For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MDEFPQDYELFDLGDVTLQHGATLRDAKLAYKTYGELNADKSNAIVYPTWYSGRHWDNEWLIGEGKALDP AKYFIIVPNMLGNGLSTSPSNTPPPYNAARFPHVTFYDQVEVQHQLVTSFGIETLALVTGWSMGAGQTYQ WAVSYPDMVQRALPFCGSSKTSEHNIVFLEGVKSALTADAAFKEGWYTEKPTKGIRAAARVYAGWGFSQA FYWHQEYKKMGYSSLEDFLVGFWEGFFLDRRDPNNLLAMLWTWQNGNVGNTPGRGFHGDQVAALKTIKAK MIVAPAEKDLYFPPEDEEFAVKHIPDAELRVIPGIYGHFAGGDANPEDNKFIDGLVRELLAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6772 | - | - | 100% (342) | hypothetical protein MSMEG_6772 |
| M. smegmatis MC2 155 | MSMEG_1651 | metX | 3e-19 | 25.54% (372) | homoserine O-acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3373 | metX | 1e-18 | 24.46% (368) | homoserine O-acetyltransferase |
| M. gilvum PYR-GCK | Mflv_4876 | metX | 6e-18 | 29.03% (217) | homoserine O-acetyltransferase |
| M. tuberculosis H37Rv | Rv3341 | metX | 1e-18 | 24.46% (368) | homoserine O-acetyltransferase |
| M. leprae Br4923 | MLBr_00682 | metX | 8e-18 | 23.97% (363) | homoserine O-acetyltransferase |
| M. abscessus ATCC 19977 | MAB_3688 | metX | 3e-17 | 25.41% (366) | homoserine O-acetyltransferase |
| M. marinum M | MMAR_1184 | metX | 1e-16 | 26.70% (221) | homoserine O-acetyltransferase MetA |
| M. avium 104 | MAV_4316 | metX | 1e-16 | 23.30% (339) | homoserine O-acetyltransferase |
| M. thermoresistible (build 8) | TH_1969 | metA | 1e-15 | 23.91% (343) | PROBABLE HOMOSERINE O-ACETYLTRANSFERASE META (HOMOSERINE |
| M. ulcerans Agy99 | MUL_1437 | metX | 2e-16 | 26.24% (221) | homoserine O-acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1553 | metX | 6e-16 | 27.19% (217) | homoserine O-acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1184|M.marinum_M MTIS-DVPTQ--TLPAEGEVRLVDIGSLRLESGAVIDNVCIALQRWGELS
MUL_1437|M.ulcerans_Agy99 MTIS-DVPTQ--TLPAEGEVRLVDIGSLRLESGAVIDNVCIALQRWGELS
MLBr_00682|M.leprae_Br4923 MTIS-KVPTQ--KLPAEGEVGLVDIGSLTTESGAVIDDVCIAVQRWGELS
Mb3373|M.bovis_AF2122/97 MTIS-DVPTQ--TLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWGKLS
Rv3341|M.tuberculosis_H37Rv MTIS-DVPTQ--TLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWGKLS
MAV_4316|M.avium_104 MTIP-DVPTQ--TLPDEGEIGFVHIGSLTTEAGAVIDDVHIAVQRWGELS
Mflv_4876|M.gilvum_PYR-GCK MTIV-DILSERVALPPEGEIGIVDIGTLTLESGEVIEDAFIAVQRWGELS
Mvan_1553|M.vanbaalenii_PYR-1 MTIV-DLLTERVALPPEGEIAIVDIGPLTLENGEVIDDVSIAVQRWGELS
TH_1969|M.thermoresistible__bu VTIL-DVTRT-PTLPAEGELAVVDIGPLQLECGEVLDNVSIAVQRWGELS
MAB_3688|M.abscessus_ATCC_1997 MTIEQQLPVPHIALPQGDEIAYVPIGSITLESGAVIDDVTIAVQSWGELS
MSMEG_6772|M.smegmatis_MC2_155 ------------MDEFPQDYELFDLGDVTLQHGATLRDAKLAYKTYGELN
: . :* : : * .: :. :* : :*:*.
MMAR_1184|M.marinum_M PTRDNVVMVLHALTGDSHVTGPAGPGHSTPGWWDGMVGPGAPIDTNRWCA
MUL_1437|M.ulcerans_Agy99 PTRDNVVMVLHALTGDSHVTGPAGPGHSTPGWWDGMVGPGAPIDTNRWCA
MLBr_00682|M.leprae_Br4923 PTRDNVVMVLHALTGDSHITGPAGPGHPTPGWWDWIAGPGAPIDTNRWCA
Mb3373|M.bovis_AF2122/97 PARDNVVVVLHALTGDSHITGPAGPGHPTPGWWDGVAGPGAPIDTTRWCA
Rv3341|M.tuberculosis_H37Rv PARDNVVVVLHALTGDSHITGPAGPGHPTPGWWDGVAGPGAPIDTTRWCA
MAV_4316|M.avium_104 PTRDNVVVVLHALTGDSHVTGPAGPGHPTGGWWDEMVGPGAPIDTDRWCA
Mflv_4876|M.gilvum_PYR-GCK PDRDNVVMVLHALTGDSHITGPAGPDHPTPGWWDGVAGPGAPIDTDTWCA
Mvan_1553|M.vanbaalenii_PYR-1 ARRDNVVVVLHALTGDSHITGPAGPDHPTPGWWDGVAGPGAPIDTDRWCA
TH_1969|M.thermoresistible__bu PNRDNVVMVLHALTGDSHITGPAGPQHPTPGWWDGVAGPGAPIDTDRWCA
MAB_3688|M.abscessus_ATCC_1997 PRRDNVVFVCHALTADSHVVGPAGPDHITGGWWEGIIGPGAAIDTDHWCA
MSMEG_6772|M.smegmatis_MC2_155 ADKSNAIVYPTWYSGRHWDN-------------EWLIGEGKALDPAKYFI
. :.*.:. :. : : * * .:*. :
MMAR_1184|M.marinum_M VATNVLGGCRGSTGPSSLARDGKPWGSRFPLISVRDQVEADMAALAALGI
MUL_1437|M.ulcerans_Agy99 VATNVLGGCRGSTGPSSLARDGKPWGSRFPLISVRDQVEADMAALAALGI
MLBr_00682|M.leprae_Br4923 IATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVEADIAALAAMGI
Mb3373|M.bovis_AF2122/97 VATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVQADVAALAALGI
Rv3341|M.tuberculosis_H37Rv VATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVQADVAALAALGI
MAV_4316|M.avium_104 VATNVLGGCRGSTGPSSRTRDGKPWGSRFPRISIRDQVEADIAALAALGI
Mflv_4876|M.gilvum_PYR-GCK ISTNVLGGCRGSIGPSSTAPDGKAWGSRFPVITVRDQVAADVAALARLGI
Mvan_1553|M.vanbaalenii_PYR-1 ISTNVLGGCRGSTGPSSLAPDGKAWGSRFPTISIRDQVAADVAALERFGI
TH_1969|M.thermoresistible__bu VATNALGGCRGSTGPGSIAPDGKPWGSRFPTVTVRDQVNADLAALAALGI
MAB_3688|M.abscessus_ATCC_1997 VATNVLGGCRGTTGPTSLARDGKPWGSRFPEVSVRDQVNADVAALAQLGI
MSMEG_6772|M.smegmatis_MC2_155 IVPNMLGNGLSTSPSNTPPPYN---AARFPHVTFYDQVEVQHQLVTSFGI
: .* **. .: . : . . .:*** ::. *** .: : :**
MMAR_1184|M.marinum_M TQVAAVVGGSMGGARALEWIVGHPDRVRSALLLAVGARATADQIGTQTTQ
MUL_1437|M.ulcerans_Agy99 TQVAAVVGGSMGGARALEWIVGHPDRVRSALLLAVGARATADQIGTQTTQ
MLBr_00682|M.leprae_Br4923 TKVAAVVGGSMGGARALEWIIGHPDQVRAGLLLAVGVRATADQIGTQTTQ
Mb3373|M.bovis_AF2122/97 TEVAAVVGGSMGGARALEWVVGYPDRVRAGLLLAVGARATADQIGTQTTQ
Rv3341|M.tuberculosis_H37Rv TEVAAVVGGSMGGARALEWVVGYPDRVRAGLLLAVGARATADQIGTQTTQ
MAV_4316|M.avium_104 DEVAAVVGGSMGGARALEWIVGHPSRVRAGLLLAVGARATADQIGTQCTQ
Mflv_4876|M.gilvum_PYR-GCK TEVAAVIGGSMGGARALEWAVTYPDSVRSALVLAVGARATADQIGTQSTQ
Mvan_1553|M.vanbaalenii_PYR-1 TEVAAVIGGSMGGARALEWMMLHPDSVRAALVLAVGARATADQIGTQCTQ
TH_1969|M.thermoresistible__bu TEVAAVVGGSLGGARALEWMVGHPDTVRAGLVLAVGARATADQIGTQSTQ
MAB_3688|M.abscessus_ATCC_1997 TEVAAVVGGSMGGARALEWAVMHPDAVRAALVLAVGARATGDQIGTQSTQ
MSMEG_6772|M.smegmatis_MC2_155 ETLALVTGWSMGAGQTYQWAVSYPDMVQRALPFCGSSKTSEHNIVFLEGV
:* * * *:*..:: :* : :*. *: .* :. . ::: .:*
MMAR_1184|M.marinum_M IAAIKADPNWRNGDYHETGCKPEAGLKVARRFAHLTYRGEIELDSRFAND
MUL_1437|M.ulcerans_Agy99 IAAIKADPNWRNGDYHETGCRPEAGLKVARRFAHLTYRGEIELDSRFAND
MLBr_00682|M.leprae_Br4923 IAAIKTDPNWQGGDYYETGRAPENGLTIARRFAHLTYRSEVELDTRFANN
Mb3373|M.bovis_AF2122/97 IAAIKADPDWQSGDYHETGRAPDAGLRLARRFAHLTYRGEIELDTRFANH
Rv3341|M.tuberculosis_H37Rv IAAIKADPDWQSGDYHETGRAPDAGLRLARRFAHLTYRGEIELDTRFANH
MAV_4316|M.avium_104 IAAIKSDPNWQGGDYHDTGRTPDAGLAIARRFAHLTYRGEVELDTRFGND
Mflv_4876|M.gilvum_PYR-GCK VAAIKADPNWAGGDYHDTGRSPDAGLEIARRFAHLTYRGEAELDDRFGND
Mvan_1553|M.vanbaalenii_PYR-1 VAAIKSDPNWRGGDYHGTGRSPDHGLEIARRFAHLTYRGETELDERFGND
TH_1969|M.thermoresistible__bu IAAIKADPDWQGGDYYGTGRAPLTGMMIARRFAHLTYRGEVELDNRFGNK
MAB_3688|M.abscessus_ATCC_1997 IAAIQTDPDWQGGDYHGSGRSPGKGLNLARRIAHLTYRGEVELDTRFGND
MSMEG_6772|M.smegmatis_MC2_155 KSALTADAAFKEGWYTEKPTKGIR--AAARVYAGWGFSQAFYWHQEYKKM
:*: :*. : * * . ** * : . .: :
MMAR_1184|M.marinum_M GQGG----EDPADGGRYAIQSYLEHQGDKLLARFDAGSYVILTEALNRHD
MUL_1437|M.ulcerans_Agy99 GQGG----EDPADGGRYAIQSYLEHQGDKLLARFDAGSYVILTEALSRHD
MLBr_00682|M.leprae_Br4923 NQGN----EDPATGGRYAVQSYLEHQGDKLLARFDAGSYVVLTETLNSHD
Mb3373|M.bovis_AF2122/97 NQGN----EDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEALNSHD
Rv3341|M.tuberculosis_H37Rv NQGN----EDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEALNSHD
MAV_4316|M.avium_104 AQLD----EDPANGGRYAVQSYLEYQGVKLVERFDAGSYVVLTEALNSHD
Mflv_4876|M.gilvum_PYR-GCK AQTG----EDPTTGGRYAVQSYLEYQGRKLLARFDAGTYVLLTDALSSHD
Mvan_1553|M.vanbaalenii_PYR-1 AQPG----EDPATGGRYSVQSYLEHQGRKLLARFDAGTYVTLTDALSSHD
TH_1969|M.thermoresistible__bu PQGD----EDPLAGGRYAVQSYLEHQGEKLAARFDPGTYVALTEALSSHD
MAB_3688|M.abscessus_ATCC_1997 PQVGPDGPEDPWADGRYAVQSYLEHQGNKFVRRFDAGSYVILTESLNRHD
MSMEG_6772|M.smegmatis_MC2_155 GYSS---LEDFLVG--FWEGFFLDRRDP---NNLLAMLWTWQNGNVGNTP
. ** . : :*: :. .: . :. . :.
MMAR_1184|M.marinum_M VGRGRDGIHAALRGCPVPVVVGGITSDRLYPLRLQQELADLLPGCAGLEV
MUL_1437|M.ulcerans_Agy99 VGRGRDGIHAALRGCPVPVVVGGITSDRLYPLRLQQELADLLPGCAGLEV
MLBr_00682|M.leprae_Br4923 VGRGRGGIGTALRGCPVPVVVGGITSDRLYPLRLQQELAEMLPGCTGLQV
Mb3373|M.bovis_AF2122/97 VGRGRGGVSAALRACPVPVVVGGITSDRLYPLRLQQELADLLPGCAGLRV
Rv3341|M.tuberculosis_H37Rv VGRGRGGVSAALRACPVPVVVGGITSDRLYPLRLQQELADLLPGCAGLRV
MAV_4316|M.avium_104 VGRARGGVRKALRSCPVPVVVGGITSDRLYPLRLQQELAEQLPGCAELQV
Mflv_4876|M.gilvum_PYR-GCK VGRGRGGIAAALAGCPVPTVVGGITSDRLYPLRLQAELAELLPGCDALDV
Mvan_1553|M.vanbaalenii_PYR-1 IGRGRGGVAAALQSCPVPTVVGGITSDRLYPLRLQAELAELLPGCDGLDV
TH_1969|M.thermoresistible__bu VGRGRGGVEAALRSCPVPALVGGITSDRLYPLRLQEELAERLPGCRDLDI
MAB_3688|M.abscessus_ATCC_1997 VGRGRGGVEKALRGCPVPVVVGGITSDRLYPLRLQEELADLLPGCTGLRV
MSMEG_6772|M.smegmatis_MC2_155 GRGFHGDQVAALKTIKAKMIVAPAEKDLYFPPEDEEFAVKHIP-DAELRV
:.. ** . :*. .* :* . : .. :* * :
MMAR_1184|M.marinum_M VDSIRGHDGFLVESEAVGELIHKTLRLAEDRSSRPW-------------
MUL_1437|M.ulcerans_Agy99 VDSIRGHDGFLVESEAVGELIHKTLRLAEDRSSRPW-------------
MLBr_00682|M.leprae_Br4923 VDSTYGHDGFLVESEAVGKLIRQTLELADVGSKEDACSQ----------
Mb3373|M.bovis_AF2122/97 VESVYGHDGFLVETEAVGELIRQTLGLADREGACRR-------------
Rv3341|M.tuberculosis_H37Rv VESVYGHDGFLVETEAVGELIRQTLGLADREGACRR-------------
MAV_4316|M.avium_104 VDSICGHDGFLVESEAVGEMIRKTLLLAGSQSAGPGGAGPGSRKGTTRR
Mflv_4876|M.gilvum_PYR-GCK VESAYGHDGFLVETDAVGKLIRRTLDLAGK-------------------
Mvan_1553|M.vanbaalenii_PYR-1 VDSACGHDGFLVETDAVGKLIRRTLELAAR-------------------
TH_1969|M.thermoresistible__bu IDSMYGHDGFLVETEAVGKLIRRTLELADR-------------------
MAB_3688|M.abscessus_ATCC_1997 VESVHGHDAFLIEFDAVSELVRETLALAKATQAS---------------
MSMEG_6772|M.smegmatis_MC2_155 IPGIYGHFAGGDANPEDNKFIDGLVRELLAR------------------
: . ** . .::: :