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FVSGIASSGPSGRTAAILHADLDSFYASVEQRDDPSLRGRPVLVGGGVVLAASYEAKAFGVRTAMGGRQA RALCPQAIVVAPRMRAYSDASAAVFEVFRDTTPVVEPVSVDEAFLDVSGLRRVSGTPVQIATRLRERVRD EVGLPITVGIARTKFLAKVASQEAKPDGLLLVPPDRELAFLHPLPVRRLWGVGAKTADKLRAHGIETVAD VAELSETTLSSLVGGAMGRQLFALAHNVDRRRVVTGQRRRSVGAQRALGRAGSAMTVDQVDAVVVNLIDR ITRRMRAADRTGRTVVLRLRFADFSRATRSHTMPWATASTDAILDAARGLVAAAAPLIGERGLTLIGFAV CNIDRDGAQQMELPFASPAEARDPLGVDLAIDRVRGRYGNAALTRGVLLGRDPGWEVPMLAE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1122 | - | - | 100% (413) | DNA polymerase IV |
| M. gilvum PYR-GCK | Mflv_3642 | - | 3e-52 | 38.64% (339) | DNA polymerase IV |
| M. gilvum PYR-GCK | Mflv_4310 | - | 1e-34 | 33.63% (339) | DNA polymerase IV |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1564 | dinX | 4e-59 | 41.47% (340) | DNA polymerase IV |
| M. tuberculosis H37Rv | Rv1537 | dinX | 4e-59 | 41.47% (340) | DNA polymerase IV |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0977c | - | 1e-134 | 63.98% (397) | DNA polymerase IV |
| M. marinum M | MMAR_5406 | dinP | 1e-170 | 77.64% (398) | nucleotidyltransferase/DNA polymerase DinP |
| M. avium 104 | MAV_0172 | - | 1e-171 | 78.39% (398) | DNA polymerase IV |
| M. smegmatis MC2 155 | MSMEG_6443 | dinP | 0.0 | 81.34% (402) | DNA polymerase IV |
| M. thermoresistible (build 8) | TH_1151 | dinP | 2e-85 | 83.68% (190) | DNA polymerase IV |
| M. ulcerans Agy99 | MUL_5028 | dinP | 1e-166 | 76.38% (398) | DNA polymerase IV |
| M. vanbaalenii PYR-1 | Mvan_5685 | - | 0.0 | 87.94% (398) | DNA polymerase IV |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1122|M.gilvum_PYR-GCK ------------------------------MFVSGIASSGPSG-------
Mvan_5685|M.vanbaalenii_PYR-1 ------------------------------MFVSAARVPQPAQPAQPAPV
MSMEG_6443|M.smegmatis_MC2_155 ------------------------------MFVSAAES------------
MMAR_5406|M.marinum_M ------------------------------MFVRGDAS------------
MUL_5028|M.ulcerans_Agy99 MWSTPWCTSGSAASTARLANQELVGPRCEHMFVHGDAS------------
MAV_0172|M.avium_104 ------------------------------MFVRCDAS------------
MAB_0977c|M.abscessus_ATCC_199 --------------------------------MTGTAS------------
TH_1151|M.thermoresistible__bu ------------------------------VFVSGPAGHG----------
Mb1564|M.bovis_AF2122/97 --------------------------------MESR--------------
Rv1537|M.tuberculosis_H37Rv --------------------------------MESR--------------
:
Mflv_1122|M.gilvum_PYR-GCK ----RTAAILHADLDSFYASVEQRDDPSLRGRPVLVG----GGVVLAASY
Mvan_5685|M.vanbaalenii_PYR-1 SLPAQPAAILHADLDSFYASVEQRDDPSLRGRPVIVG----GGVVLAASY
MSMEG_6443|M.smegmatis_MC2_155 ------ASILHADLDSFYASVEQRDDPALRGRPVIVG----GGVVLAASY
MMAR_5406|M.marinum_M --------ILHADLDSFYASVEQRDDPSLRGRPVIVG----GGVVLAASY
MUL_5028|M.ulcerans_Agy99 --------ILHADLASFYASVEQRDAPSLRGRPVIVG----GGVVLAASY
MAV_0172|M.avium_104 --------ILHADLDSFYASVEQRDDPTLRGRPVIVG----GGVVLAASY
MAB_0977c|M.abscessus_ATCC_199 --------ILHADLDSFYASVEQRDAPALRDRPVIVG----GGVVLAASY
TH_1151|M.thermoresistible__bu ------ATILHADLDAFYASVEQRDDPALRGRPVIVG----GGVVLAASY
Mb1564|M.bovis_AF2122/97 -------WVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASY
Rv1537|M.tuberculosis_H37Rv -------WVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASY
:** *: :*:***** *:**.***:** *** .***
Mflv_1122|M.gilvum_PYR-GCK EAKAFGVRTAMGGRQARALC-PQAIVVAPRMRAYSDASAAVFEVFRDTTP
Mvan_5685|M.vanbaalenii_PYR-1 EAKAYGVRTAMGGRQARALC-PQAIVVPPRMSAYSSASAAVFEVFHDTTP
MSMEG_6443|M.smegmatis_MC2_155 EAKAYGVRTAMSGGQARALC-PQAIVVPPRMAAYTQASRDVFAVFHDTTP
MMAR_5406|M.marinum_M EAKAYGVRTAMGGTQARRLC-PQAVVVPPRMRAYMRASDAVFEVFRDCTP
MUL_5028|M.ulcerans_Agy99 EAKAYGVRTAMGGAQARRLC-PQAVVVPPRMRAYMRASDAVFEVFRDCTP
MAV_0172|M.avium_104 EAKAYGVRTAMGGAQARRLC-PHAVVVPPRMHAYTRASDAVFRVFRECTP
MAB_0977c|M.abscessus_ATCC_199 EAKHCGVRTAMGGRQALRLC-PHAVVVPPRFDAYSAASKLVFEVFRDTTP
TH_1151|M.thermoresistible__bu EAKAYGVRTAMSGGQARALC-PHAIVVPPRMAAYSQASAAVFDVFRDTTP
Mb1564|M.bovis_AF2122/97 EARAYGARSAMPMHQARRLIGVTAVVLPPRGVVYGIASRRVFDTVRGLVP
Rv1537|M.tuberculosis_H37Rv EARAYGARSAMPMHQARRLIGVTAVVLPPRGVVYGIASRRVFDTVRGLVP
**: *.*:** ** * *:*:.** .* ** ** ..: .*
Mflv_1122|M.gilvum_PYR-GCK VVEPVSVDEAFLDVSGLR-RVSGTPVQIATRLRERVRDEVGLPITVGIAR
Mvan_5685|M.vanbaalenii_PYR-1 VVEPLSVDEAFLDVSGLR-RVSGTPVQIGARLRERVRDEVGLPITVGIAR
MSMEG_6443|M.smegmatis_MC2_155 LVEPLSVDEAFLDVSGLA-RVSGTPVEIAARLRARVREQVGLPITVGIAR
MMAR_5406|M.marinum_M LVEPLSVDEAFLDVAGLR-RVSGTPVQIAARLREDVRGRVGLPITVGVAR
MUL_5028|M.ulcerans_Agy99 LVEPLSVDEAFLDVAGLR-RVSGTPVQIAARLREDVRGRVGLPITVGVAR
MAV_0172|M.avium_104 LVEALSVDEAFLDVGGLR-RVSGTPVAIAQRLRADVRDRVGLPITVGIAR
MAB_0977c|M.abscessus_ATCC_199 LVEPLSIDEAFLDVSGLQ-RISGAPSDIAAALRLEVRRRAGLPITVGIAR
TH_1151|M.thermoresistible__bu LVEPLSVDEAFLDVGGLG-RLAGTPVQIAARLRERVRAEVGLPITVGIAR
Mb1564|M.bovis_AF2122/97 VVEQLSFDEAFAEPPQLAGAVAEDVETFCERLRRRVRDETGLIASVGAGS
Rv1537|M.tuberculosis_H37Rv VVEQLSFDEAFAEPPQLAGAVAEDVETFCERLRRRVRDETGLIASVGAGS
:** :*.**** : * :: : ** ** ..** :** .
Mflv_1122|M.gilvum_PYR-GCK TKFLAKVASQEAKPDGLLLVPPDRELAFLHPLPVRRLWGVGAKTADKLRA
Mvan_5685|M.vanbaalenii_PYR-1 TKFLAKVASQQAKPDGLLLVPPDRELAFLHPLPVRRLWGVGAKTADKLRV
MSMEG_6443|M.smegmatis_MC2_155 TKFLAKVASQEGKPDGLLLVPPDRELAFLHPLPVRRLWGVGAKTAEKLRA
MMAR_5406|M.marinum_M TKFLAKVASQEAKPDGLLLVPPEDELAFLHPLPVRRLWGVGAKTAAKLQS
MUL_5028|M.ulcerans_Agy99 TEFLAKVASQEAKPDGLLLVPPEDELAFLHPLPVRRLWEVGAKTAAKLQS
MAV_0172|M.avium_104 TKFLAKVASQQAKPDGLLLVPPDQELAFLRPLPVRRLWGVGAVTAEKLRA
MAB_0977c|M.abscessus_ATCC_199 TKFLAKVASRQGKPDGLLVVEPHEELSFLRPLPVQALWGVGSVTAEKLRV
TH_1151|M.thermoresistible__bu TKFLAKVASQEAKPDGLLLVPPDREPAFLHPLPVQRLXXXAADPALEVAL
Mb1564|M.bovis_AF2122/97 GKQIAKIASGLAKPDGIRVVRHAEEQALLSGLPVRRLWGIGPVAEEKLHR
Rv1537|M.tuberculosis_H37Rv GKQIAKIASGLAKPDGIRVVRHAEEQALLSGLPVRRLWGIGPVAEEKLHR
: :**:** .****: :* * ::* ***: * .. . ::
Mflv_1122|M.gilvum_PYR-GCK HGIETVADVAELSETTLSSLVGGAMGRQLFALAHNVDRRRVVTGQRRRSV
Mvan_5685|M.vanbaalenii_PYR-1 HGIETVADVAELSESTLGSLVGGAMGRQLFALSHNVDSRRVVTGHRRRSV
MSMEG_6443|M.smegmatis_MC2_155 HGIETVADVAELSEATLGSMVGGAMGRQLFTLSRNIDRRRVTTGVRRSSV
MMAR_5406|M.marinum_M HGLCTVADVAELSESALSSMLGAAMGRQLYALSRNIDRRRVSTGVRRRSV
MUL_5028|M.ulcerans_Agy99 HDLCTVADVAELSESALSSMLGAAMGRQLYALSRNIDRRRVSTGVRRRSV
MAV_0172|M.avium_104 HGIATVADVAELSESTLGSMVGAAMGRQLYALSRNIDRRRVSTGVRRRSV
MAB_0977c|M.abscessus_ATCC_199 YGIRTVADVADLGESTLASMVGRAMGHQLHCLANNIDPRRVDGGRRRRSI
TH_1151|M.thermoresistible__bu T-----VDVPVQGWPGEVGLVTEPLRRLELDPTRTAAFLCGPEPMMRHSA
Mb1564|M.bovis_AF2122/97 LGIETIGQLAALSDAEAANILGATIGPALHRLARGIDDRPVVERAEAKQI
Rv1537|M.tuberculosis_H37Rv LGIETIGQLAALSDAEAANILGATIGPALHRLARGIDDRPVVERAEAKQI
::. . . .:: .: :. .
Mflv_1122|M.gilvum_PYR-GCK GAQRALGRAGSAMTVDQVDAVVVNLIDRITRRMRAADRTGRTVVLRLRFA
Mvan_5685|M.vanbaalenii_PYR-1 GAQRALGRAGSTMSAAEVDAVVVNLIDRITRRMRKAGRSGRTVVLRLRFD
MSMEG_6443|M.smegmatis_MC2_155 GAQRALGRRGNSMSAAEVDAVVVNLVDRITRRMRAAGRTGRTVVLRLRFD
MMAR_5406|M.marinum_M GAQRALGRAGNALSPAELDAVVVTLIDRITGRMRAAGRTGRTVVLRLRFD
MUL_5028|M.ulcerans_Agy99 GAQRALGRAGNALSPAELDAVVVTLIDRITGRMRAAGRTGRTVVLRLRFD
MAV_0172|M.avium_104 GAQRALGRAGNTMSDSEIDAVVVNLIDRITGRMRAAGRTGRTVVLRLRFD
MAB_0977c|M.abscessus_ATCC_199 GAQCALGRG--PRADSEIDAIATQLMERIARRMRGTGRSCRTVVLRLRFG
TH_1151|M.thermoresistible__bu AALLAKGVP--------AENIRVSLERNMQCGIGWCG-------------
Mb1564|M.bovis_AF2122/97 SAESTFAVD--LTTMEQLHEAIDSIAEHAHQRLLRDGRGARTITVKLKKS
Rv1537|M.tuberculosis_H37Rv SAESTFAVD--LTTMEQLHEAIDSIAEHAHQRLLRDGRGARTITVKLKKS
.* : . . : . : .
Mflv_1122|M.gilvum_PYR-GCK DFSRATRSHTMPWATASTDAILDAARGLVAAAAPLIGERGLTLIGFAVCN
Mvan_5685|M.vanbaalenii_PYR-1 DFARATRSHTMPRATASTDAILAAARGLVGAASPLIAERGLTLIGFAVCN
MSMEG_6443|M.smegmatis_MC2_155 DFGRATRSHTMPWATASTDVILCAARELVAAAAPLIAERGLTLIGFAVSN
MMAR_5406|M.marinum_M DFSRATRSHTLPWATSSTQPILAAARQLVRSAAPAITQRGLTLVGFAVSS
MUL_5028|M.ulcerans_Agy99 DFSRATRSHTLPWATSSTQPILAAARQLVRSAAPAIAQRGLTLVGFAVSS
MAV_0172|M.avium_104 DFTRATRSHTLPWATSSTAPILAAARRLVAGAAPMIARRGLTLVGFAVSG
MAB_0977c|M.abscessus_ATCC_199 DYTRATRSRTVPRPTTSTERLLSVARELVKDAGPLIKERGITLIGFSVSN
TH_1151|M.thermoresistible__bu ----------------------------HCQLGPLLLCRDGPVVGYDVA-
Mb1564|M.bovis_AF2122/97 DMSTLTRSATMPYPTTDAGALFTVARRLLPDPLQIGPIRLLGVGFSGLSD
Rv1537|M.tuberculosis_H37Rv DMSTLTRSATMPYPTTDAGALFTVARRLLPDPLQIGPIRLLGVGFSGLSD
* : :.
Mflv_1122|M.gilvum_PYR-GCK IDRD--------GAQQMELPFASPAEARDPLGVDLAIDRVRGRYGNAALT
Mvan_5685|M.vanbaalenii_PYR-1 IDRE--------GAQQLELPFGRDHGAGDSLTIDLAIDKVRGRYGNAAVT
MSMEG_6443|M.smegmatis_MC2_155 IDRG--------GTQQLELPFAEQP---DPVAIDSAIDQVRQRFGNAVLT
MMAR_5406|M.marinum_M IDPG--------GAQQLMLPFGGEP-----EAIDAAVDRIRRRYGNSALT
MUL_5028|M.ulcerans_Agy99 IDPG--------GAQQLMLPFGGEP-----EAIDAAVDRIRRRYGNSALT
MAV_0172|M.avium_104 IDRD--------GAQQLMLPFEGRPP----DAIDAAIDRVRRRYGKAALT
MAB_0977c|M.abscessus_ATCC_199 FDPC--------GAAQLELPFSDAAEN--TLALDSTLDGLRDRFGTRSVT
TH_1151|M.thermoresistible__bu -------------------------------APLLAVEEL----------
Mb1564|M.bovis_AF2122/97 IRQESLFADSDLTQETAAAHYVETPGAVVPAAHDATMWRVGDDVAHPELG
Rv1537|M.tuberculosis_H37Rv IRQESLFADSDLTQETAAAHYVETPGAVVPAAHDATMWRVGDDVAHPELG
:: :
Mflv_1122|M.gilvum_PYR-GCK RGVLLGRD------------------------------------------
Mvan_5685|M.vanbaalenii_PYR-1 RGVLLGRD------------------------------------------
MSMEG_6443|M.smegmatis_MC2_155 RGVLVGRD------------------------------------------
MMAR_5406|M.marinum_M RAVLVGRA------------------------------------------
MUL_5028|M.ulcerans_Agy99 RAVLVGRA------------------------------------------
MAV_0172|M.avium_104 PAVLLGRD------------------------------------------
MAB_0977c|M.abscessus_ATCC_199 RANLLHGGG-----------------------------------------
TH_1151|M.thermoresistible__bu --------------------------------------------------
Mb1564|M.bovis_AF2122/97 HGWVQGAGHGVVTVRFETRGSGPGSARTFPVDTGDISNASPLDSLDWPDY
Rv1537|M.tuberculosis_H37Rv HGWVQGAGHGVVTVRFETRGSGPGSARTFPVDTGDISNASPLDSLDWPDY
Mflv_1122|M.gilvum_PYR-GCK ---------PGWEVPMLAE----
Mvan_5685|M.vanbaalenii_PYR-1 ---------PGLEMPMLPD----
MSMEG_6443|M.smegmatis_MC2_155 ---------PGLEMPMLPD----
MMAR_5406|M.marinum_M ---------PDQEVPRLPD----
MUL_5028|M.ulcerans_Agy99 ---------PDQEVPRLPD----
MAV_0172|M.avium_104 ---------PGLEMPHLPD----
MAB_0977c|M.abscessus_ATCC_199 --------REEWGIPTFEDL---
TH_1151|M.thermoresistible__bu -----------------------
Mb1564|M.bovis_AF2122/97 IGQLSVEGSAGASAPTVDDVGDR
Rv1537|M.tuberculosis_H37Rv IGQLSVEGSAGASAPTVDDVGDR