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AITDVDVFAHLTDGDIENLSTELDDIRRDIEESRGERDARYIYRTIAAQRALEVSGRLVLAASSRRSAWW VGAVTLSVAKIIENMEIGHNVMHGQWDWMNDPEVHSSTWEWDMASTSKHWRYTHNVVHHKYTNILDMDHD VGYGMLRVTRDQGWRRRDAFNLAINALLAIGFEWGIALRHLEARDLFKDGPEREAAKFRLREFSGKAGRQ AVKDYVAFPALTSVSPAATYRSTLTANAFANVIRNVWSNAVIFCGHFPDGAEKFTKTELVDETQGQWYLR QMLGSANFNAGAAMRFMSGSLSHQIEHHLYPDLPSNRLAEVSVRVREICDKYDLPYTTGSFPLQYAKTWR TLAKLSLPNKYLRDNADDAPETRSERMFAGLEAGFAATDPMTGRRRGLKAAITAVRAWRRAKPGKAKKAG GTDGLAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2564 | desA3_1 | - | 100% (428) | linoleoyl-CoA desaturase, DesA3_1 |
| M. ulcerans Agy99 | MUL_2565 | desA3 | 0.0 | 79.44% (428) | linoleoyl-CoA desaturase, DesA3 |
| M. ulcerans Agy99 | MUL_4785 | desA3_2 | 5e-86 | 44.80% (346) | linoleoyl-CoA desaturase, DesA3_2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3258c | - | 0.0 | 80.14% (428) | linoleoyl-CoA desaturase |
| M. gilvum PYR-GCK | Mflv_4698 | - | 1e-174 | 67.92% (424) | fatty acid desaturase |
| M. tuberculosis H37Rv | Rv3229c | - | 0.0 | 80.14% (428) | linoleoyl-CoA desaturase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2148 | - | 1e-174 | 70.70% (413) | putative linoleoyl-CoA desaturase |
| M. marinum M | MMAR_1316 | desA3_1 | 0.0 | 99.07% (428) | linoleoyl-CoA desaturase, DesA3_1 |
| M. avium 104 | MAV_4192 | - | 0.0 | 77.07% (423) | Fatty acid desaturase |
| M. smegmatis MC2 155 | MSMEG_1886 | - | 0.0 | 70.95% (420) | Fatty acid desaturase |
| M. thermoresistible (build 8) | TH_0650 | desA3 | 0.0 | 73.85% (413) | POSSIBLE LINOLEOYL-CoA DESATURASE (DELTA(6)-DESATURASE) |
| M. vanbaalenii PYR-1 | Mvan_1768 | - | 1e-176 | 69.98% (413) | fatty acid desaturase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2564|M.ulcerans_Agy99 MAITDVDVFAHLTDGDIENLSTELDDIRRDIEESRGERDARYIYRTIAAQ
MMAR_1316|M.marinum_M MAITDVDVFAHLTDGDIENLSTELDDIRRDIEESRGERDARYIYRTIAAQ
Mflv_4698|M.gilvum_PYR-GCK MAITDVPEFAHLTDADIENLGRELDAIRQDIEDSRGAQDARYIRRTIAIQ
Mvan_1768|M.vanbaalenii_PYR-1 MAITDVPQFAHLTEADVENLGRELDAIRQDIEDSRGERDARYIRRTIAIQ
MSMEG_1886|M.smegmatis_MC2_155 MAVTDVPAFAHLTEADIENLGIELDAIRQDIEDSRGERDARYIRRTIAVQ
TH_0650|M.thermoresistible__bu MAITDVPAYAHLTEVDIDALAVELDAIRRDIEDSLGERDARYIRRTIATQ
MAV_4192|M.avium_104 MAITDVDVFAHLTDADIENLAVELDAIRQDVEDSRGERDARYIRRTIAAQ
Mb3258c|M.bovis_AF2122/97 MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRRTIAAQ
Rv3229c|M.tuberculosis_H37Rv MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRRTIAAQ
MAB_2148|M.abscessus_ATCC_1997 MAITDISAFAHLTSEDVENLAVELDGLRREIEESRGARDARYIRRTIAAQ
**:**: :****. *:: *. *** :*:::*:* * :***** **** *
MUL_2564|M.ulcerans_Agy99 RALEVSGRLVLAASSRRSAWWVGAVTLSVAKIIENMEIGHNVMHGQWDWM
MMAR_1316|M.marinum_M RALEVGGRLVLAASSRRSAWWVGAVTLSVAKIIENMEIGHNVMHGQWDWM
Mflv_4698|M.gilvum_PYR-GCK RGLEVAGRLMLAGSAKRSYWWAGTATLGVAKIIENMEIGHNVMHGQWDWM
Mvan_1768|M.vanbaalenii_PYR-1 RGLEVTGRLLLAGSAKRRFWWAGTATLGVAKIIENMEIGHNVMHGQWDWM
MSMEG_1886|M.smegmatis_MC2_155 RSLDLAGRLMLTASKRRSAWWAGTATLGVAKIIENMEIGHNVMHGQWDWM
TH_0650|M.thermoresistible__bu RGLEVAGRLLLAASSRRSAWWAGAVTLAAAKIIENMEIGHNVMHGQWDWM
MAV_4192|M.avium_104 RALEVTGRLLLAASSRRSAWWAGTVTLGVAKIIENMEIGHNVMHGQWDWM
Mb3258c|M.bovis_AF2122/97 RALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWM
Rv3229c|M.tuberculosis_H37Rv RALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWM
MAB_2148|M.abscessus_ATCC_1997 RALELGGRVLLAASTKRAAWWAGTVTLAVAKIIENMEIGHNVLHGQWDWM
*.*:: **::*:.* :* **.*: **..*************:*******
MUL_2564|M.ulcerans_Agy99 NDPEVHSSTWEWDMASTSKHWRYTHNVVHHKYTNILDMDHDVGYGMLRVT
MMAR_1316|M.marinum_M NDPEVHSSTWEWDMASTSKHWRYTHNVVHHKYTNILDMDHDVGYGMLRVT
Mflv_4698|M.gilvum_PYR-GCK NDPEIHSSSWEWDMSGASKHWRFTHNFMHHKYTNILGMDDDVGYGVIRVT
Mvan_1768|M.vanbaalenii_PYR-1 NDPEIHSSSWEWDMSGASKHWRFTHNFMHHKYTNILGMDDDVGYGVIRVT
MSMEG_1886|M.smegmatis_MC2_155 NDPEIHSSSWEWDMSGASKHWRFTHNFMHHKYTNILGMDDDVGYGLLRVT
TH_0650|M.thermoresistible__bu NDPEIHSSTWEWDMTGASKHWRFTHNFMHHKYTNILGMDDDVGYGLLRVT
MAV_4192|M.avium_104 NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
Mb3258c|M.bovis_AF2122/97 NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
Rv3229c|M.tuberculosis_H37Rv NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MAB_2148|M.abscessus_ATCC_1997 NDPEIHSSTWEWDMAGAAKHWRITHNVEHHKYTNILDLDDDVGYGLLRVT
****:***:*****:.::**** ***. ********.:*.*****::***
MUL_2564|M.ulcerans_Agy99 RDQGWRRRDAFNLAINALLAIGFEWGIALRHLEARDLFKDGPEREAAKFR
MMAR_1316|M.marinum_M RDQGWRRRDAFNLAINALLAIGFEWGIALRHLEARDLFKDGPEREAAKFR
Mflv_4698|M.gilvum_PYR-GCK RDQRWTPMNLGNLFFNTLLCVAFEWGVGLQHLELGKIFKGRDDRKATMGR
Mvan_1768|M.vanbaalenii_PYR-1 RDQRWRPMNLLNLFFNTLLSVAFEWGVGLQHLELGKIFKGRDDRKATMGR
MSMEG_1886|M.smegmatis_MC2_155 RDQKWKPHNLLNLVYNTMLCIFFEWGVGLQHLEVGKIFKGRDDRNATLVR
TH_0650|M.thermoresistible__bu RDQKWKPFNLGNLLYNTLLALAFEWGVGLQHVELGKIFKRRHDPDESRVR
MAV_4192|M.avium_104 RDQRWKRFNLFNLVWNTLLALLFEWGVGLQHVEIGKILKRRMDHEEARQR
Mb3258c|M.bovis_AF2122/97 RDQRWKRYNIFNVVWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTR
Rv3229c|M.tuberculosis_H37Rv RDQRWKRYNIFNVVWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTR
MAB_2148|M.abscessus_ATCC_1997 RDESWKIRNLFNIPFNFMLAAGFEWGIALQHLELRKIWK-KETREATKQR
**: * : *: * :*. ****:.*:*:* .: * . : *
MUL_2564|M.ulcerans_Agy99 LREFSGKAGRQAVKDYVAFPALTSVSPAATYRSTLTANAFANVIRNVWSN
MMAR_1316|M.marinum_M LREFSGKAGRQAVKDYVAFPALTSVSPAATYRSTLTANAFANVIRNVWSN
Mflv_4698|M.gilvum_PYR-GCK VKEFGVKAGQQVVKDYVAYPAITSLSPRATFKSTLTANAVANVIRNVWAN
Mvan_1768|M.vanbaalenii_PYR-1 VKEFGVKAGQQVVKDYVAYPAITSLSPRATFRSTLTANAVANVIRNVWAN
MSMEG_1886|M.smegmatis_MC2_155 LREFGTKAGGQVFKDYVAWPAITSLSPGATFKSTAKANAVANIIRNIWSN
TH_0650|M.thermoresistible__bu VREFLRKAGRQVFKDYVAYPALSSLSPAASYRSTLTANAMANVIRNVWSN
MAV_4192|M.avium_104 IDEFLAKAGRQVVKDYVAFPALTSLSPGATFLSTLKANAMANVIRNVWAN
Mb3258c|M.bovis_AF2122/97 LREFSAKAGRQVFKDYVAFPALTSLSPGATYRSTLTANVVANVIRNVWSN
Rv3229c|M.tuberculosis_H37Rv LREFSAKAGRQVFKDYVAFPALTSLSPGATYRSTLTANVVANVIRNVWSN
MAB_2148|M.abscessus_ATCC_1997 LRELVRSAASQLFKDYVAFPAITAASPGATYRSTLTANATANLLRNFWSN
: *: .*. * .*****:**::: ** *:: ** .**. **::**.*:*
MUL_2564|M.ulcerans_Agy99 AVIFCGHFPDGAEKFTKTELVDETQGQWYLRQMLGSANFNAGAAMRFMSG
MMAR_1316|M.marinum_M AVIFCGHFPDGAEKFTKTDLVDETQGQWYLRQMLGSANFNAGTAMRFMSG
Mflv_4698|M.gilvum_PYR-GCK AVIFCGHFPDGAEKFTKTDMIGESRGQWYLRQMLGSANFEGGPLLRFMSG
Mvan_1768|M.vanbaalenii_PYR-1 AVIFCGHFPDGAEKFTKTDMVGESRGQWYLRQMLGSANFEGGPLLRFMSG
MSMEG_1886|M.smegmatis_MC2_155 AVIFCGHFPDGAEKFTKTDMIGESRGQWYLRQMLGSANFEGGWLLRFMSG
TH_0650|M.thermoresistible__bu AVIFCGHFPDGAEKFTKTDMVGESKGQWYLRQMLGSANFEGGWLLRFMSG
MAV_4192|M.avium_104 AVIFCGHFPDGAEKFTKTDMIGETKGQWYLRQMLGSANFEAGPVLRFMSG
Mb3258c|M.bovis_AF2122/97 AVIFCGHFPDGAEKFTKTDMIGEPKGQWYLRQMLGSANFNAGPALRFMSG
Rv3229c|M.tuberculosis_H37Rv AVIFCGHFPDGAEKFTKTDMIGEPKGQWYLRQMLGSANFNAGPALRFMSG
MAB_2148|M.abscessus_ATCC_1997 AVIFCGHFPDGAEKFTVTDMENETRGQWYLRQLLGSANFNAGPTMRLMSG
**************** *:: .*.:*******:******:.* :*:***
MUL_2564|M.ulcerans_Agy99 SLSHQIEHHLYPDLPSNRLAEVSVRVREICDKYDLPYTTGSFPLQYAKTW
MMAR_1316|M.marinum_M SLSHQIEHHLYPDLPSNRLAEVSVRVREICDKYDLPYTTGSFPLQYAKTW
Mflv_4698|M.gilvum_PYR-GCK NLSQQIEHHLFPDLPSNRYYEISLRVRELCDKYDLPYTTGNFLVQYGKSW
Mvan_1768|M.vanbaalenii_PYR-1 NLSQQIEHHLFPDLPSNRYYEISLRVRELCDKYDLPYTTGNFLVQYGKSW
MSMEG_1886|M.smegmatis_MC2_155 NLCHQIEHHLYPDLPSNRLHEISIRVRALCDKYDLPYTTGSFLVQYGKTW
TH_0650|M.thermoresistible__bu NLCHQIEHHLYPDLPSNRLHEASIRVREVCDKYDLPYTTGPFLVQYAKTW
MAV_4192|M.avium_104 NLCHQIEHHLYPDLPSNRLHEISVRVRQVCDKYDLPYTTGSFLFQYAKTW
Mb3258c|M.bovis_AF2122/97 NLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTGSFLVQYGKTW
Rv3229c|M.tuberculosis_H37Rv NLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTGSFLVQYGKTW
MAB_2148|M.abscessus_ATCC_1997 NLCHQIEHHIYPDLPSNRLHEISVRVREICERYDLPYTTGSMLFQYAKTW
.*.:*****::******* * *:*** :*::******** : .**.*:*
MUL_2564|M.ulcerans_Agy99 RTLAKLSLPNKYLRDNADDAPETRSERMFAGLEAGFAATDPMTGRRRGLK
MMAR_1316|M.marinum_M RTLAKLSLPNKYLRDNADDAPETRSERMFAGLEAGFAGTDPMTGRRRGLK
Mflv_4698|M.gilvum_PYR-GCK RTIAKLSLPDRFLSDTRDDAPETRSERMFDGLE-------PTE--RSGLK
Mvan_1768|M.vanbaalenii_PYR-1 RTIAKLSLPDRFLTDTADDAPETRSERMFDGLE-------PSE--RRGLR
MSMEG_1886|M.smegmatis_MC2_155 RTIAKLSLPDKFLKDTADNAPETRSERMFAELDG-FGVTDPATGRRRGLK
TH_0650|M.thermoresistible__bu RTLAKLSLPDRFLKATADNAPETRSERMFAELGPGFAGVDPATGRRRGLK
MAV_4192|M.avium_104 RTLAKLSLPNKYLRDDADNAPETRSERMFAELDPDFLGTDPATGRRRGLK
Mb3258c|M.bovis_AF2122/97 RTLAKLSLPDKYLRDNADDAPETRSERMFAGLGPGFAGADPVTGRRRGLK
Rv3229c|M.tuberculosis_H37Rv RTLAKLSLPDKYLRDNADDAPETRSERMFAGLGPGFAGADPVTGRRRGLK
MAB_2148|M.abscessus_ATCC_1997 RTIAKLSLPDRFLHATADNAPETRSERMFVVLEQ-PQVPGVESVPRRGLK
**:******:::* *:********** * * **:
MUL_2564|M.ulcerans_Agy99 AAITAVRAWRRAKPGKAKKAGGTDGLAA----------------------
MMAR_1316|M.marinum_M AAITAVRAWRRAKPGKAKKAGGTDGLAA----------------------
Mflv_4698|M.gilvum_PYR-GCK SAIAAVRSRRRAK--RAQKAAVKGQDLAA---------------------
Mvan_1768|M.vanbaalenii_PYR-1 SAIAAVRKRRRAK--AAEKAAVK---LAA---------------------
MSMEG_1886|M.smegmatis_MC2_155 TAIETVRGWRRSS--RAKRAA-----------------------------
TH_0650|M.thermoresistible__bu SAFAAVRNWRRDK--QAAKAXXXGELYPRPGTLRRDVGVRLRRGGVPGPA
MAV_4192|M.avium_104 SAIAAVRGWRRGK--RASVARRTGGELAA---------------------
Mb3258c|M.bovis_AF2122/97 TAIAAVRGRRRSK--RMAKSVTEPDDLAA---------------------
Rv3229c|M.tuberculosis_H37Rv TAIAAVRGRRRSK--RMAKSVTEPDDLAA---------------------
MAB_2148|M.abscessus_ATCC_1997 TAIAMVRERRRNK-----VAV-----------------------------
:*: ** ** . :
MUL_2564|M.ulcerans_Agy99 ----------------------------------------
MMAR_1316|M.marinum_M ----------------------------------------
Mflv_4698|M.gilvum_PYR-GCK ----------------------------------------
Mvan_1768|M.vanbaalenii_PYR-1 ----------------------------------------
MSMEG_1886|M.smegmatis_MC2_155 ----------------------------------------
TH_0650|M.thermoresistible__bu GLWSGEHDRRGHRPPRSGPQRIRRPRGHAVLRRRDRAVRR
MAV_4192|M.avium_104 ----------------------------------------
Mb3258c|M.bovis_AF2122/97 ----------------------------------------
Rv3229c|M.tuberculosis_H37Rv ----------------------------------------
MAB_2148|M.abscessus_ATCC_1997 ----------------------------------------