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NIAAWVLCAGAVVGAPPVQAAPGAVLPPIPSTGGGPIIGGGDEAAQSRIARQLMSVGNADVQEGDGADAA SFIMDSAQVADSRLASAFAPLQRALGCQKVNTSFGARAYRRSDGGGGGGGGGGGGGMLVIAKSATSDMQA LTGCIRSVWPAATAGGSNAMCAHGWTYPTSGQDHRPETYHILLAGTAADFCAKLDEDYANFATNWP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4889 | - | - | 100% (207) | hypothetical protein MUL_4889 |
| M. ulcerans Agy99 | MUL_4581 | - | 9e-05 | 26.97% (152) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0404c | - | 5e-50 | 48.83% (213) | hypothetical protein Mb0404c |
| M. gilvum PYR-GCK | Mflv_3843 | - | 6e-05 | 28.77% (146) | hypothetical protein Mflv_3843 |
| M. tuberculosis H37Rv | Rv0398c | - | 5e-50 | 48.83% (213) | hypothetical protein Rv0398c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0225 | - | 1e-109 | 93.24% (207) | hypothetical protein MMAR_0225 |
| M. avium 104 | MAV_4770 | - | 1e-47 | 51.94% (206) | hypothetical protein MAV_4770 |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK MSRTKKSIVVVMMGSAGLFLSAPLLGPAANATPTRGGVPCVGILQQIVTR
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK PGEIPQALTDTARSFTEPPKPAPPVVRPPASSSSSAGTPPVPGRPPASVV
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK TPSSGATPPVPPSPGTPASTSTRGGTPPVPPAPPAPAGTPASGATPPAPP
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK VPGVPAVTSTGGGTPPVPPVPGAPVGAPVANPGLPTPPVPGAPVFGDGGA
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK VLPPLPPAPAGPAGGPAGLVAPPAPPVPGGPAAVPAGVALPPAPPGAPGA
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK PVFGEAGAAPSGAAAPVAPAAGSGGAGGAGGGSGIGGPGGGGAPVEGTGG
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK AVPAGAPLAAAGGEVPPPAPPIPGAPVIGEAGVVPPPAPPAPAPPAGGLG
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK GAVPPPVPGAPGVPVVDEAGVVTPPAPGGPGVPTGGEGGVVTPPAPGAPG
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK VPVVDEAGVVTPPAPGGPGVPTGGEGGVVTPPAPGAPGAPVVDEAGVVTP
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK PAPGGPGVPAVGDTAVVTPPAPGAPGTPAVNSVETFSPPAPPAATPPSSG
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK SVETFSPPAPPAPGTGTNSTVEISTPPPPGTPGLPSEGSTTYTTPPTPEI
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK TLNPANSGIDIATPPAPGLPGAPLEATANITTPGTPGVPGAPVNSSIDVA
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK TPGEVGVPAAPIERSMTVTTPDTPGAPGAPANAAVDVATPPAPGVPGAPV
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK VGEAGVTTPGAPGAPGAPANAAVDVATPPAPGVPGAPVVGEAAVTTPGAP
MUL_4889|M.ulcerans_Agy99 ----------------------------------------MNIAAWVLCA
MMAR_0225|M.marinum_M ----------------------------------MAFRIGMNIAAWVLCA
Mb0404c|M.bovis_AF2122/97 ---------------------------------MGVIARVVGVAACGLSL
Rv0398c|M.tuberculosis_H37Rv ---------------------------------MGVIARVVGVAACGLSL
MAV_4770|M.avium_104 ---------------------------------MSATARRIG-ALTALAT
Mflv_3843|M.gilvum_PYR-GCK GVPGVPAGGDAGVVTPPAPGVPGAPVVGEAGVTTPGAPGVPGVPAGGDAG
. . .
MUL_4889|M.ulcerans_Agy99 GAVVGAPPVQAAPGA-----VLPPIPSTGGGPIIGGGDEAAQSRIARQLM
MMAR_0225|M.marinum_M GAVVGAPPVQAAPGA-----VLPPIPSTGGGPIIGGGDEAAQSRIARQLT
Mb0404c|M.bovis_AF2122/97 AVLAAAPTAGAEPTG-----ALPPMTSSGSGPVIGDGDAALRQRISQQLF
Rv0398c|M.tuberculosis_H37Rv AVLAAAPTAGAEPTG-----ALPPMTSSGSGPVIGDGDAALRQRISQQLF
MAV_4770|M.avium_104 LYAGTAP-AAADPPP-----GLPPMTSGGSGPIIGGGSAAA-QGISQQLF
Mflv_3843|M.gilvum_PYR-GCK VVTPPAPGVPGAPAATEAGLATPPGPGAPGAPVVGDAGVATPPGPGVPGA
** . . * ** .. ..*::*... * .
MUL_4889|M.ulcerans_Agy99 SVGNA--------DVQEGDGA----------------DAASFIMDSAQVA
MMAR_0225|M.marinum_M SVGNA--------DVQEGDGA----------------DAASFIMDSARVA
Mb0404c|M.bovis_AF2122/97 SFGDP--------TVQEVDGS----------------DAAQFITAAAAVA
Rv0398c|M.tuberculosis_H37Rv SFGDP--------TVQEVDGS----------------DAAQFITAAAAVA
MAV_4770|M.avium_104 SFGNPG-------VVQEIDGS----------------DAAQFITAAAGAA
Mflv_3843|M.gilvum_PYR-GCK PIVDEAGLATPPAPVAPVEGAGGAVPPAGPPPAPVFGDAGAPVEAAAGGA
.. : * :*: **. : :* *
MUL_4889|M.ulcerans_Agy99 DSRLASAFAPLQRALGCQKVNTS----FGARAYRRS--------------
MMAR_0225|M.marinum_M DSRLASAFVPLQRALGCQKVNTS----FGARAYRRS--------------
Mb0404c|M.bovis_AF2122/97 DRDVASVFLPLQRVLGCQQNTAGSGAGFGARAYRRT--------------
Rv0398c|M.tuberculosis_H37Rv DRDVASVFLPLQRVLGCQQNTAGSGAGFGARAYRRT--------------
MAV_4770|M.avium_104 NQQLAAPFSLLRRALTCQDNNAG----FGARAYRRN--------------
Mflv_3843|M.gilvum_PYR-GCK PVEAAAGVTGGGSVAGAGAGGGAGGAAGGAGVEGASGAVGAAGGPGAGAA
*: . . . . ** . .
MUL_4889|M.ulcerans_Agy99 -------------------DGGGGGGGGGGGGGMLVIAKSATSDM-----
MMAR_0225|M.marinum_M -------------------DGGWGG-------AMLVIAESATSDM-----
Mb0404c|M.bovis_AF2122/97 -------------------DGQWGG-------AMLVVAKSTVSDV-----
Rv0398c|M.tuberculosis_H37Rv -------------------DGQWGG-------AMLVVAKSTVSDV-----
MAV_4770|M.avium_104 -------------------DGQWGG-------AMLVAAKSATPSP-----
Mflv_3843|M.gilvum_PYR-GCK PAAAGGAAPGGAPGGPVAGGGPVGGPGALPAPGAPIVGEAGVVSPPAPGV
.* ** . : .:: . .
MUL_4889|M.ulcerans_Agy99 ------------------------------------------QALTGCIR
MMAR_0225|M.marinum_M ------------------------------------------QALTGCIR
Mb0404c|M.bovis_AF2122/97 ------------------------------------------DALKACVK
Rv0398c|M.tuberculosis_H37Rv ------------------------------------------DALKACVK
MAV_4770|M.avium_104 ------------------------------------------DNLAACAK
Mflv_3843|M.gilvum_PYR-GCK PGGAAAVPAGAVTPPAPGVPGAPVFGEAGVVTPPAPGVPGGAAAVPAGVV
: .
MUL_4889|M.ulcerans_Agy99 SVWPAATAGGSNAMCAHGWTYPTSGQDHRPE-----TYHILLAGTAADFC
MMAR_0225|M.marinum_M SVWPAATAGGSNAMCAHGWTYPTSGQDHRPE-----TYHILLAGTAADFC
Mb0404c|M.bovis_AF2122/97 SGWRKATAGTPTSMCNNGWTYPPFADTRRGEE----GYFVLLAGTASDFC
Rv0398c|M.tuberculosis_H37Rv SGWRKATAGTPTSMCNNGWTYPPFADTRRGEE----GYFVLLAGTASDFC
MAV_4770|M.avium_104 TNWRRATAGGETAMCNSGCTTPTSYESRRGE-----TYYILLAGTAADFC
Mflv_3843|M.gilvum_PYR-GCK TPPAPGVPGGAAAVPAGAVTPPAPGVPGAPVFGDAGVATPPVPGVPGGGT
: ...* :: . * *. :.*....
MUL_4889|M.ulcerans_Agy99 AKLDEDYANFATNWP-----------------------------------
MMAR_0225|M.marinum_M AKFDEDYANFATNWP-----------------------------------
Mb0404c|M.bovis_AF2122/97 SAPNANYRTTASSWPG----------------------------------
Rv0398c|M.tuberculosis_H37Rv SAPNANYRTTASSWPG----------------------------------
MAV_4770|M.avium_104 SDLNAKYKSDATGWPF----------------------------------
Mflv_3843|M.gilvum_PYR-GCK TVPAASVTPPAPGVPGGASTVPGNAGTPSTPGLPPGSTDTYINYPAPPVP
: . *.. *
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK PTPPNSTGVSAGTPGSPAPGTPGSTLTLTDLLTPPGIARTLQNTASSVMG
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK ATPPGTPPVPGGSGSVSLAVPGTPSPIAPLAATGLSNLVSPPSLTIPSIP
MUL_4889|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0225|M.marinum_M --------------------------------------------------
Mb0404c|M.bovis_AF2122/97 --------------------------------------------------
Rv0398c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4770|M.avium_104 --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK GLPVPLPNTVPVPSDLLCVGTDWSASQGDSAATPPAAEVPRVVTGAAPTG
MUL_4889|M.ulcerans_Agy99 ---------
MMAR_0225|M.marinum_M ---------
Mb0404c|M.bovis_AF2122/97 ---------
Rv0398c|M.tuberculosis_H37Rv ---------
MAV_4770|M.avium_104 ---------
Mflv_3843|M.gilvum_PYR-GCK DRRDRWGNR