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TAPADSSPLEARVGHHYQMAGTYLVGREKVREYARAVQDYHPAHWDVAAAQALGFPDVVAPLTFTSAPGM QCNRRMFEEIVVGYDTYLQTEEVFEQHRPIVAGDELVIDVELTSVRRTAGRDFITVTNTFTDPAGERVHT LHTTVVGVTADDIDAGVKIAVQNAMMHDMNILDIPGTDADYEKQERPGGEVRISEGGLTRTPGSVSFDGL KVGDEIPVHHTRLSRGDLVNYAGVAGDANPIHWDEEIAKLAGLPDVIAHGMLTMGLGAGFVSAWSGDPGA VTRYSIRLSQPAIVSAKEGADIEYSGRIKSLDPETRSGVVLVGAKSAGRKIFGLASLHIRFR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0994 | - | - | 100% (343) | dehydratase |
| M. gilvum PYR-GCK | Mflv_5120 | - | 3e-37 | 55.38% (130) | (3R)-hydroxyacyl-ACP dehydratase subunit HadB |
| M. gilvum PYR-GCK | Mflv_5121 | - | 9e-22 | 38.67% (150) | (3R)-hydroxyacyl-ACP dehydratase subunit HadA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0655 | - | 2e-37 | 53.08% (130) | (3R)-hydroxyacyl-ACP dehydratase subunit HadB |
| M. tuberculosis H37Rv | Rv0636 | - | 2e-37 | 53.08% (130) | (3R)-hydroxyacyl-ACP dehydratase subunit HadB |
| M. leprae Br4923 | MLBr_01909 | - | 2e-36 | 52.31% (130) | (3R)-hydroxyacyl-ACP dehydratase subunit HadB |
| M. abscessus ATCC 19977 | MAB_4780 | - | 1e-152 | 76.32% (342) | MaoC-like dehydratase |
| M. marinum M | MMAR_0106 | - | 1e-154 | 75.44% (342) | hypothetical protein MMAR_0106 |
| M. avium 104 | MAV_4526 | - | 3e-36 | 54.33% (127) | (3R)-hydroxyacyl-ACP dehydratase subunit HadB |
| M. smegmatis MC2 155 | MSMEG_6754 | - | 1e-152 | 75.73% (342) | MaoC like domain-containing protein |
| M. thermoresistible (build 8) | TH_0193 | - | 1e-157 | 79.06% (339) | MaoC like domain protein |
| M. ulcerans Agy99 | MUL_0721 | - | 5e-37 | 52.31% (130) | (3R)-hydroxyacyl-ACP dehydratase subunit HadB |
| M. vanbaalenii PYR-1 | Mvan_5844 | - | 1e-180 | 88.92% (343) | dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0994|M.gilvum_PYR-GCK MTAPADSSPLEARVGHHYQMAGTYLVGREKVREYARAVQDYHPAHWDVAA
Mvan_5844|M.vanbaalenii_PYR-1 MTATAQTSPLEARVGHHYQMAGTYLVGREKVREYARAVQDYHPAHWDVAA
TH_0193|M.thermoresistible__bu -MTTAESPALEARVGHWYQMDNTYLVGREKLREYARAVQDYHPAHWDVAA
MMAR_0106|M.marinum_M MTAAAEASAMESRVGHYYRLDETYRVGREKVREYARAVQDYHPAHWDMAA
MSMEG_6754|M.smegmatis_MC2_155 MTAPADTSTLESRVGHYYQMEDTYLVGREKVREFARAVQDYHPAHWNLAT
MAB_4780|M.abscessus_ATCC_1997 MTAPVDGSALEARVGHYYQMDNPYLVGREKVREYARAVQDYHPSHWDAAA
Mb0655|M.bovis_AF2122/97 --------------------------------------------------
Rv0636|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0721|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01909|M.leprae_Br4923 --------------------------------------------------
MAV_4526|M.avium_104 --------------------------------------------------
Mflv_0994|M.gilvum_PYR-GCK AQALGFPDVVAPLTFTSAPGMQCNRRMFEEIVVGYDTYLQTEEVFEQHRP
Mvan_5844|M.vanbaalenii_PYR-1 AAELGYSDVVAPLTFTSAPGMQCNRRMFEEIVVGYDTYLQTEEVFEQHRP
TH_0193|M.thermoresistible__bu AAELGYSDLVAPLTFTSAPGMTCNREMFESVVVGYDTYMQTEEVFEQHRP
MMAR_0106|M.marinum_M AEKLGYSGLVTPLTFTSIPAMAANRYLFESVVVGYDTYMQTEEVFEQHRP
MSMEG_6754|M.smegmatis_MC2_155 AADLGHPGLIAPLTFTSAPAMACNQRMFESVVVGYDMYLQTEEVFEQHRP
MAB_4780|M.abscessus_ATCC_1997 AADLGYSGVVAPLTFTSTPAMACNRRMFESVVVGYDTYLQTEEVFEQHRP
Mb0655|M.bovis_AF2122/97 --------------------------------------------------
Rv0636|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0721|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01909|M.leprae_Br4923 --------------------------------------------------
MAV_4526|M.avium_104 --------------------------------------------------
Mflv_0994|M.gilvum_PYR-GCK IVAGDELVIDVELTSVRRTAGRDFITVTNTFTDPAGERVHTLHTTVVGVT
Mvan_5844|M.vanbaalenii_PYR-1 IVAGDELVIDVELTSVRRTAGRDFITVTNTFTDTHGERVHTLHTTVVGVT
TH_0193|M.thermoresistible__bu IVAGDELTIDVELTSVRRIAGRDLITVTNTFTDTAGEVVHTLHTTVVGVT
MMAR_0106|M.marinum_M IVADDELHVDVELSSVRRIAGRDLITVTNTFTDTAGERVHTLHTTVVGIT
MSMEG_6754|M.smegmatis_MC2_155 IVEGDELSIDIELTSVRRIAGRDLITVTNTFTDTAGEVVHTLHTTVVGIT
MAB_4780|M.abscessus_ATCC_1997 IVAGDELHIDVELTSIRRVAGRDLITVTNTFTDMAGERVHTLHTTVVGIT
Mb0655|M.bovis_AF2122/97 --------------------------------------------------
Rv0636|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0721|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01909|M.leprae_Br4923 --------------------------------------------------
MAV_4526|M.avium_104 --------------------------------------------------
Mflv_0994|M.gilvum_PYR-GCK ADDIDAGVKIAVQNAMMHDMNILDIPGTDADYEKQERPGGEVRISEGGLT
Mvan_5844|M.vanbaalenii_PYR-1 AEDIDAGVKVAVQNAMMHDMNILDIGGSDADYEKTVRPGHDIRISEGTLT
TH_0193|M.thermoresistible__bu AEDVDPAIKTAVQNAMMHDVDIFSVG--ETEYRKTVRPEGEVRISDGGLT
MMAR_0106|M.marinum_M AEDVDPAIKSAVQNTIMHDVNILEIAAADAAYQKTVRPEGEIRIADSGTT
MSMEG_6754|M.smegmatis_MC2_155 AEDVDPAIRPAVQGVMMHGINMLGVEETNAPYEKTVRPEGELRIAQGGAT
MAB_4780|M.abscessus_ATCC_1997 ADEISPGTMAAVQKAMMHDVDFSGIGAPGDSYIKTVRPAGEVRVAQD-TA
Mb0655|M.bovis_AF2122/97 --------------------------------------------------
Rv0636|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0721|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01909|M.leprae_Br4923 --------------------------------------------------
MAV_4526|M.avium_104 --------------------------------------------------
Mflv_0994|M.gilvum_PYR-GCK RTPGSVSFDGLKVGDEIPVHHTRLSRGDLVNYAGVAGDANPIHWDEEIAK
Mvan_5844|M.vanbaalenii_PYR-1 RTPGTASFDDVKVGDALPAHHTRLSRGDLVNYAGVAGDANPIHWDEDIAK
TH_0193|M.thermoresistible__bu RTPGTPAFEDVQVGDELGVHHAKLSRGDLVNYAGVAGDANPIHWDEDIAK
MMAR_0106|M.marinum_M RTPGTPSFEDVQVGDELPVRHARLSRGDLVNYSGVAGDANPIHWDENIAK
MSMEG_6754|M.smegmatis_MC2_155 RTPTSLNFDDLKVGEELPVHTARLSRGDLVNYAGVAGDANPLHWDENIAK
MAB_4780|M.abscessus_ATCC_1997 RNPGTPSFDDVKVGDELPVHHTRLSRGDLVNYAGVAGDANPIHWDEEIAK
Mb0655|M.bovis_AF2122/97 --MALREFSSVKVGDQLPEKTYPLTRQDLVNYAGVSGDLNPIHWDDEIAK
Rv0636|M.tuberculosis_H37Rv --MALREFSSVKVGDQLPEKTYPLTRQDLVNYAGVSGDLNPIHWDDEIAK
MUL_0721|M.ulcerans_Agy99 --MALREFSSVNVGDQLPERTYPLTRQDLVNYAGVSGDLNPIHWDDEIAK
MLBr_01909|M.leprae_Br4923 --MARREFSSVKVGDLLPEKTYPLTRQDLVNYAGVSGDLNPIHWDDEIAK
MAV_4526|M.avium_104 ----------MKVGDLLPEKVYPLTRQDLVNYAGVSGDLNPIHWDDEMAK
::**: : : *:* *****:**:** **:***:::**
Mflv_0994|M.gilvum_PYR-GCK LAGLPDVIAHGMLTMGLGAGFVSAWSGDPGAVTRYSIRLSQPAIVSA-KE
Mvan_5844|M.vanbaalenii_PYR-1 LAGLPDVIAHGMLTMGLGAGFVSAWSGDPGAVTRYTVRLSQPAVVSA-KE
TH_0193|M.thermoresistible__bu LAGLPDVIAHGMLTMGLGAGFVSRWSGDPGAVTRYAVRLSAPAIVSA-KE
MMAR_0106|M.marinum_M LAGLPDVIAHGMLTMGLGAGFLSAWSGDPGAVTRYAVRLSQPAIVSA-AE
MSMEG_6754|M.smegmatis_MC2_155 LAGQPDVIAHGMLTMGLGAGFVSSWSGDPGAITRYAVRLSQPAVVP--AE
MAB_4780|M.abscessus_ATCC_1997 LAGLPDVIAHGMLTMGLGAGFFSAWSGDPGAVTRYAVRLSAPAIVSA-AE
Mb0655|M.bovis_AF2122/97 VVGLDAAIAHGMLTMGIGGGYVTSWVGDPGAVTEYNVRFTAVVPVPNDGK
Rv0636|M.tuberculosis_H37Rv VVGLDTAIAHGMLTMGIGGGYVTSWVGDPGAVTEYNVRFTAVVPVPNDGK
MUL_0721|M.ulcerans_Agy99 LVGLDTAIAHGMLTMGIGGGYVTSWVGDPGAVTEYNVRFTAVVPVPNDGK
MLBr_01909|M.leprae_Br4923 VVGLDTAIAHGMLTMGIGGGYVTSWVGDPGAVIEYNVRFTAVVPVPNDGQ
MAV_4526|M.avium_104 VVGLDTAIAHGMLTMGIGGGYVTAWIGDPGAVTEYNVRFTAVVPVPNDGK
:.* .*********:*.*:.: * *****: .* :*:: . *. :
Mflv_0994|M.gilvum_PYR-GCK GADIEYSGRIKSLDPETRSGVVLVGAKSAGRKIFGLASLHIRFR
Mvan_5844|M.vanbaalenii_PYR-1 GADIEYSGKIKSLDPETRSGVVIVGAKSAGKKIFGLATVNLRFR
TH_0193|M.thermoresistible__bu GCDIEFSGRVKSLDPQTRSGVIVVTAKSGGKKIFGLATMNIRFR
MMAR_0106|M.marinum_M GADIEYSGRIKSLDPATRTGVVIVAAKSGGRKIFGLATLNVRFS
MSMEG_6754|M.smegmatis_MC2_155 GTEIEYSGRIKSLDPETRTGVVIVAAKSGGRKIFGLATATIRFS
MAB_4780|M.abscessus_ATCC_1997 GADIEFGGKIKSLDPQTRTGIVVVTAKASGKKIFGLATMSVRFS
Mb0655|M.bovis_AF2122/97 GAELVFNGRVKSVDPESKSVTIALTATTGGKKIFGRAIASAKLA
Rv0636|M.tuberculosis_H37Rv GAELVFNGRVKSVDPESKSVTIALTATTGGKKIFGRAIASAKLA
MUL_0721|M.ulcerans_Agy99 GAELVFNGRVKSVDPDSKSVTIALTATTGGKKIFGRAIASAKLA
MLBr_01909|M.leprae_Br4923 GAVLVFSGKVKSVDPDTKSVTIALSATTGGKKIFGRAIASAKLA
MAV_4526|M.avium_104 GAELVFNGRVKSADPETKSVTIALTATTGGKKIFGRAIASAILA
* : :.*::** ** ::: : : *.:.*:**** * :