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RGDRLRKLARRPRPLTRATAELVNAANGLRPISRNPYAAFFVFSLGWPTSEVPGLYLTASVVDALRRGRR GDFAGPKGKVALALTAAAWATLGVIRYRGITTPGPVLEEGLTEGLGADYAQELATLPAEPTRRGRRNLPL RTTVARRLYVEKTNIVAYGPHRRANLADIWRRRDLPRDGKAPVLVQVPGGAWVLGSRRPQAYPLMSNLVS RGWVCVSLNYRVSPLHTWPAHIVDVKRALAWVKENIADYGGDPDFVAISGGSAGGHLSALAALTPNEPRF QPGFEEADTSVAAAVPIYGRYDWYSTEAEGRPEFVELLARFVVKRKFRDHREVFVDASPIHHVQADAPPF FVLHGQDDSLIPVVEAREFVEELRAVSKSPVAYAELPNAQHAFDIFGSPRAHKASEAVARFLSWVYVTNG PGPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1819 | lipO | - | 100% (425) | esterase LipO |
| M. ulcerans Agy99 | MUL_2704 | lipM | 5e-99 | 48.64% (403) | membrane-bound esterase LipM |
| M. ulcerans Agy99 | MUL_3766 | lipQ | 2e-84 | 45.19% (385) | carboxylesterase LipQ |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1461c | lipO | 0.0 | 79.90% (418) | esterase LipO |
| M. gilvum PYR-GCK | Mflv_0436 | - | 1e-147 | 62.35% (409) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1426c | lipO | 0.0 | 79.90% (418) | esterase LipO |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2814 | - | 2e-15 | 42.55% (94) | lipase LipH |
| M. marinum M | MMAR_2232 | lipO | 0.0 | 98.59% (427) | esterase LipO |
| M. avium 104 | MAV_3350 | - | 0.0 | 75.66% (419) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0302 | - | 1e-137 | 59.17% (409) | peptidase, S9A/B/C families |
| M. thermoresistible (build 8) | TH_1904 | - | 1e-156 | 64.79% (409) | peptidase, S9A/B/C families |
| M. vanbaalenii PYR-1 | Mvan_0231 | - | 1e-144 | 63.12% (404) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1819|M.ulcerans_Agy99 MRGDRLRKLARRPRP--LTRATAELVNAANGLRPISRNPYAAFFVFSLGW
MMAR_2232|M.marinum_M MRGDRLRKLARRPRPRPLTRATAELVNAANGLRPISRNPYAAFFVFWLGW
Mb1461c|M.bovis_AF2122/97 MR---FRRMAR-PRP--LTRAAVELLNAANGLRPLSGSGYSTVLAFWLGW
Rv1426c|M.tuberculosis_H37Rv MR---FRRMAR-PRP--LTRAAVELLNAANGLRPLSGSGYSTVLAFWLGW
MAV_3350|M.avium_104 MR---LMRTLRKPRP--LARATLELANAANGFRPLARKGYSTVLVFWFGW
Mflv_0436|M.gilvum_PYR-GCK ---------MPKPRP--LLRAAAELLNAANGVQPLARDGYPTIPVFAFGW
Mvan_0231|M.vanbaalenii_PYR-1 ---------MPKRRP--LLRAVAELLNAANGLRPLARDGYLTIPVFAFGW
TH_1904|M.thermoresistible__bu -------VAVRKRRP--LLRAAAELANAANGVRPLGREGYITIPAFAFGW
MSMEG_0302|M.smegmatis_MC2_155 -----------MAKP--LLTASAEVLNAVNAVKPFGRKGYSTVVAFAFGW
MAB_2814|M.abscessus_ATCC_1997 -------------------------MTATAGIDPIIVKILEAVPIQLVSP
.*. .. *: . :. ..
MUL_1819|M.ulcerans_Agy99 PTSEVPGLYLTASVVDALRRGRRGDFAGPKGKVALALTAAAWATLGVIRY
MMAR_2232|M.marinum_M PTSEVPGLYLTASVVDALRRGRRGDFAGPKGKVALALTAAAWATLGVIRY
Mb1461c|M.bovis_AF2122/97 PTSEVPGVYLGASVLDALRRGRRGDFGGLKGKAALALTAAAWVILAVIRY
Rv1426c|M.tuberculosis_H37Rv PTSEVPGVYLGASVLDALRRGRRGDFGGLKGKAALALTAAAWVILAVIRY
MAV_3350|M.avium_104 PASEVPGIYFSASLLDALRRGRRGDFAGRRGKAALALTAASWAILGVIKY
Mflv_0436|M.gilvum_PYR-GCK PTSELSPLYMAGSMADAVRRGIRGDFRGPRGRIALGLTAVAWALLYLIHR
Mvan_0231|M.vanbaalenii_PYR-1 PTSEVSPLYMAGSMLDAIRRGVRGDFRGARGRIALLLTAAAWALLYLIHR
TH_1904|M.thermoresistible__bu PTSEAAPLYLLASVLDALRRGLRGDFSGARGRIALLLTGVTWALLGLLMY
MSMEG_0302|M.smegmatis_MC2_155 PTSENGPLITTVSALDALRRAVRGDYRTTPGRISLLLKAVAWALLYIVHR
MAB_2814|M.abscessus_ATCC_1997 DGPQAS--------RDAYR--------------AIATARPPWIEVANIED
.: ** * :: .* : :
MUL_1819|M.ulcerans_Agy99 RGITTPGPVLEEGLTEGLGADYAQELATLP-AEPTRRGRRNLPLRTTVAR
MMAR_2232|M.marinum_M RGITTPGPVLEEGLTEGLGADYAQELATLP-TEPTRRGRRNLPLRTTVAR
Mb1461c|M.bovis_AF2122/97 RGATTPGPVLEAGLTEQLGPDYAKELATLP-TEPMRSRGRNLPLRTAMAR
Rv1426c|M.tuberculosis_H37Rv RGATTPGPVLEAGLTEQLGPDYAKELATLP-TEPMRSRGRNLPLRTAMAR
MAV_3350|M.avium_104 RGITTPGPVLEVGLRDQLGDDYTEALNKLPQSRPTRSGRRTLPLGNIVAR
Mflv_0436|M.gilvum_PYR-GCK RNVASQ-PHFEEPLRDVLGDDYQEIAEKAKSSRR-RYFG---VFPNEVIR
Mvan_0231|M.vanbaalenii_PYR-1 RNVAAQ-PYFEDPLREALGENYQRIAEAAKSSRR-RRVG---VFPPDLVR
TH_1904|M.thermoresistible__bu RNVRSE-RYFEAGLRETLGDDYETVADRSQPARQLRRRG---IVGTSLSR
MSMEG_0302|M.smegmatis_MC2_155 RNRTSR-RFFEEPLRSALGADYA-VARRAR-----RPGG---VIRTSWAR
MAB_2814|M.abscessus_ATCC_1997 RTIPGP--------------------------------------AGEIPV
*
MUL_1819|M.ulcerans_Agy99 RLYVEKTNIVAYGPHRRANLADIWRRRDLPRDGKAPVLVQVPGGAWVLGS
MMAR_2232|M.marinum_M RLYVEKTNIVAYGPHRRANLADIWRRRDLPRDGKAPVLVQVPGGAWVLGW
Mb1461c|M.bovis_AF2122/97 RRYVETTNVVCYGPYGRANLADIWRRRDLPRDAKAPVLVQVPGGAWVLGW
Rv1426c|M.tuberculosis_H37Rv RRYVETTNVVCYGPYGRANLADIWRRRDLPRDAKAPVLVQVPGGAWVLGW
MAV_3350|M.avium_104 RRYVEKTNVVSYGPHGRANLADIWRRRDLPRDGKAPVLLQVPGGAWAIGM
Mflv_0436|M.gilvum_PYR-GCK RRYVEKAGTVQYGPLR-VNRADIWRRPDLPRDGKAPVLLQVPGGAWAIGM
Mvan_0231|M.vanbaalenii_PYR-1 RRYVESV--VQYGPLR-VNRADIWRRADLPRDGKAPVLLQVPGGAWAIGM
TH_1904|M.thermoresistible__bu RRYVQRHSVVRYGPHGNANLADIWRRSDLPPDAKAPVLLQVPGGAWSIGM
MSMEG_0302|M.smegmatis_MC2_155 HRYATTT--VRYGPHR-ANLADIWMRPDLPRDGKAPVLLQVPGGAWMIGM
MAB_2814|M.abscessus_ATCC_1997 RIYSPAEG------------------------GVRPVFVLIHGGGWVIGD
: * . **:: : **.* :*
MUL_1819|M.ulcerans_Agy99 RRPQAYPLMSNLVSRGWVCVSLNYRVSPLHTWPAHIVDVKRALAWVKENI
MMAR_2232|M.marinum_M RRPQAYPLMSNLVSRGWVCVSLNYRVSPLHTWPAHIVDVKRALAWVKENI
Mb1461c|M.bovis_AF2122/97 RRPQAYPLMSHLAARGWVCVSLNYRVSPRHTWPDHIVDVKRALAWVKENI
Rv1426c|M.tuberculosis_H37Rv RRPQAYPLMSHLAARGWVCVSLNYRVSPRHTWPDHIVDVKRALAWVKENI
MAV_3350|M.avium_104 RRPQAYPLMSHLAARGWVCVSIGYRVSPRHTWPDHIVDVKRALAWVKENI
Mflv_0436|M.gilvum_PYR-GCK RKPQSYPLMSHLADHGWICVSIDYRVSPRNTWPDHIVDVKRALAWIKEHI
Mvan_0231|M.vanbaalenii_PYR-1 RRPQAYPLLSHLADHGWICVSIDYRVSPRNTWPDHIVDVKRALAWIKEHI
TH_1904|M.thermoresistible__bu RRPQAYPLLSRLAERGWVCVSIAYRVSPRHTWPDHIVDVKRALAWIKENI
MSMEG_0302|M.smegmatis_MC2_155 RRPQSYPLMSHLAEQGWICVSIGYRISPKHSWPDHIVDVKQALAWVKANI
MAB_2814|M.abscessus_ATCC_1997 LDTHDAVARAAAVQADAVVVSVDYRLAPEHPYPAAVEDCWAALQWVHEHA
.: : . . : **: **::* :.:* : * ** *:: :
MUL_1819|M.ulcerans_Agy99 ADYGGDPDFVAISGGSAGGHLSALAALTPNEPRFQPGFEEADTSVAAAVP
MMAR_2232|M.marinum_M ADYGGDPDFVAISGGSAGGHLSALAALTPNEPRFQPGFEEADTSVAAAVP
Mb1461c|M.bovis_AF2122/97 AAYGGDPNFVAISGGSAGGHLCALAALTPNDPRFQPGFEQVDTSVAAAVP
Rv1426c|M.tuberculosis_H37Rv AAYGGDPNFVAISGGSAGGHLCALAALTPNDPRFQPGFEQVDTSVAAAVP
MAV_3350|M.avium_104 ARYGGDPNFVAITGGSAGGHLCSLAALTPNDPKYQPGFEDADTSVVAAVP
Mflv_0436|M.gilvum_PYR-GCK AEYGGDPDFVAITGGSAGGHLSSLAALTADDPQFQPGFEDADTSVVAAVP
Mvan_0231|M.vanbaalenii_PYR-1 AEYGGDPDFVAITGGSAGGHLSALAALTADDPQFQPGFEDADTSVAAAVP
TH_1904|M.thermoresistible__bu ADYGGDPDQVSITGGSAGGHLTALAALTQNDPVWQPGFEDADTSVVAAVP
MSMEG_0302|M.smegmatis_MC2_155 ADFGGDPESVCITGGSAGGHLTALAALTPNDPKWQPGFEDADTSVVAAVP
MAB_2814|M.abscessus_ATCC_1997 AEIGGDPGRLAVGGDSAGGNLSAVMAQLARDNGIDLAFQVLWYPATTFDT
* **** :.: *.****:* :: * : : .*: ...: .
MUL_1819|M.ulcerans_Agy99 IYGRYDWYSTEAEGRPEFVELLARFVVKRKFRDHREVFVDASPIHHVQAD
MMAR_2232|M.marinum_M IYGRYDWYSTEAEGRPEFVELLARFVVKRKFRDHREVFVDASPIHHVRAD
Mb1461c|M.bovis_AF2122/97 VYGRYDWFTTDAPGRREFVGLLETFVVKRKFSTHRDIFVDASPIHHVRAD
Rv1426c|M.tuberculosis_H37Rv VYGRYDWFTTDAPGRREFVGLLETFVVKRKFSTHRDIFVDASPIHHVRAD
MAV_3350|M.avium_104 VYGRYDWFTTEGEGRREFVQLLEKFVVKKKFATHRDIYVDASPIRRLRAD
Mflv_0436|M.gilvum_PYR-GCK VYGRYDWVSAQGSGRREFLAFLQKFVVKKPVTRNRQVYVDASPTHRLRAD
Mvan_0231|M.vanbaalenii_PYR-1 IYGRYDWVSGRGSGRREFIAFLQEFVVKKPISGNRQLYVDASPRYRLRAD
TH_1904|M.thermoresistible__bu IYGRYDWYSSTGPGRREFIYFLQRLVVKKRITENRQIYLDASPIRHVRAD
MSMEG_0302|M.smegmatis_MC2_155 VYGRYDWYSTTGPGRTEFMEILERLIVKRPLDGNAELYRDASPIMLVRPD
MAB_2814|M.abscessus_ATCC_1997 TLPSMVENAEAPVLDFKTVGALSKWYLGDTNPATAGPTLVPARAENFEGL
: : : * : .: ..
MUL_1819|M.ulcerans_Agy99 APPFFVLHGQDDSLIPVVEAREFVEELRAVSKSPVAYAELPNAQHAFDIF
MMAR_2232|M.marinum_M APPFFVLHGQDDSLIPVVEAREFVEELRAVSKSPVAYAELPNAQHAFDIF
Mb1461c|M.bovis_AF2122/97 APPFFVLHGRHDSLIPVAEAHAFVEELRAVSKSPVAYADLPHAQHAFDVF
Rv1426c|M.tuberculosis_H37Rv APPFFVLHGRHDSLIPVAEAHAFVEELRAVSKSPVAYADLPHAQHAFDVF
MAV_3350|M.avium_104 APPFFVLHGRDDSLIPVGEAQEFVEELRAVSKSPVAYAELPHAQHAFDIF
Mflv_0436|M.gilvum_PYR-GCK APPFFILHGQDDSIIPVPEGREFAEALKEVSTSPVVYAEIPYAQHAFDFY
Mvan_0231|M.vanbaalenii_PYR-1 APPFFILHGRDDSIIPVPEGRAFAEALRNVSTSPVVYAEIPHAQHAFDFY
TH_1904|M.thermoresistible__bu APPFFVLHGVDDSIIPVGEAREFVEALRAVSTAPVAYVEVPHAQHAFDFF
MSMEG_0302|M.smegmatis_MC2_155 APPFFVLHGTNDSLIPVVEGRDFVAALREVSNSPVVYAEIPHAQHAFDFF
MAB_2814|M.abscessus_ATCC_1997 APAFIGTAQFDP---LRDDGAKYAELLRDAG-VPVQLHNAPTLIHGYLGY
**.*: . :. :. *: .. ** : * *.: :
MUL_1819|M.ulcerans_Agy99 -GSPRAHKASEAVARFLSWVYVTNGPGPR----------
MMAR_2232|M.marinum_M -GSPRAHKASEAVARFLSWVYVTNGPGPR----------
Mb1461c|M.bovis_AF2122/97 -GSPRAHHTAEAVARFLSWVYATNPPAT-----------
Rv1426c|M.tuberculosis_H37Rv -GSPRAHHTAEAVARFLSWVYATNPPAT-----------
MAV_3350|M.avium_104 -SSPRAHRSAEAVARFLSWVYATNPPERD----------
Mflv_0436|M.gilvum_PYR-GCK YGSPRAHYTAQAIETFLSWVMATRRSESADRPTSPVRAS
Mvan_0231|M.vanbaalenii_PYR-1 YGSPRAHYTAQAVEEFLSWVQGER---MLARKAG-----
TH_1904|M.thermoresistible__bu -GSPRGHYTAEAVETFLSWVQATRR--------------
MSMEG_0302|M.smegmatis_MC2_155 -GSPHGHFTADAVEKFLNWVLAKRGVAQNR---------
MAB_2814|M.abscessus_ATCC_1997 -ADIVPSATEERDLSLAALKQALHG--------------
.. : : : .