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TNDSHPSDTGPDRGADLDLSGKVAVVTGAAAGLGRAEAIGLAKAGATVVVNDIAGALEGSDVLDEIAAAG SKGVAVAGDISQRSTADELVETAEGLGGLDIVVNNAGITRDRILFNMSDEEWDAVIAVHLRGHFLLTRNA AAYWRSKAKAGDGTVYGRVINTSSEAGLSGPVGQPNYGAAKAGITALTLSAARALERFGVRANAIAPRAR TAMTAGVFGDAPELAEGQMDPLSTDHVVTLVQFLAAPASEGVNGQLFIVYGPSVTLVAAPTAEKQFVADE DAWEPADLSVTLRDYFADRDPERGFSATALMESRD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5903 | fabG | - | 100% (316) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. smegmatis MC2 155 | MSMEG_5999 | - | 2e-65 | 46.76% (293) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0096 | - | 3e-35 | 37.15% (253) | peroxisomal hydratase-dehydrogenase-epimerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3532c | fabG | 1e-124 | 73.87% (310) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_1553 | fabG | 1e-144 | 85.67% (300) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv3502c | fabG | 1e-124 | 73.87% (310) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 6e-32 | 37.22% (266) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_4156c | - | 1e-127 | 77.78% (297) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_4990 | fabG | 1e-127 | 76.19% (294) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_0654 | fabG | 1e-124 | 77.08% (288) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. thermoresistible (build 8) | TH_3743 | - | 1e-141 | 84.90% (298) | PUTATIVE oxidoreductase, short chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_4065 | fabG | 1e-127 | 76.19% (294) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_5205 | fabG | 1e-140 | 87.12% (295) | 3-ketoacyl-(acyl-carrier-protein) reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1553|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5205|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5903|M.smegmatis_MC2_155 --------------------------------------------------
TH_3743|M.thermoresistible__bu --------------------------------------------------
Mb3532c|M.bovis_AF2122/97 --------------------------------------------------
Rv3502c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4990|M.marinum_M --------------------------------------------------
MUL_4065|M.ulcerans_Agy99 --------------------------------------------------
MAV_0654|M.avium_104 --------------------------------------------------
MAB_4156c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mflv_1553|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5205|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5903|M.smegmatis_MC2_155 --------------------------------------------------
TH_3743|M.thermoresistible__bu --------------------------------------------------
Mb3532c|M.bovis_AF2122/97 --------------------------------------------------
Rv3502c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4990|M.marinum_M --------------------------------------------------
MUL_4065|M.ulcerans_Agy99 --------------------------------------------------
MAV_0654|M.avium_104 --------------------------------------------------
MAB_4156c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mflv_1553|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5205|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5903|M.smegmatis_MC2_155 --------------------------------------------------
TH_3743|M.thermoresistible__bu --------------------------------------------------
Mb3532c|M.bovis_AF2122/97 --------------------------------------------------
Rv3502c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4990|M.marinum_M --------------------------------------------------
MUL_4065|M.ulcerans_Agy99 --------------------------------------------------
MAV_0654|M.avium_104 --------------------------------------------------
MAB_4156c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mflv_1553|M.gilvum_PYR-GCK -----------------------------------------------MPD
Mvan_5205|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5903|M.smegmatis_MC2_155 -----------------------------------------MTNDSHPSD
TH_3743|M.thermoresistible__bu --------------------------------------------------
Mb3532c|M.bovis_AF2122/97 -------------------------------------------MKLTESN
Rv3502c|M.tuberculosis_H37Rv -------------------------------------------MKLTESN
MMAR_4990|M.marinum_M --------------------------------------------------
MUL_4065|M.ulcerans_Agy99 --------------------------------------------------
MAV_0654|M.avium_104 --------------------------------------------------
MAB_4156c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mflv_1553|M.gilvum_PYR-GCK SASLRGTENDLSGRVAVVTGAAAGLGRAEAIGLAKAGATVVVNDMAAALD
Mvan_5205|M.vanbaalenii_PYR-1 -----MTHTDLSGHVAVVTGAAAGLGRAEAIGLAKAGATVVVNDIAPALD
MSMEG_5903|M.smegmatis_MC2_155 TGPDRGADLDLSGKVAVVTGAAAGLGRAEAIGLAKAGATVVVNDIAGALE
TH_3743|M.thermoresistible__bu LTTNTPATNDLSGLVAVVTGAAAGLGRAEAIGLARAGATVVVNDIASALD
Mb3532c|M.bovis_AF2122/97 RSPRTTNTTDLSGKVAVVTGAAAGLGRAEALGLARLGATVVVNDVASALD
Rv3502c|M.tuberculosis_H37Rv RSPRTTNTTDLSGKVAVVTGAAAGLGRAEALGLARLGATVVVNDVASALD
MMAR_4990|M.marinum_M -MTSSTNVTDLSGRVAVVTGAAAGLGRAEAVGLARLGATVVVNDIGSALD
MUL_4065|M.ulcerans_Agy99 -------MTDLSGRVAVVTGAAAGLGRAEAVGLARLGATVVVNDIGSALD
MAV_0654|M.avium_104 ----------------MVTGAAAGLGRAEALGLARLGATVVVNDIATALD
MAB_4156c|M.abscessus_ATCC_199 --MSAIADADLSGRVAIVTGAAAGLGRAEAIGLARSGATVVVNDIAPALD
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
:***** *:* * * :*: ** **. *: * :
Mflv_1553|M.gilvum_PYR-GCK KSDVLDEISS----AGSKGVAVAGDISQRSTADELVETADGLGG--LAIV
Mvan_5205|M.vanbaalenii_PYR-1 KSDVLDEIAA----AGSKGVAVAGDISQRSTADELVETADGLGG--LAIV
MSMEG_5903|M.smegmatis_MC2_155 GSDVLDEIAA----AGSKGVAVAGDISQRSTADELVETAEGLGG--LDIV
TH_3743|M.thermoresistible__bu TSDVLDEIAA----AGSKGVAVAGDISQRATADELVQTADNLGG--LGIV
Mb3532c|M.bovis_AF2122/97 ASDVVDEIGAAAADAGAKAVAVAGDISQRATADELLASAVGLGG--LDIV
Rv3502c|M.tuberculosis_H37Rv ASDVVDEIGAAAADAGAKAVAVAGDISQRATADELLASAVGLGG--LDIV
MMAR_4990|M.marinum_M ASDVIDEISA----VGAKAIAVAGDISQRATADELIATADGLGG--LDVV
MUL_4065|M.ulcerans_Agy99 ASDVIDEISA----VGAKAIAVAGDISQRATADELIATADGLGG--LDVV
MAV_0654|M.avium_104 ASDVIDEINA----AGSKAVAVAGDISERATADELVAQADGLGG--LDIV
MAB_4156c|M.abscessus_ATCC_199 KSDVLDEIAA----AGSKGVTVAGDIGERATADELISTAESLGG--LHVV
MLBr_02565|M.leprae_Br4923 ALDETANRVG--------GTTLSLDVTADDAVDKITEHLHDYQGGHADIL
* : . . ::: *: :.*:: . * ::
Mflv_1553|M.gilvum_PYR-GCK VNNAGITRDRILFNMTDEEWDAVIAVHLRGHFLLTRNAATYWRSKAKEG-
Mvan_5205|M.vanbaalenii_PYR-1 VNNAGITRDRILFNMTDEEWDAVIAVHLRGHFLLTRNAATYWRSKAKQGG
MSMEG_5903|M.smegmatis_MC2_155 VNNAGITRDRILFNMSDEEWDAVIAVHLRGHFLLTRNAAAYWRSKAKAG-
TH_3743|M.thermoresistible__bu VNNAGITRDKMLFNMSDEDWDAVIAVHLRGHFLLTRNAAAYWRAKAKES-
Mb3532c|M.bovis_AF2122/97 VNNAGITRDRMLFNMSDEEWDAVIAVHLRGHFLLTRNAAAYWRDKAKDAE
Rv3502c|M.tuberculosis_H37Rv VNNAGITRDRMLFNMSDEEWDAVIAVHLRGHFLLTRNAAAYWRDKAKDAE
MMAR_4990|M.marinum_M VNNAGITRDRMLFNMTDEDWDQVIGVHLRGHFLLTRNAATYWRQKAKAA-
MUL_4065|M.ulcerans_Agy99 VNNAGITRDRMLFNMTDEDWDQVIGVHLRGHFLLTRNAATYWRQKAKAA-
MAV_0654|M.avium_104 VNNAGITRDRMLFNMSDEEWDLVIAVHLRGHFLLTRNAAAYWRSRAKEA-
MAB_4156c|M.abscessus_ATCC_199 VNNAGITRDRMLFNMSDEEFDAVIHVHLRGHFLLTRNAATYWRGASKAA-
MLBr_02565|M.leprae_Br4923 VNNAGITRDKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNG--------
*********::* ** * :* *: *:* . **.. .
Mflv_1553|M.gilvum_PYR-GCK ----DGTIYGRIINTSSEAGLSGPVGQPNYGAAKAGITALTLSAARALER
Mvan_5205|M.vanbaalenii_PYR-1 PGVENGQIYGRIINTSSEAGLSGPVGQPNYGAAKAGITALTLSAARALGR
MSMEG_5903|M.smegmatis_MC2_155 ----DGTVYGRVINTSSEAGLSGPVGQPNYGAAKAGITALTLSAARALER
TH_3743|M.thermoresistible__bu ----GGQVYGRIINTSSEAGLSGPIGQANYGAAKAGITALTLTAARALER
Mb3532c|M.bovis_AF2122/97 ----GGSVFGRLVNTSSEAGLVGPVGQANYAAAKAGITALTLSAARALGR
Rv3502c|M.tuberculosis_H37Rv ----GGSVFGRLVNTSSEAGLVGPVGQANYAAAKAGITALTLSAARALGR
MMAR_4990|M.marinum_M ----GGSIFGRLVNTSSEAGLVGPVGQANYGAAKAGITALTLSAARALGR
MUL_4065|M.ulcerans_Agy99 ----GGSIFGRLVNTSSEAGLVGPVGQANYGAAKAGITALTLSAARALGR
MAV_0654|M.avium_104 ----GGRIFGRIVNTASEAGLVGPVGQANYGAAKAGIISLTLTAARALGR
MAB_4156c|M.abscessus_ATCC_199 ----GAPTYGRLINTSSEAGLLGPEGQANYGAAKAGITALTLSAARALGR
MLBr_02565|M.leprae_Br4923 ----SISKGGRVIVLSSMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAE
. **:: :* **: * **.**.:****: .** : * .* .
Mflv_1553|M.gilvum_PYR-GCK FGVRANAIAP-RARTAMTAGVFGDAPELADGAVDPLS---PEHVVNLVRF
Mvan_5205|M.vanbaalenii_PYR-1 FGVRANAIAP-RARTAMTAGVFGDAPELPEGAVDPLS---PDHVVNLVRF
MSMEG_5903|M.smegmatis_MC2_155 FGVRANAIAP-RARTAMTAGVFGDAPELAEGQMDPLS---TDHVVTLVQF
TH_3743|M.thermoresistible__bu YGVRANAIAP-RARTAMTAAVFGDEPELAEGQIDPLS---PEHVVTLVRF
Mb3532c|M.bovis_AF2122/97 YGVCANVICP-RARTAMTADVFGAAPDVEAGQIDPLS---PQHVVSLVQF
Rv3502c|M.tuberculosis_H37Rv YGVCANVICP-RARTAMTADVFGAAPDVEAGQIDPLS---PQHVVSLVQF
MMAR_4990|M.marinum_M YGVCANAICP-RARTAMTADVFGATPDVAAGEIDPLS---PEHVVTLVQF
MUL_4065|M.ulcerans_Agy99 YGVCANAICP-RARTAMTADVFGATPDVAAGEIDPLS---PEHVVTLVQF
MAV_0654|M.avium_104 YGVCANAICP-RARTAMTADVFGDAPEVPAGGVDPLS---PEHVVNLVTF
MAB_4156c|M.abscessus_ATCC_199 YGVRANAIAP-RARTAMTADVFGDAP---EDSIDPLS---PEHVVTLVRY
MLBr_02565|M.leprae_Br4923 KGITINAVAPGFIETQMTAAIPLATREVGRRLNSLLQGGLPVDVAETIAY
*: *.:.* .* *** : . *. . .*. : :
Mflv_1553|M.gilvum_PYR-GCK LASPASEGVNGQLFIVYGPTVTLIAAPTAERQFSADGDAWDPSALSGTLQ
Mvan_5205|M.vanbaalenii_PYR-1 LASPAAEGVNGQLFIVYGPTVTLMAAPTAERQFSADGAEWDPADLSDTLR
MSMEG_5903|M.smegmatis_MC2_155 LAAPASEGVNGQLFIVYGPSVTLVAAPTAEKQFVADEDAWEPADLSVTLR
TH_3743|M.thermoresistible__bu LASPASEAVNGQLFIVYGPTVTLVAAPTAERRFEARADAWDPADLSETLR
Mb3532c|M.bovis_AF2122/97 LASPAAAEVNGQVFIVYGPQVTLVSPPHMERRFSADGTSWDPTELTATLR
Rv3502c|M.tuberculosis_H37Rv LASPAAAEVNGQVFIVYGPQVTLVSPPHMERRFSADGTSWDPTELTATLR
MMAR_4990|M.marinum_M LASPAAAAVNGQLFIVYGPQVTLVAAPTAEHKFSADGPAWEPGQLTDTLH
MUL_4065|M.ulcerans_Agy99 LASPAAAAVNGQLFIVYGPQVTLVAAPTAEHKFSADGPAWEPGQLTDTLH
MAV_0654|M.avium_104 LSSPAAAEVNGQVFIVYGPQVTLVAAPTAEHKFSAQGPAWDPAELSATLQ
MAB_4156c|M.abscessus_ATCC_199 LAAPAAEAVNGQLFIVYGPTVTLLAAPTVEAKFTADSDAWDPSALNSTLA
MLBr_02565|M.leprae_Br4923 FAIPASNAVTGNVIRVCGQAMLGA--------------------------
:: **: *.*::: * * :
Mflv_1553|M.gilvum_PYR-GCK GYFAERDPGRSFSAAMGLGDPV
Mvan_5205|M.vanbaalenii_PYR-1 NYFADRDPERSFSAAMGLGDPH
MSMEG_5903|M.smegmatis_MC2_155 DYFADRDPERGFSATALMESRD
TH_3743|M.thermoresistible__bu SYFADRDPNRGFSATELMGVTD
Mb3532c|M.bovis_AF2122/97 DYFAGRDPEQSFSATDLMRQ--
Rv3502c|M.tuberculosis_H37Rv DYFAGRDPEQSFSATDLMRQ--
MMAR_4990|M.marinum_M DYFAGRNPEHNFSASSLMA---
MUL_4065|M.ulcerans_Agy99 DYFAGRNPEHNFSASSLMA---
MAV_0654|M.avium_104 DYFAGRDPEHNFSASALMEQ--
MAB_4156c|M.abscessus_ATCC_199 DFFAGHDPKRTFSATALMVED-
MLBr_02565|M.leprae_Br4923 ----------------------