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VLSSEASSAADHSAAAPIPTSSWPQLLGRLTEGKHLEPGQAGWAMEQIMSGNARPAQVAAFAVAMKMKVP TAGEVGELADVMLAYARPMPADLIRDDTVDIVGTGGDGVNTVNLSTMASIVVAAAGVPVVKHGNRAASSL AGGADTLESLGVRIDLGPDQVARSLNENGIGFCFAPQFHPSYRQASVVRREIGVPTVFNLLGPLTNPARP RAGLIGCAFADLAEIMAGVFATRGSSVLVVHGDDGLDELTTTTTSTIWRVQAGTVDKLTFDPGDFGFARA ELSQLLGGDPQANAAEARAVLGGAAGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWQDGLQRAAVAIDSG AAEQLLARWVRFSQHV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3549 | trpD | - | 100% (367) | anthranilate phosphoribosyltransferase |
| M. ulcerans Agy99 | MUL_1365 | deoA | 3e-05 | 25.61% (164) | thymidine phosphorylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2215c | trpD | 1e-167 | 79.57% (372) | anthranilate phosphoribosyltransferase |
| M. gilvum PYR-GCK | Mflv_2957 | trpD | 1e-155 | 77.71% (350) | anthranilate phosphoribosyltransferase |
| M. tuberculosis H37Rv | Rv2192c | trpD | 1e-167 | 79.57% (372) | anthranilate phosphoribosyltransferase |
| M. leprae Br4923 | MLBr_00883 | trpD | 1e-159 | 78.38% (370) | anthranilate phosphoribosyltransferase |
| M. abscessus ATCC 19977 | MAB_1970 | trpD | 1e-149 | 75.93% (349) | anthranilate phosphoribosyltransferase |
| M. marinum M | MMAR_3236 | trpD | 0.0 | 99.46% (367) | anthranilate phosphoribosyltransferase TrpD |
| M. avium 104 | MAV_2301 | trpD | 1e-164 | 79.56% (367) | anthranilate phosphoribosyltransferase |
| M. smegmatis MC2 155 | MSMEG_4258 | trpD | 1e-158 | 78.25% (354) | anthranilate phosphoribosyltransferase |
| M. thermoresistible (build 8) | TH_1040 | trpD | 1e-154 | 78.10% (347) | Probable anthranilate phosphoribosyltransferase TrpD |
| M. vanbaalenii PYR-1 | Mvan_3556 | trpD | 1e-157 | 78.96% (347) | anthranilate phosphoribosyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2957|M.gilvum_PYR-GCK ------------------------------------------MTTPPPRP
Mvan_3556|M.vanbaalenii_PYR-1 ------------------------------------------MTTPPPQL
MSMEG_4258|M.smegmatis_MC2_155 ------------------------------------------MTSGPSQP
TH_1040|M.thermoresistible__bu ------------------------------------------MT------
MUL_3549|M.ulcerans_Agy99 ----------------------------------------MVLSSEASSA
MMAR_3236|M.marinum_M ----------------------------------------MVLSSEASSA
Mb2215c|M.bovis_AF2122/97 ----------------------------------------MALSAEGSSG
Rv2192c|M.tuberculosis_H37Rv ----------------------------------------MALSAEGSSG
MLBr_00883|M.leprae_Br4923 ----------------------------------------MVLSSQPPSS
MAV_2301|M.avium_104 MNSTRVWNFAICGGARRAPAPTGPFAARLGPLCPAWDHRRVALSSESSAA
MAB_1970|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2957|M.gilvum_PYR-GCK AAPT----TDPGDTPTWAMILGRLTTGQSLLPGQTAWAMDQIMTGVATPA
Mvan_3556|M.vanbaalenii_PYR-1 ASAQ----NPSGDTPTWAMILGRLTTGQGLAPGQTAWAMDQIMTGTATPA
MSMEG_4258|M.smegmatis_MC2_155 FPSA----SGPDDGPSWPRILGRLTTGQNLPNGHAAWAMDQIMTGAATPA
TH_1040|M.thermoresistible__bu ----------LADTPAWASVLARLTTNESLPVGHAAWAMDQIMTGAATPA
MUL_3549|M.ulcerans_Agy99 ADHS---AAAPIPTSSWPQLLGRLTEGKHLEPGQAGWAMEQIMSGNARPA
MMAR_3236|M.marinum_M ADHS---AAAPIPTSSWPQLLGRLTEGKHLEPGQAGWAMEQIMSGNARPA
Mb2215c|M.bovis_AF2122/97 GSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPA
Rv2192c|M.tuberculosis_H37Rv GSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPA
MLBr_00883|M.leprae_Br4923 -------RSATGSVLSWPQVLGRLTAGQDLTRGQAAWAMGQVMTGNARPA
MAV_2301|M.avium_104 SAAR---RPSGGPATSWRQVLARLTGGDDLARGQAAWAMDQIMTGEASPA
MAB_1970|M.abscessus_ATCC_1997 -----------MLEHSWPRVLGELTNRRDLTAGQAAWAMDQIMTGTATPA
:* :*..** * *::.*** *:*:* * **
Mflv_2957|M.gilvum_PYR-GCK QIAAFAVSMKMKRPTSAEVTELAEIMLKHALPVPTDTIGTHT----VDIV
Mvan_3556|M.vanbaalenii_PYR-1 QIAAFAVSMKMKRPTSAEVTELADIMLKHARRVPTDVIGTAT----VDIV
MSMEG_4258|M.smegmatis_MC2_155 QISGFAVSMKMKRPTASEVRELADIMLTHARRVPTDEIGTDT----VDIV
TH_1040|M.thermoresistible__bu QIAAFAVALRMKRPTPAEVHELAEIMLSHARRVPTDEIGTDT----VDIV
MUL_3549|M.ulcerans_Agy99 QVAAFAVAMKMKVPTAGEVGELADVMLAYARPMPADLIRDDT----VDIV
MMAR_3236|M.marinum_M QVAAFAVAMKMKVPTAGEVGELADVMLAYARPMPADLIRDDT----VDIV
Mb2215c|M.bovis_AF2122/97 QIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDA----VDVV
Rv2192c|M.tuberculosis_H37Rv QIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDA----VDVV
MLBr_00883|M.leprae_Br4923 QIAAFAVAMKMKVPTAAEVSELADVMLSHARKLPTEAICQDIGE-TVDIA
MAV_2301|M.avium_104 QIAAFAVAMQVKVPTSAEVIELAEVMLNHALPFPAGAIRDDT----VDIV
MAB_1970|M.abscessus_ATCC_1997 QIAAFGVSMRMKRPTSDEVGELADTMLSHAITFPGDPQGAQIGANAVDIV
*::.*.*:: :* **. ** *** ** :* .* **:.
Mflv_2957|M.gilvum_PYR-GCK GTGGDGANTVNLSTMASIVVAAAGVPVVKHGNRAASSLSGGADTLEALGL
Mvan_3556|M.vanbaalenii_PYR-1 GTGGDGANTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGL
MSMEG_4258|M.smegmatis_MC2_155 GTGGDGANTVNLSTMASIVVAACGVPVVKHGNRAASSLSGGADTLEALGV
TH_1040|M.thermoresistible__bu GTGGDGHNTVNLSTMAAIVVAACGVPVVKHGNRAASSLSGGADTLEALGV
MUL_3549|M.ulcerans_Agy99 GTGGDGVNTVNLSTMASIVVAAAGVPVVKHGNRAASSLAGGADTLESLGV
MMAR_3236|M.marinum_M GTGGDGVNTVNLSTMASIVVAAAGVPVVKHGNRAASSLAGGADTLEALGV
Mb2215c|M.bovis_AF2122/97 GTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGV
Rv2192c|M.tuberculosis_H37Rv GTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGV
MLBr_00883|M.leprae_Br4923 GTGGDGANTVNLSTMAAIVVAAAGVPVVKHGNRASSSLSGGADTLEALGV
MAV_2301|M.avium_104 GTGGDGVNTVNLSTMAAIVAAAAGVPVVKHGNRAASSLSGGADTLEELGV
MAB_1970|M.abscessus_ATCC_1997 GTGGDGANTVNLSTMASIVVAACGVPVVKHGNRAASSLAGGADTLEKLGV
****** *********:**.**.***********:***:******* **:
Mflv_2957|M.gilvum_PYR-GCK RIDLGPDDVARCVAEVGIGFAFAPQFHPSYRHAGAVRREIGVPTVFNLLG
Mvan_3556|M.vanbaalenii_PYR-1 RIDLGPDEVARCVAEVGIGFAFAPQFHPSYRHAGAVRREIGVPTVFNLLG
MSMEG_4258|M.smegmatis_MC2_155 RIDLGPDDVARSVREVGIGFAFAPQFHPSYKHASIVRREIGVPTVFNLLG
TH_1040|M.thermoresistible__bu RIDLSPEEVQRSVREVGIGFAFAPQFHPSYRHASVVRREIGVPTVFNLLG
MUL_3549|M.ulcerans_Agy99 RIDLGPDQVARSLNENGIGFCFAPQFHPSYRQASVVRREIGVPTVFNLLG
MMAR_3236|M.marinum_M RIDLGPDQVARSLNEIGIGFCFAPQFHPSYRQASVVRREIGVPTVFNLLG
Mb2215c|M.bovis_AF2122/97 RIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLG
Rv2192c|M.tuberculosis_H37Rv RIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLG
MLBr_00883|M.leprae_Br4923 RIDLGPEQVANSLAEIGIGFCFAPLFQPSYRYASAVRHEIGVPTVFNILG
MAV_2301|M.avium_104 RIDLGPEQVARSVAEVGIGFCFAPLFHPSYRHTSAVRREIGVPTVFNLLG
MAB_1970|M.abscessus_ATCC_1997 RIDLGPEQVVRSLAEVGIGFCFAPHFHPSYRYASAVRREIGVPTVFNLLG
****.*: * ..: * ****.*** *:***: :. **:*********:**
Mflv_2957|M.gilvum_PYR-GCK PLTNPAKPRAGLIGCAWGDLAEVMAGVFATRGSSALVVHGDDGLDELTTT
Mvan_3556|M.vanbaalenii_PYR-1 PLTNPASPRAGLIGCAWADLAEVMAGVFATRGSSVLVVHGDDGLDELTTT
MSMEG_4258|M.smegmatis_MC2_155 PLTNPAGPRAGLIGCAWADLAEVMAGVFAARGSSVLVVHGDDGLDELTTT
TH_1040|M.thermoresistible__bu PLTNPAAPRAGLIGCAWADLAEVMAGVFATRGSSVLVVHGDDGLDELTTT
MUL_3549|M.ulcerans_Agy99 PLTNPARPRAGLIGCAFADLAEIMAGVFATRGSSVLVVHGDDGLDELTTT
MMAR_3236|M.marinum_M PLTNPARPRAGLIGCAFADLAEIMAGVFATRGSSVLVVHGDDGLDELTTT
Mb2215c|M.bovis_AF2122/97 PLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTT
Rv2192c|M.tuberculosis_H37Rv PLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTT
MLBr_00883|M.leprae_Br4923 PLTNPAWPRAGLIGCAFGNLAEVMAGVFAARRSSVLVVHGDDGLDELTTT
MAV_2301|M.avium_104 PLTNPARPRAGLIGCAFAELAEVMAGVFAARRSSVLVVHGDDGLDELTTT
MAB_1970|M.abscessus_ATCC_1997 PLTNPARPRAGLIGCAFADLAEVTAGVFAGRGSSVLVVHGDDGLDELTTT
****** *********:.:***: ***** * **.***************
Mflv_2957|M.gilvum_PYR-GCK TTSTIWRVQAGTVERLTFDPAAFGFARAHVSELTGGDAEANAASAREVLG
Mvan_3556|M.vanbaalenii_PYR-1 TTSTIWRVQAGTVERLTFDPAAFGFARAHVSELTGGDAESNAASARAVLG
MSMEG_4258|M.smegmatis_MC2_155 TTSTIWRVQGGTMERLTFDPAAFGFKRAEISELVGGDASENAAEARAVLG
TH_1040|M.thermoresistible__bu TTSTIWRVQAGTVERLTFDPAAFGFPRADLSALVGGDAQANAAEVRAVLG
MUL_3549|M.ulcerans_Agy99 TTSTIWRVQAGTVDKLTFDPGDFGFARAELSQLLGGDPQANAAEARAVLG
MMAR_3236|M.marinum_M TTSTIWRVQAGTVDKLTFDPGDFGFARAELSQLLGGDPQANAAEARAVLG
Mb2215c|M.bovis_AF2122/97 TTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLG
Rv2192c|M.tuberculosis_H37Rv TTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLG
MLBr_00883|M.leprae_Br4923 TTSTIWRVQAGTVDKLTFDPVEFGFARAHLDDLLGGDAQTNAAKVRAVLA
MAV_2301|M.avium_104 TTSTIWRVQAGTVDRLTFDPAGFGFPRAELDDLLGGDAQTNAAEVRAVLA
MAB_1970|M.abscessus_ATCC_1997 TTSTIWRVQAGTVDKLRFDPAAFGFARARLEELVGGDPEFNAAEVRAVLA
******** .*::::* *** *** ** :. * ***.. *** .* **.
Mflv_2957|M.gilvum_PYR-GCK GATGPVRDAVLLNAAGAMVAHAGLSSDAKWVPAWESGLARAKEAIDSGAA
Mvan_3556|M.vanbaalenii_PYR-1 GAKGPVRDAVVLNAAGALVAHAGLSSDAKWVPAWESGLARAKDAIDSGAA
MSMEG_4258|M.smegmatis_MC2_155 GAKGPVRDAVVLNAAGAMVAHAGLASDAQWLPAWEAGLARAVEAIDSGAA
TH_1040|M.thermoresistible__bu GAKGPVRDAVILNAAGAMVAHAGLSSDAKWVPAWESGLARATEAIDSGAA
MUL_3549|M.ulcerans_Agy99 GAAGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWQDGLQRAAVAIDSGAA
MMAR_3236|M.marinum_M GAAGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWQDGLQRAAVAIDSGAA
Mb2215c|M.bovis_AF2122/97 GARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAA
Rv2192c|M.tuberculosis_H37Rv GARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAA
MLBr_00883|M.leprae_Br4923 GAKGPVRDAVVLNAAGAIVAYAGLSSHAEWSPAWDDGLARASAAIDSGAA
MAV_2301|M.avium_104 GGQGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEDGLARASAAIDSGAA
MAB_1970|M.abscessus_ATCC_1997 GGTGAVRDAVLLNAAGAMVAHAGLASDAQWLPAWESALARVSTAIDSGAA
*. *.*****:******:**:***:* *:* ***: .* *. ***:***
Mflv_2957|M.gilvum_PYR-GCK EQLLARWVRFTQEL----
Mvan_3556|M.vanbaalenii_PYR-1 EQLLARWVRFTQQL----
MSMEG_4258|M.smegmatis_MC2_155 EQLLARWVRFGQQL----
TH_1040|M.thermoresistible__bu EQLLARWVRFGQQL----
MUL_3549|M.ulcerans_Agy99 EQLLARWVRFSQHV----
MMAR_3236|M.marinum_M EQLLARWVRFSQHV----
Mb2215c|M.bovis_AF2122/97 EQLLARWVRFGRQI----
Rv2192c|M.tuberculosis_H37Rv EQLLARWVRFGRQI----
MLBr_00883|M.leprae_Br4923 EQLLARWVRFSQQV----
MAV_2301|M.avium_104 EQLLARWVRFGQQL----
MAB_1970|M.abscessus_ATCC_1997 AALLDRWIAVSQRLGTGQ
** **: . :.: