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MDIVLGVSMEPGAVRLVLVEGIDADGVTVEEDTFELDTADRSQGAPAAAVAALIGTREGAIEGGYRLMSA GVTWTDPTDVAALRAELAGHDVGSVMLVSPLLAAAALAQTVGCALDYEYIAMLFVEADSATLAVVDIGDG SIVDLHRRSLGAESTAADLTSLVGGLATAQSVAEGVFVVGCGVDIVALKPVLEAATSLVVSVPEEPDMAL ARRAALASANAPLFASSTSALAYALDPGTGEVNPRALAPSYLDVCANADRGAGSLAYSALADDGEDAVEG RRRPLVLAGSAMLGIAAFAAGLMVVTLTSDVRPAAATQPSPREGVLTPASPAAPPKTATPVPAKAPAQVP APGPAPAASPVPVAAPPSVVQPPPVVRAPRPTVVKPPPQYIAPATQPRRTPAPQAPAPTPVQAPAPEVPP PVAVPEPAPAPPVPALVVERLVIQNDGVDLAE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1227 | - | - | 100% (452) | hypothetical protein MUL_1227 |
| M. ulcerans Agy99 | MUL_0637 | - | 2e-26 | 25.74% (505) | hypothetical protein MUL_0637 |
| M. ulcerans Agy99 | MUL_1004 | - | 3e-17 | 41.27% (126) | hypothetical protein MUL_1004 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0552 | - | 4e-28 | 28.60% (465) | hypothetical protein Mb0552 |
| M. gilvum PYR-GCK | Mflv_0290 | - | 7e-78 | 39.60% (495) | hypothetical protein Mflv_0290 |
| M. tuberculosis H37Rv | Rv0538 | - | 2e-28 | 27.62% (478) | hypothetical protein Rv0538 |
| M. leprae Br4923 | MLBr_00048 | - | 1e-10 | 35.25% (122) | hypothetical protein MLBr_00048 |
| M. abscessus ATCC 19977 | MAB_4296c | - | 5e-70 | 38.91% (442) | hypothetical protein MAB_4296c |
| M. marinum M | MMAR_0563 | - | 0.0 | 98.16% (434) | hypothetical protein MMAR_0563 |
| M. avium 104 | MAV_4848 | - | 1e-119 | 55.56% (450) | hypothetical protein MAV_4848 |
| M. smegmatis MC2 155 | MSMEG_0679 | - | 4e-81 | 40.22% (450) | hypothetical protein MSMEG_0679 |
| M. thermoresistible (build 8) | TH_3900 | - | 1e-67 | 40.50% (400) | PUTATIVE conserved hypothetical protein |
| M. vanbaalenii PYR-1 | Mvan_0590 | - | 9e-77 | 40.70% (457) | hypothetical protein Mvan_0590 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0552|M.bovis_AF2122/97 --------MDVALGVAVTDRVARLALVDS--------------AAPGTVI
Rv0538|M.tuberculosis_H37Rv --------MDVALGVAVTDRVARLALVDS--------------AAPGTVI
MUL_1227|M.ulcerans_Agy99 --------MDIVLGVSMEPGAVRLVLVEGI-------------DADGVTV
MMAR_0563|M.marinum_M --------MDIVLGVSMEPGAVRLVLVEGI-------------DADGVTV
MAV_4848|M.avium_104 --------MDIVLGVSMAPGTVRLVAIEGQ-------------NADGVTV
Mflv_0290|M.gilvum_PYR-GCK --------MDIVLGVSMTPTTVRMVLVEGE-------------KADGVTV
Mvan_0590|M.vanbaalenii_PYR-1 ----------------MTPTTVRMVLVEGE-------------KADGVTV
MSMEG_0679|M.smegmatis_MC2_155 --------MDIVLGVSMTPTTVRMVLVEGE-------------NADGITV
TH_3900|M.thermoresistible__bu --------VDIVLGVSMTPTTVRMVLVEGE-------------KADGVTV
MAB_4296c|M.abscessus_ATCC_199 --------MDVVLGVSMTPTTARLVLVEGA-------------GADGRIV
MLBr_00048|M.leprae_Br4923 MAADYDKLFRLDDGAYASPDQAAEQLFDDAPLYPPPIIPTCTTTPNGEVA
. .:. . *
Mb0552|M.bovis_AF2122/97 D-----QFVLDVAEH-------PVEVLTETVVGTDRSLAGENHRLVATRL
Rv0538|M.tuberculosis_H37Rv D-----QFVLDVAEH-------PVEVLTETVVGTDRSLAGENHRLVATRL
MUL_1227|M.ulcerans_Agy99 E-----EDTFELDTADRSQ--GAPAAAVAALIGTREGAIEGGYRLMSAGV
MMAR_0563|M.marinum_M E-----EDTFELDTADRSQ--SAPAAAVAALIGTREGAIEGGYRLMSAGV
MAV_4848|M.avium_104 E-----QEEFAVGAAGNSAN-SAADQVIDAIIGTREGVFEGGHRLTSTGV
Mflv_0290|M.gilvum_PYR-GCK D-----HDTFAVDSVEGSAN--AAEHVVSAVLGTRESAETGGHHLKSIGV
Mvan_0590|M.vanbaalenii_PYR-1 D-----HDVFHVDSADGSAN--VAEHVVSAIQGTKESAETGGHHLRSIGV
MSMEG_0679|M.smegmatis_MC2_155 D-----HDVFDVTAVEDAATMSAADQVVAAILGTQESADAGGHHLKSIGV
TH_3900|M.thermoresistible__bu D-----HDVFDISAVDGSATPSAAEQVVAAVLGTQESAAAGGHRLISIGV
MAB_4296c|M.abscessus_ATCC_199 D-----TDTIVVSEGEGTTS----EQVLSAIVGTRDGMLDGGHNLVSTGV
MLBr_00048|M.leprae_Br4923 SPMPDWSEQLPPNPPAASKSPLPPMPIGSSVQPPPASSESPRAPMPVSAP
. : :: . . :
Mb0552|M.bovis_AF2122/97 CWPDQAKADELQHALQDSGVHD-VAVISEAQAATALVGAA-----HAGSA
Rv0538|M.tuberculosis_H37Rv CWPDQAKADELQHALQDSGVHD-VAVISEAQAATALVGAA-----HAGSA
MUL_1227|M.ulcerans_Agy99 TWTDPTDVAALRAELAGHDVGS-VMLVSPLLAAAALAQTVGCALDYEYIA
MMAR_0563|M.marinum_M TWTDPTDVAALRAELAGHDAGS-VMLVSPLLAAAALAQTVGCALDYEYIA
MAV_4848|M.avium_104 TWTDPTGAAALRDAIASHELGN-VMLVSPLLAAAALAQTVGYALGYGHIG
Mflv_0290|M.gilvum_PYR-GCK TWSDHAEATALRDALAAHGIDD-VMLVSESHAAASLAQAVGRAVDYDTTA
Mvan_0590|M.vanbaalenii_PYR-1 TWSDHTEATALRDALATHGIDD-VMLVSEGHAAASLAQAVGRAVGYDTTA
MSMEG_0679|M.smegmatis_MC2_155 TWSDHSDASALRDSLTAHGIDD-VMLVSEGHAAAALAQAVGRAVGYDTTA
TH_3900|M.thermoresistible__bu AWSDHAEAAALREALAARGLDD-VMLVSELHAAGALAQAVGRRVGYDTTA
MAB_4296c|M.abscessus_ATCC_199 VWSDHAEAAELRDSLASRGIDG-VEFFSALHAGGALAKAASSVTGYDKSA
MLBr_00048|M.leprae_Br4923 PRSPAASLMPISEPPQWPPAEAPEHQFAKAEPPSVPIPINEPSPAKPATP
. : : .: .
Mb0552|M.bovis_AF2122/97 VLLVGDETATLSVVGDPDAPPTMVAVAPVAGADATSTVDTLMARLGD---
Rv0538|M.tuberculosis_H37Rv VLLVGDETATLSVVGDPDAPPTMVAVAPVAGADATSTVDTLMARLGD---
MUL_1227|M.ulcerans_Agy99 MLFVEADSATLAVVDIGDGSIVDLHRRSLG---AESTAADLTSLVGGLAT
MMAR_0563|M.marinum_M MLFVEADSATLAVVDIGDGSIVDLHRRSLG---AESTAADLTSLVGGLAT
MAV_4848|M.avium_104 MLFVEPRSATLAVVDVSDGSIVDLHRHQIPHGPGAPVAAELAAMVAGLDA
Mflv_0290|M.gilvum_PYR-GCK LLFVDRDTATLSVVKTDDGSVVKVLSRSLHSADAMAVLAEMAAAIDTRT-
Mvan_0590|M.vanbaalenii_PYR-1 LLFVDRDTATLSVVQTDDGSVVKVLSRSLHSADAMAVLTEMAEAVAA---
MSMEG_0679|M.smegmatis_MC2_155 LLFIDRDAATLSVVQTEDGSVVKVLGSSLHSTDAMAVLSDMAAAVVA---
TH_3900|M.thermoresistible__bu LFFIERDTATMAVVQTDDGSVVKVLSRDLHNADAMATLTEMALTVDG---
MAB_4296c|M.abscessus_ATCC_199 LLVIEPQTATLAVVDSADGSIVGLASEPLITGVTSGVLANLVNPLKG---
MLBr_00048|M.leprae_Br4923 MPMTPIDGSQRTPVTSPEPSLAEFEAQPPATPKPSLLPRPMSSPPEAPRP
: . : : * : . . . :
Mb0552|M.bovis_AF2122/97 QALAPGDVFLVGRSAEHTTVLADQLRAASTMRVQTPDDPTFALARGAAMA
Rv0538|M.tuberculosis_H37Rv QALAPGDVFLVGRSAEHTTVLADQLRAASTMRVQTPDDPTFALARGAAMA
MUL_1227|M.ulcerans_Agy99 AQSVAEGVFVVG-CGVDIVALKPVLEAATSLVVSVPEEPDMALARRAALA
MMAR_0563|M.marinum_M AQSVAEGVFVVG-CGVDIVALKPVLEVATSLVVSVPEEPDMALARGAALA
MAV_4848|M.avium_104 RDTRADGVFVVG-CGTDIVAVKPALEAASPVPVTGPEEPDMALARGAALA
Mflv_0290|M.gilvum_PYR-GCK QDAPPQGIFVVG-SGVDISSVKDHLKHLVAVPIHAPDDAELALARGAALA
Mvan_0590|M.vanbaalenii_PYR-1 QEAPPQGMFVVG-SGVDISSVKAHLEHLVSLPVSAPDDAELALARGAALA
MSMEG_0679|M.smegmatis_MC2_155 QETPPDGMFIVG-SGVDVSSVKEHLQHLVSMPVNAPEEPELALARGAALA
TH_3900|M.thermoresistible__bu QDSPPQGMFLIG-SGVDISELKAHLDKLLRLPVHAPEESDLALCRGAALA
MAB_4296c|M.abscessus_ATCC_199 KENAPDGVFLLG-LGTDVSDLAESLGDAIALPVNSPDQPELALARGAALA
MLBr_00048|M.leprae_Br4923 SANQHSRHARRGHHHRDETQQANPASATEPMIAPRARTAELRQAPHAAAE
* . : . . : . **
Mb0552|M.bovis_AF2122/97 AGAATMAHPALVADATTSLPPA--------------------------EA
Rv0538|M.tuberculosis_H37Rv AGAATMAHPALVADATTSLPRA--------------------------EA
MUL_1227|M.ulcerans_Agy99 SANAPLFASSTSALAYALDPGT--------------G-----------EV
MMAR_0563|M.marinum_M SANAPLFASSTSALAYALDPGT--------------G-----------EV
MAV_4848|M.avium_104 SANAPLFASSTAALAYALDPGT--------------G-----------EM
Mflv_0290|M.gilvum_PYR-GCK SASAPAFEATTVGLAYSQDPDG-----------------TTAG----SVF
Mvan_0590|M.vanbaalenii_PYR-1 SAAAPAFEATTVGLAYSQDPDG-----------------TTAG----SVY
MSMEG_0679|M.smegmatis_MC2_155 SATAPALEASTVGLAYSQDPDG-----------------PTAG----SAY
TH_3900|M.thermoresistible__bu AANAPTFEPSTVGLAYSQVPDGGPTVPASVYAAGFGADAATAGGHPYAAY
MAB_4296c|M.abscessus_ATCC_199 SAQEPDFEASTALLGQAYSLEG------------------PTG-------
MLBr_00048|M.leprae_Br4923 PAPTQHLTRPDGLVSHRTALHDS---------------TATSAIGVQTGR
.. . .
Mb0552|M.bovis_AF2122/97 GQSGSEGEQLAYSQASDYELLPVDEYEEHDEYGAAADRSAPLSRRSLLIG
Rv0538|M.tuberculosis_H37Rv GQSGSEGEQLAYSQASDYELLPVDEYEEHDEYGAAADRSAPLSRRSLLIG
MUL_1227|M.ulcerans_Agy99 NPRALAPSYLDVCAN---ADRGAGSLAYSALADDGEDAVEGRRRPLVLAG
MMAR_0563|M.marinum_M NPRALAPSYLDVCAN---ADRGAGALAYSALADDGEDAVEGRRRPLVLAG
MAV_4848|M.avium_104 DPPAFNPTYLDVWGD---TGAGTGVRAYSAVPDE-EEPAPRRPWSMLLAG
Mflv_0290|M.gilvum_PYR-GCK AGLAGAQTQMAPVG------GDVPVDEFAP---TEMRPVDEERKPFLLVG
Mvan_0590|M.vanbaalenii_PYR-1 AGLAGADTQLAPVG------AEDVVDEFAP---TEMRPVDEGRKPFLLVG
MSMEG_0679|M.smegmatis_MC2_155 A-LAGLDTQLAPAGSDLGSLVDGGVDELDPAVFNEVAAADEERKPFLLVG
TH_3900|M.thermoresistible__bu AAFAGAQTQLASIG--------GAAPSPVP----GEPPVDEDRKPFLLVG
MAB_4296c|M.abscessus_ATCC_199 TGFAHPDAVTESAG--------EANTELREFEDFDDQPAE--RKPFLLVG
MLBr_00048|M.leprae_Br4923 STGAKKPSKVVAKRGWRHWVHTVTRINLGLSPDERYELDLRTRVRRPPRG
. *
Mb0552|M.bovis_AF2122/97 NAVVAFAVIGFASLAVAVAVTIRPTAASKPVEGHQNAQPGKFMPLLPTQQ
Rv0538|M.tuberculosis_H37Rv NAVVAFAVIGFASLAVAVAVTIRPTAASKPVEGHQNAQPGKFMPLLPTQQ
MUL_1227|M.ulcerans_Agy99 SAMLGIAAFAAGLMVVTLTSDVRPAAATQPSPREGVLTPASPAAPPKTAT
MMAR_0563|M.marinum_M SAMLGIAAFAAGLMVVTLTSDVRPAAATQPSPREGVLTPASPAAPPKTAA
MAV_4848|M.avium_104 GALAGIAAVIGGVVLVTLTSDG-HSTNTRHNQGVSVATPGIQLPAPPPSN
Mflv_0290|M.gilvum_PYR-GCK SALTSLFVVGVVALVISLAISIRPTADQRPSPAQAAIVPS---SQAPTAE
Mvan_0590|M.vanbaalenii_PYR-1 SALTSLFVIGVAALVVSLAISIRPTADQRPSPAQSAIVP----SQLPAPA
MSMEG_0679|M.smegmatis_MC2_155 SALTSVFVIGVVALVISLAVSIRPTVDQRPAPAQGAVVPTAPVAKAPAPA
TH_3900|M.thermoresistible__bu SALTSIFVVGVVALVVSLAVSIRPTVDQRPSPADSALAPG----VAAPVQ
MAB_4296c|M.abscessus_ATCC_199 APLLLVFGICSIALAVSLTVTVRSTVDQGPSSPDRGVVQNPLPAEAPKQA
MLBr_00048|M.leprae_Br4923 SYQIGILGLKGGAGKTTVTVTLGSMFARVRNDRILVVDADTSCGNLADRA
. . :::
Mb0552|M.bovis_AF2122/97 QAPVPPPPPDDPTAGFQGG-TIPAVQNVVPRPGTSPGVGGTPASPAPEAP
Rv0538|M.tuberculosis_H37Rv QAPVPPPPPDDPTAGFQGG-TIPAVQNVVPRPGTSPGVGGTPASPAPEAP
MUL_1227|M.ulcerans_Agy99 PVPAKAPA-QVPAPGPAPAASPVPVAAPPSVVQ-----PPPVVRAPRPTV
MMAR_0563|M.marinum_M PVPAKAPA-QVPAPGPAPAASPVPVAAPPSVVQ-----PPPVVRAPRPTV
MAV_4848|M.avium_104 PPAAQPPAPSTPAPAPTPTEVAAPAPEPVQQAA-----PQTPVTTAPPAP
Mflv_0290|M.gilvum_PYR-GCK PAPARQEAAQIPPP-PSTAETIKPPVPVVQQAP--QQAPRTVFVEQAPAP
Mvan_0590|M.vanbaalenii_PYR-1 PAPARQEAADVPAN-PPSAETIKPPIPVVQEAP--QQAPRTVYVEQAPAP
MSMEG_0679|M.smegmatis_MC2_155 PAPEAKPVQEAPPP-APPPETIKAPVPVVQEAPQPQAPPRTVYVEQPQAP
TH_3900|M.thermoresistible__bu PETVPEALXXXPPH-PSPAPNVKP----LRCAG-----GFSAVVARTTAP
MAB_4296c|M.abscessus_ATCC_199 APPPSPVEAPAPAVSPAPVQQVVAPAPQHNPAPAPKQVAPAPVQAAPQAP
MLBr_00048|M.leprae_Br4923 GRFSEANIADLLADKDVKSYNDIRTHTSVNAVN-LEVLPAAEYSTAQHAL
. . :
Mb0552|M.bovis_AF2122/97 AVPGVVPAPVPIPVPIIIPPFPGWQPGMPTIPTAPPTTPVTTSATTPPTT
Rv0538|M.tuberculosis_H37Rv AVPGVVPAPVPIPVPIIIPPFPGWQPGMPTIPTAPPTTPVTTSATTPPTT
MUL_1227|M.ulcerans_Agy99 VK----PPPQYIAPATQPRR------------------------------
MMAR_0563|M.marinum_M VK----PPPQYIAPATQPRR------------------------------
MAV_4848|M.avium_104 VY----RAPARPTPQYQPR-------------------------------
Mflv_0290|M.gilvum_PYR-GCK APAAPAPAPAPVAPPPAPAP--IPAAPPVVAPVVLPPPVVVLPRPQWNPP
Mvan_0590|M.vanbaalenii_PYR-1 A----VPAPAPAAPPPAPA----PAAPPVVAPVVVPPPVIVLPRPQWTPP
MSMEG_0679|M.smegmatis_MC2_155 APAPAAPPPAPEAPPPAPVAPVLPAPAPVYQPPGYIPPVVVLPR---VPS
TH_3900|M.thermoresistible__bu G-------PFPTG-------------------------------------
MAB_4296c|M.abscessus_ATCC_199 APAPEAPAPAAPAPVPEEQP-----APVAPPPAVVPVPIPLFPPVWEPPR
MLBr_00048|M.leprae_Br4923 SGEDWNFAAATVSKYYNVMLADCGVGLFDPVTRGVLSTASGVVIVTSTSV
.
Mb0552|M.bovis_AF2122/97 PPTTPVTTP--------------------PTTPPTTPVTTPPTTPPTTPV
Rv0538|M.tuberculosis_H37Rv PPTTPVTTP--------------------PTTPPTTPVTTPPTTPPTTPV
MUL_1227|M.ulcerans_Agy99 ---------------------------------------------TPAPQ
MMAR_0563|M.marinum_M ---------------------------------------------TPAPQ
MAV_4848|M.avium_104 -----------------------------------------------PVE
Mflv_0290|M.gilvum_PYR-GCK RPAWTWPNQ--RPDVDDDSDDSPWTPQKPPR-TPSQP-PTTRPPVPQVPQ
Mvan_0590|M.vanbaalenii_PYR-1 KPAWTWPTQTVEPDEPDEPWQPPWEDDDDDKPTPTLPTQTVVPTRPQVPT
MSMEG_0679|M.smegmatis_MC2_155 IFRPPWEPQ--RPPQQN-PWNPPWDPPKQAP-KPQWPGSGPGGWDPGPGR
TH_3900|M.thermoresistible__bu -----WSRR------------------------------------SAAAE
MAB_4296c|M.abscessus_ATCC_199 RQENPWWPD---------RDRPRYTPPAQTQQPPIISIPGLPPIGGGDSD
MLBr_00048|M.leprae_Br4923 DAARQAAIA-------------------------LDWLRHNGYQDLLSRA
Mb0552|M.bovis_AF2122/97 TTPPTTVAPTTVAPTTVAPTTVAPTTVAPATATPTTVAPQPTQQPTQQPT
Rv0538|M.tuberculosis_H37Rv TTPPTTVAPTTVAPTTVAPTTVAPTTVAPATATPTTVAPQPTQQPTQQPT
MUL_1227|M.ulcerans_Agy99 APAPTPVQAPAP------------EVPPPVAVPEPAPAPPVPALVVERLV
MMAR_0563|M.marinum_M APALTPVQAPAP------------EVRPPVAVPEPAPAPPVPTQAPMTMY
MAV_4848|M.avium_104 QPAPPPAAAPAP------------AAPPPAPAPPPA-APPVPHQPPVTMY
Mflv_0290|M.gilvum_PYR-GCK VPQIPQVPQVPQVPQWPGAGSGSGSGSGSSSGSGSSRGDSGSRGGDSSSG
Mvan_0590|M.vanbaalenii_PYR-1 VPQVPTVPQVPQQPQWPGSGSGAGSGSGSSSGSYGGSGSYGGGRGDSGSS
MSMEG_0679|M.smegmatis_MC2_155 GSDNGPGRGGGDNDWNPGRGSG-GPGRGDSGNSGWNPGSGGGRNGGGG--
TH_3900|M.thermoresistible__bu LVSHATVRCS-------------GDGPGSAGVPGWDPDPSIKADGGRHRF
MAB_4296c|M.abscessus_ATCC_199 RGSHGGSRGGSGRGGWGDDGDSRGGSDSGSRGGWGDNGGSRGGWGDSGSS
MLBr_00048|M.leprae_Br4923 CVVINHVMPKEPNIASKDLVQQFEQQIQPGRVVVLPWDKHIAAGTEIRLD
Mb0552|M.bovis_AF2122/97 QQMPTQQQTVAPQTVAPAPQPPSGGRNGSGGGDLFGGF
Rv0538|M.tuberculosis_H37Rv QQMPTQQQTVAPQTVAPAPQPPSGGRNGSGGGDLFGGF
MUL_1227|M.ulcerans_Agy99 IQNDGVDLAE----------------------------
MMAR_0563|M.marinum_M LHLPFVSIPIPINPPPPPAPPPEPAPVEPPPPEPGP--
MAV_4848|M.avium_104 LHFPFVTVPIPITPPAPPPGP-----------------
Mflv_0290|M.gilvum_PYR-GCK RG-SGSGVPGDINGDGCFLIFCGSGRN-----------
Mvan_0590|M.vanbaalenii_PYR-1 RGGSGSGVPGDVNGDGCFLIFCAPGGGRG---------
MSMEG_0679|M.smegmatis_MC2_155 -GHNGGGHNGGGGGGPVWPFPFGGGHH-----------
TH_3900|M.thermoresistible__bu RFAVQMTTRCGLIAHP----------------------
MAB_4296c|M.abscessus_ATCC_199 RGGSDSGSRGGWGGNSGSHGGGSGGGSNSGFPWPFGGR
MLBr_00048|M.leprae_Br4923 RLDPLYRRRILELAAALSDDFERAGRH-----------