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RLRRGCSATGERARDNRCMAAAVTIRILGVGMGPQHVTPEVADALNGVDYVLAADKGEDDALLALRREIV RAHGGAEVLGLRDPARDRSDGLSTGAYESAVADWHDARAAQYADVLRRRGGTAAFLVWGDPSLYDSTIRV VEKVRDLLGPDTDVDFDVLPGISAPQLLAARHRIVLHEVGRPVHITTGRRLQEAVAAGLDNILAMLNPAP DRLDFTGLDDWTIWWGANLGAAGERLVAGRVGDVLPAIADARAAAHADDGWVMDAFLIRRTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0361 | - | - | 100% (273) | precorrin 6A synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1037 | - | 8e-46 | 45.10% (255) | precorrin 6A synthase |
| M. marinum M | MMAR_4563 | - | 2e-41 | 42.52% (254) | hypothetical protein MMAR_4563 |
| M. avium 104 | MAV_1065 | cobF | 8e-46 | 44.02% (259) | precorrin 6A synthase |
| M. smegmatis MC2 155 | MSMEG_5548 | cobF | 3e-44 | 43.70% (254) | precorrin 6A synthase |
| M. thermoresistible (build 8) | TH_2324 | cobF | 8e-47 | 43.80% (258) | precorrin-6A synthase (deacetylating) |
| M. ulcerans Agy99 | MUL_4422 | - | 1e-41 | 42.52% (254) | precorrin 6A synthase |
| M. vanbaalenii PYR-1 | Mvan_0376 | - | 1e-120 | 82.68% (254) | precorrin 6A synthase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5548|M.smegmatis_MC2_155 ----------------------MRRIHVIGIGAGDPDYVTAQAVAALNDT
TH_2324|M.thermoresistible__bu ---------------------VPRHIHVIGIGAGDPDYVTAQAVAALNDT
MMAR_4563|M.marinum_M --------------------MVSRHIHVIGIGAGDPDYVTVQAINALNDT
MUL_4422|M.ulcerans_Agy99 --------------------MVSRHIHVIGIGAGDPDYVTVQAINALNDT
MAV_1065|M.avium_104 ---------------------MGRHIHVIGIGAGDPDYLTVQAIEALNDT
MAB_1037|M.abscessus_ATCC_1997 ----------------------MRRIRVIGIGAGHPEYLTVQAIAALNEV
Mflv_0361|M.gilvum_PYR-GCK MRLRRGCSATGERARDNRCMAAAVTIRILGVGMG-PQHVTPEVADALNGV
Mvan_0376|M.vanbaalenii_PYR-1 -------------------MVAAVKVRILGVGMG-PQHVTPEVADALRTV
::::*:* * *:::* :. **. .
MSMEG_5548|M.smegmatis_MC2_155 EVFFAMDKGQSKDELVALRRLICERFITEARYRFVELADPKRAE-----D
TH_2324|M.thermoresistible__bu DVFFAMDKGEAKDDLVALRRQICERFIERPGYRFVELPDPPRAR-----D
MMAR_4563|M.marinum_M QVFFAMDKGEAKSELVELRRAICARFIREPRYRFVELPDPKRAV-----D
MUL_4422|M.ulcerans_Agy99 QVFFAMDKGEAKSELVELRRAICARFIREPRYRFVELPDPKRAV-----D
MAV_1065|M.avium_104 QVFFAMDKGEQKSDLVALRREICSRFIRQPGYRFVELPDPKRSD-----R
MAB_1037|M.abscessus_ATCC_1997 DVFFVADKGDIKDDLVELRRHICERYITDPDYRFVELPDPVRG------K
Mflv_0361|M.gilvum_PYR-GCK DYVLAADKGE-DDALLALRREIVR---AHGGAEVLGLRDPARDRSDGLST
Mvan_0376|M.vanbaalenii_PYR-1 DYVLAAEKAD-DDRLLALRRAIVR---AHGGAELVALPDPPRDRSERLSA
: .:. :*.: .. *: *** * ..: * ** *
MSMEG_5548|M.smegmatis_MC2_155 GDYRQIVADWHAERARIWARAIESELGPDGVGAFLAWGDPSLYDSTLRIL
TH_2324|M.thermoresistible__bu GDYRQAVSDWHAARARIWADAIATELGPDGVGAFLAWGDPSLYDSTLRIL
MMAR_4563|M.marinum_M AHYEDAVSQWHAQRARIWARAISTELGPGGVGAFLAWGDPSLYDSTLRIL
MUL_4422|M.ulcerans_Agy99 AHYEDAVSQWHAQRARIWARAISTELGPGGVGAFLAWGDPSLYDSTLRIL
MAV_1065|M.avium_104 ADYRDAVAEWHAARAQIWADAIAAELGPHGVGGFLAWGDPSLYDSTLRIL
MAB_1037|M.abscessus_ATCC_1997 GEYRGAVTQWHAERAALWAKAIASDLPDGGTGAFLAWGDPSLYDSTLRIL
Mflv_0361|M.gilvum_PYR-GCK GAYESAVADWHDARAAQYADVLR---RRGGTAAFLVWGDPSLYDSTIRVV
Mvan_0376|M.vanbaalenii_PYR-1 GGYESAVSDWHDARAAQYAGVLK---ERGGTAAFLVWGDPSLYDSTIRVV
. *. *::** ** :* .: *...**.**********:*::
MSMEG_5548|M.smegmatis_MC2_155 EM----VGEHVEFDYDVIPGVTAIQALTARHRIPLNDVGEPVLITTGRRL
TH_2324|M.thermoresistible__bu DR----VAEHVEISYDVIPGITAIQALTARHRIPLNDVGEPVLITTGRRL
MMAR_4563|M.marinum_M DA----VSAEVDFSYDVIPGITAVQALTARHRIPLNDVGAPVVITTGRQL
MUL_4422|M.ulcerans_Agy99 DA----VSAEVDFSYDVIPGITAVQALTARHRIPLNDVGAPVVITTGRQL
MAV_1065|M.avium_104 DT----VAGHVEFTFDVIPGITAVQALTARHRIPLNEVGEPVLVTTGRQL
MAB_1037|M.abscessus_ATCC_1997 DAI--LVDDPAAFEYDVLPGITAISALTARHRIVLNGIGEPVLITTGRRL
Mflv_0361|M.gilvum_PYR-GCK EKVRDLLGPDTDVDFDVLPGISAPQLLAARHRIVLHEVGRPVHITTGRRL
Mvan_0376|M.vanbaalenii_PYR-1 EKVRALLEPHVALDFDVLPGISAPQLLAARHRIVLHEVGKPVHVTTGRRL
: : . . :**:**::* . *:***** *: :* ** :****:*
MSMEG_5548|M.smegmatis_MC2_155 R-EHGLTG--SAVVMLDA---DCSFRTCDPRTRIWWGAYLGTPDELLVAG
TH_2324|M.thermoresistible__bu R-EHGLTG--AAVVMLDG---ECSFLTCPPQTRIWWGAYLGTPDELLLAG
MMAR_4563|M.marinum_M R-ARQVAG--TAVVMLDA---DCSFRACPPQTRIWWGAYLGTEDELLVAG
MUL_4422|M.ulcerans_Agy99 R-TRQVAG--TAVVMLDA---DCSFRACPTQTRIWWGAYLGTEDELLVAG
MAV_1065|M.avium_104 R-AHGISG--SAVVMLDA---DCSFQRCAPETRIWWGAYLGTADELLVAG
MAB_1037|M.abscessus_ATCC_1997 LDEWPRAG--TVVVMLDG---DCAFRQLDPSTQIWWGAYLGTEHELLVAG
Mflv_0361|M.gilvum_PYR-GCK Q-EAVAAGLDNILAMLNPAPDRLDFTGLDDWT-IWWGANLGAAGERLVAG
Mvan_0376|M.vanbaalenii_PYR-1 Q-EAVAAGMDNIVAMLNPPPERLDFTGLDDWT-IWWGANLGAPGERLVTG
:* :.**: * * ***** **: * *::*
MSMEG_5548|M.smegmatis_MC2_155 TVGDVAEDIVRMRAEARTRHGWIMDTYLLRSAD-
TH_2324|M.thermoresistible__bu TVGAVGKRIETVRAEARARHGWIMDTYLLRP---
MMAR_4563|M.marinum_M TVGEVGERIAALRAEARARHGWIMDTYLIRTY--
MUL_4422|M.ulcerans_Agy99 TVGEVGERIAALRAEARARHGWIMDTYLIRTY--
MAV_1065|M.avium_104 TVGEVGPRIAALRAQARARHGWIMDTYLLRPAH-
MAB_1037|M.abscessus_ATCC_1997 TVGEVGDRIAQVRTEARADHGWIMDTYLLRSVGA
Mflv_0361|M.gilvum_PYR-GCK RVGDVLPAIADARAAAHADDGWVMDAFLIRRTR-
Mvan_0376|M.vanbaalenii_PYR-1 RLRDVLPAVADARAAADAYDGWVMDVFLIRRDR-
: * : *: * : .**:**.:*:*