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VPWWGAVLAAVTATAIGFAFDAGAGSRELSGVFGFCYVVGCLAAVLAVRQSGVFTAVIQPPLILFFAVPG SYFLFHGGEINGLKDLAINCGYPLIERFPLMLFTSAAVLLIGLGRWYVGLTSRDTGDTESATPSTRKRAS DEAPNAVVASITSKLSSLLFRKPATDRSASRQRARQSTRRDRAERAGTGAAPRKRTGERPPRRRPAAAAA ADAKEPTRNGRPTKRTAPPRARRPRDPELDPTLDAPERPRRPRSARTEPPVVPPAEPRRRVRTQPREPRE PRKQPPGDRLGPYERPQRRRRFDDYRPFEDPFDAPMEPPFEPRTNGHPGRSTHHPVSRVRYRGGEDEDHR SEYRTRPRPPARGRHSRD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5223 | - | - | 100% (368) | hypothetical protein MSMEG_5223 |
| M. smegmatis MC2 155 | MSMEG_6285 | - | 5e-07 | 35.82% (134) | DNA polymerase III subunits gamma and tau |
| M. smegmatis MC2 155 | MSMEG_6099 | - | 3e-06 | 27.62% (210) | transmembrane protein rich in alanine |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1141c | - | 2e-57 | 41.53% (366) | hypothetical protein Mb1141c |
| M. gilvum PYR-GCK | Mflv_2081 | - | 2e-71 | 42.86% (385) | hypothetical protein Mflv_2081 |
| M. tuberculosis H37Rv | Rv1111c | - | 2e-57 | 41.53% (366) | hypothetical protein Rv1111c |
| M. leprae Br4923 | MLBr_01937 | - | 7e-59 | 41.02% (373) | putative integral membrane protein |
| M. abscessus ATCC 19977 | MAB_1258c | - | 3e-44 | 38.06% (289) | hypothetical protein MAB_1258c |
| M. marinum M | MMAR_4354 | - | 1e-70 | 44.25% (391) | hypothetical protein MMAR_4354 |
| M. avium 104 | MAV_1231 | - | 1e-65 | 43.52% (386) | hypothetical protein MAV_1231 |
| M. thermoresistible (build 8) | TH_1237 | - | 6e-37 | 46.96% (181) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0167 | - | 4e-69 | 43.47% (398) | hypothetical protein MUL_0167 |
| M. vanbaalenii PYR-1 | Mvan_4626 | - | 1e-75 | 45.90% (366) | hypothetical protein Mvan_4626 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1141c|M.bovis_AF2122/97 -------------------------------MSAQRARSAVQASHRSIHP
Rv1111c|M.tuberculosis_H37Rv -------------------------------MSAQRARSAVQASHRSIHP
MMAR_4354|M.marinum_M -------------------------------MSADRARTAVPPSHRSIVP
MUL_0167|M.ulcerans_Agy99 -------------------------------MSADRARTAVPPSHRSIVP
MAV_1231|M.avium_104 --------------------------------------------------
MLBr_01937|M.leprae_Br4923 MERPNEYMARQRSILNKVFTGFSAYCRYGQHVSKQQARSTVESTYRSILP
MSMEG_5223|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2081|M.gilvum_PYR-GCK -------------------------------MSGQRARPAVAADHRSAHP
Mvan_4626|M.vanbaalenii_PYR-1 -------------------------------MSEQRARPAVAPEHSSAHP
MAB_1258c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1237|M.thermoresistible__bu ----------------------------------------VPAELRSAHP
Mb1141c|M.bovis_AF2122/97 HIPGVPWWAAILIAVTATAIGYAIDAGSGHKALTLVFTGCYIAGCVGAVL
Rv1111c|M.tuberculosis_H37Rv HIPGVPWWAAILIAVTATAIGYAIDAGSGHKALTLVFTGCYIAGCVGAVL
MMAR_4354|M.marinum_M NIPGAPWWGAVLIAVSTTALGYAFDAG--HKDLTHVFAGFYIVGCIAAVL
MUL_0167|M.ulcerans_Agy99 NIPGAPWWGAVLIAVSTTALGYAFDAG--HKDLTHVFAGFYIVGCIAAVL
MAV_1231|M.avium_104 ----------MLVAVTATAIGYGIDAG--HKELTHVFAGFYIAGCVAAVL
MLBr_01937|M.leprae_Br4923 NIPGVPWWAALLIATTASAIGYAIDAG--NTDLTTVFTGFYITGCVAAVL
MSMEG_5223|M.smegmatis_MC2_155 ----MPWWGAVLAAVTATAIGFAFDAGAGSRELSGVFGFCYVVGCLAAVL
Mflv_2081|M.gilvum_PYR-GCK NVAGIPWWGAILSAVVASLIGFAFDAGSGGGALTGAFATLYVIGCLIGVL
Mvan_4626|M.vanbaalenii_PYR-1 NIAGIPWWGAILTAVIASAIGFAFDAGSGGGQLTAAFAALYVVGCLVAVL
MAB_1258c|M.abscessus_ATCC_199 ----MPWWGAILIAVAGTLFGFALDAMINGEKLTGAFAGCYAAGCVVAVL
TH_1237|M.thermoresistible__bu DIPGVPWWGAALIALTATALGFAFDAGSGSKELSVVFSGTYMLGCLVAVL
* * : :*:.:** *: .* * **: .**
Mb1141c|M.bovis_AF2122/97 AVRQSDLFTALVQPPLILFCAVPGAYWLFHGGTIGKFKDLLINCGYSLIE
Rv1111c|M.tuberculosis_H37Rv AVRQSDLFTALVQPPLILFCAVPGAYWLFHGGTIGKFKDLLINCGYSLIE
MMAR_4354|M.marinum_M AVRQSGVFTAVIQPPLILFITVPGAYWLFHSAKIGKFKDLLINCGYPLIE
MUL_0167|M.ulcerans_Agy99 AVRQSGVFTAVIQPPLILFITVPGAYWLFHSAKIGKFKDLLINCGYPLIE
MAV_1231|M.avium_104 AVRQDGIFTTIIQPPLILFCAVPGAYWLFHDAKVGRLKDLLINCGYPLIE
MLBr_01937|M.leprae_Br4923 AVRQSGLFTAVIQPPLILFCAVPAAYWLFHGSKIKSLKDLLINCGYPLIE
MSMEG_5223|M.smegmatis_MC2_155 AVRQSGVFTAVIQPPLILFFAVPGSYFLFHGGEINGLKDLAINCGYPLIE
Mflv_2081|M.gilvum_PYR-GCK AVQQSALFTAVIQPPLVLFVTVPAAYFLMHSSEIQGVKDILINCGYPLIQ
Mvan_4626|M.vanbaalenii_PYR-1 AVQQSNLFTAVIQPPLVLFVTVPAAYFLMHSSDIQGLKDILINCGYPLIE
MAB_1258c|M.abscessus_ATCC_199 AVRYASIFTAVVQPPLILFASIPMAYLIMSQAPLAGGKSTAITIGYPLIE
TH_1237|M.thermoresistible__bu AVRPG-------RPPIVLFAAVPSAYFLFHGGQIRGLKDLAINCGYPLIE
**: :**::** ::* :* :: . : *. *. **.**:
Mb1141c|M.bovis_AF2122/97 RFPLMLG-------------------------------------------
Rv1111c|M.tuberculosis_H37Rv RFPLMLG-------------------------------------------
MMAR_4354|M.marinum_M RFPLMLG-------------------------------------------
MUL_0167|M.ulcerans_Agy99 RFPLMLG-------------------------------------------
MAV_1231|M.avium_104 RFPLMLG-------------------------------------------
MLBr_01937|M.leprae_Br4923 RFPLMLG-------------------------------------------
MSMEG_5223|M.smegmatis_MC2_155 RFPLMLF-------------------------------------------
Mflv_2081|M.gilvum_PYR-GCK RFPLMFF-------------------------------------------
Mvan_4626|M.vanbaalenii_PYR-1 RFPLMFF-------------------------------------------
MAB_1258c|M.abscessus_ATCC_199 RFPLMIS-------------------------------------------
TH_1237|M.thermoresistible__bu RFPVXXXPFYTATAANPEGMRRRRQFHSRGRQLTGFTDEILGRPDAGEDL
***:
Mb1141c|M.bovis_AF2122/97 --------------------------------------------------
Rv1111c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4354|M.marinum_M --------------------------------------------------
MUL_0167|M.ulcerans_Agy99 --------------------------------------------------
MAV_1231|M.avium_104 --------------------------------------------------
MLBr_01937|M.leprae_Br4923 --------------------------------------------------
MSMEG_5223|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2081|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4626|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1258c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1237|M.thermoresistible__bu TGDPDAALLAAINAPRGPGMRDIVATIQAEQDAVIRLDHPGVLVIEGGPG
Mb1141c|M.bovis_AF2122/97 ----------------------TAAGVLLIGLVRWYLG------------
Rv1111c|M.tuberculosis_H37Rv ----------------------TAAGVLLIGLVRWYLG------------
MMAR_4354|M.marinum_M ----------------------TAGTVLLIGLIRWYIGMAQRTS------
MUL_0167|M.ulcerans_Agy99 ----------------------TAGTVLLIGLIRWYIGMAQRTS------
MAV_1231|M.avium_104 ----------------------TAGAVLAIGLVRWYFGHGQRST------
MLBr_01937|M.leprae_Br4923 ----------------------TAGSVLLIGLVRWFFQLMYRTT------
MSMEG_5223|M.smegmatis_MC2_155 ----------------------TSAAVLLIGLGRWYVGLTSRDTG-----
Mflv_2081|M.gilvum_PYR-GCK ----------------------TSAAVLLIGLARWYFAKS----------
Mvan_4626|M.vanbaalenii_PYR-1 ----------------------TSAAVLMIGLARWYFAKSGHQF------
MAB_1258c|M.abscessus_ATCC_199 ----------------------TALGVLIIGVVRWYWG------------
TH_1237|M.thermoresistible__bu TGKTAVALHRVAYLLYTRRSQLSGSGVLVVGPNPTFLDHIGRVLPNLGES
:. ** :* :
Mb1141c|M.bovis_AF2122/97 --------------------------------------------------
Rv1111c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4354|M.marinum_M ------------------------------------ALATGDDGEP-TTA
MUL_0167|M.ulcerans_Agy99 ------------------------------------ALATGDDGEP-TTA
MAV_1231|M.avium_104 ------------------------------------TAAGSDDAAAGPSV
MLBr_01937|M.leprae_Br4923 ------------------------------------ASSNSEDD---TVS
MSMEG_5223|M.smegmatis_MC2_155 ----------------------------------DTESATPSTRKRASDE
Mflv_2081|M.gilvum_PYR-GCK --------------------------------------HPAGESQPAGVG
Mvan_4626|M.vanbaalenii_PYR-1 ------------------------------------GAQARGKGAPAGAG
MAB_1258c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1237|M.thermoresistible__bu DVVFMTPGDLVPGLRVTAQDSDDAARVKGSLEILDVLRAAVADRQRLPEE
Mb1141c|M.bovis_AF2122/97 --TALFDSIARKLSSLMTGDSDD-------------------------DG
Rv1111c|M.tuberculosis_H37Rv --TALFDSIARKLSSLMTGDSDD-------------------------DG
MMAR_4354|M.marinum_M ARTPILHSLAEKLSALLGGDSDDPDDVADAAPPAPEAGRRSSRSSRSSTG
MUL_0167|M.ulcerans_Agy99 ARTPILHSLAEKLSALLGGDSDDPDDVADAAPPAPEAGRRSSRSGRSSTG
MAV_1231|M.avium_104 DIQSLVGGLVAKVRAALHPDSDGDTTEESAQRRRTRRSGSSSRTRRTARS
MLBr_01937|M.leprae_Br4923 KPNSLISGITAVLNSILCIYSNDQNHRANQDTADTELMHSDPPLR---TR
MSMEG_5223|M.smegmatis_MC2_155 APNAVVASITSKLSSLLFRKPATDRSASRQRARQSTRRDRAERAGTGAAP
Mflv_2081|M.gilvum_PYR-GCK GVAAKLAGLVGGLRRPGGARADGAKTRPRRQADRRRPRDAKPTARRSAHS
Mvan_4626|M.vanbaalenii_PYR-1 -LSAKLSSLLGGSATAVDGDAVADEP-PRRRATDRRRAAPKPAARKSSRG
MAB_1258c|M.abscessus_ATCC_199 ----IFSGRPARDKTAKPAKPKATKS--------AKPRTTRTRVQTLVDA
TH_1237|M.thermoresistible__bu PLPIELSDVTVRIDAETAQWARQEARDSGLPHNEARAVFADVVTWVLTER
. . .
Mb1141c|M.bovis_AF2122/97 GRRSAQRPARTRSRHARPPSEDNREPI--AER------------------
Rv1111c|M.tuberculosis_H37Rv GRRSAQRPARTRSRHARPPSEDNREPI--AER------------------
MMAR_4354|M.marinum_M GRSTTRRTDRTRARRTRPPVEDQPDPG--AERPR---------RRRPTPP
MUL_0167|M.ulcerans_Agy99 GRSTTRRTDRTRARRTRPPVEDQPDPG--AERPR---------RRRPTPP
MAV_1231|M.avium_104 TRSSAS-SSRTRSRHARPPLDDAAEPAERPERPRRAARRSAAARNYDTAG
MLBr_01937|M.leprae_Br4923 QTARDNRSARTHSGQARRVVEYTSEPLVEPWQHS--------SQRSSEQA
MSMEG_5223|M.smegmatis_MC2_155 RKRTGERPPRRRPAAAAAADAKEPTRNGRPTKRTAP------PRARRPRD
Mflv_2081|M.gilvum_PYR-GCK GAPSTRGAPSRRHSRAPETEIIDPVVDEQPRRRR----------------
Mvan_4626|M.vanbaalenii_PYR-1 DRPVKRSAPRARQAPAPETEIIDPVAD-RPRRRR----------------
MAB_1258c|M.abscessus_ATCC_199 ETDATAKTGGTAVRSRRPRVEEAAARTRHGRHES----------------
TH_1237|M.thermoresistible__bu AIARIGRGWLTRDDRAAWEELRADLLDELANNADYAAALDQLWPILTPQQ
.
Mb1141c|M.bovis_AF2122/97 ----------RSRRR----PRP--------------QNDPHPRRN---AH
Rv1111c|M.tuberculosis_H37Rv ----------RSRRR----PRP--------------QNDPHPRRN---AH
MMAR_4354|M.marinum_M PDHDAAEPPRRARRR----PRPPGDSDLRATPPRQPRRDPHTRRNPYESY
MUL_0167|M.ulcerans_Agy99 PDNDAAEPPRWARRR----PRPPGDSDLRATPPRQPRRDPHTRRNPYESY
MAV_1231|M.avium_104 RNYDAAEPPRRTRRR----PRPDADPELRGQPPREPRREPRPRRS---PY
MLBr_01937|M.leprae_Br4923 RDFDAGESPRRSRRQ----PTPQSDPELRSQPPREIRRDAYGHRS--GPY
MSMEG_5223|M.smegmatis_MC2_155 PELDPTLDAPERPRR----PRS-----ARTEPPVVPPAEPRRRVRTQPRE
Mflv_2081|M.gilvum_PYR-GCK PRPDGQ--SPEPRRR----PRPSSSREPREPRRSRESREDRESRG--APS
Mvan_4626|M.vanbaalenii_PYR-1 PRPEEQPPTPEPRRR----PRTSSAREPRNAR-----------------S
MAB_1258c|M.abscessus_ATCC_199 ----------PTRRR----PTRDSEPVSRRASSIGTPWEDERPMR---TE
TH_1237|M.thermoresistible__bu LLADLYTSPERLRAVGADPALYRADGEAWTVSDVPLLDELIDLLGPDKPA
.
Mb1141c|M.bovis_AF2122/97 ERPAPRSSRFDSYRSYQPSEPSGPAEPVNRYERRGAR---YQPYARYEPT
Rv1111c|M.tuberculosis_H37Rv ERPAPRSSRFDSYRSYQPSEPSGPAEPVNRYERRGAR---YQPYARYEPT
MMAR_4354|M.marinum_M ERPAPRTSRFDPYSGYEPPE---APESFDRYERRAGR---YEPYEPFEP-
MUL_0167|M.ulcerans_Agy99 ERPAPRTSRFDPYSGYEPPE---AAESFDRYERRAGRYEPYEPYEPFEP-
MAV_1231|M.avium_104 ERPVPRSSRFD---GYDPPS---GPENLGRYDT-------------PEPP
MLBr_01937|M.leprae_Br4923 EWPTNHSSHLEPYRRYKQPG---PPEHFTEHGQLYER-------------
MSMEG_5223|M.smegmatis_MC2_155 PREPRKQPPGDRLGPYERPQ---RRRRFDDYRPFEDP---------FDAP
Mflv_2081|M.gilvum_PYR-GCK REPRERRVRRDRYDPYDRGD---TYDRGDAYERPRPQRE------RPQRP
Mvan_4626|M.vanbaalenii_PYR-1 RDPLPPRERRSPYDGDDRHD---HRPQRDRGPREQPRR-------RSRFD
MAB_1258c|M.abscessus_ATCC_199 RRPARRLRDEYDYDDYGYDE------------------------------
TH_1237|M.thermoresistible__bu DDTAERERQKQAEYAAEVLESLVRREDLMDDEDRLLPTDMLFGEDLAERF
Mb1141c|M.bovis_AF2122/97 YEPQRRRARPSEP----------TNPTHHPISQVRYRGSATRDARRDNYR
Rv1111c|M.tuberculosis_H37Rv YEPQRRRARPSEP----------TNPTHHPISQVRYRGSATRDARRDNYR
MMAR_4354|M.marinum_M FEPPRRRGSTGGPNN--------ANPKHHPISQVRYRGAAPRDEGRDQYR
MUL_0167|M.ulcerans_Agy99 FEPPRWRGSTGGPNN--------ANPKHHPISQVRYRGAAPRDEGRDQYR
MAV_1231|M.avium_104 YEPRRRRPASTGA-----------NGTHHPISQVRYRGAAAPGQPREPHT
MLBr_01937|M.leprae_Br4923 YKQPRRRATPPRA------------SSVNPISQVRYRGSTARDDPR----
MSMEG_5223|M.smegmatis_MC2_155 MEPPFEPRTNGHP----------GRSTHHPVSRVRYRGGEDE--------
Mflv_2081|M.gilvum_PYR-GCK RYDDYEPYGSDGP------------SSHHPVSRVRYRG-EESGE------
Mvan_4626|M.vanbaalenii_PYR-1 DHEPFDPYSSAGT------------SSHHPISRVRYRGADDVDD------
MAB_1258c|M.abscessus_ATCC_199 -RPRYREPRAEAP-----------REPHRPA--VRYRD------------
TH_1237|M.thermoresistible__bu AERDHRDLAERAAADRDWVYGHIVVDEAQELSEMDWRALMRRCPSRSFTV
. . : :*
Mb1141c|M.bovis_AF2122/97 EEQRFDRRDRS------RAPRRPPAESWEYDV------------------
Rv1111c|M.tuberculosis_H37Rv EEQRFDRRDRS------RAPRRPPAESWEYDV------------------
MMAR_4354|M.marinum_M DEPRPDRRSRP------RAPRRPQAESWEYDA------------------
MUL_0167|M.ulcerans_Agy99 DEPRPSPRTAP------APGRIPGVRRLTP--------------------
MAV_1231|M.avium_104 -ERRTRSRTPG------RTQGRPPAESWEYDA------------------
MLBr_01937|M.leprae_Br4923 -----VDRQRS------QTPRRPVTESWEFDV------------------
MSMEG_5223|M.smegmatis_MC2_155 -----DHRSEY------RTRPRPPARGRHSRD------------------
Mflv_2081|M.gilvum_PYR-GCK ---RAEYRSRR------REPR--DADRWEYDI------------------
Mvan_4626|M.vanbaalenii_PYR-1 ---RAEHRSRR------HSPRDADADRWEFDI------------------
MAB_1258c|M.abscessus_ATCC_199 -----ERPPVP------PRRRQDRYDAWDYDR------------------
TH_1237|M.thermoresistible__bu VGDLSQRRSAAGTTSWDSMFERYVPGRWVYRTLTVNYRTPAEIMAVAAAL
Mb1141c|M.bovis_AF2122/97 --------------------------------------------------
Rv1111c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4354|M.marinum_M --------------------------------------------------
MUL_0167|M.ulcerans_Agy99 --------------------------------------------------
MAV_1231|M.avium_104 --------------------------------------------------
MLBr_01937|M.leprae_Br4923 --------------------------------------------------
MSMEG_5223|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2081|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4626|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1258c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1237|M.thermoresistible__bu LAEFAPGVAPPESVRASGVPPWSRRVTADELPAAVEEFVRAEADRPGTSV
Mb1141c|M.bovis_AF2122/97 --------------------------------------------------
Rv1111c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4354|M.marinum_M --------------------------------------------------
MUL_0167|M.ulcerans_Agy99 --------------------------------------------------
MAV_1231|M.avium_104 --------------------------------------------------
MLBr_01937|M.leprae_Br4923 --------------------------------------------------
MSMEG_5223|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2081|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4626|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1258c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1237|M.thermoresistible__bu VIGPPDVPGAVAPSQTKGLEFDAVLVVEPERILADGPRGAAELYVALTRA
Mb1141c|M.bovis_AF2122/97 --------------------------------
Rv1111c|M.tuberculosis_H37Rv --------------------------------
MMAR_4354|M.marinum_M --------------------------------
MUL_0167|M.ulcerans_Agy99 --------------------------------
MAV_1231|M.avium_104 --------------------------------
MLBr_01937|M.leprae_Br4923 --------------------------------
MSMEG_5223|M.smegmatis_MC2_155 --------------------------------
Mflv_2081|M.gilvum_PYR-GCK --------------------------------
Mvan_4626|M.vanbaalenii_PYR-1 --------------------------------
MAB_1258c|M.abscessus_ATCC_199 --------------------------------
TH_1237|M.thermoresistible__bu TQRLGVLHIDPLPSALSGLTPLEDPAGTPAPA