For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MRVGIPTETKNNEFRVAITPAGVAELTRRGHEVLIQAGAGEGSAITDADFKAAGAQLVGTADQVWADADL LLKVKEPIAAEYGRLRHGRSCSRSCIWPRHVLAPMRCWIPAPRQLPTRPSRPPTAHYPCLPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2802 | alda | - | 100% (132) | L-alanine dehydrogenase |
| M. bovis AF2122 / 97 | Mb0160 | pntAa | 2e-13 | 43.82% (89) | NAD(P) transhydrogenase subunit alpha |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4017 | - | 6e-36 | 75.56% (90) | alanine dehydrogenase |
| M. tuberculosis H37Rv | Rv2780 | ald | 5e-46 | 88.35% (103) | secreted L-alanine dehydrogenase ALD (40 kDa antigen) (TB43) |
| M. leprae Br4923 | MLBr_01532 | ald | 5e-38 | 80.90% (89) | L-alanine dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3100 | - | 2e-35 | 74.44% (90) | L-alanine dehydrogenase (ALD) |
| M. marinum M | MMAR_1928 | ald | 9e-41 | 86.67% (90) | secreted L-alanine dehydrogenase Ald (40 kDa antigen) |
| M. avium 104 | MAV_3674 | ald | 2e-36 | 69.90% (103) | alanine dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2659 | ald | 5e-37 | 78.89% (90) | alanine dehydrogenase |
| M. thermoresistible (build 8) | TH_3398 | - | 6e-09 | 41.33% (75) | PUTATIVE NAD(P) transhydrogenase (subunit alpha) PntAa |
| M. ulcerans Agy99 | MUL_2154 | ald | 2e-40 | 85.56% (90) | secreted L-alanine dehydrogenase Ald (40 kDa antigen) |
| M. vanbaalenii PYR-1 | Mvan_2355 | - | 7e-37 | 71.84% (103) | alanine dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01532|M.leprae_Br4923 MRVGIPTETKNNEFRVAITPAGVAALTHRGHEVLVQAGAGEGSAIADAEF
MAV_3674|M.avium_104 MRVGVPTETKTNEFRVALTPAGVAELTRRGHEVLVQSGAGEGSSIPDSEF
Mflv_4017|M.gilvum_PYR-GCK MRVGIPTEIKNNEFRVAITPSGVAELVQRGHEVLIQSGAGDGSSISDADF
Mvan_2355|M.vanbaalenii_PYR-1 MRVGIPTEIKNNEYRVAVTPAGVAELVRRGHEVLIQSGAGDGSAISDADF
MSMEG_2659|M.smegmatis_MC2_155 MLVGIPTEIKNNEYRVAITPAGVAELTRRGHEVIIQAGAGEGSAISDRDF
MAB_3100|M.abscessus_ATCC_1997 MRVGIPTEIKNNEYRVATTPAGVAELTRRGHEVIIQSGAGDGSSISDVDF
MMAR_1928|M.marinum_M MRVGIPTETKDNEFRVAITPAGVAALTKRGHEVLIQAGAGEGSAISDSDF
MUL_2154|M.ulcerans_Agy99 MRVGIPTETKDNEFRVAITPAGVAALTKRGHEVLIQVGAGEGSAISDSDF
Rv2780|M.tuberculosis_H37Rv MRVGIPTETKNNEFRVAITPAGVAELTRRGHEVLIQAGAGEGSAITDADF
Mb2802|M.bovis_AF2122/97 MRVGIPTETKNNEFRVAITPAGVAELTRRGHEVLIQAGAGEGSAITDADF
TH_3398|M.thermoresistible__bu ---------------VALVPKAVATLVKSGLSVVVESGAGERALLPDALY
** .* .** *.: * .*::: ***: : :.* :
MLBr_01532|M.leprae_Br4923 KAAGAQLISTPEQVWTEVDLLLKVKEPMPAEYVHLRHGQILFTYLHLAAS
MAV_3674|M.avium_104 KAAGAQLADTAEQVWADAELLLKVKEPVPAEYDLLRRNQILFTFLHLAAS
Mflv_4017|M.gilvum_PYR-GCK KRAGAQLITGADEVWSEADLLLKVKEPIEAEYSKMREGQTLFTYLHLAAS
Mvan_2355|M.vanbaalenii_PYR-1 KRAGGQLVTGADEVWAEAELLLKVKEPIEAEYSRMREGQTLFTYLHLAAS
MSMEG_2659|M.smegmatis_MC2_155 KAAGAEIVNTADQVWSEAELLLKVKEPIEPEYSRMRKGQTLFTYLHLAAS
MAB_3100|M.abscessus_ATCC_1997 KAAGAQVINGAEQVWAEADLLLKVKEPIEPEYALMRRGQTLFTYLHLAAS
MMAR_1928|M.marinum_M KAAGAQLISTADQVWADADLLLKVKEPIESEYGRLRRGQTLFTYLHLAAS
MUL_2154|M.ulcerans_Agy99 KAAGAQLISTADQVWADADLLLKVKEPIESEYGRLRRGQTLFTYLHLAAS
Rv2780|M.tuberculosis_H37Rv KAAGAQLVGTADQVWADADLLLKVKEPIAAEYGRLRHGQILFTFLHLAAS
Mb2802|M.bovis_AF2122/97 KAAGAQLVGTADQVWADADLLLKVKEPIAAEYGRLRHG------------
TH_3398|M.thermoresistible__bu TEAGATIG----DAWA-ADVVVKVAPPTAEEVKRLRSGQTLIGFLAPRNA
. **. : :.*: .::::** * * :* .
MLBr_01532|M.leprae_Br4923 RPCTDALLASGTTSIAYETVQ--TADGALPLLAPMSEVAGRLSAQVGAYH
MAV_3674|M.avium_104 RACTEALLSSGTTSIAYETVQ--TADGTLPLLAPMSEVAGRLSAQVGAYH
Mflv_4017|M.gilvum_PYR-GCK KPCTDALMASGTTSIAYETVQ--LTDGSLPLLAPMSEVAGRLSAQVGSYH
Mvan_2355|M.vanbaalenii_PYR-1 RSCTDALMASRTTSIAYETVQ--TADGALPLLAPMSEVAGRLSAQVGAYH
MSMEG_2659|M.smegmatis_MC2_155 KPCTDALLASGTTSIAYETVQ--TAEGALPLLAPMSEVAGRLSAQVGAYH
MAB_3100|M.abscessus_ATCC_1997 LPCTQALLKSETTSIAYETVQ--TSDGALPLLAPMSEVAGRLAAQVGAYH
MMAR_1928|M.marinum_M RPCTDALLKSGTTSIAYETVQ--TADGALPLLAPMSEVAGRLSAQAGAYH
MUL_2154|M.ulcerans_Agy99 RPCTDALLKSGTTSIAYETVQ--TADGALPLLAPMSEVAGRLSAQAGAYH
Rv2780|M.tuberculosis_H37Rv RACTDALLDSGTTSIAYETVQ--TADGALPLLAPMSEVAGRLAAQVGAYH
Mb2802|M.bovis_AF2122/97 RSCSRSCIWPR------------------HVLAPMR--------------
TH_3398|M.thermoresistible__bu DNQIEALKSAGVQAFALEAIPRISRAQVMDALSSQANVAGYKAVLLGAME
: . *:.
MLBr_01532|M.leprae_Br4923 LMRTHRGCGVLMGGVPGVEPADVVVIGGGTAGYNAARIANGMGATVTVFD
MAV_3674|M.avium_104 LMRTHGGRGVLMGGVPGVKPADVVVVGAGTAGYNAARVAGGMGAMVTVLD
Mflv_4017|M.gilvum_PYR-GCK LMRSHGGRGVLMGGVPGVAPAEVVVIGGGVAGYNAARIAKGMGAHVNVFD
Mvan_2355|M.vanbaalenii_PYR-1 LMRTQGGRGVLMGGVPGVAPAKVVVIGGGMAGDNAAAVAWGMGAHVTVFD
MSMEG_2659|M.smegmatis_MC2_155 LMRSYGGRGVLMGGVPGVAPAEVVVIGAGTAGYNAARVAAGMGAHVTVFD
MAB_3100|M.abscessus_ATCC_1997 LMTPVGGRGLVMGGVPGVGPADVVVIGGGVAGYNAARIAAGMGAHVTVFD
MMAR_1928|M.marinum_M LMRTHGGRGVLMGGVPGVKPADVVVIGAGTAGYNAARVANGMGAMVTVLD
MUL_2154|M.ulcerans_Agy99 LMRTHGGRGVLMGGVPGVKPADVVVIGAGTAGYNAARVANGMGAMVTVLD
Rv2780|M.tuberculosis_H37Rv LMRTQGGRGVLMGGVPGVEPADVVVIGAGTAGYNAARIANGMGATVTVLD
Mb2802|M.bovis_AF2122/97 --------------------------------------------------
TH_3398|M.thermoresistible__bu LTRFFP---MLTTAAGTVKPASVLVLGVGVAGLQALATAKRLGARTTGYD
MLBr_01532|M.leprae_Br4923 VNINRLRELDAEFGGRLRT------------------RYSSAYDLEGAVK
MAV_3674|M.avium_104 VNINKLRLLDAEFDGQVRT------------------RYSSAYDLEGTVK
Mflv_4017|M.gilvum_PYR-GCK VNINTLRKIDNENNGAIET------------------RYSSSLDLEDAVK
Mvan_2355|M.vanbaalenii_PYR-1 LNVNTLRKIDAEYGGAIET------------------RYSSRLDLEDAVK
MSMEG_2659|M.smegmatis_MC2_155 LNINTLRRVDGEFGGRIET------------------RYSSSLELEEAVK
MAB_3100|M.abscessus_ATCC_1997 VNLGKLRELDGEFGGTIRT------------------RYSSTMELEGAVK
MMAR_1928|M.marinum_M VNINKLRQIDAEFGGRVRT------------------RYSSTLDLEDAAV
MUL_2154|M.ulcerans_Agy99 VNINKLRQIDAEFGGRVRT------------------RYSSTLDLEDAAV
Rv2780|M.tuberculosis_H37Rv INIDKLRQLDAEFCGRIHT------------------RYSSAYELEGAVK
Mb2802|M.bovis_AF2122/97 --------------------------------------------------
TH_3398|M.thermoresistible__bu VRPEVADQVRSVGAQWLDLGIEAAGEGGYARELTEEERAQQQRALEEAIK
MLBr_01532|M.leprae_Br4923 HADLVIGAVLVPGAKAPRLISNSLVAHMKPGAVLVDIAIDQGGCFEDSQP
MAV_3674|M.avium_104 RADLVIGAVLLPGAKAPNLISNSLVAQMKSGAVLVDISIDQGGCFEDSRP
Mflv_4017|M.gilvum_PYR-GCK HADLVIGAVLVPGARAPKLVSNSTVAAMKPGAVLVDIAIDQGGCFEDSRP
Mvan_2355|M.vanbaalenii_PYR-1 QADLVIGAVLVPGHKAPKLVTNSTVAAMKPGAVLVDIAIDQGGCFEDSRP
MSMEG_2659|M.smegmatis_MC2_155 KADLVIGAVLVPGAKAPKLVTNSTVAHMKPGAVLVDIAIDQGGCFEDSRP
MAB_3100|M.abscessus_ATCC_1997 RADLVIGAVLIPGAKAPKLISNSLVSQMKPGSVLVDIAIDQGGCFADSRP
MMAR_1928|M.marinum_M NADLLIGAVLVPGAKAPKLIPNSLVARMKKGAVLVDISIDQGGCFEDSRP
MUL_2154|M.ulcerans_Agy99 NADLLIGAVLVPGAKAPKLIPNSLVARMKKGAVLVDISIDQGGCFEDSRP
Rv2780|M.tuberculosis_H37Rv RADLVIGAVLVPGAKAPKLVSNSLVAHMKPGAVLVDIAIDQGGCFEGSRP
Mb2802|M.bovis_AF2122/97 --------CWIP---APRQLP------TRP-----------------SRP
TH_3398|M.thermoresistible__bu GFDVVITTALVPGRPAPRLVTADAVRGMKPGSVVVDLAGETGGNCELTEP
:* **. :. : :.*
MLBr_01532|M.leprae_Br4923 TTHDQPTFAVHDTLFYCVANMPSAVPKTSTFALTNATMPYILKLADQGWQ
MAV_3674|M.avium_104 TTHDDPTFAVHDTVFYCVANMPSAVPKTSTVALTNATMPYVLALADRGWR
Mflv_4017|M.gilvum_PYR-GCK TTHDDPTFAVHDTVFYCVANMPGAVPRTSTYALTNATLPYVLKLAGRGWR
Mvan_2355|M.vanbaalenii_PYR-1 TTHDDPTFTVHDTVFYCVANMPGAVPRTSTWALTNATMPYVLKIADKGWR
MSMEG_2659|M.smegmatis_MC2_155 TTHDEPTFKVHDTIFYCVANMPGAVPRTSTFALTNSTMPYVLKLADKGWQ
MAB_3100|M.abscessus_ATCC_1997 TTHDEPTYTVHDSVFYCVANMPGAVPRTSTFALTNATMPYVLALADKGWR
MMAR_1928|M.marinum_M TTHTSPTFTVHDTVFYCVANMPGAAPRTSTYALTNATMPYVLKLADLGWQ
MUL_2154|M.ulcerans_Agy99 TTHTSPTFTVHDTVFYCVANMPGAAPRTSTYALTNATMPYVLKLADLGWQ
Rv2780|M.tuberculosis_H37Rv TTYDHPTFAVHDTLFYCVANMPASVPKTSTYALTNATMPYVLELADHGWR
Mb2802|M.bovis_AF2122/97 PTAHYP-----------------CLPR-----------------------
TH_3398|M.thermoresistible__bu G----QTVVKHGVTIASPLNLPATMPEHASELYSKNITALLDLLITDGAL
*.
MLBr_01532|M.leprae_Br4923 EACQSDPALAKGLSTHNGALLSEQVATDLGLAFTEPASVLA--
MAV_3674|M.avium_104 AACRSDHALAKGLSTHDGTLLSQQVAADLGLPCTDPAGVLQQD
Mflv_4017|M.gilvum_PYR-GCK DACRADPALAKGLSTHEGALLSEQVAADLDVPYTDPAELLA--
Mvan_2355|M.vanbaalenii_PYR-1 DACRADAALANGLSTHEGALLSDEVAADLDLPYTDPADVLA--
MSMEG_2659|M.smegmatis_MC2_155 AACASDSALAKGLSTHDGKLLSEAVAKDLDLPFTDAAQFLA--
MAB_3100|M.abscessus_ATCC_1997 QACRDDAALAQGLSTHEGALLNTHVAHDLGLAFTDPAEVLG--
MMAR_1928|M.marinum_M AACLSDSALAKGLSTHEGALLADHVAADLDLPFTDPANVLG--
MUL_2154|M.ulcerans_Agy99 AACLSDSALAKGLSTHEGALLADHVAADLDLPFTDPASVLG--
Rv2780|M.tuberculosis_H37Rv AACRSNPALAKGLSTHEGALLSERVATDLGVPFTEPASVLA--
Mb2802|M.bovis_AF2122/97 -------------------------------------------
TH_3398|M.thermoresistible__bu APDFTDEVVAEACVTRGKDA-----------------------