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VPDRQYTRFRLVRNGAVLRVVFDHPPMNLFDQTMISECSALLDFLRADRSVRVVLFSSAGPDFFLGHADL SLFLAPREGVPPKPVRLTLLQDLFERLRTVPQATIAVVEGRATGAGVELVTSCDMAFAARGRAVLTLFET AVGVLPGATGTQRLPRLMGRQRSLEFILGCQDFDTDLAERYGVVNRAFDATELWPFVENLAQRIGTFPSE AIAMNKVAVDASEHPLAVGLLEETHALDHALATGEGQRRMAALLELGAQTPEFELRKFTAALATLGGSDD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6795 | - | - | 100% (280) | enoyl-CoA hydratase/isomerase family protein |
| M. smegmatis MC2 155 | MSMEG_6777 | - | 1e-17 | 30.25% (238) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_2220 | - | 2e-17 | 30.22% (268) | enoyl-CoA hydratase/isomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1099c | echA8 | 4e-18 | 37.21% (172) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2036 | - | 1e-17 | 38.41% (164) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv1070c | echA8 | 4e-18 | 37.21% (172) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 4e-19 | 30.92% (249) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_0316 | - | 8e-48 | 42.37% (262) | enoyl-CoA hydratase |
| M. marinum M | MMAR_0646 | echA8_1 | 5e-53 | 43.02% (265) | enoyl-CoA hydratase, EchA8_1 |
| M. avium 104 | MAV_1195 | - | 4e-18 | 29.67% (273) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_4102 | - | 5e-18 | 38.41% (164) | PUTATIVE short chain enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_0126 | echA8_1 | 2e-54 | 43.02% (265) | enoyl-CoA hydratase, EchA8_1 |
| M. vanbaalenii PYR-1 | Mvan_4681 | - | 2e-16 | 37.20% (164) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1099c|M.bovis_AF2122/97 ------MTYETILVERDQRVGIITLNRPQALNALNSQVMNEVTSAATELD
Rv1070c|M.tuberculosis_H37Rv ------MTYETILVERDQRVGIITLNRPQALNALNSQVMNEVTSAATELD
MLBr_02402|M.leprae_Br4923 ------MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNEITNAAKELD
MAV_1195|M.avium_104 MTDSTDRTFETILVEREERVGIITLNRPKALNALNTQVMNEVTTAATDFD
TH_4102|M.thermoresistible__bu ---MSAKNYETILVTREDRVGIITLNRPKALNALNSQVMTEVTDAAAEFD
Mflv_2036|M.gilvum_PYR-GCK ------MTFETILVDRDDRVATITLNRPKALNALNTQVMNEVTTAAAELD
Mvan_4681|M.vanbaalenii_PYR-1 ---MGSQNFETIIVERDDRVATITLNRPKALNALNSQVMDEVTTAAAELD
MSMEG_6795|M.smegmatis_MC2_155 -MPD--RQYTRFRLVRNGAVLRVVFDHP-PMNLFDQTMISECSALLDFLR
MAB_0316|M.abscessus_ATCC_1997 -MNAGIPELTGLRCALDDRVLTVLFDHG-QLNLLDGPLMSSLSRLARWLS
MMAR_0646|M.marinum_M -MHQ---DFRLLRVVSADGICRATIDHP-PVNLLDVDLLTEIEILTNQVA
MUL_0126|M.ulcerans_Agy99 -MHQ---DFRLLRVVSADGICRATIDHP-PVNLLDVDLLTEIEILTNQVA
: : ::: :* :: :: . .
Mb1099c|M.bovis_AF2122/97 DDPDIGAIIITGS-AKAFAAGADIKEMADLTFADAFT----ADFFATWGK
Rv1070c|M.tuberculosis_H37Rv DDPDIGAIIITGS-AKAFAAGADIKEMADLTFADAFT----ADFFATWGK
MLBr_02402|M.leprae_Br4923 IDPDVGAILITGS-PKVFAAGADIKEMASLTFTDAFD----ADFFSAWGK
MAV_1195|M.avium_104 ADPGIGAIIITGS-AKAFAAGADIKEMAELTFADAYG----ADFFAPWGK
TH_4102|M.thermoresistible__bu SDPGIGAIIVTGN-EKAFAAGADIKEMADLEFADVFA----ADFFAPWSK
Mflv_2036|M.gilvum_PYR-GCK AEPGVGAIIVTGS-ERAFAAGADIKEMASLSFADVFS----SDFFAAWGK
Mvan_4681|M.vanbaalenii_PYR-1 ADAGVGAIILTGS-EKAFAAGADIKEMAGLSFADVFS----SDFFAGWGK
MSMEG_6795|M.smegmatis_MC2_155 ADRSVRVVLFSSAGPDFFLGHADLSLFLAPREGVPPKPVRLTLLQDLFER
MAB_0316|M.abscessus_ATCC_1997 GSDDVTVVLFGSANPDFFIAHLNVEILQSATARTAES---VASFQRLVGR
MMAR_0646|M.marinum_M ADNEVRVLIVDSADPEFFIAHADVSLISDLPADDTARHDELSRFNAAMQA
MUL_0126|M.ulcerans_Agy99 ADNEVRVLIVDSADPEFFIAHADVSLISDLPADDTARHDELSRFNAAMQA
. : .::. . * . ::. : : :
Mb1099c|M.bovis_AF2122/97 LAAVRTPTIAAVAGYALGGGCELAMMCDVLIAAD-TAKFGQPEIKLGVLP
Rv1070c|M.tuberculosis_H37Rv LAAVRTPTIAAVAGYALGGGCELAMMCDVLIAAD-TAKFGQPEIKLGVLP
MLBr_02402|M.leprae_Br4923 LAAVRTPMIAAVAGYALGGGCELAMMCDLLIAAD-TAKFGQPEIKLGVLP
MAV_1195|M.avium_104 LAALRTPTIAAVAGHALGGGCELAMMCDVLIAAD-TAKFGQPEIKLGVLP
TH_4102|M.thermoresistible__bu FAATRTPTIAAVAGYALGGGCELAMMCDLLIAAD-TAKFGQPEIKLGVLP
Mflv_2036|M.gilvum_PYR-GCK FAATRTPTIAAVAGYALGGGCELAMMCDILIAAD-TAKFGQPEIKLGVLP
Mvan_4681|M.vanbaalenii_PYR-1 FAATRTPTIAAVAGYALGGGCELAMMCDILIAAD-TAKFGQPEIKLGVLP
MSMEG_6795|M.smegmatis_MC2_155 LRTVPQATIAVVEGRATGAGVELVTSCDMAFAARGRAVLTLFETAVGVLP
MAB_0316|M.abscessus_ATCC_1997 FRALRQATIALVEGRVAGGGSEFLLNLDMRFAVRGKALFNQVETGLGIVP
MMAR_0646|M.marinum_M LRGLPKATIAVIEGACRGGGCEFAMAFDMRYAALGTTVLGHPEVSVGIIP
MUL_0126|M.ulcerans_Agy99 LRGLPKGTIAVIEGACRGGGCEFAMAFDMRYAALGTTVLGHPEVSVGIIP
: ** : * *.* *: *: *. : : * :*::*
Mb1099c|M.bovis_AF2122/97 GMGGSQRLTRAIGKAKAMDLILTGRTMDAAEAERSGLVSRVVPADDLLTE
Rv1070c|M.tuberculosis_H37Rv GMGGSQRLTRAIGKAKAMDLILTGRTMDAAEAERSGLVSRVVPADDLLTE
MLBr_02402|M.leprae_Br4923 GMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVLADDLLPE
MAV_1195|M.avium_104 GMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVPADDLLTE
TH_4102|M.thermoresistible__bu GMGGSQRLTRAIGKAKAMDLILTGRTIDAEEAERSGLVSRVVPADKLLDE
Mflv_2036|M.gilvum_PYR-GCK GMGGSQRLTRAIGKAKAMDLILTGRNMDAEEAERAGLVSRVVPADSLLSE
Mvan_4681|M.vanbaalenii_PYR-1 GMGGSQRLTRAIGKAKAMDLILTGRNMGAEEAERAGLVSRVVPADTLLEE
MSMEG_6795|M.smegmatis_MC2_155 GATGTQRLPRLMGRQRSLEFILGCQDFDTDLAERYGVVNRAFDATELWPF
MAB_0316|M.abscessus_ATCC_1997 AGSGPQHLVQGMGRARALEVILGHEDFGADLAERYGWVNRALNPDEGWRF
MMAR_0646|M.marinum_M GGGGTQRLPHLVGRARALEVILGCRDIDAATAQAWGYVNRALPGEELRRF
MUL_0126|M.ulcerans_Agy99 GGGGTQRLPHLVGRARALEVILGCRDIDAATAQAWGYVNRALPGEELWRF
. *.*:* : :*: ::::.** . :.: *: * *.*..
Mb1099c|M.bovis_AF2122/97 ARATATTISQMSASAARMAKEAVNRAFES--SLSEGLLYERRLFHSAFAT
Rv1070c|M.tuberculosis_H37Rv ARATATTISQMSASAARMAKEAVNRAFES--SLSEGLLYERRLFHSAFAT
MLBr_02402|M.leprae_Br4923 AKAVATTISQMSRSATRMAKEAVNRSFES--TLAEGLLHERRLFHSTFVT
MAV_1195|M.avium_104 AKKVATTISQMSRSAARMAKEAVNRAFET--TLAEGLLYERRLFHSTFAT
TH_4102|M.thermoresistible__bu AKETAATIAAMSLSAARMAKEAVNRAFET--SLAEGLLFERRVFHSAFAT
Mflv_2036|M.gilvum_PYR-GCK AKAVAQTIAGMSLSASRMAKEAVDRAFET--TLSEGLLYERRLFHSAFAT
Mvan_4681|M.vanbaalenii_PYR-1 ARSVAKTIAGMSLSASRMAKEAVDRAFET--TLTEGLLYERRLFHSAFAT
MSMEG_6795|M.smegmatis_MC2_155 VENLAQRIGTFPSEAIAMNKVAVDASEHP---LAVGLLEETHALDHALAT
MAB_0316|M.abscessus_ATCC_1997 VNRLARRIAANPLDLIAGVKNTVDALASD---LEPGLAAERAAIVAAFAD
MMAR_0646|M.marinum_M VDKLAGRIASYPKEAIAAAKRAVDVALDPRTDLTTGLRIEDQLLRETLAL
MUL_0126|M.ulcerans_Agy99 VDKLAGRIASYPEEAIAAAKRAVDVALDPRTDLTTGLRIEDQLLRETLAL
. * *. . . * :*: * ** * : ::.
Mb1099c|M.bovis_AF2122/97 EDQSEGMAAFIEKRAPQFTHR----------------
Rv1070c|M.tuberculosis_H37Rv EDQSEGMAAFIEKRAPQFTHR----------------
MLBr_02402|M.leprae_Br4923 DDQSEGMAAFIEKRAPQFTHR----------------
MAV_1195|M.avium_104 ADQSEGMAAFVEKRAPNFTHR----------------
TH_4102|M.thermoresistible__bu ADQSEGMAAFTEKRPPKFTHR----------------
Mflv_2036|M.gilvum_PYR-GCK DDQTEGMNAFSEKRSPNFTHR----------------
Mvan_4681|M.vanbaalenii_PYR-1 DDQTEGMNAFTEKRSPNFTHR----------------
MSMEG_6795|M.smegmatis_MC2_155 GEGQRRMAALLELGAQTPEFELRKFTAALATLGGSDD
MAB_0316|M.abscessus_ATCC_1997 EHSARRIAHFLQRGGQTVEGERR-----LGDLVSEP-
MMAR_0646|M.marinum_M PDTRRRLQAVIEAGAQTREFELG-----AAPKPPAT-
MUL_0126|M.ulcerans_Agy99 PDTRRRLQAVIEAGAQTREFELG-----AAPKPPAT-
. . : . : .