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RRVGVIGLGGMGSALAASLLATDHYVVCFDIRPDVLRPIVELGAEAAADARELAGACDVVLTFLPGPSQV LEVALGSERGVLAGLADGAALLDMSTCNPEVAAIIGQAYDAAGRRFVDCPVSRKAPNMTVLVGGPSGVLG PDADVLAAVSRTLVYCGQRGAGYATKLLNQHIKYSWYLASAEALLIAEAMGLNAGDVADAIAECSGGDSG LTTAAAYFRHDTESVRNRAPASTITKDSALAERMATNAGIRSRTLEPVVDFFQSVAASEFRDRAYPESTE LLQRIRSMPPK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0547 | - | - | 100% (292) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. gilvum PYR-GCK | Mflv_0629 | - | e-164 | 100.00% (292) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. gilvum PYR-GCK | Mflv_5012 | - | 1e-20 | 31.60% (212) | 3-hydroxyisobutyrate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0773c | mmsB | 6e-19 | 29.72% (212) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. tuberculosis H37Rv | Rv0751c | mmsB | 6e-19 | 29.72% (212) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1186c | - | 1e-21 | 31.02% (216) | 3-hydroxyisobutyrate dehydrogenase |
| M. marinum M | MMAR_4926 | - | 2e-19 | 28.82% (229) | dehydrogenase/reductase |
| M. avium 104 | MAV_4419 | mmsB | 3e-19 | 27.49% (291) | 3-hydroxyisobutyrate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4816 | - | 1e-20 | 30.77% (221) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. thermoresistible (build 8) | TH_2512 | - | 4e-20 | 28.95% (266) | PUTATIVE 6-phosphogluconate dehydrogenase, NAD-binding |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 8e-19 | 29.52% (210) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_0536 | - | 1e-163 | 100.00% (292) | 6-phosphogluconate dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4419|M.avium_104 ----MVVAFLGLGNMGAPMAANLVAAQHAVRGFDPVPAALSAATASGVTG
MUL_0835|M.ulcerans_Agy99 MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASATAAKGATM
Mb0773c|M.bovis_AF2122/97 ---MTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAV
Rv0751c|M.tuberculosis_H37Rv ---MTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAV
MAB_1186c|M.abscessus_ATCC_199 ---MTNIAFIGLGHMGLPMAVNLTKAGHTVAAFDLSEQARDAATQAGVPL
MSMEG_4816|M.smegmatis_MC2_155 ----MRVGFIGLGSQGAPMARRIVEGGFETTLWARRPASLEPFADTAAKV
TH_2512|M.thermoresistible__bu ----MRVGFIGLGSQGGPMARRIAENGYETTLWARRAATLEPFADTPAKT
Mflv_0547|M.gilvum_PYR-GCK ---MRRVGVIGLGGMGSALAASLLATDHYVVCFDIRPDVLRPIVELGAEA
Mvan_0536|M.vanbaalenii_PYR-1 ---MRRVGVIGLGGMGSALAASLLATDHYVVCFDIRPDVLRPIVELGAEA
MMAR_4926|M.marinum_M MSEHPKLGYIGLGNQGAPMAKRLLDWPGGLVVYDVRAEAMTPLAEAGASA
:. :*** * .:: : : . .
MAV_4419|M.avium_104 FDTATDAVTGADVVITMLPNGEVVKRCYA----EILPAARPGALFIDSST
MUL_0835|M.ulcerans_Agy99 FDSAAEAVARADVVITMLPNGAVVKRCYA----EVLPAARSGALFIDSST
Mb0773c|M.bovis_AF2122/97 FRSAPEAVAEADVVITMLPTGEVVRRCYT----DVLAAARPATLFIDSST
Rv0751c|M.tuberculosis_H37Rv FRSAPEAVAEADVVITMLPTGEVVRRCYT----DVLAAARPATLFIDSST
MAB_1186c|M.abscessus_ATCC_199 AESGAAAASTADVVITMLPKGAHVLAAYE----DLLPAARPGTLFIDSST
MSMEG_4816|M.smegmatis_MC2_155 AGTPAELAAASDLVCLCVVGDDDVREVLDG-ETGVLAGLAPGGIIAIHST
TH_2512|M.thermoresistible__bu AGSPAELGAASDLVCLCVVGDDDVREVLYG-DTGVLAGLAPGGVVAIHST
Mflv_0547|M.gilvum_PYR-GCK AADARELAGACDVVLTFLPGPSQVLEVALGSERGVLAGLADGAALLDMST
Mvan_0536|M.vanbaalenii_PYR-1 AADARELAGACDVVLTFLPGPSQVLEVALGSERGVLAGLADGAALLDMST
MMAR_4926|M.marinum_M AASVAEVAG-ADIISVTVLNDAQVREVITG-ANGLAAHARAGTIIAIHST
.*:: : * : . . . **
MAV_4419|M.avium_104 ISVADAREVHAQAQSHGVAQLDAPVSGGVKGAVAGTLAFMVGGEPEALER
MUL_0835|M.ulcerans_Agy99 ISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSALAQ
Mb0773c|M.bovis_AF2122/97 ISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRR
Rv0751c|M.tuberculosis_H37Rv ISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRR
MAB_1186c|M.abscessus_ATCC_199 VDVADARAAHEAATAAGHRFADAPVSGGVPGATAATLTFMVGADDAVFVA
MSMEG_4816|M.smegmatis_MC2_155 VHPDTCTEIAEQVAEKGISLIDAPVSGGEPAAKAGTLLVMAGGDEDIVDK
TH_2512|M.thermoresistible__bu VHPDTCREISEKAAAQQVSVIDAPVSGGGPAVEEGKLLVMVGGDEEVVER
Mflv_0547|M.gilvum_PYR-GCK CNPEVAAIIGQAYDAAGRRFVDCPVSR-----KAPNMTVLVGGPSGVLGP
Mvan_0536|M.vanbaalenii_PYR-1 CNPEVAAIIGQAYDAAGRRFVDCPVSR-----KAPNMTVLVGGPSGVLGP
MMAR_4926|M.marinum_M ISDTTAEELARELRPRGIHVIDAPVSGGAGAASKGQLATMVGAGDDVFAR
. *.*** : :.*. .
MAV_4419|M.avium_104 ARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIGEAFILAEKLG
MUL_0835|M.ulcerans_Agy99 ARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIGEAFVLAENLG
Mb0773c|M.bovis_AF2122/97 ARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLG
Rv0751c|M.tuberculosis_H37Rv ARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLG
MAB_1186c|M.abscessus_ATCC_199 AEPILDAMGKRVVHCGGPGVGQAAKICNNMILGVSMIAISEAFVLGEKLG
MSMEG_4816|M.smegmatis_MC2_155 VRPVFATYADPVVRLGGVGSGQVAKILNNLLFSANLGAAMSALELGEALG
TH_2512|M.thermoresistible__bu CRPVFASYADPIVHLGPLGSGQVTKILNNLLFTANLGSALSTLELGESLG
Mflv_0547|M.gilvum_PYR-GCK DADVLAAVSRTLVYCGQRGAGYATKLLNQHIKYSWYLASAEALLIAEAMG
Mvan_0536|M.vanbaalenii_PYR-1 DADVLAAVSRTLVYCGQRGAGYATKLLNQHIKYSWYLASAEALLIAEAMG
MMAR_4926|M.marinum_M VKEPFSCWASLVVHAGPPGAGTRMKLARNMLTFTIYAAVGEAWKLAEASG
: . :: * * * *: .: : : .: :.* *
MAV_4419|M.avium_104 LSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFAAALMN-
MUL_0835|M.ulcerans_Agy99 LDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFATALMN-
Mb0773c|M.bovis_AF2122/97 LSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALMN-
Rv0751c|M.tuberculosis_H37Rv LSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALMN-
MAB_1186c|M.abscessus_ATCC_199 LSHQALFDVAANASGQCWALTSNCPVPGPVPTSPANRDYAPGFAVALMA-
MSMEG_4816|M.smegmatis_MC2_155 VPRSALCEVITRGSANSKALGSIAMFGGTLDN------LAP-IAGALLQ-
TH_2512|M.thermoresistible__bu IPRVKLAEVLNGGSATSKALGSISVFGGTVEG------LAP-IAGALLQ-
Mflv_0547|M.gilvum_PYR-GCK LNAGDVADAIAECSGGDSGLTTAAAYFRHDTES-----VRNRAPASTIT-
Mvan_0536|M.vanbaalenii_PYR-1 LNAGDVADAIAECSGGDSGLTTAAAYFRHDTES-----VRNRAPASTIT-
MMAR_4926|M.marinum_M VNLQDLGNVVRHTDKLTSGAGSIMFRDNTKDLEPGHFLYDGFVHARDLGE
: : :. . : :
MAV_4419|M.avium_104 KDLGLAMDAVTSTGAAAPLGRHAAEIYAKFAASHGD-KDFSAVIEMLRGA
MUL_0835|M.ulcerans_Agy99 KDLGLAMDAVTSTASAAPLGSHAAEIYAKFATDHAD-QDFSAVIEMLRGS
Mb0773c|M.bovis_AF2122/97 KDLGLAMDAVAATGATAPLGSHAADIYAKFAADHAD-LDFSAVIHTLRAR
Rv0751c|M.tuberculosis_H37Rv KDLGLAMDAVAATGATAPLGSHAADIYAKFAADHAD-LDFSAVIHTLRAR
MAB_1186c|M.abscessus_ATCC_199 KDLGLAANAVRANGVDAQLGLAAAHIYDDFNSTGGSGLDFSAIFSRIQGA
MSMEG_4816|M.smegmatis_MC2_155 KDCRHAASLADAASASQGAVFGAADEALRLMNVPR---------------
TH_2512|M.thermoresistible__bu KDVRHAANIAASASVPEGTVFTVADTALTAMGHARR--------------
Mflv_0547|M.gilvum_PYR-GCK KDSALAERMATNAGIRSRTLEPVVDFFQSVAASEFRDRAYPESTELLQRI
Mvan_0536|M.vanbaalenii_PYR-1 KDSALAERMATNAGIRSRTLEPVVDFFQSVAASEFRDRAYPESTELLQRI
MMAR_4926|M.marinum_M KDLGLALALGEALSVDLPLARLALERLAPGLGVPHTQKDA----------
** * . . .
MAV_4419|M.avium_104 C----------
MUL_0835|M.ulcerans_Agy99 -----------
Mb0773c|M.bovis_AF2122/97 ADA--------
Rv0751c|M.tuberculosis_H37Rv ADA--------
MAB_1186c|M.abscessus_ATCC_199 S----------
MSMEG_4816|M.smegmatis_MC2_155 -----------
TH_2512|M.thermoresistible__bu -----------
Mflv_0547|M.gilvum_PYR-GCK RSMPPK-----
Mvan_0536|M.vanbaalenii_PYR-1 RSMPPKSTSTP
MMAR_4926|M.marinum_M -----------