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MIGGLVAMTLDRSVLRQLASGRRTVVITGTNGKSTTTRMTAAALSTLGAVATNAEGANMDAGLVAALAAD RRAGLAALEVDEMHVPHVSDAVEPAVLVLLNLSRDQLDRVGEINVIERTLRAGLARHPNAVVVANCDDVL MTSAAYDSPNVVWVAAGGSWSNDSVSCPRSGEVIVREPGHWYSAGADFKRPRPQWWFDDEAVYGPDGLAL PMRLALPGAVNRGNATQAVAAAVALGADPALAVAAVAEVDEVAGRYRSFALGRHQARILLAKNPAGWQEA LSMVDERAAGVVISVNGQVPDGEDLSWLWDVRFEHFAEAFKTTPVVAAGERGTDLAVRLGYAGVQHTLVH DTVAAIESCPPGPVEVVANYTAFLQLQRRLTRNG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4304 | - | - | 100% (384) | UDP-N-acetylmuramyl tripeptide synthase |
| M. ulcerans Agy99 | MUL_3505 | murF | 5e-10 | 26.94% (271) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- |
| M. ulcerans Agy99 | MUL_3503 | murD | 1e-06 | 26.61% (248) | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3739 | - | 0.0 | 85.57% (388) | ligase |
| M. gilvum PYR-GCK | Mflv_1291 | - | 1e-178 | 82.37% (380) | hypothetical protein Mflv_1291 |
| M. tuberculosis H37Rv | Rv3712 | - | 0.0 | 85.57% (388) | ligase |
| M. leprae Br4923 | MLBr_02326 | - | 1e-180 | 81.61% (386) | putative ligase |
| M. abscessus ATCC 19977 | MAB_0324c | - | 1e-164 | 74.16% (387) | putative Mur ligase family protein |
| M. marinum M | MMAR_5229 | - | 0.0 | 99.22% (384) | UDP-N-acetylmuramyl tripeptide synthase |
| M. avium 104 | MAV_0390 | - | 0.0 | 86.56% (387) | mur ligase family protein |
| M. smegmatis MC2 155 | MSMEG_6276 | - | 1e-177 | 80.89% (382) | mur ligase family protein |
| M. thermoresistible (build 8) | TH_2285 | - | 1e-180 | 81.36% (381) | POSSIBLE LIGASE |
| M. vanbaalenii PYR-1 | Mvan_5520 | - | 0.0 | 83.77% (382) | hypothetical protein Mvan_5520 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1291|M.gilvum_PYR-GCK -----------------MVTGRGRLALAAGAGARWASRVTGRGAGAMIGG
Mvan_5520|M.vanbaalenii_PYR-1 MPCSITPRVGPSSKLPGMVTPRGRIALAAGAGARWASRVTGRGAGAMIGG
MUL_4304|M.ulcerans_Agy99 ----------------------------------------------MIGG
MMAR_5229|M.marinum_M ----------------------------------------------MIGG
MAV_0390|M.avium_104 -----------------MLTTRARLALAAGASARWASRVTGRGAGAMIGG
Mb3739|M.bovis_AF2122/97 -----------------MVTTRARLALAAGAGARWASRVTGRGAGAMIGG
Rv3712|M.tuberculosis_H37Rv -----------------MVTTRARLALAAGAGARWASRVTGRGAGAMIGG
MLBr_02326|M.leprae_Br4923 -----------------MFTVRARLALAAGASARWTSRITGRGAGTMIGG
MSMEG_6276|M.smegmatis_MC2_155 -----------------MLTVRGRAALAAGAAARWASRVTGRGAGAMIGG
TH_2285|M.thermoresistible__bu -----------------MVTLRGRLALAAGTAARWASRATGRGEGAMIGG
MAB_0324c|M.abscessus_ATCC_199 -------------MPIEHLSPRGRIALAAGSAARWASRISGRGAGSMIGG
****
Mflv_1291|M.gilvum_PYR-GCK LVAMTLDKSILGQLGHGRRSVVITGTNGKSTTTRMTAAALATLG--PVAT
Mvan_5520|M.vanbaalenii_PYR-1 LVAMTLDRSILGQLGRGRRTVVITGTNGKSTTTRMTAAALATVG--PVAT
MUL_4304|M.ulcerans_Agy99 LVAMTLDRSVLRQLASGRRTVVITGTNGKSTTTRMTAAALSTLG--AVAT
MMAR_5229|M.marinum_M LVAMTLDRSVLRQLASGRRTVVITGTNGKSTTTRMTAAALSTLG--AVAT
MAV_0390|M.avium_104 LVAMTLDRSVLRQLATGRRTVVVTGTNGKSTTTRMTAAALATMG--SVAT
Mb3739|M.bovis_AF2122/97 LVAMTLDRSILRQLGMGRRTVVVTGTNGKSTTTRMTAAALGTLG--AVAT
Rv3712|M.tuberculosis_H37Rv LVAMTLDRSILRQLGMGRRTVVVTGTNGKSTTTRMTAAALGTLG--AVAT
MLBr_02326|M.leprae_Br4923 LVAITLDRSILSQLGAGRRTIVVTGTNGKSTTTRMTVDALSTLAPGSVAT
MSMEG_6276|M.smegmatis_MC2_155 LVAMTLDRSVLRQLGQGRRTAIVTGTNGKSTTTRMIAAALAPLG--PVAS
TH_2285|M.thermoresistible__bu LIAMTLDRSILRQLGQGRRTALVTGTNGKSTTTRMLAAALGTVG--GVAT
MAB_0324c|M.abscessus_ATCC_199 LIALKLDGSVLAQLGRGRRTVLITGTNGKSTTTRMTAAALATVG--PVAT
*:*:.** *:* **. ***: ::************ . **..:. **:
Mflv_1291|M.gilvum_PYR-GCK NSEGANMDAGLVAALAAAPDATLAALEVDEMHVPHVSDAVDPSVVVLLNL
Mvan_5520|M.vanbaalenii_PYR-1 NAEGANMDAGLVAALAAAPGAPLAALEVDEMHVPHVSDAVSPAVIVLLNL
MUL_4304|M.ulcerans_Agy99 NAEGANMDAGLVAALAADRRAGLAALEVDEMHVPHVSDAVEPAVLVLLNL
MMAR_5229|M.marinum_M NAEGANMDAGLVAALAADRRAGLAALEVDEMHVPHVSDAVEPAVLVLLNL
MAV_0390|M.avium_104 NAEGANMDAGLVAALAANRGARLAALEVDEMHVPHVSDAVRPGVVVLLNL
Mb3739|M.bovis_AF2122/97 NAEGANMDAGLVAALAAHRDAELAVLEVDEMHVPHISDAVDPAVVVLLNL
Rv3712|M.tuberculosis_H37Rv NAEGANMDAGLVAALAAHRDAELAVLEVDEMHVPHISDAVDPAVVVLLNL
MLBr_02326|M.leprae_Br4923 NAEGANMDAGLVAALAANRAATLAVLEVDEMHVPRVADALTPHIVVLLNL
MSMEG_6276|M.smegmatis_MC2_155 NTEGANMDAGLVSALAANRDAGLAALEVDEMHVPHVSDAVSPSVIVLLNL
TH_2285|M.thermoresistible__bu NAEGANMDAGLVSALAVNRDAGLAALEVDEMHTPQVADALRPAVVVLLNL
MAB_0324c|M.abscessus_ATCC_199 NTEGSNMDAGLVAALAGTREADVAVLEVDEMHVPHVADAVNPAVIVLLNL
*:**:*******:*** * :*.*******.*:::**: * ::*****
Mflv_1291|M.gilvum_PYR-GCK SRDQLDRVGEINHIERTLRAGLARHPSAVVVANCDDVLMTSAAYDHPNVV
Mvan_5520|M.vanbaalenii_PYR-1 SRDQLDRVGEINHIERTLRAGLARHPSAVVVANCDDVLMTSAAYDSPDVV
MUL_4304|M.ulcerans_Agy99 SRDQLDRVGEINVIERTLRAGLARHPNAVVVANCDDVLMTSAAYDSPNVV
MMAR_5229|M.marinum_M SRDQLDRVGEINVIERTLRAGLARHPNAVVVANCDDVLMTSAAYDSPNVV
MAV_0390|M.avium_104 SRDQLDRVGEINVIERTLRAGLARHPDAVVVANCDDVLMTSAAYDSPHVV
Mb3739|M.bovis_AF2122/97 SRDQLDRVGEINVIERTLRAGLARHPDAVVVANCDDVLMTSAAYDSPNVV
Rv3712|M.tuberculosis_H37Rv SRDQLDRVGEINVIERTLRAGLARHPDAVVVANCDDVLMTSAAYDSPNVV
MLBr_02326|M.leprae_Br4923 SRDQLDRVGEINVIERTLRTGLARHPTAVVIANCDDVLMTSVAYDSPNVV
MSMEG_6276|M.smegmatis_MC2_155 SRDQLDRVGEINHIERTLRAGLARHPDAVIVANCDDVLMTSAAYDNPDVV
TH_2285|M.thermoresistible__bu SRDQLDRVGEINHIERTLRAGLARHPDAVVVANCDDVLMTSAAYDSPNVV
MAB_0324c|M.abscessus_ATCC_199 SRDQLDRVGEINNIERTLRKGLARHRDAVIVANCDDVLMASAAYDSPHVV
************ ****** ***** **::********:*.*** *.**
Mflv_1291|M.gilvum_PYR-GCK WVAAGGGWASDSVSCPRSGETIVRDG----AHWYSTGCEFKRPTPAWWFD
Mvan_5520|M.vanbaalenii_PYR-1 WVAAGGGWASDSVSCPRSGEIIVRDG----AHWYSTGCDFKRPTPDWWFD
MUL_4304|M.ulcerans_Agy99 WVAAGGSWSNDSVSCPRSGEVIVREP----GHWYSAGADFKRPRPQWWFD
MMAR_5229|M.marinum_M WVAAGGSWSNDSVSCPRSGEVIVREP----GHWYSTGADFKRPSPQWWFD
MAV_0390|M.avium_104 WVAAGGSWANDSVSCPRSGEVIVREQ----GHWYSTGADFKRPSPHWWFD
Mb3739|M.bovis_AF2122/97 WVAAGGAWSNDSVSCPRSSEVIVRKAPSQEDHWYSTGADFKRPAPHWWFD
Rv3712|M.tuberculosis_H37Rv WVAAGGAWSNDSVSCPRSGEVIVRKAPSQEDHWYSTGADFKRPAPHWWFD
MLBr_02326|M.leprae_Br4923 WVAAGGTWSNDSVSCPRSGEVIVRKN----RHWYSTGADFKRPSPHWWFD
MSMEG_6276|M.smegmatis_MC2_155 WVAAGGTWANDSVSCPRSGEVIVRDG----RDWYSTGTDFKRPSPQWWFD
TH_2285|M.thermoresistible__bu WVAAGAGWANDSVSCPRSGEVIVRDG----AHWYSTGTDFKRPTPQWWFD
MAB_0324c|M.abscessus_ATCC_199 WVAAGGGWAGDSVSCPRSGELIMRDG----NRWYSTGTDFARPDPDWWFD
*****. *:.********.* *:*. ***:* :* ** * ****
Mflv_1291|M.gilvum_PYR-GCK DTH---LHGPDGLTLPMTLNLPGTVNRGNATQAVAAAVTLGADPAAAVTA
Mvan_5520|M.vanbaalenii_PYR-1 DTH---IHGPDGLTLPMTLTLPGTVNRGNATQAVAAAVVLGADPAAAVAA
MUL_4304|M.ulcerans_Agy99 DEA---VYGPDGLALPMRLALPGAVNRGNATQAVAAAVALGADPALAVAA
MMAR_5229|M.marinum_M DEA---VYGPDGLALPMRLALPGAVNRGNATQAVAAAVALGADPALAVAA
MAV_0390|M.avium_104 PQDGGNLYGPGGVALPMRLALPGAVNRGNAAQAVAAAVALGADPAAAVTA
Mb3739|M.bovis_AF2122/97 DAT---LYGPDGLALPMRLALPGSVNRGNAAQAVAAAVALGADPAVAVAA
Rv3712|M.tuberculosis_H37Rv DAT---LYGPDGLALPMRLALPGSVNRGNAAQAVAAAVALGADPAVAVAA
MLBr_02326|M.leprae_Br4923 DNT---LYGPDELALPMRLALPGSVNRGNAAQAVATAVMLGADATTAVAA
MSMEG_6276|M.smegmatis_MC2_155 ETH---IHGPDGLSVPMELALPGTVNRGNATQAVAAAVALGADPVAAVAA
TH_2285|M.thermoresistible__bu DTS---IHGPDGLCLPMRLALPGVVNRGNATQAVAAAVAMGADPGAAVSA
MAB_0324c|M.abscessus_ATCC_199 DDR---IYGPSGISLPMSLTLPGTANRGNATLAVAAAVELGARPGPAVDA
::**. : :** * *** .*****: ***:** :** . ** *
Mflv_1291|M.gilvum_PYR-GCK VSAVDEVAGRYRTVRIG-SHTARLLLAKNPAGWQEALSMVDRDAAGVVIA
Mvan_5520|M.vanbaalenii_PYR-1 VSAVDEVAGRYRTVQIG-GHTARILLAKNPAGWQEALSMVDRDAAGVVIA
MUL_4304|M.ulcerans_Agy99 VAEVDEVAGRYRSFALG-RHQARILLAKNPAGWQEALSMVDERAAGVVIS
MMAR_5229|M.marinum_M VAAVDEVAGRYRSFALG-RHQARILLAKNPAGWQEALSMVDERAAGVVIS
MAV_0390|M.avium_104 VSTVDEVAGRYRTVRVG-RHDVRMLLAKNPAGWQEALSMVDPHADGVVIS
Mb3739|M.bovis_AF2122/97 VCQVDEVAGRYRTVRIG-AHQARILLAKNPAGWQEALAMVDKHADGVVIA
Rv3712|M.tuberculosis_H37Rv VCQVDEVAGRYRTVRIG-AHQARILLAKNPAGWQEALAMVDKHADGVVIA
MLBr_02326|M.leprae_Br4923 VSKVDEVAGRYRSVRIG-EHTTRILLAKNPAGWQEALSMVDTQAAGVVIS
MSMEG_6276|M.smegmatis_MC2_155 VSTVDEVAGRYRTVQVGPRHTARVLLAKNPAGWQEALSMVDRTGAGVVIA
TH_2285|M.thermoresistible__bu VSGVDEVAGRYRTVSLG-DHTVRVLLAKNPAGWQESLSMVDKTAAGVVIA
MAB_0324c|M.abscessus_ATCC_199 VSAVDQVAGRYRSINLG-DHTIRLLLAKNPAGWQEALSMVDTDADGLVIA
*. **:******:. :* * *:***********:*:*** . *:**:
Mflv_1291|M.gilvum_PYR-GCK VNGQVPDGEDLSWLWDVRFEHF-------EKAQVVAAGERGTDLAVRLGY
Mvan_5520|M.vanbaalenii_PYR-1 VNGQVPDGEDLSWLWDVRFEHF-------ESVPVVAAGERGTDLAVRLGY
MUL_4304|M.ulcerans_Agy99 VNGQVPDGEDLSWLWDVRFEHFAE---AFKTTPVVAAGERGTDLAVRLGY
MMAR_5229|M.marinum_M VNGQVPDGEDLSWLWDVRFEHFAE---AFKTTPVVAAGERGTDLAVRLGY
MAV_0390|M.avium_104 VNGRVPDGEDLSWLWDVRFEHFND---AFQTTPVVAAGERGTDLAVRLGY
Mb3739|M.bovis_AF2122/97 VNGRVPDGEDLSWLWDVRFEHF-------ETTRVVAAGERGTDLAVRLGY
Rv3712|M.tuberculosis_H37Rv VNGRVPDGEDLSWLWDVRFEHF-------EKTRVVAAGERGTDLAVRLGY
MLBr_02326|M.leprae_Br4923 INGQVPDGKDLSWLWDVRFEHF-------EKIPVVAAGERGTDLAVRLRY
MSMEG_6276|M.smegmatis_MC2_155 VNGQVPDGEDLSWLWDVRFEDF-------SGVQVVAAGERGTDLAVRLGY
TH_2285|M.thermoresistible__bu VNGQVPDGEDLSWLWDVRFEHF-------ERTSVVAAGERGTDLAVRLTY
MAB_0324c|M.abscessus_ATCC_199 VNGQVPDGEDLSWLWDVNFEHFACDNGESPVPPVVAAGERGTDLAVRLTY
:**:****:********.**.* *************** *
Mflv_1291|M.gilvum_PYR-GCK AGVEHTLVHDTVAAIASCPPGHVEVLANYTAFLQLNRRIP-----
Mvan_5520|M.vanbaalenii_PYR-1 AGVEHTLVHDTVAAIASCPPGHVEVLANYTAFLQLNRVLDRV---
MUL_4304|M.ulcerans_Agy99 AGVQHTLVHDTVAAIESCPPGPVEVVANYTAFLQLQRRLTRNG--
MMAR_5229|M.marinum_M AGVQHTLVHDTVAAIESCPPGPVEVVANYTAFLQLQRRLTRNG--
MAV_0390|M.avium_104 AGVEHTLVHDTVAAIESCPPGRVEVVANYTAFLALQRALARHG--
Mb3739|M.bovis_AF2122/97 AGVEHTLVHDTVAAIASCPPGRVEVVANYTAFLQLQRALARRG--
Rv3712|M.tuberculosis_H37Rv AGVEHTLVHDTVAAIASCPPGRVEVVANYTAFLQLQRALARRG--
MLBr_02326|M.leprae_Br4923 AGVEHTLVHDTVAAIASCPPGQVEVVANYTAFRQLQRRLARHG--
MSMEG_6276|M.smegmatis_MC2_155 ADVEHTLVHDTISAIKSCPPGHVEVIANYTAFLQLNRRLS-----
TH_2285|M.thermoresistible__bu ADVAHTLVHDTVAAIKSCPPGHVEVIANYTAFLHLNRRLS-----
MAB_0324c|M.abscessus_ATCC_199 ASVTHTLQHDPVQAIKACPPGRVDVIANYTAFLNLNRALAKGGAA
*.* *** **.: ** :**** *:*:****** *:* :