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MSQSRDAVIVGAVRTPIGKGKANGALHQVLPADLLAHSLRELAARTGVDPVQVDDVIAGAVTQVGDQAVN IARNALLGAGFPESVPGVTIDRQCGSSQQAISFAAQGVLAGAYDLVIAGGVESMSRVPMGTSVLPGSNPF GPDMNNRYPDGLVPQGISAELIAARWGLSRTQLDEFSAASHDKAARATKDGLFDNELIPIAGLTHDEIIR PGATVDTLAALRPAFYSDAIKERFPQINWSITPGNSSPLSDSSAAVMITSSDVARKLGLRPLARIHTTTV VGSDPLYMLTGVIAATEKALRRAGLALRDIDLFEVNEAFAPVVLAWAKDTGADLAKTNVNGGAIAIGHPL GASGARIMTTLVNASEQRGGRYGLQTMCEGGGMANATIIERLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2563 | fadA6_4 | - | 100% (393) | acetyl-CoA acetyltransferase FadA6_4 |
| M. ulcerans Agy99 | MUL_0971 | fadA6_3 | e-115 | 55.47% (393) | acetyl-CoA acetyltransferase FadA6_3 |
| M. ulcerans Agy99 | MUL_4119 | fadA6_1 | 3e-91 | 45.34% (397) | acetyl-CoA acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3586c | fadA6 | 4e-94 | 46.73% (398) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_3782 | - | 0.0 | 83.97% (393) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv3556c | fadA6 | 4e-94 | 46.73% (398) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_02162 | fadA | 6e-83 | 45.70% (407) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_3455c | - | 1e-143 | 63.48% (397) | putative acyl-CoA thiolase |
| M. marinum M | MMAR_1317 | fadA6_4 | 0.0 | 98.98% (393) | acetyl-CoA acetyltransferase FadA6_4 |
| M. avium 104 | MAV_4185 | - | 0.0 | 87.66% (389) | FadA6_4 |
| M. smegmatis MC2 155 | MSMEG_3012 | - | 0.0 | 85.31% (388) | acetyl-CoA acetyltransferases |
| M. thermoresistible (build 8) | TH_0255 | - | 1e-110 | 54.34% (392) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2617 | - | 0.0 | 84.79% (388) | acetyl-CoA acetyltransferases |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3586c|M.bovis_AF2122/97 -----MTEAYVIDAVRTAVGK--RGGALAGIHPVDLGALAWRGLLDR-TD
Rv3556c|M.tuberculosis_H37Rv -----MTEAYVIDAVRTAVGK--RGGALAGIHPVDLGALAWRGLLDR-TD
TH_0255|M.thermoresistible__bu -----MRETVIVEAVRTAVGK--RNGALADVHAADLSAVVLSELVER-AG
MUL_2563|M.ulcerans_Agy99 --MSQSRDAVIVGAVRTPIGKGKANGALHQVLPADLLAHSLRELAAR-TG
MMAR_1317|M.marinum_M --MSQSRDAVIVGAVRTPIGKGKANGALHQVLPADLLAHSLRELAAR-TG
MAV_4185|M.avium_104 ----MNRDAVIVGAVRTPIGKGKASGALHDVLPADLLAHSLRELVAR-TG
Mflv_3782|M.gilvum_PYR-GCK MAAHSDRDAVIVGAVRTPVGKGKAGGALHGVLPADLLAHSLRELVGR-TG
Mvan_2617|M.vanbaalenii_PYR-1 MTGYTDRDAVIVAAVRTPVGKGKANGALHDVLPADLLAHSLREVVTR-AG
MSMEG_3012|M.smegmatis_MC2_155 MSGFAGRDAVIVGAVRTPVGKGKANGALHGVLPADLLAHSLRELISR-TG
MAB_3455c|M.abscessus_ATCC_199 -----MRDAVIIDAVRTPVGKGKPGGSLSGVHPVDLHAHAIRELVER-AG
MLBr_02162|M.leprae_Br4923 ----MSEEAFIYEAIRTPRGK-QKNGSLHEVKPVSLVVGLVEELRKRNPD
:: : *:**. ** .*:* : ...* . : * ..
Mb3586c|M.bovis_AF2122/97 IDPAAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVPGVTVDRQCGSS
Rv3556c|M.tuberculosis_H37Rv IDPAAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVPGVTVDRQCGSS
TH_0255|M.thermoresistible__bu IDPELIDDVIWGCVSQVGDQSSNIGRYAVLAAGWPETIPGTTVNRACGSS
MUL_2563|M.ulcerans_Agy99 VDPVQVDDVIAGAVTQVGDQAVNIARNALLGAGFPESVPGVTIDRQCGSS
MMAR_1317|M.marinum_M VDPVQVDDVIAGAVTQVGDQAVNIARNALLGAGFPESVPGVTIDRQCGSS
MAV_4185|M.avium_104 VDPAQVDDVIAGAVTQVGDQAVNIARNALLGAGFPESVPGVTIDRQCGSS
Mflv_3782|M.gilvum_PYR-GCK VDPAEVDDVIAGAVTQVGDQAVNIARNALLGAGFPESVPGTTVDRQCGSS
Mvan_2617|M.vanbaalenii_PYR-1 VDPAEVDDVIAGAVTQVGDQAVNIARNALLGAGFPESVPGTTVDRQCGSS
MSMEG_3012|M.smegmatis_MC2_155 VDSAQVDDVIAGAVTQVGDQAVNIARNALLGAGFPESVPGTTVDRQCGSS
MAB_3455c|M.abscessus_ATCC_199 IDPALIDDVISGAVGQVGEQSSNTARWAALAAGLPETVPAVTVDRQCGSS
MLBr_02162|M.leprae_Br4923 LDENLISDVILGCVSPVGDQGGDIARATVLAAGLPVTAGGVQLNRFCASG
:* :.*** *.* :* *. : .* : *.** * .. ::* *.*.
Mb3586c|M.bovis_AF2122/97 QQAISFGAQAIMSGTADVIVAGGVQNMSQIPIS-SAMTVGEQFGFTSPTN
Rv3556c|M.tuberculosis_H37Rv QQAISFGAQAIMSGTADVIVAGGVQNMSQIPIS-SAMTVGEQFGFTSPTN
TH_0255|M.thermoresistible__bu QQALDFAVHAVMSGQQDVVVAGGVEVMSRVPLG-AARATGMPYG------
MUL_2563|M.ulcerans_Agy99 QQAISFAAQGVLAGAYDLVIAGGVESMSRVPMGTSVLPGSNPFG------
MMAR_1317|M.marinum_M QQAISFAAQGVLAGAYDLVIAGGVESMSRVPMGTSVLPGSNPFG------
MAV_4185|M.avium_104 QQAISFAAQGVIAGAYDVVIAAGVESMGRVPMGSQVLPGSNPFG------
Mflv_3782|M.gilvum_PYR-GCK QQAISFAAQGVLSGAYDVVIAAGVESMSRVPMGSSVLPGSNPFG------
Mvan_2617|M.vanbaalenii_PYR-1 QQAISFAAQGVLAGAYDIVIAAGVESMSRVPMGSSVLPGSNPFG------
MSMEG_3012|M.smegmatis_MC2_155 QQAISFAAQGVLAGAYDIVIAAGVESMSRVPMGSSVLPGSDPFG------
MAB_3455c|M.abscessus_ATCC_199 QQAIHFAAQGVIAGAYDVVIASGIESMSRVPMGSQSL-GKDFFG------
MLBr_02162|M.leprae_Br4923 LEAVNTAAQKVRSGWDDLVLAGGVESMSRVPMG----SDGGAMG------
:*: ..: : :* *:::*.*:: *.::*:. *
Mb3586c|M.bovis_AF2122/97 ESKQWLHRYGDQEISQFRGSELIAEKWNLSREEMERYSLTSHERAFAAIR
Rv3556c|M.tuberculosis_H37Rv ESKQWLHRYGDQEISQFRGSELIAEKWNLSREEMERYSLTSHERAFAAIR
TH_0255|M.thermoresistible__bu --PKVLERYDNFGFNQGISAELIAERWNLSRTRLDEYSAQSHERAAAAQS
MUL_2563|M.ulcerans_Agy99 --PDMNNRYPDGLVPQGISAELIAARWGLSRTQLDEFSAASHDKAARATK
MMAR_1317|M.marinum_M --ADMNNRYPDGLVPQGISAELIAARWGLSRTQLDEFSAASHDKAARATK
MAV_4185|M.avium_104 --EAMNARYPEGLVPQGISAELIAAKWGFSRTQLDEFSAASHEKAARATK
Mflv_3782|M.gilvum_PYR-GCK --RDMAGRYPEGLVSQGISAELIAAKWNLSRARLDEFSAESHQKAARATK
Mvan_2617|M.vanbaalenii_PYR-1 --TGMAERYPEGLVAQGVSAELIAAKWNLSRTQLDEFSAESHQKAARATK
MSMEG_3012|M.smegmatis_MC2_155 --VAFAERYSEGIVPQGISAELIAAKWNLSRAQLDEFSAASHEKAARATK
MAB_3455c|M.abscessus_ATCC_199 --SEVARRYPEGLVPQGISAELIAAKWNLSREQLDTFAAESHRRAAQAWS
MLBr_02162|M.leprae_Br4923 --LDPATNYDVMFVPQGIGADLIATIEGFSRDDVDVYALRSQEKAAAAWS
.* . * .::*** .:** :: :: *: :* *
Mb3586c|M.bovis_AF2122/97 AGHFENEIITVETESG-----PFRVDEGPRE-SSLEKMAGLQP-LVEGGR
Rv3556c|M.tuberculosis_H37Rv AGHFENEIITVETESG-----PFRVDEGPRE-SSLEKMAGLQP-LVEGGR
TH_0255|M.thermoresistible__bu SGAFKDQIVPVFTDDA-----VVTEDEGIRRGTTVEKLATLKPAFTENGV
MUL_2563|M.ulcerans_Agy99 DGLFDNELIPIAG---------LTHDEIIRPGATVDTLAALRPAFYSDAI
MMAR_1317|M.marinum_M DGLFDNELIPIAG---------LTHDEIIRPGTTVDTLAALRPAFYSDAI
MAV_4185|M.avium_104 DGLFDNELIPIAG---------LATDEFIRPGTTVQTLAGLQPAFYSEAT
Mflv_3782|M.gilvum_PYR-GCK DGLFDNELAPIAG---------LEYDEIIRPDTTVETLAGLRPAFFDDAI
Mvan_2617|M.vanbaalenii_PYR-1 DGLFDHELAPIAG---------LSTDEIIRPDTTVETLAGLRPAFYNEAI
MSMEG_3012|M.smegmatis_MC2_155 EGLFEAELAPIAG---------LSTDEIIRPGTTVETLAGLKPAFYHESY
MAB_3455c|M.abscessus_ATCC_199 EGRFARDVVPIKAPDVNGDLVEVSTDESVRPSTTVEVLAGLKPAFRNELW
MLBr_02162|M.leprae_Br4923 GGYFAKSVVPVRDQNG---LLILDHDEHMRPDTSKEGLAKLKPAFEGLAA
* * .: .: . ** * :: : :* *:* :
Mb3586c|M.bovis_AF2122/97 ---------------------LTAAMASQISDGASAVLLASERAVKDHGL
Rv3556c|M.tuberculosis_H37Rv ---------------------LTAAMASQISDGASAVLLASERAVKDHGL
TH_0255|M.thermoresistible__bu ---------------------IHAGNSSQISDGAAALLVMTAETAVTLGL
MUL_2563|M.ulcerans_Agy99 K-----------ERFPQINWSITPGNSSPLSDSSAAVMITSSDVARKLGL
MMAR_1317|M.marinum_M K-----------ERFPQINWSITPGNSSPLSDGSAAVMITSSDVARKLGL
MAV_4185|M.avium_104 E-----------ARFPQINWEITAGNSSPLSDGSAAVLITSSETAARLGL
Mflv_3782|M.gilvum_PYR-GCK G-----------ARFPQIGWEITPGNSSPLSDGSAAVMITSGAAARRLGL
Mvan_2617|M.vanbaalenii_PYR-1 G-----------ARFPQIGWNITPGNSSPLSDGSAAVLITSGAAARRLGL
MSMEG_3012|M.smegmatis_MC2_155 A-----------ARFPQINWEITPGNSSPLSDGSAAVMITSGETAKRLGL
MAB_3455c|M.abscessus_ATCC_199 Q-----------QRFPGLDWKVTAGNSSPINDGASAVLITSSETAHRLGL
MLBr_02162|M.leprae_Br4923 MGGFDDVALQKYHWVEKINHVHTGGNSSGIVDGAALVMIGSEAVGKSQGL
. :* : *.:: ::: : . **
Mb3586c|M.bovis_AF2122/97 RPRARIHHISARAADPVFMLTGPIPATRYALDKTGLAIDDIDTVEINEAF
Rv3556c|M.tuberculosis_H37Rv RPRARIHHISARAADPVFMLTGPIPATRYALDKTGLAIDDIDTVEINEAF
TH_0255|M.thermoresistible__bu TPIVRYRAGAVTGADPVLMLTGPIPATEKVLRKTGLNIDDIGVFEVNEAF
MUL_2563|M.ulcerans_Agy99 RPLARIHTTTVVGSDPLYMLTGVIAATEKALRRAGLALRDIDLFEVNEAF
MMAR_1317|M.marinum_M RPLARIHTTTVVGSDPLYMLTGVIAATEKALRRAGLALRDIDLFEVNEAF
MAV_4185|M.avium_104 RPLARIHTTAVVGSDPLYMLTGVIPATEKVLSKAGLTLADIDLFEVNEAF
Mflv_3782|M.gilvum_PYR-GCK RPLARIHTTVVVGSDPLYMLTGVIPATEKALARSGLTLSDIDLFEVNEAF
Mvan_2617|M.vanbaalenii_PYR-1 RPLARIHTTVAVGSDPLYMLTGVIPATEKVLARSGLSLSDIDLFEVNEAF
MSMEG_3012|M.smegmatis_MC2_155 KPLARIHTTTVVGSDPLYMLTGVIPATEKVLRRAGLTLADIDLFEVNEAF
MAB_3455c|M.abscessus_ATCC_199 TPRARVHSVAVVGDDPLYMLTGIIPATAKVLDRAGLSLADIDAFEVNEAF
MLBr_02162|M.leprae_Br4923 TPRARMVATATSGADPVIMLTGPTPATRKVLDRAGLTVDDIDLFELNEAF
* .* . . **: **** .** .* ::** : **. .*:****
Mb3586c|M.bovis_AF2122/97 APVVMAWLKEIKAD-----PAKVNPNGGAIALGHPLGATGAKLFTTMLGE
Rv3556c|M.tuberculosis_H37Rv APVVMAWLKEIKAD-----PAKVNPNGGAIALGHPLGATGAKLFTTMLGE
TH_0255|M.thermoresistible__bu APVPLAWQAETGAD-----PAKLNPLGGAIALGHPLGASGAVLMTRMVHH
MUL_2563|M.ulcerans_Agy99 APVVLAWAKDTGAD-----LAKTNVNGGAIAIGHPLGASGARIMTTLVNA
MMAR_1317|M.marinum_M APVVLAWAKDTGAD-----LAKTNVNGGAIAIGHPLGASGARIMTTLVNA
MAV_4185|M.avium_104 APVVLAWAQDTGAD-----LDKTNVNGGAIAIGHPLGASGARIITTLVNA
Mflv_3782|M.gilvum_PYR-GCK APVVLSWAADVGGGDGADVLSRTNVHGGAIAIGHPLGASGARIMTTLVNA
Mvan_2617|M.vanbaalenii_PYR-1 APVVLAWARDTGAD-----LARTNVHGGAIAIGHPLGASGARIMTTLVNA
MSMEG_3012|M.smegmatis_MC2_155 APVVLAWAADTGAD-----LSKTNVNGGAIAIGHPLGASGARIMTTLVNA
MAB_3455c|M.abscessus_ATCC_199 ASVVLAWQAETGAD-----LSKVNVNGGATAIGHPLGASGGRLMTTLVSV
MLBr_02162|M.leprae_Br4923 ASVVLKFQKDLNIP-----DEKLNVNGGAIAMGHPLGATGAMILGTMVDE
*.* : : : : * *** *:******:*. :: ::
Mb3586c|M.bovis_AF2122/97 LERIGGRYGLQTMCEGGGTANVTIIERL-
Rv3556c|M.tuberculosis_H37Rv LERIGGRYGLQTMCEGGGTANVTIIERL-
TH_0255|M.thermoresistible__bu MRANGIRYGLQTMCEGGGTANATVVELLA
MUL_2563|M.ulcerans_Agy99 SEQRGGRYGLQTMCEGGGMANATIIERLG
MMAR_1317|M.marinum_M LEQRGGRYGLQTMCEGGGMANATIIERLG
MAV_4185|M.avium_104 LEQRGGRYGLQTMCEGGGMANATIIERLS
Mflv_3782|M.gilvum_PYR-GCK LEQRAGRYGLQTMCEGGGMANATIIERL-
Mvan_2617|M.vanbaalenii_PYR-1 LEQRDGRYALQTMCEGGGMANATIIERL-
MSMEG_3012|M.smegmatis_MC2_155 LHQRGARYGLQTMCEGGGMANATIIERL-
MAB_3455c|M.abscessus_ATCC_199 LEQGGGRYGLQTMCEAGGLANATILERL-
MLBr_02162|M.leprae_Br4923 LERCNARRALVTLCIGAGMGVATIIERV-
. * .* *:* ..* . .*::* :