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MTTEAPPAHDLEARRPFPPRMGPKGSLIYKIITTTDHKMIGIMYMVACFIFFFIGGLMALLMRAALATPG LQFLSNEQYNQLFTMHGTAMLLFYATPVVFGFANLVLPLQIGAADVAFPRLNALSFWLFVFGALIALSGF IVPGGAADFGWRTAYTPLSNAAHSPGVGPDLWILGLAVGGLGTILGGVNMLTTVVCLRAPGMTMFRMPIF TWNIMVTSLLVLMIFPLLTAALFGLAADRHFGAHIYDPANGGVILFQQLFWFFGHPEVYVIALPFFGIVS EVIPVFSRKPIFGYTTLVYATLSIAALSVAVWAHHMFATGAVLLPFFSFMTFLIAVPTGLKFFNWIGTMW RGQLTFESPMLFSLGFLVTFLAGGLTGVLLASPPLDFHVSDTYFVVAHFHYTLFGTIVFATYAGIYFWFP KMTGRLLDERLAKFHFWLTFLGFHATFLVQHWLGNSGMPRRYADYLPTDGFQTLNVISTIGAFTLGVSVL PFVWNVFKSWRFGEPVLVDDPWGHGNSLGWATSCPPPRHNFTELPRIRSERPAFELHYPHMVKRLRAEAH VGRHEIETDTSELAGSPT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1333 | ctaD_1 | - | 100% (578) | cytochrome C oxidase polypeptide I CtaD_1 |
| M. ulcerans Agy99 | MUL_1887 | ctaD | 0.0 | 83.95% (567) | cytochrome C oxidase polypeptide I CtaD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3069c | ctaD | 0.0 | 85.36% (567) | cytochrome C oxidase polypeptide I |
| M. gilvum PYR-GCK | Mflv_4277 | - | 0.0 | 84.37% (563) | cytochrome-c oxidase |
| M. tuberculosis H37Rv | Rv3043c | ctaD | 0.0 | 85.36% (567) | cytochrome C oxidase polypeptide I |
| M. leprae Br4923 | MLBr_01728 | - | 0.0 | 83.77% (567) | cytochrome C oxidase, polypeptide I |
| M. abscessus ATCC 19977 | MAB_3389c | - | 0.0 | 83.63% (562) | cytochrome c oxidase polypeptide I |
| M. marinum M | MMAR_3296 | ctaD_1 | 0.0 | 98.96% (578) | cytochrome C oxidase polypeptide I CtaD_1 |
| M. avium 104 | MAV_3908 | ctaD | 0.0 | 85.33% (525) | cytochrome c oxidase, subunit I |
| M. smegmatis MC2 155 | MSMEG_4437 | ctaD | 0.0 | 82.06% (563) | cytochrome c oxidase, subunit I |
| M. thermoresistible (build 8) | TH_1815 | ctaD | 1e-157 | 80.67% (300) | PROBABLE CYTOCHROME C OXIDASE POLYPEPTIDE I CTAD (CYTOCHROME |
| M. vanbaalenii PYR-1 | Mvan_2082 | - | 0.0 | 84.55% (563) | cytochrome-c oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1333|M.ulcerans_Agy99 MTTEAPPAHDLEARRPFPPRMGPKGSLIYKIITTTDHKMIGIMYMVACFI
MMAR_3296|M.marinum_M MTTEAPPAHDLEARRPFPPRMGPKGSLIYKIITTTDHKMIGIMYMVACFI
Mb3069c|M.bovis_AF2122/97 MTAEAPPLGELEAIRPYPARTGPKGSLVYKLITTTDHKMIGIMYCVACIS
Rv3043c|M.tuberculosis_H37Rv MTAEAPPLGELEAIRPYPARTGPKGSLVYKLITTTDHKMIGIMYCVACIS
MLBr_01728|M.leprae_Br4923 MTAEALSSGELKAIRPYPARTGPKGNLVYKLITTTDHKMIGIMYCVACFI
MAV_3908|M.avium_104 --------------------------------------MIGIMYTVTCFA
Mflv_4277|M.gilvum_PYR-GCK MVAEAPPIGELEARRPFPERIGPKGNLIYKLITTTDHKLIGIMYCVACFA
Mvan_2082|M.vanbaalenii_PYR-1 MVAEAPPIGELEIRRPYPERLGPKGNLIYKLITTTDHKLIGIMYCVVCFA
MAB_3389c|M.abscessus_ATCC_199 MTAEAPPIGGLQASRPFPPRMGARGTLIYRLITTTDHKLIGIMYLVACFA
MSMEG_4437|M.smegmatis_MC2_155 MTTHAPSAGELLARRPFPQRLGPRWTLLYKLVTTTDHKLIGMMYVVACFI
TH_1815|M.thermoresistible__bu --------------------------------------------------
MUL_1333|M.ulcerans_Agy99 FFFIGGLMALLMRAALATPGLQFLSNEQYNQLFTMHGTAMLLFYATPVVF
MMAR_3296|M.marinum_M FFFIGGLMALLMRAELATPGLQFLSNEQYNQLFTMHGTAMLLFYATPVVF
Mb3069c|M.bovis_AF2122/97 FFFIGGLLALLMRTELAAPGLQFLSNEQFNQLFTMHGTIMLLFYATPIVF
Rv3043c|M.tuberculosis_H37Rv FFFIGGLLALLMRTELAAPGLQFLSNEQFNQLFTMHGTIMLLFYATPIVF
MLBr_01728|M.leprae_Br4923 FFFVGGLLALLMRTELAAPGLQFLSNEQFNQLFTMHGTIMLLFYATPIVF
MAV_3908|M.avium_104 FFFIGGLMALLMRTELAAPGLQFLSNEQFNQLFTMHGTIMLLLYATPVVF
Mflv_4277|M.gilvum_PYR-GCK FFLIGGLMALFMRTELALPGLQFLSNEQFNQLFTMHGTVMLLFYATPIVF
Mvan_2082|M.vanbaalenii_PYR-1 FFLIGGLMALFMRTELATPGLQFLSNEQFNQLFTMHGTVMLLFYATPIVF
MAB_3389c|M.abscessus_ATCC_199 FFLIGGLMALFMRAELAVPGLQFLSNEQFNQLFTMHGTVMLLFYATPIVF
MSMEG_4437|M.smegmatis_MC2_155 FFFIGGLMALLLRTELAVPGLQFLSNEQYNQLFTMHGTVMLLFYATPIVF
TH_1815|M.thermoresistible__bu --------------------------------------------------
MUL_1333|M.ulcerans_Agy99 GFANLVLPLQIGAADVAFPRLNALSFWLFVFGALIALSGFIVPGGAADFG
MMAR_3296|M.marinum_M GFANLVLPLQIGAPDVAFPRLNALSFWLFVFGALIALSGFIVPGGAADFG
Mb3069c|M.bovis_AF2122/97 GFANLVLPLQIGAPDVAFPRLNAFSFWLFVFGATIGAAGFITPGGAADFG
Rv3043c|M.tuberculosis_H37Rv GFANLVLPLQIGAPDVAFPRLNAFSFWLFVFGATIGAAGFITPGGAADFG
MLBr_01728|M.leprae_Br4923 GFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGAAIGMAGFITPGGAADFG
MAV_3908|M.avium_104 GFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGGLIAASGFIVPGGAADFG
Mflv_4277|M.gilvum_PYR-GCK GFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGALIATAGFITPGGAADFG
Mvan_2082|M.vanbaalenii_PYR-1 GFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGALIATAGFITPGGAADFG
MAB_3389c|M.abscessus_ATCC_199 GFANVVLPLQIGAPDVAFPRLNAFSFWLFLFGALIGIAGFITPGGAADFG
MSMEG_4437|M.smegmatis_MC2_155 GFANLVVPLQIGAPDVAFPRLNALSFWLFLFGASIALGGFLAPGGPADFG
TH_1815|M.thermoresistible__bu -------------------------------------VGRIR----ADLC
* : **:
MUL_1333|M.ulcerans_Agy99 WRTAYTPLSNAAHSPGVGPDLWILGLAVGGLGTILGGVNMLTTVVCLRAP
MMAR_3296|M.marinum_M W-TAYTPLSNAAHSPGVGPDLWILGLAVGGLGTILGGVNMLTTVVCLRAP
Mb3069c|M.bovis_AF2122/97 W-TAYTPLTDAIHSPGAGGDLWIMGLIVAGLGTILGAVNMITTVVCMRAP
Rv3043c|M.tuberculosis_H37Rv W-TAYTPLTDAIHSPGAGGDLWIMGLIVAGLGTILGAVNMITTVVCMRAP
MLBr_01728|M.leprae_Br4923 W-TAYTPLTDAIHSPGVGGDLWIMGLIVAGLGTILGAVNMITTVVCLRAP
MAV_3908|M.avium_104 W-TAYTPLSDAVHSPGAGGDLWITGLIVAGLGTILGAVNMITTVVCMRAP
Mflv_4277|M.gilvum_PYR-GCK W-TAYSPLTDAIHSPGAGADLWIMGLAVGGLGTILGGVNMITTVVCMRAP
Mvan_2082|M.vanbaalenii_PYR-1 W-TAYSPLTDAIHSPGAGGDLWIMGLAVGGLGTILGAVNMITTVVCMRAP
MAB_3389c|M.abscessus_ATCC_199 W-TAYTPLTDAIHSPGAGADLWIMGLAVGGLGTILGAVNMITTVVCMRAP
MSMEG_4437|M.smegmatis_MC2_155 W-TAYTPLSNAMHSPGAGGDLWIFGLIVGGLGTILGAVNMITTVVCMRAP
TH_1815|M.thermoresistible__bu W-------DRAMRSR---------------------YVPYATTPARLLAQ
* * :* * ** . : *
MUL_1333|M.ulcerans_Agy99 GMTMFRMPIFTWNIMVTSLLVLMIFPLLTAALFGLAADRHFGAHIYDPAN
MMAR_3296|M.marinum_M GMTMFRMPIFTWNIMVTSLLVLMIFPLLTAALFGLAADRHLGAHIYDPAN
Mb3069c|M.bovis_AF2122/97 GMTMFRMPIFTWNIMVTSILILIAFPLLTAALFGLAADRHLGAHIYDAAN
Rv3043c|M.tuberculosis_H37Rv GMTMFRMPIFTWNIMVTSILILIAFPLLTAALFGLAADRHLGAHIYDAAN
MLBr_01728|M.leprae_Br4923 GMTMFRMPIFTWNILVTSILVLIAFPLLTAALFGLAADRHLGAHIYDAAN
MAV_3908|M.avium_104 GMTMFRMPIFTWNILVTSILILIAFPILTAALFGLAADRHLGAHVYDAAN
Mflv_4277|M.gilvum_PYR-GCK GMTMFRMPIFTWNILVTSILVLLAFPILTAALFGLAADRHLGAHVYDPAN
Mvan_2082|M.vanbaalenii_PYR-1 GMTMFRMPIFTWNILVTSILVLIAFPILTAALFGLAADRHLGAHVYDPAN
MAB_3389c|M.abscessus_ATCC_199 GMTMFRMPIFTWNILVTSVLVLLAFPLLTAALFGLAADRHLGAHVFDPAN
MSMEG_4437|M.smegmatis_MC2_155 GMIMFRMPIFTWNILVTSVIVLVAFPLLTSALFGLAADRNLGAHVFDPAN
TH_1815|M.thermoresistible__bu LLSDIVIALW------IAVWVLVGMAVHTA----VSTIAEVGRNVHTGAT
: : :.:: :: :*: :.: *: ::: ..* ::. *.
MUL_1333|M.ulcerans_Agy99 GGVILFQQLFWFFGHPEVYVIALPFFGIVSEVIPVFSRKPIFGYTTLVYA
MMAR_3296|M.marinum_M GGVILFQHLFWFFGHPEVYVIALPFFGIVSEVIPVFSRKPIFGYTTLVYA
Mb3069c|M.bovis_AF2122/97 GGVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLVYA
Rv3043c|M.tuberculosis_H37Rv GGVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLVYA
MLBr_01728|M.leprae_Br4923 GGVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLVYA
MAV_3908|M.avium_104 GGVLLWQHLFWFFGHPEVYIIALPFFGIITEIIPVFARKPVFGYTTLVYA
Mflv_4277|M.gilvum_PYR-GCK GGVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLIYA
Mvan_2082|M.vanbaalenii_PYR-1 GGVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLIYA
MAB_3389c|M.abscessus_ATCC_199 GGVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLIYA
MSMEG_4437|M.smegmatis_MC2_155 GGTMLWEHLFWFFGHPEVYIIALPFFGIVTEIFPVFSRKPVFGYTTLVYA
TH_1815|M.thermoresistible__bu G-------------VSEXXXVALPFFGIVTEIFPVFSRKPVFGYTALVYA
* .* :*******::*::***:***:****:*:**
MUL_1333|M.ulcerans_Agy99 TLSIAALSVAVWAHHMFATGAVLLPFFSFMTFLIAVPTGLKFFNWIGTMW
MMAR_3296|M.marinum_M TLSIAALSVAVWAHHMFATGAVLLPFFSFMTFLIAVPTGLKFFNWIGTMW
Mb3069c|M.bovis_AF2122/97 TLSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIAVPTGIKFFNWIGTMW
Rv3043c|M.tuberculosis_H37Rv TLSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIAVPTGIKFFNWIGTMW
MLBr_01728|M.leprae_Br4923 TLSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIAVPTGIKFFNWVGTMW
MAV_3908|M.avium_104 TLSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIAVPTGIKFFNWIGTMW
Mflv_4277|M.gilvum_PYR-GCK TLGIAALSVAVWAHHMYATGAVLLPFFSFMTFLIAVPTGIKFFNWIGTMW
Mvan_2082|M.vanbaalenii_PYR-1 TLGIAALSVAVWAHHMYATGAVLLPFFSFMTFLIAVPTGIKFFNWIGTMW
MAB_3389c|M.abscessus_ATCC_199 TLGIAALSIAVWAHHMYATGAVLLPFFSFMTFLIAVPTGIKFFNWIGTMW
MSMEG_4437|M.smegmatis_MC2_155 TISIGALSIAVWAHHLYATGAVLLPFFSFMTFMIAVPTGIKFVNWIGTMW
TH_1815|M.thermoresistible__bu TVGIGALSMAVWAHHMFATGAVLLPFFAFTTYLIAVPTGIKFFNWIGTMW
*:.*.***:******::**********:* *::******:**.**:****
MUL_1333|M.ulcerans_Agy99 RGQLTFESPMLFSLGFLVTFLAGGLTGVLLASPPLDFHVSDTYFVVAHFH
MMAR_3296|M.marinum_M RGQLTFESPMLFSLGFLVTFLAGGLTGVLLASPPLDFHVSDTYFVVAHFH
Mb3069c|M.bovis_AF2122/97 KGQLTFETPMLFSVGFMVTFLLGGLTGVLLASPPLDFHVTDSYFVVAHFH
Rv3043c|M.tuberculosis_H37Rv KGQLTFETPMLFSVGFMVTFLLGGLTGVLLASPPLDFHVTDSYFVVAHFH
MLBr_01728|M.leprae_Br4923 KGQLTFETPMLFSVGFAVTFLLGGLTGVLLASPPLDFHVTDSYFVVAHFH
MAV_3908|M.avium_104 KGQLTFETPMLFCVGFLLTFLLGGLTGVMLASPPLDFHVTDTYFVVAHFH
Mflv_4277|M.gilvum_PYR-GCK KGQLTFETPMLFSVGFILTFLLGGLSGVLLASPPLDFHVTDSYFVIAHFH
Mvan_2082|M.vanbaalenii_PYR-1 KGQLTFETPMLFSIGFIATFLLGGLSGVLLASPPLDFHVTDSYFVIAHFH
MAB_3389c|M.abscessus_ATCC_199 KGQLTFETPMIFSVGFLVTFLFGGLTGVLLAMPPVDFHVTDSYFVIAHFH
MSMEG_4437|M.smegmatis_MC2_155 KGQLTFETPMLFSVGFLVTFLLGGLTGVILASPPLDFHVTDSYFVVAHFH
TH_1815|M.thermoresistible__bu KGQLTFESPMLFSVGFILTFLIGGLSGVMLASPPLDFHVTDTYFLVAHFH
:******:**:*.:** *** ***:**:** **:****:*:**::****
MUL_1333|M.ulcerans_Agy99 YTLFGTIVFATYAGIYFWFPKMTGRLLDERLAKFHFWLTFLGFHATFLVQ
MMAR_3296|M.marinum_M YTLFGTIVFATYAGIYFWFPKMTGRLLDERLAKFHFWLTFLGFHATFLVQ
Mb3069c|M.bovis_AF2122/97 YVLFGTIVFATFAGIYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQ
Rv3043c|M.tuberculosis_H37Rv YVLFGTIVFATFAGIYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQ
MLBr_01728|M.leprae_Br4923 YVLFGTIVFSTFAGIYFWFPKMTGRLLDEQLGKLHFWLTFIGFHTTFLVQ
MAV_3908|M.avium_104 YVLFGTIVFATFAGVYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQ
Mflv_4277|M.gilvum_PYR-GCK YVLFGTIVFATYAGIYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQ
Mvan_2082|M.vanbaalenii_PYR-1 YVLFGTIVFATYAGIYFWFPKMTGRLLDERLGKVHFWLTFIGFHATFLVQ
MAB_3389c|M.abscessus_ATCC_199 YVLFGTIVFATYAGIYFWFPKMTGRLLDERLGKFHFWLTFIGFHSTFLVQ
MSMEG_4437|M.smegmatis_MC2_155 YVLFGTIVFATYAGVYFWFPKMTGRLLDDRLGKLHFWLTLIGFHTTFLVH
TH_1815|M.thermoresistible__bu YVLFGTIVFATFAGVYFWFPKMTGRMLDERLAKLHFWLTFIGFHTTFLVQ
*.*******:*:**:**********:**::*.*.*****::***:****:
MUL_1333|M.ulcerans_Agy99 HWLGNSGMPRRYADYLPTDGFQTLNVISTIGAFTLGVSVLPFVWNVFKSW
MMAR_3296|M.marinum_M HWLGNSGMPRRYADYLPTDGFQTLNVISTIGAFTLGVSVLPFVWNVFKSW
Mb3069c|M.bovis_AF2122/97 HWLGDEGMPRRYADYLPTDGFQGLNVVSTIGAFILGASMFPFVWNVFKSW
Rv3043c|M.tuberculosis_H37Rv HWLGDEGMPRRYADYLPTDGFQGLNVVSTIGAFILGASMFPFVWNVFKSW
MLBr_01728|M.leprae_Br4923 HWLGDMGMPRRYADYLPTDGFQGLNVVSTIGSFILGASMFPFVWNVFKSW
MAV_3908|M.avium_104 HWLGDLGMPRRYADYLPSDGFQPYNVASTVGAFILGASMFPFVWNVFKSW
Mflv_4277|M.gilvum_PYR-GCK HWLGDEGMPRRYADYLPSDGFTTLNIVSTIGAFILGLSTLPFLWNVFKSW
Mvan_2082|M.vanbaalenii_PYR-1 HWLGDEGMPRRYADYLPTDGFTTLNVVSTIGAFILGASTLPFLWNVFKSW
MAB_3389c|M.abscessus_ATCC_199 HWLGNQGMPRRYADYLPTDGFTFLNSFSTVGAFILGASTLPFLWNVFKSY
MSMEG_4437|M.smegmatis_MC2_155 HWLGAEGMPRRYADYLPTDGFTTLNIVSTIGSFILGVSMLPFVWNVFKSW
TH_1815|M.thermoresistible__bu HWLGNEGMPRRYADYLPTDGFTELNIVSSVGAFILGASMLPFIWNVFKSW
**** ***********:*** * *::*:* ** * :**:******:
MUL_1333|M.ulcerans_Agy99 RFGEPVLVDDPWGHGNSLGWATSCPPPRHNFTELPRIRSERPAFELHYPH
MMAR_3296|M.marinum_M RFGEPVLVDDPWGHGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPH
Mb3069c|M.bovis_AF2122/97 RYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPH
Rv3043c|M.tuberculosis_H37Rv RYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPH
MLBr_01728|M.leprae_Br4923 RYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPH
MAV_3908|M.avium_104 RYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPH
Mflv_4277|M.gilvum_PYR-GCK RYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPH
Mvan_2082|M.vanbaalenii_PYR-1 RYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPH
MAB_3389c|M.abscessus_ATCC_199 RYGEVVTVDDPWGYGNSLEWATSCPPPRHNFSELPRIRSERPAFELHYPH
MSMEG_4437|M.smegmatis_MC2_155 RYGEPVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPH
TH_1815|M.thermoresistible__bu RYGDPVTVDDPWGYGNSLEWATTCPPPRHNFYELPRIRSERPAFELHYPH
*:*: * ******:**** ***:******** ******************
MUL_1333|M.ulcerans_Agy99 MVKRLRAEAHVGRHEIETDTSELAGSPT------
MMAR_3296|M.marinum_M MVKRLRAEAHVGRHEIETDTSELAGSPT------
Mb3069c|M.bovis_AF2122/97 MVERLRAEAHVGRHHDEPAMVTSS----------
Rv3043c|M.tuberculosis_H37Rv MVERLRAEAHVGRHHDEPAMVTSS----------
MLBr_01728|M.leprae_Br4923 MVERLRDEAYVGRRHAEELVEVSLH---------
MAV_3908|M.avium_104 MVERLRAEAHVGRAHGPADKDVTRLDDVQVRS--
Mflv_4277|M.gilvum_PYR-GCK MIDRMRREAHVGRAHGPEDGDVTR-NEENVRT--
Mvan_2082|M.vanbaalenii_PYR-1 MVERMRTEAHVGRAHGPEDGDVTRLDDENVRT--
MAB_3389c|M.abscessus_ATCC_199 MSERMRAEAHVGGGH-------------------
MSMEG_4437|M.smegmatis_MC2_155 MIERLRAESHPGRTQGGPGAVTLPQPQARSHPVE
TH_1815|M.thermoresistible__bu MIERMRAESHIGRSHGPADGDVTRMEDTNVRT--
* .*:* *:: * .