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VRSGAGPTVAGMGTELPVQRLRRRLGSDTDATTDTIDAADAGDTEDSESGVAPDTALSKWLPDTTEGQRP AWLNVIRADPGRVGVLALATLGVLAVLITVFVVLRDRPAPVMSANLPPVQMVSSSAPTPEAAAGPVVVSV VGLVHKPGLVTLSSGARIADALTAAGGALDGADLIGLNMARRVADGEQIVVGIAAPAGQPTTMGSSVSTA EATGAAEPAAGGGGQTASGPLDLNTATVEQLDALPGVGPVTAEAIVSWRNANGQFASVDQLGEVDGIGPA RLEKLRGLVRV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4574 | - | - | 100% (292) | DNA-binding protein |
| M. smegmatis MC2 155 | MSMEG_2839 | - | 1e-05 | 30.61% (147) | transcriptional accessory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2438c | - | 3e-86 | 58.03% (305) | hypothetical protein Mb2438c |
| M. gilvum PYR-GCK | Mflv_2662 | - | 5e-90 | 63.21% (280) | helix-hairpin-helix repeat-containing competence protein ComEA |
| M. tuberculosis H37Rv | Rv2415c | - | 2e-85 | 57.70% (305) | hypothetical protein Rv2415c |
| M. leprae Br4923 | MLBr_02420 | hemD | 4e-06 | 26.89% (212) | putative uroporphyrin-III C-methyltransferase |
| M. abscessus ATCC 19977 | MAB_1626 | - | 6e-74 | 56.72% (268) | hypothetical protein MAB_1626 |
| M. marinum M | MMAR_3736 | comEA | 7e-83 | 59.32% (295) | membrane protein ComEA |
| M. avium 104 | MAV_1767 | - | 1e-79 | 56.46% (294) | helix-hairpin-helix repeat-containing competence protein ComEA |
| M. thermoresistible (build 8) | TH_2831 | - | 2e-23 | 49.59% (121) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_3680 | comEA | 3e-80 | 58.31% (295) | membrane protein ComEA |
| M. vanbaalenii PYR-1 | Mvan_3915 | - | 8e-92 | 64.56% (285) | helix-hairpin-helix repeat-containing competence protein ComEA |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2662|M.gilvum_PYR-GCK ----------------------------------------------MSTE
Mvan_3915|M.vanbaalenii_PYR-1 ----------------------------------------------MSTE
MSMEG_4574|M.smegmatis_MC2_155 ----------------------------------MVRSGAGPTVAGMGTE
Mb2438c|M.bovis_AF2122/97 ----------------------------------------------MRTE
Rv2415c|M.tuberculosis_H37Rv ----------------------------------------------MRTE
MAV_1767|M.avium_104 ----------------------------------------------MRTE
MMAR_3736|M.marinum_M ----------------------------------------------MRTE
MUL_3680|M.ulcerans_Agy99 ----------------------------------------------MRTE
MAB_1626|M.abscessus_ATCC_1997 ----------------------------------------------MEPE
TH_2831|M.thermoresistible__bu ----------------------------------------------MRTE
MLBr_02420|M.leprae_Br4923 MVGATMTTRGRKLRPGRITFVGAGPGAPGLLTAQAVAVLANAALVFIDPD
: .:
Mflv_2662|M.gilvum_PYR-GCK LPADRLR---RRLGSD-------------------------------PDT
Mvan_3915|M.vanbaalenii_PYR-1 LPAERLR---RRLGADG-----------------------------HADT
MSMEG_4574|M.smegmatis_MC2_155 LPVQRLR---RRLGSDTDAT---------------------TDTIDAADA
Mb2438c|M.bovis_AF2122/97 LPAERLQ---RRLGAVPDIDSHAA-------------SAHLDPEPHDPTD
Rv2415c|M.tuberculosis_H37Rv LPAERLQ---RRLGAVPDIDSHAA-------------SAHLDPEPHDPTD
MAV_1767|M.avium_104 LPAERLQ---RRLRAEPDAD------------------AAVQPEEPGPIA
MMAR_3736|M.marinum_M LPAERLQ---RRLSTAPDLR--------------------LHAESGAAES
MUL_3680|M.ulcerans_Agy99 LPAERLQ---RRLTTAPDLR--------------------LHAESGAAES
MAB_1626|M.abscessus_ATCC_1997 LLHRRLAPAGREFDDDDDDD---------------------DDDEDDDED
TH_2831|M.thermoresistible__bu LPAARLY---RRLGAGHHPDSGSGRTDTG----EDRGEDRGEERGEDRGE
MLBr_02420|M.leprae_Br4923 VPEPVLALIGKDLPPVSGPAPAGPAAVTAGRAADGTLEGDHYQAAPMVMS
: * : :
Mflv_2662|M.gilvum_PYR-GCK AED------DAPDTSLSRWLPAD---------------------------
Mvan_3915|M.vanbaalenii_PYR-1 GDDE-----DPPDTTLSRWLPAS---------------------------
MSMEG_4574|M.smegmatis_MC2_155 GDTEDSESGVAPDTALSKWLPDT---------------------------
Mb2438c|M.bovis_AF2122/97 DGPDHDEPRDDPNSLLPRWLPDT---------------------------
Rv2415c|M.tuberculosis_H37Rv DGPDHDEPRDDPNSLLPRWLPDT---------------------------
MAV_1767|M.avium_104 G---EDFPDDDQNSLLPRWLPGA---------------------------
MMAR_3736|M.marinum_M GADPHDDRDDDPNSLLPRWLPEA---------------------------
MUL_3680|M.ulcerans_Agy99 GADPHDDRDDDPNSLLPRWLSEA---------------------------
MAB_1626|M.abscessus_ATCC_1997 EDLARAAAGSEPESAL-RWLPDSL--------------------------
TH_2831|M.thermoresistible__bu EGTAANESGTAPDAVLSKWLPDN---------------------------
MLBr_02420|M.leprae_Br4923 GGADIRPALGDPTEVAKTLTAEARSGVDVVRLVAGDPLTVDAVIAEVNAV
.
Mflv_2662|M.gilvum_PYR-GCK ---------------------EPSGPSAWLTRIRADPGRAGVIALGVVGV
Mvan_3915|M.vanbaalenii_PYR-1 ---------------------APGGPSALMARVRADPGRAGVVALGVIGI
MSMEG_4574|M.smegmatis_MC2_155 ---------------------TEGQRPAWLNVIRADPGRVGVLALATLGV
Mb2438c|M.bovis_AF2122/97 ---------------------SRG--QGWADRIRADPGRAGAVALAVIAA
Rv2415c|M.tuberculosis_H37Rv ---------------------SRG--QGWADRIRADPGRAGAVALAVIAA
MAV_1767|M.avium_104 ---------------------PEH--RGWVARIRADPGRAGAIGLAIVAA
MMAR_3736|M.marinum_M ---------------------GDG--SGLLSRVRADPGRAGAIALAVVAA
MUL_3680|M.ulcerans_Agy99 ---------------------GDG--SGLLSRVRADPGRAGAIALAVVAA
MAB_1626|M.abscessus_ATCC_1997 ---------------------TAGGTRGWLESVRTDPGRAGVVALGAIGV
TH_2831|M.thermoresistible__bu ---------------------TDGASGGWLAAIRADPGRAGAVALVAVGV
MLBr_02420|M.leprae_Br4923 ARTNLQIEIVPGLVTSSVVPTYAGLPLGSSHTVADVRGDVDWEALAAAPG
. : * .. .*
Mflv_2662|M.gilvum_PYR-GCK VAVLVTVLTLIGDSPPAVVSAKLPPVDMAS---SAAPGA-----------
Mvan_3915|M.vanbaalenii_PYR-1 VAVLVTVLSLIRDSPPAVVSAKLPPVEMVS---SPAPGAGP---------
MSMEG_4574|M.smegmatis_MC2_155 LAVLITVFVVLRDRPAPVMSANLPPVQMVS---SSAPTP-----------
Mb2438c|M.bovis_AF2122/97 LAVLVTVFTLIRDRTEPVMSAKLPPVEPVS---PTNPRS-----------
Rv2415c|M.tuberculosis_H37Rv LAVLVTVFTLIRDRTEPVMSAKLPPVEPVS---PTNPRS-----------
MAV_1767|M.avium_104 LAVLVTVFTLIRDRPAPVMSAKLPPVEKVS---TASPRS-----------
MMAR_3736|M.marinum_M LAVLVTAFTLLRDRPAPVMSAKLPAVEHVSGSSGASPGS-----------
MUL_3680|M.ulcerans_Agy99 LAVLVTAFTLLHDRPAPVMSAKLPAVEHVSGSSGASPGS-----------
MAB_1626|M.abscessus_ATCC_1997 LAVLVTVFTVMRQPPAPVS-ANLPPVQPVS----SSSVS-----------
TH_2831|M.thermoresistible__bu TAVLITIFALVRDETPPVMSANXX--------------------------
MLBr_02420|M.leprae_Br4923 PLILQATASHLADAAHILIDHGLDDATPCVVTAQGTTCQQRSVETTLEGL
:* : : : . :
Mflv_2662|M.gilvum_PYR-GCK ---------PAPAE---PVVVSVVGLVHTPGLV-----------------
Mvan_3915|M.vanbaalenii_PYR-1 AA-------PGPAG---PVVVSVVGLVHTPGLV-----------------
MSMEG_4574|M.smegmatis_MC2_155 ---------EAAAG---PVVVSVVGLVHKPGLV-----------------
Mb2438c|M.bovis_AF2122/97 --SASP---GSPDRSGLPVVVSVVGLVHTPGLV-----------------
Rv2415c|M.tuberculosis_H37Rv --SASP---GSPDRSGLPVVVSVVGLVHTPGLV-----------------
MAV_1767|M.avium_104 --SASPS--GGPDR---PVVVSVVGLVHTPGLV-----------------
MMAR_3736|M.marinum_M --SASPAAAAGPDR---PVVVSVVGLVHTPGLF-----------------
MUL_3680|M.ulcerans_Agy99 --SASPAAAAGPDR---PVVVSVVGLVHTSGLF-----------------
MAB_1626|M.abscessus_ATCC_1997 ----------APSS----LVISVVGLVKRPGLV-----------------
TH_2831|M.thermoresistible__bu --------------------------------------------------
MLBr_02420|M.leprae_Br4923 ADSAVLVGTDTAGPLTGPLVVTIGKTVTSRARLNWWESRALYGWTVLVPR
Mflv_2662|M.gilvum_PYR-GCK TLPPGSRIADALDAAGGALDGADMLGLNMARRVADGEQIVVGLGA-----
Mvan_3915|M.vanbaalenii_PYR-1 TLAPGARIADALDAAGGALDGADVLGLNMARRVADGEQIVVGIGA-----
MSMEG_4574|M.smegmatis_MC2_155 TLSSGARIADALTAAGGALDGADLIGLNMARRVADGEQIVVGIAA-----
Mb2438c|M.bovis_AF2122/97 TLAPGARIADALQAAGGAVDGADTVGLNMARQLGDGEQIVVGLAP-----
Rv2415c|M.tuberculosis_H37Rv TLAPGARIADALQAAGGAVDGADTVGLNMARQLGDGEQIVVGLAP-----
MAV_1767|M.avium_104 TLAPGARIADAVQAAGGAVNGADTAGLNMARPLDDGEQIVVGLAP-----
MMAR_3736|M.marinum_M TLAPGARVADALQAAGGALAGADTIGLNMARQLADGEQIVVGLAP-----
MUL_3680|M.ulcerans_Agy99 TLAPGARVADALQAAGGALAGADTIGLNMARQLADGEQIVVGLAP-----
MAB_1626|M.abscessus_ATCC_1997 TLATGARVADAVTAAGGAVDGADVITLNMARPVADGDQIVVGLAP-----
TH_2831|M.thermoresistible__bu -----------------------------------------XVGR-----
MLBr_02420|M.leprae_Br4923 TKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW
:
Mflv_2662|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3915|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4574|M.smegmatis_MC2_155 --------------------------------------------------
Mb2438c|M.bovis_AF2122/97 --------------------------------------------------
Rv2415c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1767|M.avium_104 --------------------------------------------------
MMAR_3736|M.marinum_M --------------------------------------------------
MUL_3680|M.ulcerans_Agy99 --------------------------------------------------
MAB_1626|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2831|M.thermoresistible__bu --------------------------------------------------
MLBr_02420|M.leprae_Br4923 VVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGEATADRVRAFGISPE
Mflv_2662|M.gilvum_PYR-GCK --PPGQPTRM----------------------------------------
Mvan_3915|M.vanbaalenii_PYR-1 --PAGQPTEM----------------------------------------
MSMEG_4574|M.smegmatis_MC2_155 --PAGQPTTM----------------------------------------
Mb2438c|M.bovis_AF2122/97 --PSGQPRVL----------------------------------------
Rv2415c|M.tuberculosis_H37Rv --PSGQPRVL----------------------------------------
MAV_1767|M.avium_104 --VPGQPPVL----------------------------------------
MMAR_3736|M.marinum_M --VAGQPKRF----------------------------------------
MUL_3680|M.ulcerans_Agy99 --VAGQPKRF----------------------------------------
MAB_1626|M.abscessus_ATCC_1997 --VPGQPVGM----------------------------------------
TH_2831|M.thermoresistible__bu --PPAHPR------------------------------------------
MLBr_02420|M.leprae_Br4923 LVPAGEQSSLGLLDEFPPYDSVFDPVNRVLLPRADIATETLAEGLRGCGW
...
Mflv_2662|M.gilvum_PYR-GCK -GSAV-VADAGSPGGGAMPENSP----GSPGLVDLNSATVEQLDTLPG--
Mvan_3915|M.vanbaalenii_PYR-1 -GSSI-VSQAAEPG-AASPQTPA----ASTGLVDLNTATAEQLDTLPG--
MSMEG_4574|M.smegmatis_MC2_155 -GSSVSTAEATGAAEPAAGGGGQ----TASGPLDLNTATVEQLDALPG--
Mb2438c|M.bovis_AF2122/97 -GSSVGAGTPGPAGTSGTATTGPKTAPKTAEVLDLNTATVEQLDALPG--
Rv2415c|M.tuberculosis_H37Rv -GSSVGAGTPGPAGTSGTATTGPKTAPKTAEVLDLNTATVEQLDALPG--
MAV_1767|M.avium_104 -GSSVAAGST-PAPKPPPGPGAAKAKPKTSDAVDLNTATVQELDALPG--
MMAR_3736|M.marinum_M -GSSIGAATPSPAPAATSGTRSP--GPNPAEVLDLNTATVEQLDSLPG--
MUL_3680|M.ulcerans_Agy99 -GSSIGAATPSPAPAATSGTRSP--GPNLAEVLDLNTATVEQLDSLPG--
MAB_1626|M.abscessus_ATCC_1997 -ASSIVAAGQTPAG--STGSKGP----GAPGRVNLNTATESELDALPG--
TH_2831|M.thermoresistible__bu -HSS----------------------------------------------
MLBr_02420|M.leprae_Br4923 EIEDVTAYRTVRAAPPPAATREMIKTGGFDAVCFTSSSTVRNLVGIAGKP
.
Mflv_2662|M.gilvum_PYR-GCK --------VGPVTAAAIVAWRDANGRFTSVDQLGDVDGIGPARLDKLRDL
Mvan_3915|M.vanbaalenii_PYR-1 --------VGPVTAAAILAWRDANGRFSSVEQLGDVDGIGPARLDKLRAL
MSMEG_4574|M.smegmatis_MC2_155 --------VGPVTAEAIVSWRNANGQFASVDQLGEVDGIGPARLEKLRGL
Mb2438c|M.bovis_AF2122/97 --------IGPVTAAAIVAWRQRNGRFTSVDQLADVDGIGPARLDKLRNL
Rv2415c|M.tuberculosis_H37Rv --------IGPVTAAAIVAWRQRNGRFTSVDQLADVDGIGPARLDKRRNL
MAV_1767|M.avium_104 --------VGPVTAAAIVAWRQTNGRFTSVDQLADVEGIGPARLEKLRAL
MMAR_3736|M.marinum_M --------VGPVTAAAIVSWRAANGKFTSVDQLAEVDGIGPARLQKLRSL
MUL_3680|M.ulcerans_Agy99 --------VGPVTAAAIVSWRAANGNFTSVDQLAEVDGIGPARLQKLRSL
MAB_1626|M.abscessus_ATCC_1997 --------VGPVMAASIVRWRSEHGKFTSIDQLAEVDGIGPSRLDKLRDF
TH_2831|M.thermoresistible__bu --------------------------------------------------
MLBr_02420|M.leprae_Br4923 HARTVIACIGPKTAETASEFGLRVDVQPETAAVGPLVDALAEHVARLRAE
Mflv_2662|M.gilvum_PYR-GCK VRV----------
Mvan_3915|M.vanbaalenii_PYR-1 VRV----------
MSMEG_4574|M.smegmatis_MC2_155 VRV----------
Mb2438c|M.bovis_AF2122/97 VRV----------
Rv2415c|M.tuberculosis_H37Rv VRV----------
MAV_1767|M.avium_104 VRV----------
MMAR_3736|M.marinum_M VRV----------
MUL_3680|M.ulcerans_Agy99 VRV----------
MAB_1626|M.abscessus_ATCC_1997 VVL----------
TH_2831|M.thermoresistible__bu -------------
MLBr_02420|M.leprae_Br4923 GALPPPRKKSRRR