For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. ulcerans Agy99 MUL_3728 (clpX)

annotation: ATP-dependent protease ATP-binding subunit ClpX
coordinates: 4158310 - 4159590
length: 426

ARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELADADDVKLDELPKPVEIREFL
EGYVIGQDTAKRTLAVAVYNHYKRIQAGEKSHDSRCEAVELTKSNILMLGPTGCGKTYLAQTLAKMLNVP
FAIADATALTEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSITRDVSGEGVQQ
ALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVAGAFAGLEKIIYERVGKRGLGFGAEVRSKAEI
DTTDHFAEVMPEDLIKFGLIPEFIGRLPVVASVTNLDKESLVKILSEPKNALVKQYTRLFEMDGVELEFT
DDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTKETVQDNVLPTIVPRKPSRSER
RDKSA*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_3728clpX-100% (426)ATP-dependent protease ATP-binding subunit ClpX
M. ulcerans Agy99MUL_1716ruvB6e-0526.76% (142) Holliday junction DNA helicase RuvB

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2484cclpX0.098.59% (426) ATP-dependent protease ATP-binding subunit ClpX
M. gilvum PYR-GCKMflv_2591clpX0.096.24% (426) ATP-dependent protease ATP-binding subunit
M. tuberculosis H37RvRv2457cclpX0.098.59% (426) ATP-dependent protease ATP-binding subunit ClpX
M. leprae Br4923MLBr_01477clpX0.095.54% (426) ATP-dependent protease ATP-binding subunit ClpX
M. abscessus ATCC 19977MAB_1583clpX0.094.13% (426) ATP-dependent protease ATP-binding subunit ClpX
M. marinum MMMAR_3805clpX0.099.77% (426) ATP-dependent Clp protease ATP-binding subunit ClpX
M. avium 104MAV_1716clpX0.098.36% (426) ATP-dependent protease ATP-binding subunit
M. smegmatis MC2 155MSMEG_4671clpX0.096.95% (426) ATP-dependent protease ATP-binding subunit
M. thermoresistible (build 8)TH_0353clpX0.094.60% (426) PROBABLE ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX
M. vanbaalenii PYR-1Mvan_4036clpX0.095.77% (426) ATP-dependent protease ATP-binding subunit

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2591|M.gilvum_PYR-GCK          MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEEL
Mvan_4036|M.vanbaalenii_PYR-1       MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEEL
MUL_3728|M.ulcerans_Agy99           MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEEL
MMAR_3805|M.marinum_M               MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEEL
MLBr_01477|M.leprae_Br4923          MARIGDSGDLLKCSFCGKSQTQVKKLIAGPGVYICDECIDLCNEIIEEEL
MAV_1716|M.avium_104                MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEEL
Mb2484c|M.bovis_AF2122/97           MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEEL
Rv2457c|M.tuberculosis_H37Rv        MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEEL
MSMEG_4671|M.smegmatis_MC2_155      MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEEL
TH_0353|M.thermoresistible__bu      MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEEL
MAB_1583|M.abscessus_ATCC_1997      MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEEL
                                    ******.*************.*****************************

Mflv_2591|M.gilvum_PYR-GCK          ADADDVKLDELPKPAEIRDFLEGYVIGQDTAKRTLAVAVYNHYKRIQAGE
Mvan_4036|M.vanbaalenii_PYR-1       ADADDVKLDELPKPAEIREFLEGYVIGQDTAKRTLAVAVYNHYKRIQAGE
MUL_3728|M.ulcerans_Agy99           ADADDVKLDELPKPVEIREFLEGYVIGQDTAKRTLAVAVYNHYKRIQAGE
MMAR_3805|M.marinum_M               ADADDVKLDELPKPVEIREFLEGYVIGQDTAKRTLAVAVYNHYKRIQAGE
MLBr_01477|M.leprae_Br4923          ADADDVQLDELPKPVEIREFLEGYVIGQDTAKRTLAVAVYNHYKRIQAGE
MAV_1716|M.avium_104                ADADDVKLDELPKPIEIREFLEGYVIGQDTAKRTLAVAVYNHYKRIQAGE
Mb2484c|M.bovis_AF2122/97           ADADDVKLDELPKPAEIREFLEGYVIGQDTAKRTLAVAVYNHYKRIQAGE
Rv2457c|M.tuberculosis_H37Rv        ADADDVKLDELPKPAEIREFLEGYVIGQDTAKRTLAVAVYNHYKRIQAGE
MSMEG_4671|M.smegmatis_MC2_155      ADADDVKLDELPKPAEIREFLEGYVIGQDSAKRTLAVAVYNHYKRIQAGE
TH_0353|M.thermoresistible__bu      ADADEVKLDELPKPAEIHEFLESYVIGQESAKRTLAVAVYNHYKRIQAGE
MAB_1583|M.abscessus_ATCC_1997      ADADDVKLDELPKPAEIRDFLENYVIGQDTAKKTLAVAVYNHYKRIQAGD
                                    ****:*:******* **::***.*****::**:****************:

Mflv_2591|M.gilvum_PYR-GCK          KARDSRAEPVELAKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATAL
Mvan_4036|M.vanbaalenii_PYR-1       KARDSRSEPVELAKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATAL
MUL_3728|M.ulcerans_Agy99           KSHDSRCEAVELTKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATAL
MMAR_3805|M.marinum_M               KSRDSRCEAVELTKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATAL
MLBr_01477|M.leprae_Br4923          KGRDSKREPVELAKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATAL
MAV_1716|M.avium_104                KGRDSRHEPVELTKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATAL
Mb2484c|M.bovis_AF2122/97           KGRDSRCEPVELTKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATAL
Rv2457c|M.tuberculosis_H37Rv        KGRDSRCEPVELTKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATAL
MSMEG_4671|M.smegmatis_MC2_155      KSRDSRSEPVELTKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATAL
TH_0353|M.thermoresistible__bu      KSRDSRSEPVELAKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATAL
MAB_1583|M.abscessus_ATCC_1997      KARDARGETVELAKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATAL
                                    *.:*:: *.***:*************************************

Mflv_2591|M.gilvum_PYR-GCK          TEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSI
Mvan_4036|M.vanbaalenii_PYR-1       TEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSI
MUL_3728|M.ulcerans_Agy99           TEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSI
MMAR_3805|M.marinum_M               TEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSI
MLBr_01477|M.leprae_Br4923          TEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSI
MAV_1716|M.avium_104                TEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSI
Mb2484c|M.bovis_AF2122/97           TEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSI
Rv2457c|M.tuberculosis_H37Rv        TEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSI
MSMEG_4671|M.smegmatis_MC2_155      TEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSI
TH_0353|M.thermoresistible__bu      TEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSI
MAB_1583|M.abscessus_ATCC_1997      TEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSI
                                    **************************************************

Mflv_2591|M.gilvum_PYR-GCK          TRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVA
Mvan_4036|M.vanbaalenii_PYR-1       TRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVA
MUL_3728|M.ulcerans_Agy99           TRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVA
MMAR_3805|M.marinum_M               TRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVA
MLBr_01477|M.leprae_Br4923          TRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVA
MAV_1716|M.avium_104                TRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVA
Mb2484c|M.bovis_AF2122/97           TRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVA
Rv2457c|M.tuberculosis_H37Rv        TRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVA
MSMEG_4671|M.smegmatis_MC2_155      TRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVA
TH_0353|M.thermoresistible__bu      TRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVA
MAB_1583|M.abscessus_ATCC_1997      TRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVA
                                    **************************************************

Mflv_2591|M.gilvum_PYR-GCK          GAFAGLEKIVSDRVGKRGLGFGAEVHSKAEIDTQDHFAEVMPEDLIKFGL
Mvan_4036|M.vanbaalenii_PYR-1       GAFAGLERIVSDRVGKRGLGFGAEVKSKAEIDTQDHFAEVMPEDLIKFGL
MUL_3728|M.ulcerans_Agy99           GAFAGLEKIIYERVGKRGLGFGAEVRSKAEIDTTDHFAEVMPEDLIKFGL
MMAR_3805|M.marinum_M               GAFAGLEKIIYERVGKRGLGFGAEVRSKAEIDTTDHFAEVMPEDLIKFGL
MLBr_01477|M.leprae_Br4923          GAFAGLDKIIYERIGKRGLGFGAEVRSKAEIDTTDHFADVMPEDLIKFGL
MAV_1716|M.avium_104                GAFAGLEKIIYERVGKRGLGFGAEVRSKAEIDTTDHFAEVMPEDLIKFGL
Mb2484c|M.bovis_AF2122/97           GAFAGLEKIIYERVGKRGLGFGAEVRSKAEIDTTDHFADVMPEDLIKFGL
Rv2457c|M.tuberculosis_H37Rv        GAFAGLEKIIYERVGKRGLGFGAEVRSKAEIDTTDHFADVMPEDLIKFGL
MSMEG_4671|M.smegmatis_MC2_155      GAFAGLEKIVSDRVGKRGLGFGAEVRSKAEIDTQDHFAEVMPEDLIKFGL
TH_0353|M.thermoresistible__bu      GAFAGLEKIVQDRVGKRGLGFGAEVHSKSEIDTTDHFAEVMPEDLIKYGL
MAB_1583|M.abscessus_ATCC_1997      GAFAGLEKIVSDRVGKRGLGFGAEVKSKADIDTTDHFAEVMPEDLIKFGL
                                    ******::*: :*:***********:**::*** ****:********:**

Mflv_2591|M.gilvum_PYR-GCK          IPEFIGRLPVVASVTNLDKESLVKILSEPKNALVKQYTRLFEMDGVELEF
Mvan_4036|M.vanbaalenii_PYR-1       IPEFIGRLPVVASVTNLDKESLVQILSQPKNALVKQYTRLFEMDGVELEF
MUL_3728|M.ulcerans_Agy99           IPEFIGRLPVVASVTNLDKESLVKILSEPKNALVKQYTRLFEMDGVELEF
MMAR_3805|M.marinum_M               IPEFIGRLPVVASVTNLDKESLVKILSEPKNALVKQYTRLFEMDGVELEF
MLBr_01477|M.leprae_Br4923          IPEFIGRLPVIASVINLDMESLVKILSEPKNALVKQYTWLFEMDGVELEF
MAV_1716|M.avium_104                IPEFIGRLPVVASVTNLDRESLVKILSEPKNALVKQYTRLFEMDGVELEF
Mb2484c|M.bovis_AF2122/97           IPEFIGRLPVVASVTNLDKESLVKILSEPKNALVKQYIRLFEMDGVELEF
Rv2457c|M.tuberculosis_H37Rv        IPEFIGRLPVVASVTNLDKESLVKILSEPKNALVKQYIRLFEMDGVELEF
MSMEG_4671|M.smegmatis_MC2_155      IPEFIGRLPVVASVTNLDKASLVKILSEPKNALVKQYVRLFEMDGVELEF
TH_0353|M.thermoresistible__bu      IPEFIGRLPVVASVTNLDKNSLVQILSKPKNALVKQYTKLFEMDGVELEF
MAB_1583|M.abscessus_ATCC_1997      IPEFIGRLPIVASVTNLDRESLIKILSEPKNALVKQYTRLFEMDGVELEF
                                    *********::*** ***  **::***:*********  ***********

Mflv_2591|M.gilvum_PYR-GCK          AEDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTK
Mvan_4036|M.vanbaalenii_PYR-1       AEDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTK
MUL_3728|M.ulcerans_Agy99           TDDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTK
MMAR_3805|M.marinum_M               TDDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTK
MLBr_01477|M.leprae_Br4923          TNDALEAVADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTK
MAV_1716|M.avium_104                TDDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTK
Mb2484c|M.bovis_AF2122/97           TDDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTK
Rv2457c|M.tuberculosis_H37Rv        TDDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTK
MSMEG_4671|M.smegmatis_MC2_155      TEEALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTK
TH_0353|M.thermoresistible__bu      TDDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTK
MAB_1583|M.abscessus_ATCC_1997      SQDALEAIADQAIHRGTGARGLRAIMEEVLQPVMYDIPSRDDVAKVVVTG
                                    :::****:********************** ****************** 

Mflv_2591|M.gilvum_PYR-GCK          ETVDDNVLPTIVPRKPSRSERRDKTA
Mvan_4036|M.vanbaalenii_PYR-1       ETVLDNVLPTIVPRKPSRTERRDKSA
MUL_3728|M.ulcerans_Agy99           ETVQDNVLPTIVPRKPSRSERRDKSA
MMAR_3805|M.marinum_M               ETVQDNVLPTIVPRKPSRSERRDKSA
MLBr_01477|M.leprae_Br4923          ETVQDNVLPTIVPRKPSRTERRDKSA
MAV_1716|M.avium_104                ETVQDNVLPTIVPRKPSRTERRDKSA
Mb2484c|M.bovis_AF2122/97           ETVQDNVLPTIVPRKPSRSERRDKSA
Rv2457c|M.tuberculosis_H37Rv        ETVQDNVLPTIVPRKPSRSERRDKSA
MSMEG_4671|M.smegmatis_MC2_155      ETVQDNVLPTIVPRKPSRSERRDKSA
TH_0353|M.thermoresistible__bu      ETVLDNVLPTIVPRKPSRAERRDKTA
MAB_1583|M.abscessus_ATCC_1997      ETVIDNVLPTIVPRKPSRTERRDKSA
                                    *** **************:*****:*