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SPEPDSVPSVRIPTPLPDGVGQATIGVRGGLLRSGFEETAEAIYLTSGYVYESAAEAEKAFTGEIDRYVY SRYGNPTISMFEERLRLLEGAPACFGTASGMSAVFTSLGALLGAGDRLVAARSLFGSCFVVCNEILPRWG VETVFVDGEDLAQWEEALSVPTQAVFFETPSNPMQSLVDIAAVCDLAHAAGAKVVLDNVFATPILQQGMP LGADVVVYSGTKHIDGQGRVLGGAILGDKEYIDGPVQKLMRHTGPALSPFNAWTLLKGLETMALRVQHQN SSAHRIAEFLEGHSAVSWVKYPFLESHPQYDLAKRQMTGGGTVVTFELAGATKERAFEVLDKLQIVDISN NLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRISVGLEGTEDLIADLDRALG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0219 | - | - | 100% (407) | O-succinylhomoserine sulfhydrylase |
| M. gilvum PYR-GCK | Mflv_2046 | - | 2e-64 | 37.54% (357) | cystathionine gamma-synthase |
| M. gilvum PYR-GCK | Mflv_4875 | - | 4e-63 | 36.04% (394) | O-acetylhomoserine aminocarboxypropyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0397 | metZ | 0.0 | 84.25% (400) | O-succinylhomoserine sulfhydrylase |
| M. tuberculosis H37Rv | Rv0391 | metZ | 0.0 | 84.25% (400) | O-succinylhomoserine sulfhydrylase |
| M. leprae Br4923 | MLBr_00275 | metZ | 0.0 | 83.25% (400) | O-succinylhomoserine sulfhydrylase |
| M. abscessus ATCC 19977 | MAB_4242c | - | 0.0 | 83.74% (406) | O-succinylhomoserine sulfhydrylase |
| M. marinum M | MMAR_0688 | metZ | 0.0 | 84.13% (397) | O-succinylhomoserine sulfhydrylase, MetZ |
| M. avium 104 | MAV_4773 | metZ | 0.0 | 85.79% (401) | O-succinylhomoserine sulfhydrylase |
| M. smegmatis MC2 155 | MSMEG_0769 | metZ | 0.0 | 87.81% (402) | O-succinylhomoserine sulfhydrylase |
| M. thermoresistible (build 8) | TH_3089 | - | 0.0 | 85.19% (405) | PUTATIVE O-succinylhomoserine sulfhydrylase |
| M. ulcerans Agy99 | MUL_1438 | metC | 1e-63 | 36.13% (393) | O-acetylhomoserine aminocarboxypropyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0688 | - | 0.0 | 91.18% (408) | O-succinylhomoserine sulfhydrylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0219|M.gilvum_PYR-GCK ---MSPEPDSVPSV------RIPTPLPDGVGQATIGVRGG-LLRSGFEET
Mvan_0688|M.vanbaalenii_PYR-1 ---MT----EVPSV------RIPAVLPEGVSQETIGVRGG-LLRSGFEET
MSMEG_0769|M.smegmatis_MC2_155 ---MT---DDIPSV------RIPAPLPDGVSQATIGVRGG-LLRSGFEET
Mb0397|M.bovis_AF2122/97 ---MT----DESSV------RTPKALPDGVSQATVGVRGG-MLRSGFEET
Rv0391|M.tuberculosis_H37Rv ---MT----DESSV------RTPKALPDGVSQATVGVRGG-MLRSGFEET
MAV_4773|M.avium_104 -MSQA----GDDSV------RTPPALPDGVSQATIGVRGG-LLRSGFDET
MLBr_00275|M.leprae_Br4923 ---MT----DDRSV------RTPKALPDGVTAATVGVRGG-LLRSRFEET
MMAR_0688|M.marinum_M ---MT----DDRSVPEAERPKNPRKLPDGVSQATIGVRGG-MLRSGFDET
TH_3089|M.thermoresistible__bu ---MT----DRPPASKPS-VRTPAGLPDGVGPATIGVRGG-LLRSEFEET
MAB_4242c|M.abscessus_ATCC_199 ---MTQTPSGGSSV------RIPKALPDGVSQATIGVRGG-LLRSEFEET
MUL_1438|M.ulcerans_Agy99 MS-------AENTS-------TDADPTAHWSFETKQIHAGQQPDSATNAR
. . * ::.* * :
Mflv_0219|M.gilvum_PYR-GCK AEAIYLTSGYVYESAAEAEKAFTGEIDRYVYSRYGNPTISMFEERLRLLE
Mvan_0688|M.vanbaalenii_PYR-1 AEALYLTSGYVYESAAAAEKAFTGEIDRYVYSRYGNPTVSMFEERLRLIE
MSMEG_0769|M.smegmatis_MC2_155 AEAMYLTSGYVYETAAAAEKAFTGDIDRYVYSRYGNPTISMFEERLRLIE
Mb0397|M.bovis_AF2122/97 AEAMYLTSGYVYGSAAVAEKSFAGELDHYVYSRYGNPTVSVFEERLRLIE
Rv0391|M.tuberculosis_H37Rv AEAMYLTSGYVYGSAAVAEKSFAGELDHYVYSRYGNPTVSVFEERLRLIE
MAV_4773|M.avium_104 AEALYLTSGYVYESAAVAEQSFTGELDHFVYSRYGNPTVTMFEERLRLLE
MLBr_00275|M.leprae_Br4923 AETMYLTSGYVYESAVVAEKSFTGELDHFVYSRYGNPTVTMFEERLRLIE
MMAR_0688|M.marinum_M AEALYLTSGYVYESAAMAEQSFAGELDHFLYSRYGNPTVAMFEERLRLIE
TH_3089|M.thermoresistible__bu AEALYLTSGYVYESAADAERAFAGEIDRFVYSRYGNPTIAMFEERLRLIE
MAB_4242c|M.abscessus_ATCC_199 AEAMYLTSGYVYESAAAAERAFTGEVDRYVYSRYGNPTISMFEERLRLIE
MUL_1438|M.ulcerans_Agy99 ALPIYQTTSYTFENTAHAAALFGLEVPGNIYTRLGNPTTDVVEQRIAALE
* .:* *:.*.: .:. * * :: :*:* **** :.*:*: :*
Mflv_0219|M.gilvum_PYR-GCK GAPACFGTASGMSAVFTSLGALLGAGDRLVAARSLFGSCFVVCNEILPRW
Mvan_0688|M.vanbaalenii_PYR-1 GAPACFATSSGMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRW
MSMEG_0769|M.smegmatis_MC2_155 GAPACFATATGMAAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRW
Mb0397|M.bovis_AF2122/97 GAPAAFATASGMAAVFTSLGALLGAGDRLVAARSLFGSCFVVCSEILPRW
Rv0391|M.tuberculosis_H37Rv GAPAAFATASGMAAVFTSLGALLGAGDRLVAARSLFGSCFVVCSEILPRW
MAV_4773|M.avium_104 GAPAAFATASGMAAVFTSLGALLAAGDRLVAARSLFGSCFVVCNEILPRW
MLBr_00275|M.leprae_Br4923 GAPAAFVTASGMAAVFTSLGALLASGDRLVAARSLFGSCFVVCNEILPRW
MMAR_0688|M.marinum_M AAPAVFATASGMAAVFTALGALLGAGDRLVASRSLFGSCFVVCNEILPRW
TH_3089|M.thermoresistible__bu GAPACFATATGMAAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRW
MAB_4242c|M.abscessus_ATCC_199 GAEAAFATATGMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRW
MUL_1438|M.ulcerans_Agy99 GGVAALFLSSGQAAETFGILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKL
.. * : ::* :* .: * .:**::*:: *:*. : : *.:
Mflv_0219|M.gilvum_PYR-GCK GVETVFVDG-EDLAQWEEALSVPTQAVFFETPSNPMQSLVDIAAVCDLAH
Mvan_0688|M.vanbaalenii_PYR-1 GVETVFVDG-DDLSQWEQALSVPTQAVFFETPSNPMQSLVDIAAVCELAH
MSMEG_0769|M.smegmatis_MC2_155 GVETVFVDG-DDLSQWEEALSVPTTAVFFETPSNPMQSLVDIAAVSEMAH
Mb0397|M.bovis_AF2122/97 GVQTVFVDG-DDLSQWERALSVPTQAVFFETPSNPMQSLVDIAAVTELAH
Rv0391|M.tuberculosis_H37Rv GVQTVFVDG-DDLSQWERALSVPTQAVFFETPSNPMQSLVDIAAVTELAH
MAV_4773|M.avium_104 GVQTVFVDG-DDLAQWEEALSVPTAAVFFETPSNPMQSLVDIAAVTELAH
MLBr_00275|M.leprae_Br4923 GVETVFVDG-EDLVQWEQALSVPTQAVFFETPSNPMQSLVDIAAVTELAH
MMAR_0688|M.marinum_M GVETVFVDG-DDLEQWEQALSVPTEAVFFETPSNPMQSLVDIAAVTELAH
TH_3089|M.thermoresistible__bu GVQTVFVDG-DDLGQWERALSEPTTAVFFETPSNPMQSLVDIAAVTELAH
MAB_4242c|M.abscessus_ATCC_199 GVETVFVDG-EDISQWEEALSVPTQAVFFETPSNPMQSLVDIEAVCTLAH
MUL_1438|M.ulcerans_Agy99 GIEVSFVDDPDNLDSWQAAVRPNTKAFFGETISNPQIDLLDTPGVAEVAH
*::. ***. ::: .*: *: * *.* ** *** .*:* .* :**
Mflv_0219|M.gilvum_PYR-GCK AAGAKVVLDNVFATPILQQGMPLGADVVVYSGTKHIDGQGRVLGGAILG-
Mvan_0688|M.vanbaalenii_PYR-1 AAGAKVVLDNVFATPILQQGFPLGVDVVVYSGTKHIDGQGRVLGGAILG-
MSMEG_0769|M.smegmatis_MC2_155 AAGAKVVLDNVFATPLLQQGIPMGADVVVYSGTKHIDGQGRVLGGAILG-
Mb0397|M.bovis_AF2122/97 AAGAKVVLDNVFATPLLQQGFPLGVDVVVYSGTKHIDGQGRVLGGAILG-
Rv0391|M.tuberculosis_H37Rv AAGAKVVLDNVFATPLLQQGFPLGVDVVVYSGTKHIDGQGRVLGGAILG-
MAV_4773|M.avium_104 AAGAKVVLDNVFATPLLQQGIPLGVDVVVYSGTKHIDGQGRVLGGAILG-
MLBr_00275|M.leprae_Br4923 AAGAKVVLDNAFATPLLQHGLPLGVDVVIYSGTKHIDGQGRVLGGAILG-
MMAR_0688|M.marinum_M AAGAKVVLDNVFATPLLQQGIPLGVDVVVYSGTKHIDGQGRVLGGAILG-
TH_3089|M.thermoresistible__bu AAGAKVVLDNVFATPLLQQGFQLGVDVVVYSGTKHIDGQGRVLGGAILG-
MAB_4242c|M.abscessus_ATCC_199 ASGAKVVLDNVFATPLLQQGIPLGADVVVYSGTKHIDGQGRVLGGAILG-
MUL_1438|M.ulcerans_Agy99 RNGIPLIVDNTIATPYLIRPFTQGADIVVHSATKYLGGHGAAIAGVIVDG
* :::**.:*** * : : *.*:*::*.**::.*:* .:.*.*:.
Mflv_0219|M.gilvum_PYR-GCK -----------------------------DKEYIDGPVQKLMRHTGPALS
Mvan_0688|M.vanbaalenii_PYR-1 -----------------------------SKEYIDEPVQKLMRHTGPALS
MSMEG_0769|M.smegmatis_MC2_155 -----------------------------DQEYIDGPVQKLMRHTGPAIS
Mb0397|M.bovis_AF2122/97 -----------------------------DREYIDGPVQKLMRHTGPAMS
Rv0391|M.tuberculosis_H37Rv -----------------------------DREYIDGPVQKLMRHTGPAMS
MAV_4773|M.avium_104 -----------------------------DRDYIDGPVQKLMRHTGPAMS
MLBr_00275|M.leprae_Br4923 -----------------------------DRDYIDGPVQKLMRHTGPAMS
MMAR_0688|M.marinum_M -----------------------------DQDYIDGPVQKLMRHTGPALS
TH_3089|M.thermoresistible__bu -----------------------------DTDYIDGPVQKLMRHTGPAIS
MAB_4242c|M.abscessus_ATCC_199 -----------------------------ETEYIEGPVKTLMRHTGPALS
MUL_1438|M.ulcerans_Agy99 GTFDWTQGRFPEFTTPDPSYHGVVFAELGAPAYALKARVQLLRDLGSAAS
* . *:*. *.* *
Mflv_0219|M.gilvum_PYR-GCK PFNAWTLLKGLETMALRVQHQNSSAHRIAEFLEGHSAVSWVKYPFLESHP
Mvan_0688|M.vanbaalenii_PYR-1 PFNAWTLLKGLETLSLRVQHQNSSAHRIAEFLEQHPSVSWVKYPFLESHP
MSMEG_0769|M.smegmatis_MC2_155 AFNAWVLLKGLETLAVRVDYSNRSAQRVAEFLEGHPAVRWVKYPFLQSHP
Mb0397|M.bovis_AF2122/97 AFNAWVLLKGLETLAIRVQHSNASAQRIAEFLNGHPSVRWVRYPYLPSHP
Rv0391|M.tuberculosis_H37Rv AFNAWVLLKGLETLAIRVQHSNASAQRIAEFLNGHPSVRWVRYPYLPSHP
MAV_4773|M.avium_104 AFNAWVLLKGLETMAIRVEHSNSSAHRIAEFLETHPAVRWVRYPYLPSHP
MLBr_00275|M.leprae_Br4923 AFNAWILLKGLETLAIRVDHCNSSAHRIAEFLEKHPAVSWVRYPFLVSHP
MMAR_0688|M.marinum_M AFNAWILLKGLETLAIRVQHSNSSALRIAEFLQGHPAVRWVRYPYLPSHP
TH_3089|M.thermoresistible__bu AFNAWIMLKGLETLAVRVNHSNASAHRIAEFLEGHPAVRWVRYPFLESHP
MAB_4242c|M.abscessus_ATCC_199 PFNAWTLVKGLETLDLRVRHANDSAYKIAQFLEQHPAVRWVRYPFLGTHP
MUL_1438|M.ulcerans_Agy99 PFNAFLVAQGLETLSLRIERHVSNAQRVAEFLADREDVVTVNYAGLPGSP
.***: : :****: :*: .* ::*:** : * *.*. * *
Mflv_0219|M.gilvum_PYR-GCK QYDLAKRQMT-GGGTVVTFELAGA--------TKERAFEVLDKLQIVDIS
Mvan_0688|M.vanbaalenii_PYR-1 QYDLAKRQMT-GGGTVVTFELAGAGGAGNPDAAKERAFEVLDKLQIVDIS
MSMEG_0769|M.smegmatis_MC2_155 QYELAKRQMR-GGGTVVTFELDGDD-------GKARAFEVLDKLRVIDIS
Mb0397|M.bovis_AF2122/97 QYDLAKRQMS-GGGTVVTFALDCPE-----DVAKQRAFEVLDKMRLIDIS
Rv0391|M.tuberculosis_H37Rv QYDLAKRQMS-GGGTVVTFALDCPE-----DVAKQRAFEVLDKMRLIDIS
MAV_4773|M.avium_104 QYDLAKRQMS-GGGTVITFALDCPD-----DKAKQRAFEVLDKLTLIDIS
MLBr_00275|M.leprae_Br4923 QYDLAKRQMS-GGGTVVTFALNSPE-----DAAKQRAFEVLDRLRLIDIS
MMAR_0688|M.marinum_M QYDLAKRQMS-GGGTVVTFALDAPE-----SAAKRRAFEVLDKLRLIDIS
TH_3089|M.thermoresistible__bu QYDLAKRQMR-GGGTVITFELDAPP-----DGGKQRAFEVLDKLRLIDIS
MAB_4242c|M.abscessus_ATCC_199 QYELAKRQMR-GGGTVVTFELDADG-----DAGKQRAFQVLDGTSLIDIS
MUL_1438|M.ulcerans_Agy99 WHERAKKLSPKGTGAVLSFELAGGV---------EAGKAFVNALKLHSHV
:: **: * *:*::* * . .:: : .
Mflv_0219|M.gilvum_PYR-GCK NNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRISVGLEGTEDLIA
Mvan_0688|M.vanbaalenii_PYR-1 NNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRISIGLEGTEDLLA
MSMEG_0769|M.smegmatis_MC2_155 NNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRISIGLEGTEDLIA
Mb0397|M.bovis_AF2122/97 NNLGDAKSLVTHPATTTHRAMGPEGRAAIGLGDGVVRISVGLEDTDDLIA
Rv0391|M.tuberculosis_H37Rv NNLGDAKSLVTHPATTTHRAMGPEGRAAIGLGDGVVRISVGLEDTDDLIA
MAV_4773|M.avium_104 NNLGDAKSLVTHPATTTHRAMGPEGRAAIGLGDGVVRISVGLEGTDDLIA
MLBr_00275|M.leprae_Br4923 NNFGDVKSLITHPATTTHRAMGPEGRAAIGLGDGVVRISIGLEDAADLIA
MMAR_0688|M.marinum_M NNLGDTKSLITHPATTTHRAMGPEGRAAIGLGDAVVRISVGLEGAEDLIA
TH_3089|M.thermoresistible__bu NNLGDAKSLITHPATTTHRAMGAEGRAAIGLGDAVVRISVGLEDTEDLIA
MAB_4242c|M.abscessus_ATCC_199 NNLGDSKSLITHPATTTHRAMGPEGRAAIGLSDGVVRLSVGLESTDDLIA
MUL_1438|M.ulcerans_Agy99 ANIGDVRSLVIHPASTTHAQLSPAEQLSTGVSPGLVRLAVGIEGIEDILA
*:** :**: ***:*** :.. : : *:. .:**:::*:*. *::*
Mflv_0219|M.gilvum_PYR-GCK DLDRALG---------------
Mvan_0688|M.vanbaalenii_PYR-1 DLDRALG---------------
MSMEG_0769|M.smegmatis_MC2_155 DLDQALS---------------
Mb0397|M.bovis_AF2122/97 DIDRALS---------------
Rv0391|M.tuberculosis_H37Rv DIDRALS---------------
MAV_4773|M.avium_104 DIDRALG---------------
MLBr_00275|M.leprae_Br4923 DIDQALS---------------
MMAR_0688|M.marinum_M DIDQALG---------------
TH_3089|M.thermoresistible__bu DLDRALS---------------
MAB_4242c|M.abscessus_ATCC_199 DLERALG---------------
MUL_1438|M.ulcerans_Agy99 DLELGFAAAREFSGDSQAVAAI
*:: .:.