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MPDELKPHFANVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAKIDLALGKLGLQPGMTLLD VGCGWGATMMRAVEKYDVNVVGLTLSKNQANHVQQLVANSESLRSKRVLLAGWEQFDEPVDRIVSIGAFE HFGHERYDAFFSLAHRLLPADGVMLLHTITGLHPKEIHERGLPMSFTFARFLKFIVTEIFPGGRLPSIPM VQECASANGFTVTRVQSLQPHYAKTLDLWSAALQANKGQAIALQSEEVYERYMKYLTGCAEMFRIGYIDV NQFTCQK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3424c | cmaA1 | - | 100% (287) | cyclopropane-fatty-acyl-phospholipid synthase 1 CMAA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 1) |
| M. bovis AF2122 / 97 | Mb0663c | mmaA2 | e-125 | 73.17% (287) | methoxy mycolic acid synthase |
| M. bovis AF2122 / 97 | Mb0479c | pcaA | e-121 | 72.82% (287) | mycolic acid synthase pcaA (cyclopropane synthase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3304 | - | 1e-112 | 66.90% (284) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. tuberculosis H37Rv | Rv3392c | cmaA1 | 1e-168 | 99.65% (287) | cyclopropane-fatty-acyl-phospholipid synthase 1 CMAA1 |
| M. leprae Br4923 | MLBr_02459 | umaA2 | 1e-117 | 68.99% (287) | Mycolic acid synthase |
| M. abscessus ATCC 19977 | MAB_3881 | - | 1e-110 | 66.20% (284) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. marinum M | MMAR_0979 | mmaA5_1 | 1e-131 | 77.70% (287) | methoxy mycolic acid synthase 5 MmaA5_1 |
| M. avium 104 | MAV_0130 | - | 1e-115 | 70.32% (283) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. smegmatis MC2 155 | MSMEG_1351 | - | 1e-125 | 72.73% (286) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. thermoresistible (build 8) | TH_4640 | - | 1e-126 | 74.30% (284) | PUTATIVE methoxy mycolic acid synthase 5 MmaA5_1 |
| M. ulcerans Agy99 | MUL_3772 | mmaA5 | 1e-124 | 73.52% (287) | methoxy mycolic acid synthase 5 MmaA5 |
| M. vanbaalenii PYR-1 | Mvan_3025 | - | 1e-112 | 67.25% (284) | cyclopropane-fatty-acyl-phospholipid synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3424c|M.bovis_AF2122/97 ------MPDELKPHFANVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMT
Rv3392c|M.tuberculosis_H37Rv ------MPDELKPHFANVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMT
MMAR_0979|M.marinum_M ------MAKELKPHFDDVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMT
MUL_3772|M.ulcerans_Agy99 ------MAKHLAPRFDDVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMT
TH_4640|M.thermoresistible__bu ---MAEPAKKLKPHFADVQAHYDLSDEFFGLFLDPTRTYSCAYFERDDMS
Mflv_3304|M.gilvum_PYR-GCK MSDTPNGSADLQPHFDDVQSHYDLSDDFYRLFLDPTQTYSCAYFERDDMT
Mvan_3025|M.vanbaalenii_PYR-1 MPETTSGSADLQPHFEDVQSHYDLSDDFYRLFLDPTQTYSCAYFERDDMT
MAV_0130|M.avium_104 MSENTGDAVNLQPHFDDVQAHYDLSDEFFALFLDPTRTYSCAYFERDDMT
MLBr_02459|M.leprae_Br4923 ------MSVQLTPHFRNVQAHYDLSDDFFRLFLDPTLTYSCAYFERDDMT
MSMEG_1351|M.smegmatis_MC2_155 ---MTKQPGKLQPHFDEVQAHYDLSDDFFALFLDPSRTYSCAYFERDDMT
MAB_3881|M.abscessus_ATCC_1997 -------MSKLTPKFSDVQAHYDLSDDFFALFLDPSRTYSCAYFEPETLT
.* *:* :**:******:*: *****: ******** : ::
Mb3424c|M.bovis_AF2122/97 LQEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGLT
Rv3392c|M.tuberculosis_H37Rv LQEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGLT
MMAR_0979|M.marinum_M LEEAQIAKIDLALGKLGLEPGMTLLDVGCGWGATMRRAIEKYDVNVVGLT
MUL_3772|M.ulcerans_Agy99 LEEAQIAKIDLALGKLGLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLT
TH_4640|M.thermoresistible__bu LEEAQLAKIDLALGKLGLQPGMTLLDIGCGWGSTMLRALERHDVDVVGLT
Mflv_3304|M.gilvum_PYR-GCK LEEAQRAKIDLALGKLGLEPGMTLLDIGCGWGGTLLRALEKYDVNVIGLT
Mvan_3025|M.vanbaalenii_PYR-1 LEEAQIAKIDLSLGKLGLQPGMTLLDIGCGWGATLLRALDKYDVNVIGLT
MAV_0130|M.avium_104 LEEAQIAKVDLSLGKLGLQPGMTLLDIGCGWGTTIVRALERYDVNVVGLT
MLBr_02459|M.leprae_Br4923 LEEAQLAKVDLALGKLKLEPGMTLLDIGCGWGATMKRAIEIYDVNVIGLT
MSMEG_1351|M.smegmatis_MC2_155 LEEAQLAKIDLSLGKLGLQPGMTLLDVGCGWGATMLRALERYDVNVVGLT
MAB_3881|M.abscessus_ATCC_1997 LEQAQQAKIDLALGKLNLEPGMTLLDVGCGWGSTMKRALEHYDVNVIGLT
*::** **:**:**** *:*******:***** *: **:: :**:*:***
Mb3424c|M.bovis_AF2122/97 LSKNQANHVQQLVANSESLRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGH
Rv3392c|M.tuberculosis_H37Rv LSKNQANHVQQLVANSENLRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGH
MMAR_0979|M.marinum_M LSKNQAAHVQKSFDQLDTARTRRVLLEGWEQFDEPVDRIVSIGAFEHFGH
MUL_3772|M.ulcerans_Agy99 LSKNQAAHVQKSFDQLDTARTRRVLLEGWEQFDEPVDRIVSIGAFEHFGH
TH_4640|M.thermoresistible__bu LSANQHAHVEQLLADSPSRRSRRVLLRGWEEFDEPVDRIVSIGAFEHFGH
Mflv_3304|M.gilvum_PYR-GCK LSRNQQAHVQKVLDEHDSPRSKTVLLQGWEQFDQPVDRIVSIGAFEHFGS
Mvan_3025|M.vanbaalenii_PYR-1 LSRNQQAHVQKRLDAHGSGRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGR
MAV_0130|M.avium_104 LSRNQQAHVQRPLDNHPSPRSKRVLLQGWEQFDEKVDRIVSIGAFEHFGR
MLBr_02459|M.leprae_Br4923 LSENQAAHVQKTFDELDTPRTRRVLLEGWEKFHEPVDRIVSIGAFEHFGR
MSMEG_1351|M.smegmatis_MC2_155 LSRNQQAHVERRFSESSSPRTKRVLLAGWEEFDEPVDRIVSIGAFEHFGH
MAB_3881|M.abscessus_ATCC_1997 LSKNQFAYVNTLLDSAGSSRNYEVRLAGWEEFEGTVDRIVSIGAFEHFGH
** ** :*: . . *. * * ***:*. **************
Mb3424c|M.bovis_AF2122/97 ERYDAFFSLAHRLLPADGVMLLHTITGLHPKEIHERGLPMSFTFARFLKF
Rv3392c|M.tuberculosis_H37Rv ERYDAFFSLAHRLLPADGVMLLHTITGLHPKEIHERGLPMSFTFARFLKF
MMAR_0979|M.marinum_M DRYDDFFTLAHNILPSDGVMLLHTITGLTFQQATDRGMPLTFEIARFIKF
MUL_3772|M.ulcerans_Agy99 DRYDDFFTLAHNILPSDGVMLLHTITGLTMPQMVENGLPLTLWLARFLKF
TH_4640|M.thermoresistible__bu DRYDDFFATAHRLLPDDGVMLLHTITALTVPQMVDRGIPLTFEVARFVKF
Mflv_3304|M.gilvum_PYR-GCK DRYDEFFRRAYSVLPDDGVMLLHTIVKPSDEEFAERKLPLTMTKLKFFKF
Mvan_3025|M.vanbaalenii_PYR-1 DRYDEFFKKAYQVLPDGGVMMLHTIIKPTDEEFADRGLKLTMSIVRFSKF
MAV_0130|M.avium_104 DRYDDFFKMAYAALPDDGVMMLHTIIKPSDEEFAERGLPITMTKLRFMKF
MLBr_02459|M.leprae_Br4923 QRYARFFKMAHEVLPADSVMLLHTIVRPTFKDARARGMTLTHEIVHFTQF
MSMEG_1351|M.smegmatis_MC2_155 ERYDDFFRFAHRVLPDDGVMLLHTITGIHPKHAQELGVPLTFEMARFIRF
MAB_3881|M.abscessus_ATCC_1997 ERYDSFFAMAHRVLPSDGKMLLHTIVSHHPDEWKRMGIPLLMSRVRFIYF
:** ** *: ** .. *:**** . : : :* *
Mb3424c|M.bovis_AF2122/97 IVTEIFPGGRLPSIPMVQECASANGFTVTRVQSLQPHYAKTLDLWSAALQ
Rv3392c|M.tuberculosis_H37Rv IVTEIFPGGRLPSIPMVQECASANGFTVTRVQSLQPHYAKTLDLWSAALQ
MMAR_0979|M.marinum_M IVTEIFPGGRLPSIEKVADHSSKAGFTLTRRQSLQPHYARTLDLWAQALQ
MUL_3772|M.ulcerans_Agy99 IQTEIFPGGHPPTIEMVEEQSVKPGFTLTRRHSLQLHYAKTLDLWAEALE
TH_4640|M.thermoresistible__bu ILTEIFPGGRLPSIEKVEDHSGANGFTLTRRQSLQSHYARTLDLWAEALQ
Mflv_3304|M.gilvum_PYR-GCK IMDEIFPGGMLPKVDDVEKHATKASFKVNRIQPLRLHYARTLQIWAASLE
Mvan_3025|M.vanbaalenii_PYR-1 IMDEIFPGGDLPKPTTVAEHATKAGFRLTREQRLREHYAKTLDIWADALR
MAV_0130|M.avium_104 IMDEIFPGGDLPQAKGVIEHAQRAGFGVQRVQALRPHYARTLDTWAAALR
MLBr_02459|M.leprae_Br4923 ILAEIFPGGWLPTVPTVEEHATAAGFKFTRIQSLQLHYAKTLDLWAARLE
MSMEG_1351|M.smegmatis_MC2_155 IVTEIFPGGRLPTVDMVIDHATRASFTLERRQSLQLHYARTLDMWAAALE
MAB_3881|M.abscessus_ATCC_1997 IGTEIFPGGRLPSVPMVDKHAALAGFHITRHHSLQPHYARTLDCWATNLA
* ****** * * . : .* . * : *: ***:**: *: *
Mb3424c|M.bovis_AF2122/97 ANKGQAIALQSEEVYERYMKYLTGCAEMFRIGYIDVNQFTCQK-------
Rv3392c|M.tuberculosis_H37Rv ANKGQAIALQSEEVYERYMKYLTGCAEMFRIGYIDVNQFTCQK-------
MMAR_0979|M.marinum_M ARRDEAIEVQSEEVYERYMKYLTGCADGFRVGYIDVNQFTLEKS------
MUL_3772|M.ulcerans_Agy99 VRKDEAIKIQSDEVYERYMRYLTGCSKLFQEGYVDVNQFTLQKAR-----
TH_4640|M.thermoresistible__bu QHREEAITVQSDEVYDRYIKYLTGCAKGFRVGYIDVNQFTLQK-------
Mflv_3304|M.gilvum_PYR-GCK SRRDDAIAIQSEEVYDRYMKYLTGCAELFTEGYTDVCQFTLAK-------
Mvan_3025|M.vanbaalenii_PYR-1 KREDDAVAIQSREDYDRYMKYLTGCADLFRDGYTDICQFTLEK-------
MAV_0130|M.avium_104 ARRDEAIAIQSEEVYDRYMKYLTGCADLFREGYTDVAQFTLTKG------
MLBr_02459|M.leprae_Br4923 ANKNKAIAIQSEEVYDRYMKYLTGCAKLFRDGYTDVDQFTLEKQPATARR
MSMEG_1351|M.smegmatis_MC2_155 SHHDDAVRIQSQEVYDRYMHYLTGCANAFRVGYIDVNQFTLAK-------
MAB_3881|M.abscessus_ATCC_1997 AHEDEAISVQSQEVYDRYIKYLTGCAEGFREGWIDVVQFTCEK-------
.. .*: :** * *:**::*****:. * *: *: *** *
Mb3424c|M.bovis_AF2122/97 -
Rv3392c|M.tuberculosis_H37Rv -
MMAR_0979|M.marinum_M -
MUL_3772|M.ulcerans_Agy99 -
TH_4640|M.thermoresistible__bu -
Mflv_3304|M.gilvum_PYR-GCK -
Mvan_3025|M.vanbaalenii_PYR-1 -
MAV_0130|M.avium_104 -
MLBr_02459|M.leprae_Br4923 H
MSMEG_1351|M.smegmatis_MC2_155 -
MAB_3881|M.abscessus_ATCC_1997 -