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FVRCDASILHADLDSFYASVEQRDDPTLRGRPVIVGGGVVLAASYEAKAYGVRTAMGGAQARRLCPHAVV VPPRMHAYTRASDAVFRVFRECTPLVEALSVDEAFLDVGGLRRVSGTPVAIAQRLRADVRDRVGLPITVG IARTKFLAKVASQQAKPDGLLLVPPDQELAFLRPLPVRRLWGVGAVTAEKLRAHGIATVADVAELSESTL GSMVGAAMGRQLYALSRNIDRRRVSTGVRRRSVGAQRALGRAGNTMSDSEIDAVVVNLIDRITGRMRAAG RTGRTVVLRLRFDDFTRATRSHTLPWATSSTAPILAAARRLVAGAAPMIARRGLTLVGFAVSGIDRDGAQ QLMLPFEGRPPDAIDAAIDRVRRRYGKAALTPAVLLGRDPGLEMPHLPD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0172 | - | - | 100% (400) | DNA polymerase IV |
| M. avium 104 | MAV_3232 | - | 3e-58 | 37.47% (371) | DNA polymerase IV |
| M. avium 104 | MAV_3925 | - | 5e-35 | 33.74% (329) | DNA polymerase IV |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1564 | dinX | 5e-59 | 42.37% (321) | DNA polymerase IV |
| M. gilvum PYR-GCK | Mflv_1122 | - | 1e-171 | 78.39% (398) | DNA polymerase IV |
| M. tuberculosis H37Rv | Rv1537 | dinX | 5e-59 | 42.37% (321) | DNA polymerase IV |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0977c | - | 1e-136 | 67.10% (383) | DNA polymerase IV |
| M. marinum M | MMAR_5406 | dinP | 0.0 | 85.00% (400) | nucleotidyltransferase/DNA polymerase DinP |
| M. smegmatis MC2 155 | MSMEG_6443 | dinP | 1e-178 | 81.14% (403) | DNA polymerase IV |
| M. thermoresistible (build 8) | TH_1151 | dinP | 8e-78 | 83.43% (175) | DNA polymerase IV |
| M. ulcerans Agy99 | MUL_5028 | dinP | 0.0 | 84.00% (400) | DNA polymerase IV |
| M. vanbaalenii PYR-1 | Mvan_5685 | - | 1e-173 | 80.45% (399) | DNA polymerase IV |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5406|M.marinum_M ------------------------------MFVRGDASILHADLDSFYAS
MUL_5028|M.ulcerans_Agy99 MWSTPWCTSGSAASTARLANQELVGPRCEHMFVHGDASILHADLASFYAS
MAV_0172|M.avium_104 ------------------------------MFVRCDASILHADLDSFYAS
Mflv_1122|M.gilvum_PYR-GCK ----------MFVSGIASSGPSG-----------RTAAILHADLDSFYAS
Mvan_5685|M.vanbaalenii_PYR-1 ----------MFVSAARVPQPAQPAQPAPVSLPAQPAAILHADLDSFYAS
MSMEG_6443|M.smegmatis_MC2_155 ----------MFVSAAES------------------ASILHADLDSFYAS
MAB_0977c|M.abscessus_ATCC_199 --------------------------------MTGTASILHADLDSFYAS
TH_1151|M.thermoresistible__bu ----------VFVSGPAG----------------HGATILHADLDAFYAS
Mb1564|M.bovis_AF2122/97 ---------------------------------MESRWVLHLDMDAFFAS
Rv1537|M.tuberculosis_H37Rv ---------------------------------MESRWVLHLDMDAFFAS
:** *: :*:**
MMAR_5406|M.marinum_M VEQRDDPSLRGRPVIVG----GGVVLAASYEAKAYGVRTAMGGTQARRLC
MUL_5028|M.ulcerans_Agy99 VEQRDAPSLRGRPVIVG----GGVVLAASYEAKAYGVRTAMGGAQARRLC
MAV_0172|M.avium_104 VEQRDDPTLRGRPVIVG----GGVVLAASYEAKAYGVRTAMGGAQARRLC
Mflv_1122|M.gilvum_PYR-GCK VEQRDDPSLRGRPVLVG----GGVVLAASYEAKAFGVRTAMGGRQARALC
Mvan_5685|M.vanbaalenii_PYR-1 VEQRDDPSLRGRPVIVG----GGVVLAASYEAKAYGVRTAMGGRQARALC
MSMEG_6443|M.smegmatis_MC2_155 VEQRDDPALRGRPVIVG----GGVVLAASYEAKAYGVRTAMSGGQARALC
MAB_0977c|M.abscessus_ATCC_199 VEQRDAPALRDRPVIVG----GGVVLAASYEAKHCGVRTAMGGRQALRLC
TH_1151|M.thermoresistible__bu VEQRDDPALRGRPVIVG----GGVVLAASYEAKAYGVRTAMSGGQARALC
Mb1564|M.bovis_AF2122/97 VEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARAYGARSAMPMHQARRLI
Rv1537|M.tuberculosis_H37Rv VEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARAYGARSAMPMHQARRLI
*** *:**.***:** *** .*****: *.*:** ** *
MMAR_5406|M.marinum_M -PQAVVVPPRMRAYMRASDAVFEVFRDCTPLVEPLSVDEAFLDVAGLR-R
MUL_5028|M.ulcerans_Agy99 -PQAVVVPPRMRAYMRASDAVFEVFRDCTPLVEPLSVDEAFLDVAGLR-R
MAV_0172|M.avium_104 -PHAVVVPPRMHAYTRASDAVFRVFRECTPLVEALSVDEAFLDVGGLR-R
Mflv_1122|M.gilvum_PYR-GCK -PQAIVVAPRMRAYSDASAAVFEVFRDTTPVVEPVSVDEAFLDVSGLR-R
Mvan_5685|M.vanbaalenii_PYR-1 -PQAIVVPPRMSAYSSASAAVFEVFHDTTPVVEPLSVDEAFLDVSGLR-R
MSMEG_6443|M.smegmatis_MC2_155 -PQAIVVPPRMAAYTQASRDVFAVFHDTTPLVEPLSVDEAFLDVSGLA-R
MAB_0977c|M.abscessus_ATCC_199 -PHAVVVPPRFDAYSAASKLVFEVFRDTTPLVEPLSIDEAFLDVSGLQ-R
TH_1151|M.thermoresistible__bu -PHAIVVPPRMAAYSQASAAVFDVFRDTTPLVEPLSVDEAFLDVGGLG-R
Mb1564|M.bovis_AF2122/97 GVTAVVLPPRGVVYGIASRRVFDTVRGLVPVVEQLSFDEAFAEPPQLAGA
Rv1537|M.tuberculosis_H37Rv GVTAVVLPPRGVVYGIASRRVFDTVRGLVPVVEQLSFDEAFAEPPQLAGA
*:*:.** .* ** ** ..: .*:** :*.**** : *
MMAR_5406|M.marinum_M VSGTPVQIAARLREDVRGRVGLPITVGVARTKFLAKVASQEAKPDGLLLV
MUL_5028|M.ulcerans_Agy99 VSGTPVQIAARLREDVRGRVGLPITVGVARTEFLAKVASQEAKPDGLLLV
MAV_0172|M.avium_104 VSGTPVAIAQRLRADVRDRVGLPITVGIARTKFLAKVASQQAKPDGLLLV
Mflv_1122|M.gilvum_PYR-GCK VSGTPVQIATRLRERVRDEVGLPITVGIARTKFLAKVASQEAKPDGLLLV
Mvan_5685|M.vanbaalenii_PYR-1 VSGTPVQIGARLRERVRDEVGLPITVGIARTKFLAKVASQQAKPDGLLLV
MSMEG_6443|M.smegmatis_MC2_155 VSGTPVEIAARLRARVREQVGLPITVGIARTKFLAKVASQEGKPDGLLLV
MAB_0977c|M.abscessus_ATCC_199 ISGAPSDIAAALRLEVRRRAGLPITVGIARTKFLAKVASRQGKPDGLLVV
TH_1151|M.thermoresistible__bu LAGTPVQIAARLRERVRAEVGLPITVGIARTKFLAKVASQEAKPDGLLLV
Mb1564|M.bovis_AF2122/97 VAEDVETFCERLRRRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVV
Rv1537|M.tuberculosis_H37Rv VAEDVETFCERLRRRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVV
:: : ** ** ..** :** . : :**:** .****: :*
MMAR_5406|M.marinum_M PPEDELAFLHPLPVRRLWGVGAKTAAKLQSHGLCTVADVAELSESALSSM
MUL_5028|M.ulcerans_Agy99 PPEDELAFLHPLPVRRLWEVGAKTAAKLQSHDLCTVADVAELSESALSSM
MAV_0172|M.avium_104 PPDQELAFLRPLPVRRLWGVGAVTAEKLRAHGIATVADVAELSESTLGSM
Mflv_1122|M.gilvum_PYR-GCK PPDRELAFLHPLPVRRLWGVGAKTADKLRAHGIETVADVAELSETTLSSL
Mvan_5685|M.vanbaalenii_PYR-1 PPDRELAFLHPLPVRRLWGVGAKTADKLRVHGIETVADVAELSESTLGSL
MSMEG_6443|M.smegmatis_MC2_155 PPDRELAFLHPLPVRRLWGVGAKTAEKLRAHGIETVADVAELSEATLGSM
MAB_0977c|M.abscessus_ATCC_199 EPHEELSFLRPLPVQALWGVGSVTAEKLRVYGIRTVADVADLGESTLASM
TH_1151|M.thermoresistible__bu PPDREPAFLHPLPVQRLXXXAADPALEVALT-----VDVPVQGWPGEVGL
Mb1564|M.bovis_AF2122/97 RHAEEQALLSGLPVRRLWGIGPVAEEKLHRLGIETIGQLAALSDAEAANI
Rv1537|M.tuberculosis_H37Rv RHAEEQALLSGLPVRRLWGIGPVAEEKLHRLGIETIGQLAALSDAEAANI
* ::* ***: * .. . :: ::. . . .:
MMAR_5406|M.marinum_M LGAAMGRQLYALSRNIDRRRVSTGVRRRSVGAQRALGRAGNALSPAELDA
MUL_5028|M.ulcerans_Agy99 LGAAMGRQLYALSRNIDRRRVSTGVRRRSVGAQRALGRAGNALSPAELDA
MAV_0172|M.avium_104 VGAAMGRQLYALSRNIDRRRVSTGVRRRSVGAQRALGRAGNTMSDSEIDA
Mflv_1122|M.gilvum_PYR-GCK VGGAMGRQLFALAHNVDRRRVVTGQRRRSVGAQRALGRAGSAMTVDQVDA
Mvan_5685|M.vanbaalenii_PYR-1 VGGAMGRQLFALSHNVDSRRVVTGHRRRSVGAQRALGRAGSTMSAAEVDA
MSMEG_6443|M.smegmatis_MC2_155 VGGAMGRQLFTLSRNIDRRRVTTGVRRSSVGAQRALGRRGNSMSAAEVDA
MAB_0977c|M.abscessus_ATCC_199 VGRAMGHQLHCLANNIDPRRVDGGRRRRSIGAQCALGRG--PRADSEIDA
TH_1151|M.thermoresistible__bu VTEPLRRLELDPTRTAAFLCGPEPMMRHSAAALLAKGVP--------AEN
Mb1564|M.bovis_AF2122/97 LGATIGPALHRLARGIDDRPVVERAEAKQISAESTFAVD--LTTMEQLHE
Rv1537|M.tuberculosis_H37Rv LGATIGPALHRLARGIDDRPVVERAEAKQISAESTFAVD--LTTMEQLHE
: .: :. . .* : . .
MMAR_5406|M.marinum_M VVVTLIDRITGRMRAAGRTGRTVVLRLRFDDFSRATRSHTLPWATSSTQP
MUL_5028|M.ulcerans_Agy99 VVVTLIDRITGRMRAAGRTGRTVVLRLRFDDFSRATRSHTLPWATSSTQP
MAV_0172|M.avium_104 VVVNLIDRITGRMRAAGRTGRTVVLRLRFDDFTRATRSHTLPWATSSTAP
Mflv_1122|M.gilvum_PYR-GCK VVVNLIDRITRRMRAADRTGRTVVLRLRFADFSRATRSHTMPWATASTDA
Mvan_5685|M.vanbaalenii_PYR-1 VVVNLIDRITRRMRKAGRSGRTVVLRLRFDDFARATRSHTMPRATASTDA
MSMEG_6443|M.smegmatis_MC2_155 VVVNLVDRITRRMRAAGRTGRTVVLRLRFDDFGRATRSHTMPWATASTDV
MAB_0977c|M.abscessus_ATCC_199 IATQLMERIARRMRGTGRSCRTVVLRLRFGDYTRATRSRTVPRPTTSTER
TH_1151|M.thermoresistible__bu IRVSLERNMQCGIGWCG---------------------------------
Mb1564|M.bovis_AF2122/97 AIDSIAEHAHQRLLRDGRGARTITVKLKKSDMSTLTRSATMPYPTTDAGA
Rv1537|M.tuberculosis_H37Rv AIDSIAEHAHQRLLRDGRGARTITVKLKKSDMSTLTRSATMPYPTTDAGA
: . : .
MMAR_5406|M.marinum_M ILAAARQLVRSAAPAITQRGLTLVGFAVSSIDPG--------GAQQLMLP
MUL_5028|M.ulcerans_Agy99 ILAAARQLVRSAAPAIAQRGLTLVGFAVSSIDPG--------GAQQLMLP
MAV_0172|M.avium_104 ILAAARRLVAGAAPMIARRGLTLVGFAVSGIDRD--------GAQQLMLP
Mflv_1122|M.gilvum_PYR-GCK ILDAARGLVAAAAPLIGERGLTLIGFAVCNIDRD--------GAQQMELP
Mvan_5685|M.vanbaalenii_PYR-1 ILAAARGLVGAASPLIAERGLTLIGFAVCNIDRE--------GAQQLELP
MSMEG_6443|M.smegmatis_MC2_155 ILCAARELVAAAAPLIAERGLTLIGFAVSNIDRG--------GTQQLELP
MAB_0977c|M.abscessus_ATCC_199 LLSVARELVKDAGPLIKERGITLIGFSVSNFDPC--------GAAQLELP
TH_1151|M.thermoresistible__bu --------HCQLGPLLLCRDGPVVGYDVA---------------------
Mb1564|M.bovis_AF2122/97 LFTVARRLLPDPLQIGPIRLLGVGFSGLSDIRQESLFADSDLTQETAAAH
Rv1537|M.tuberculosis_H37Rv LFTVARRLLPDPLQIGPIRLLGVGFSGLSDIRQESLFADSDLTQETAAAH
* : :.
MMAR_5406|M.marinum_M FGGEP-----EAIDAAVDRIRRRYGNSALTRAVLVGRA------------
MUL_5028|M.ulcerans_Agy99 FGGEP-----EAIDAAVDRIRRRYGNSALTRAVLVGRA------------
MAV_0172|M.avium_104 FEGRPP----DAIDAAIDRVRRRYGKAALTPAVLLGRD------------
Mflv_1122|M.gilvum_PYR-GCK FASPAEARDPLGVDLAIDRVRGRYGNAALTRGVLLGRD------------
Mvan_5685|M.vanbaalenii_PYR-1 FGRDHGAGDSLTIDLAIDKVRGRYGNAAVTRGVLLGRD------------
MSMEG_6443|M.smegmatis_MC2_155 FAEQP---DPVAIDSAIDQVRQRFGNAVLTRGVLVGRD------------
MAB_0977c|M.abscessus_ATCC_199 FSDAAEN--TLALDSTLDGLRDRFGTRSVTRANLLHGGG-----------
TH_1151|M.thermoresistible__bu -----------APLLAVEEL------------------------------
Mb1564|M.bovis_AF2122/97 YVETPGAVVPAAHDATMWRVGDDVAHPELGHGWVQGAGHGVVTVRFETRG
Rv1537|M.tuberculosis_H37Rv YVETPGAVVPAAHDATMWRVGDDVAHPELGHGWVQGAGHGVVTVRFETRG
:: :
MMAR_5406|M.marinum_M ---------------------------------------PDQEVPRLPD-
MUL_5028|M.ulcerans_Agy99 ---------------------------------------PDQEVPRLPD-
MAV_0172|M.avium_104 ---------------------------------------PGLEMPHLPD-
Mflv_1122|M.gilvum_PYR-GCK ---------------------------------------PGWEVPMLAE-
Mvan_5685|M.vanbaalenii_PYR-1 ---------------------------------------PGLEMPMLPD-
MSMEG_6443|M.smegmatis_MC2_155 ---------------------------------------PGLEMPMLPD-
MAB_0977c|M.abscessus_ATCC_199 --------------------------------------REEWGIPTFEDL
TH_1151|M.thermoresistible__bu --------------------------------------------------
Mb1564|M.bovis_AF2122/97 SGPGSARTFPVDTGDISNASPLDSLDWPDYIGQLSVEGSAGASAPTVDDV
Rv1537|M.tuberculosis_H37Rv SGPGSARTFPVDTGDISNASPLDSLDWPDYIGQLSVEGSAGASAPTVDDV
MMAR_5406|M.marinum_M ---
MUL_5028|M.ulcerans_Agy99 ---
MAV_0172|M.avium_104 ---
Mflv_1122|M.gilvum_PYR-GCK ---
Mvan_5685|M.vanbaalenii_PYR-1 ---
MSMEG_6443|M.smegmatis_MC2_155 ---
MAB_0977c|M.abscessus_ATCC_199 ---
TH_1151|M.thermoresistible__bu ---
Mb1564|M.bovis_AF2122/97 GDR
Rv1537|M.tuberculosis_H37Rv GDR