFRD
Mflv_1273|M.gilvum_PYR-GCK ME----AVDLPVRPPLEPMLAKAQAKVPDDPGVWSYEPKWDGFRALVFRD
Mvan_5543|M.vanbaalenii_PYR-1 MEPMPLSADLPVMPPLEPMLAKAQTKVPDEPGMWSYEPKWDGFRALVFRD
MSMEG_6302|M.smegmatis_MC2_155 -------MDLPVQPPIEPMLAKAQVKVPDEAGVWSYEPKWDGFRALVFRD
TH_3157|M.thermoresistible__bu MG----RVDLPVLPPLEPMLAKAQAEVPDEPGVWSYEPKWDGFRALVFRD
****. :* . **********:: ***
MMAR_5266|M.marinum_M N----DEVELGSRNERPLTRYFPELVAAVRAELPRRCVLDGEIVIATGHG
MUL_4340|M.ulcerans_Agy99 N----DEVELGSRNERPLTRYFPELVAAVRAELPRRCVLDGEIVIATGHG
Mb3758|M.bovis_AF2122/97 G----DQVELGSRNERPMTRYFPELVAAIRAELPHRCVIDGEIIIATDHG
Rv3731|M.tuberculosis_H37Rv G----DQVELGSRNERPMTRYFPELVAAIRAELPHRCVIDGEIIIATDHG
MAV_0360|M.avium_104 G----DEVELGSRNERPMTRYFPELVAAVRAELPQRCVIDGEIVIATDHG
MAB_0279c|M.abscessus_ATCC_199 G----DEVELGSRNEKPLTRYFPELVAAVLAELPPRCVVDGEIVIATEAG
Mflv_1273|M.gilvum_PYR-GCK G----DDVVLLSRSGKDLGRYFPEVLDAVRDELAPHCVLDGEIVVPREIG
Mvan_5543|M.vanbaalenii_PYR-1 GGPGRDNVVLLSRSGKDLARYFPEVLDSVRDELAPRCVLDGEIVVPREIA
MSMEG_6302|M.smegmatis_MC2_155 G----DDVVLQSRNGKDLGRYFPELLDALRDELVEKCVLDGEVVVPRDIA
TH_3157|M.thermoresistible__bu G----DEVMLQSRNGRELGRYFPELVEALRDELADRCVLDGEVVVPREID
. *:* * **. : : *****:: :: ** :**:***:::.
MMAR_5266|M.marinum_M ----LDFEALQQRIHPADSRVRMLAEHTPASFIAFDLLALGDDDYTTRPF
MUL_4340|M.ulcerans_Agy99 ----LDFEALQQRIHHADSRVRMLAEHIPASFIAFDLLALGDDDYTTRPF
Mb3758|M.bovis_AF2122/97 ----LDFEALQQRIHPAESRVRMLADRTPASFIAFDLLALGDDDYTGRPF
Rv3731|M.tuberculosis_H37Rv ----LDFEALQQRIHPAESRVRMLADRTPASFIAFDLLALGDDDYTGRPF
MAV_0360|M.avium_104 ----LDFEALQQRIHPAESRVRMLAEATPASFIAFDLLALGDEDYTGRPF
MAB_0279c|M.abscessus_ATCC_199 ----LDFEALQQRIHPADSRVRLLAEQTPSSFIAFDLLALGDEDYTGRPF
Mflv_1273|M.gilvum_PYR-GCK GRMRLDWESLSQRIHPAESRITLLSEQTPAHFIGFDALALGDTPLMKEPF
Mvan_5543|M.vanbaalenii_PYR-1 GRTRLDWESLSQRIHPAESRVRMLAEQTPAHFIGFDALAVGDSSLMKEPF
MSMEG_6302|M.smegmatis_MC2_155 GRVRLDWESLSQRIHPAASRIKMLAEQTPAHFIGFDALALGDRSLLKEPF
TH_3157|M.thermoresistible__bu GRVRLDWESLSQRIHPAASRVAMLAEQTPAHFIGFDALATGATSLLDEPF
**:*:*.**** * **: :*:: *: **.** ** * .**
MMAR_5266|M.marinum_M VERRAALVEAV-GSGP----SIHVTPATTDQATARRWFEEFEGAGLDGVI
MUL_4340|M.ulcerans_Agy99 VERRAALVEAV-GSGP----SIHVTPATTDQATARRWFEEFEGAGLDGVI
Mb3758|M.bovis_AF2122/97 SERRAALVDAVTGSGADADLSIHVTPATTDMATAQRWFSEFEGAGLDGVI
Rv3731|M.tuberculosis_H37Rv SERRAALVDAVTGSGADADLSIHVTPATTDMATAQRWFSEFEGAGLDGVI
MAV_0360|M.avium_104 RERRAALLEAVGGPGP----SIHVTPATTDLDTARRWFDEFEGAGLDGVV
MAB_0279c|M.abscessus_ATCC_199 SERRAALTEALSSAGT----SIHLTPATTDQALAQRWFEEFEGAGTDGLI
Mflv_1273|M.gilvum_PYR-GCK RTRREALIDAVTPKQW-----CHVTRTTEDPQLGTQWLDEFEGAGLDGVI
Mvan_5543|M.vanbaalenii_PYR-1 RTRREALVDAVNEKQW-----CHVTRTTEDPALGAQWLQEFEGAGLDGVI
MSMEG_6302|M.smegmatis_MC2_155 RVRREALAEAVDNKRW-----CHVTRTSEDPALGTEWLKTFEGAGLDGVI
TH_3157|M.thermoresistible__bu RVRRDALNEAVRSKQW-----CHVTRTTEDPELGAEWLQAFEGAGLDGVI
** ** :*: *:* :: * . .*:. ***** **::
MMAR_5266|M.marinum_M AKPLAVTYQPDKRVMFKIKHERTADCVLAGYRLHKSGGDVIGSLLLGLYQ
MUL_4340|M.ulcerans_Agy99 AKPLAVTYQPDKCVMFKLKHERTADCVLAGYRLHKSGGDVIGSLLLGLYQ
Mb3758|M.bovis_AF2122/97 AKPPHITYQPDKRVMFKIKHLRTADCVVAGYRVHKSGSDAIGSLLLGLYQ
Rv3731|M.tuberculosis_H37Rv AKPPHITYQPDKRVMFKIKHLRTADCVVAGYRVHKSGSDAIGSLLLGLYQ
MAV_0360|M.avium_104 AKPLDITYQPDKRVMFKIKHERTADCVVAGYRVHKSGADAIGSLLLGLYQ
MAB_0279c|M.abscessus_ATCC_199 AKPLAIAYQPDKRVMFKIKPERTADCVVAGYRVHKSGDDAIGSLLLGLYQ
Mflv_1273|M.gilvum_PYR-GCK AKRLDGPYLPGKREMVKVKHHRDADCVAMGYRIHKSG-EGIGSILLGLYR
Mvan_5543|M.vanbaalenii_PYR-1 AKRLDGPYLPGKREMVKVKHHRDADCVAIGYRIHKSG-EGIGSILLGLHR
MSMEG_6302|M.smegmatis_MC2_155 AKRLDGPYLPGKREMVKVKHHRDADCVAMGYRIHKSG-DGIGSILLGLYR
TH_3157|M.thermoresistible__bu AKRLDGPYLPGKREMVKVKHVRDADCVAIGYRIHKSG-EGVGSILLGLYT
** .* *.* *.*:* * **** ***:**** : :**:****:
MMAR_5266|M.marinum_M DDGQLASVGVIGAFPMAERRRLFTELQELVTSFDDHPWNWAAHQSGERTP
MUL_4340|M.ulcerans_Agy99 DDGQLASVGVIGAFPMAERRRLFTELQELVTSFDDHPWNWAAHQSGERTP
Mb3758|M.bovis_AF2122/97 EDGQLASVGVIGAFPMAERRRLLTELQPLVTSFDDHPWNWAAHVAGQRTP
Rv3731|M.tuberculosis_H37Rv EDGQLASVGVIGAFPMAERRRLLTELQPLVTSFDDHPWNWAAHVAGQRTP
MAV_0360|M.avium_104 DDGQLASVGVIGAFPMAERRRLFTELQPLVTDFEDHPWNWAAHQAGERTP
MAB_0279c|M.abscessus_ATCC_199 EDGILASVGVIGAFPMAERKRLFQELQPLIIPLENHPWNWAAHEAGERTP
Mflv_1273|M.gilvum_PYR-GCK DDGELQMVGGAASFTAKARLKLLDDLEPLRI--------------GD-DL
Mvan_5543|M.vanbaalenii_PYR-1 DDGELQMVGGAASFTAKARLKLLADLEPLRI--------------GD-DV
MSMEG_6302|M.smegmatis_MC2_155 DDGELQMVGGAASFTAKDRIKLLAELEPLRE--------------GD-EM
TH_3157|M.thermoresistible__bu EDGELRMVGGAASFTARNRLRLLADLQPLRI--------------GN-EL
:** * ** .:*. * :*: :*: * *:
MMAR_5266|M.marinum_M RKNEFSRWNAGKDLSFVPLRPERVVEVRYDHMEG-----PRFRHTAQFNR
MUL_4340|M.ulcerans_Agy99 RKNEFSRWNAGKDLSFVPLRPERVVEVRYDHMEG-----PRFRHTAQFNR
Mb3758|M.bovis_AF2122/97 RKNEFSRWNVGKDLSFVPLRPERVVEVRYDHMEG-----ARFRHTAQFNR
Rv3731|M.tuberculosis_H37Rv RKNEFSRWNVGKDLSFVPLRPERVVEVRYDRMEG-----ARFRHTAQFNR
MAV_0360|M.avium_104 RKNEFSRWNAGKDLSFVPLRPERVVEVRYDHMEG-----RRFRHTAQFNR
MAB_0279c|M.abscessus_ATCC_199 QKNAGSRWNAGKDLSFVPLRPERVVEVRYDHMEG-----VRFRHTAQFNR
Mflv_1273|M.gilvum_PYR-GCK RDGEPSRWNSAADKRWIPVRPERVCEVAYDQMEGNTEHGRRFRHAVKFLR
Mvan_5543|M.vanbaalenii_PYR-1 RDGEPSRWNSAADKRWIPVRPERVCEVAYDQMEGNSANGRRFRHAVKFLR
MSMEG_6302|M.smegmatis_MC2_155 REGDPSRWNSAADKRWTPLRPEKVCEVAYDQMEGNSVEGRRFRHAVKFLR
TH_3157|M.thermoresistible__bu REGEPSRWNSAADKRWIPVRPEKVCEVVYDQMEGNSVDGRRFRHAVRFVR
:.. **** . * : *:***:* ** **:*** ****:.:* *
MMAR_5266|M.marinum_M WRPDRDPRSCTYAQLEQPLTFSLDDIVAGLGPRCGH----------
MUL_4340|M.ulcerans_Agy99 WRPDRDPRSCTYAQLEQPLMFNLDDIVAGLGPRCGH----------
Mb3758|M.bovis_AF2122/97 WRPDRDPRSCSYAQLERPLTVSLSDIVPGLR---------------
Rv3731|M.tuberculosis_H37Rv WRPDRDPRSCSYAQLERPLTVSLSDIVPGLR---------------
MAV_0360|M.avium_104 WRPDRDPRSCTYEQLEQPVTFRLGDIVPGLGASRADHKPGKQIGAP
MAB_0279c|M.abscessus_ATCC_199 WRPDRDPRSCTYEQLEQPITFSLNDIVPGLV---------------
Mflv_1273|M.gilvum_PYR-GCK WRPDRDPQSCTFDQLDVPLHFDLYDVLERS----------------
Mvan_5543|M.vanbaalenii_PYR-1 WRPDRDPASCTFDQLDVPLNYDLNDVLERS----------------
MSMEG_6302|M.smegmatis_MC2_155 WRPDREPSSCTFDQLDTPLNYDLYDVLEEQ----------------
TH_3157|M.thermoresistible__bu WRPDRDPRSCTFAQLEVPLHYDLYDVLEQA----------------
*****:* **:: **: *: * *::