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M. ulcerans Agy99 MUL_0426 (pabC)

annotation: 4-amino-4-deoxychorismate lyase
coordinates: 439630 - 440520
length: 296

MTGQTGVVVTLDGEIPEPGTPLLHADDLAAVRGDGVFETLLVRDRAPCLVEPHLQRLTTSARLMDLPAPD
LARWRHAIDVAARRWVASTGAEGSLRLIYSRGRESGSAPTAYVMVNPVPERVAAVRRAGVAAITLDRGLP
AVGADAMPWLLAGAKTLSYAVNMAALRHAANQGAGDVIFVSSDGYVLEGPRSTVVIATDCDGGAGANPCL
LTPPPWYPIVRGTTQQALFEVARAKGYDCDYRALRVNDLADAHGIWLVSSMTLAARVHTLNGRRLPRSPI
SEAFSELVDAAVVSDR
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_0426pabC-100% (296)4-amino-4-deoxychorismate lyase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0835-1e-13783.45% (290) 4-amino-4-deoxychorismate lyase
M. gilvum PYR-GCKMflv_1639-1e-11568.58% (296) 4-amino-4-deoxychorismate lyase
M. tuberculosis H37RvRv0812-1e-13783.45% (290) 4-amino-4-deoxychorismate lyase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0731-7e-8856.29% (286) 4-amino-4-deoxychorismate lyase
M. marinum MMMAR_4873pabC1e-16898.99% (296) amino acid aminotransferase, PabC
M. avium 104MAV_0751-1e-12776.90% (290) 4-amino-4-deoxychorismate lyase
M. smegmatis MC2 155MSMEG_5795-1e-10767.92% (293) 4-amino-4-deoxychorismate lyase
M. thermoresistible (build 8)TH_0072pabC1e-11168.01% (297) PROBABLE AMINO ACID AMINOTRANSFERASE
M. vanbaalenii PYR-1Mvan_5108-1e-11065.88% (296) 4-amino-4-deoxychorismate lyase

CLUSTAL 2.0.9 multiple sequence alignment


MUL_0426|M.ulcerans_Agy99           MTGQTGVVVTLDGEIPEPGTPLLHADDLAAVRGDGVFETLLVRDRAPCLV
MMAR_4873|M.marinum_M               MTGQTGVVVTLDGEIPEPGTPLLHADDLAAVRGDGVFETLLVRDGAPCLV
Mb0835|M.bovis_AF2122/97            ------MVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLV
Rv0812|M.tuberculosis_H37Rv         ------MVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLV
MAV_0751|M.avium_104                ------MIVTLDGEVHAPDAPLLHADDLAAVRGDGVFETLLVRDGRACLI
TH_0072|M.thermoresistible__bu      MANAPAVVVTLDGQLRAPGEPLLYADDLAAVRGDGIFETLLIRDGGPCLL
Mflv_1639|M.gilvum_PYR-GCK          MADHPGVLVTLDGQLHDPEVPLLHADDLAAVRGDGIFETLLVRDGRPCLL
Mvan_5108|M.vanbaalenii_PYR-1       MADHPGVVVTLDGQLHDPDAPLLYADDLAAVRGDGIFETLLIRGGRPCLL
MSMEG_5795|M.smegmatis_MC2_155      ------MLVTLDGQLHDPDAPLLCADDLAAVRGDGVFETLLVRDGQPCLL
MAB_0731|M.abscessus_ATCC_1997      --MAVAVVVTLDGEVHDPSVPLLYADELAAVRGDGAFETALVRGGAVCKL
                                          ::*****::  *  *** **:******** *** *:*.   * :

MUL_0426|M.ulcerans_Agy99           EPHLQRLTTSARLMDLPAPDLARWRHAIDVAARRWVAST---GAEGSLRL
MMAR_4873|M.marinum_M               EPHLQRLTTSARLMDLPAPDLARWRHAIDVAARRWVAST---GAEGSLRL
Mb0835|M.bovis_AF2122/97            EAHLQRLTQSARLMDLPEPDLPRWRRAVEVATQRWVAST---ADEGALRL
Rv0812|M.tuberculosis_H37Rv         EAHLQRLTQSARLMDLPEPDLPRWRRAVEVATQRWVAST---ADEGALRL
MAV_0751|M.avium_104                ESHLQRLTQSAALTELPEPDLPRWRSAIEAATRRWCAGG---ADEGAMRL
TH_0072|M.thermoresistible__bu      EAHLTRLTGSARLMDLPEPDLPAWRAAVATAVRQWCDRT---DDEGVMRL
Mflv_1639|M.gilvum_PYR-GCK          DAHLGRLAHSAQMVDLPAPNAARWRTAVDTAVRAWLDSG---GDEGVLRL
Mvan_5108|M.vanbaalenii_PYR-1       DAHLGRLAHSARQVDLPPPDAARWHAAVGIAVDSWLRTG---GDEGVLRL
MSMEG_5795|M.smegmatis_MC2_155      EAHLARLTQSARMLDLPEPDLDAWRAAVALGVKRWTSEHSANGEEGVLRL
MAB_0731|M.abscessus_ATCC_1997      EAHLGRMAASAASMDLAEPDRAAWRSAVKIAVQQWNSIS---GEDAMLRL
                                    :.** *:: **   :*. *:   *: *:  ..  *         :. :**

MUL_0426|M.ulcerans_Agy99           IYSRGRESGS-APTAYVMVNPVPERVAAVRRAGVAAITLDRGLPAVGADA
MMAR_4873|M.marinum_M               IYSRGRESGS-APTAYVMVNPVPERVAAVRRDGVAAITLDRGLPAVGADA
Mb0835|M.bovis_AF2122/97            IYSRGREGGS-APTAYVMVSPVPARVIGARRDGVSAITLDRGLPADGGDA
Rv0812|M.tuberculosis_H37Rv         IYSRGREGGS-APTAYVMVSPVPARVIGARRDGVSAITLDRGLPADGGDA
MAV_0751|M.avium_104                IYSRGREGGS-VPTAYVMVTAVPDRVTAVRRDGLAAITLDRGLPATGVDA
TH_0072|M.thermoresistible__bu      VYSRGRESGAGRPTGYVTVAALPERVAAARRDGVSAITLDRGMASTAAD-
Mflv_1639|M.gilvum_PYR-GCK          VYSRGREHGS-EPTAYATIGQVPARVARVRREGLAALTLERGLAADGIDA
Mvan_5108|M.vanbaalenii_PYR-1       VYSRGREHGS-DPTAYATIGSVPARVADVRRNGLAALTLQRSLPAEGVDA
MSMEG_5795|M.smegmatis_MC2_155      VYSRGREGGG-PPTAFATIGALADRVAGARRHGVAAITLDRGLP-VGASE
MAB_0731|M.abscessus_ATCC_1997      VYTRGRESGG-GATAYLTIAPVPERSSRARRDGVSVITLDRGLPAQPAEP
                                    :*:**** *.  .*.:  :  :. *   .** *::.:**:*.:.    . 

MUL_0426|M.ulcerans_Agy99           MPWLLAGAKTLSYAVNMAALRHAANQGAGDVIFVSSDGYVLEGPRSTVVI
MMAR_4873|M.marinum_M               MPWLLAGAKTLSYAVNMAALRHAANQGAGDVIFVSSDGYVLEGPRSTVVI
Mb0835|M.bovis_AF2122/97            MPWLMASAKTLSYAVNMAVLRHAARQGAGDVIFVSTDGYVLEGPRSTVVI
Rv0812|M.tuberculosis_H37Rv         MPWLIASAKTLSYAVNMAVLRHAARQGAGDVIFVSTDGYVLEGPRSTVVI
MAV_0751|M.avium_104                MPWLLAGAKTLSYAINMAALRHAARHDAGDVVFVSTDGYVLEGPRSTVVI
TH_0072|M.thermoresistible__bu      LPWLLAGAKTLSYAVNMAALRHAERHGAGDVIFVSTDGYLLEGPRSTVVI
Mflv_1639|M.gilvum_PYR-GCK          MPWLLAGAKTLSYAINMAALRHAERQGAGDVVFVSTDGHILEGPRSTVVI
Mvan_5108|M.vanbaalenii_PYR-1       MPWLLAGAKTLSYAVNMAALRHAERHGAGDVIFISTEGHILEGPRSTVVI
MSMEG_5795|M.smegmatis_MC2_155      MPWLAAGAKTLSYAVNMAALRHAARNGAGDVIFVSSDGFLLEGPRSTVVI
MAB_0731|M.abscessus_ATCC_1997      LPWLLSGAKTLSYAINMSALRYAETQGAQDVIFVSSDGFVLEGPRSTVIV
                                    :*** :.*******:**:.**:*  :.* **:*:*::*.:********::

MUL_0426|M.ulcerans_Agy99           ATDCDGGAGANPCLLTPPPWYPIVRGTTQQALFEVARAKGYDCDYRALRV
MMAR_4873|M.marinum_M               ATDCDGGAGANPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRV
Mb0835|M.bovis_AF2122/97            ATDGDQGGG-NPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRV
Rv0812|M.tuberculosis_H37Rv         ATDGDQGGG-NPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRV
MAV_0751|M.avium_104                ATDSEAPGG-GPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRV
TH_0072|M.thermoresistible__bu      ATEMD---G-VTCLLTPPPWYPILRGTTQQALFEVARNRGYQCDFQPLRP
Mflv_1639|M.gilvum_PYR-GCK          ATSSADG---RTCLLTPPPWYPILRGTTQQALFEVARNKGYDCDYQALTP
Mvan_5108|M.vanbaalenii_PYR-1       ATSSPDG---RTCLLTPPPWYPILRGTTQQALFELARNKGYDCDYQALTP
MSMEG_5795|M.smegmatis_MC2_155      ATRGDDG---QPLLLTPPPWYPILRGTTQQALFETARNKGIDCDYRALRP
MAB_0731|M.abscessus_ATCC_1997      DTGDA--------LVTPFPEHGILHGTTQRALFEVAASEGIPCRYEAVKP
                                     *           *:** * : *::****:**** *  .*  * :..:  

MUL_0426|M.ulcerans_Agy99           NDLADAHGIWLVSSMTLAARVHTLNGRRLPRSPISEAFSELVDAAVVSDR
MMAR_4873|M.marinum_M               NDLADAHGIWLVSSMTLAARVHTLNGRRLPRSPISEAFSELVDAAVVSDR
Mb0835|M.bovis_AF2122/97            ADLFDSQGIWLVSSMTLAARVHTLDGRRLPRTPIAEVFAELVDAAIVSDR
Rv0812|M.tuberculosis_H37Rv         ADLFDSQGIWLVSSMTLAARVHTLDGRRLPRTPIAEVFAELVDAAIVSDR
MAV_0751|M.avium_104                ADLFAAQGVWLISSMTLAARVHTLDGRPLPRAPMAAEFAELVDAAIVSDR
TH_0072|M.thermoresistible__bu      ADLFAAQGVWLVSSITLGARVHTLDGRPMPGAALAAEMAELVDAAIVSDR
Mflv_1639|M.gilvum_PYR-GCK          ADLFAAQGVWLVSSITLAARVHTLDGRPLPQAPLAGDIAALVDAAILCDR
Mvan_5108|M.vanbaalenii_PYR-1       ADLIAAQGVWLVSSITLAARVHTLDGNPLAAAPLSDEIAALVDAAILCDR
MSMEG_5795|M.smegmatis_MC2_155      ADLLTAQGIWLISSITLAARVHTLDGTRLRTSASAPDIAGLVDTAILGDR
MAB_0731|M.abscessus_ATCC_1997      ADLIAAQDVWMLASITLAARVHTLDGVARPAGPLAPRLPELVDKAIAL--
                                     **  ::.:*:::*:**.******:*      . :  :. *** *: