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M. smegmatis MC2 155 MSMEG_4454 (ltaE)

VPSSAFASDNAAPAHPNVLDAITAANTGAAPSYGADPITQRAVAALRTAFDSPDAEVLFALTGTGANVIA
LAASVRPWQSILCSDIAHSLVDEAGGPVRLSGAQLTVLPSDDGLIDAAVLDDAVVRRGDVHASQPAVVTI
TQSTENGRVWTPQTIKDFIDHAHDLGLLVHVDGARVANAVAALDVAPREAVGDADIVTVGGTKNGLLMGD
ALLVRRPELFEGIHFAQKQIGHLSSKQRFIAAQFEAMLRDDLWLRNAAHANAMAARLSSGMTERGLTLAS
PTDANEVFVNLPAATFAAVSERYAVHRLDPRHPAVRFVCSWATTDQEVDDVLALLGQL

Operon Prediction Model: Genebank

Paralogs

species	id	gene	e-value	identity (len)	annotation
M. smegmatis MC2 155	MSMEG_4454	ltaE	-	100% (338)	L-threonine aldolase, low-specificity

Closest Orthologs (e-value cutoff: 1e-4)

species	id	gene	e-value	identity (len)	annotation
M. bovis AF2122 / 97	-	-	-	-	-
M. gilvum PYR-GCK	Mflv_5153	-	1e-115	70.10% (291)	threonine aldolase
M. tuberculosis H37Rv	-	-	-	-	-
M. leprae Br4923	-	-	-	-	-
M. abscessus ATCC 19977	-	-	-	-	-
M. marinum M	MMAR_0208	glyA	4e-05	26.30% (308)	serine hydroxymethyltransferase GlyA2
M. avium 104	-	-	-	-	-
M. thermoresistible (build 8)	-	-	-	-	-
M. ulcerans Agy99	MUL_1927	iscS	3e-05	25.26% (190)	cysteine desulfurase IscS
M. vanbaalenii PYR-1	Mvan_1179	-	1e-129	67.46% (335)	threonine aldolase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_5153|M.gilvum_PYR-GCK          -----MPSAAFASDNAAPAHPSVLDALHRANDGSAPSYGDDAVTAQAADA
Mvan_1179|M.vanbaalenii_PYR-1       --MERVPSAAFASDNAAPAHPRVLEALHHVNQGPAPSYGDDPVTAEAAEA
MSMEG_4454|M.smegmatis_MC2_155      -----MPSSAFASDNAAPAHPNVLDAITAANTGAAPSYGADPITQRAVAA
MUL_1927|M.ulcerans_Agy99           MVYLDHAATTPMHPTAIEAMTAVLATVGNASSLHTTGRAARRRLEESREL
MMAR_0208|M.marinum_M               MTILNESLSTFDPDIAALIDSELNRQETGLEMIASENYAPLAVMQAQGSV
                                          . ::     *    . :       .   : . .           

Mflv_5153|M.gilvum_PYR-GCK          IRTAFDS--------PGADVLFAFTGTAANTIALA-------SATRPWHE
Mvan_1179|M.vanbaalenii_PYR-1       LRTAFES--------PGADVLFAFTGTAANIIALA-------SAVRPWHE
MSMEG_4454|M.smegmatis_MC2_155      LRTAFDS--------PDAEVLFALTGTGANVIALA-------ASVRPWQS
MUL_1927|M.ulcerans_Agy99           IAAKLGA--------RPSEVIFTAGGTESDNLAVKGMYWARRDAQPARRR
MMAR_0208|M.marinum_M               LTNKYAEGYPGRRYYGGCEFVDGVEQLAIDRVKALFG--AEYANVQPHSG
                                    :                .:.:        : :              .   

Mflv_5153|M.gilvum_PYR-GCK          IFCSDVAH-VLVDEAGGPVRLSGAQLTRLPSV----------DGLIAPED
Mvan_1179|M.vanbaalenii_PYR-1       IFCSDVAH-VLVDEAGGPVRLSGAQLTRLASD----------DGLISPDE
MSMEG_4454|M.smegmatis_MC2_155      ILCSDIAH-SLVDEAGGPVRLSGAQLTVLPSD----------DGLIDAAV
MUL_1927|M.ulcerans_Agy99           IVTTRVEHHAVLDTVDWLVEHEGAEVTWLPTDA---------DGSVSASA
MMAR_0208|M.marinum_M               ATANASAMHALLNPGDTILGLSLAHGGHLTHGMRINFSGKLYNVAAYEVS
                                       .      :::  .  :  . *.   *.            :       

Mflv_5153|M.gilvum_PYR-GCK          LERRVRGRGAVHHSQPRIVSITQSTESGRVWTTDAVADFVDHAHALGLLV
Mvan_1179|M.vanbaalenii_PYR-1       LERRVRGRSAVHHSQPRIVSITQSTENGRVWSATAVAQFVDRAHALGLLV
MSMEG_4454|M.smegmatis_MC2_155      LDDAVVRRGDVHASQPAVVTITQSTENGRVWTPQTIKDFIDHAHDLGLLV
MUL_1927|M.ulcerans_Agy99           LRDALES-----HDDVALVSVMWANN--EVGTIMPIAELAGVAAEFGVPM
MMAR_0208|M.marinum_M               KDDYLIDMDAVAQAARDHQPKMIIAGWSAYPRQLDFARFREIADEVGAVL
                                        :              .               .  :   *  .*  :

Mflv_5153|M.gilvum_PYR-GCK          HVDGAR-IANAVAALGVSPV---EAIADADIVSIGGTKNGLLFGDAILVR
Mvan_1179|M.vanbaalenii_PYR-1       HVDGAR-IANAVAALSISPL---EAIGDADIVSVGGTKNGLMFGDAILVR
MSMEG_4454|M.smegmatis_MC2_155      HVDGAR-VANAVAALDVAPR---EAVGDADIVTVGGTKNGLLMGDALLVR
MUL_1927|M.ulcerans_Agy99           HSDAVQAVGQIPVDFGACGL---AAMSVTAHKFGGPPGAGALLMRRDVSC
MMAR_0208|M.marinum_M               MVDMAHFAGLVATGLHPSPVPHAHVVTSTTHKTLGGPRGGIILSNDAAIA
                                      * .:  .   . :  .      .:  :     * .  * ::       

Mflv_5153|M.gilvum_PYR-GCK          RPE---HFDGIHWVQKQIG--------HLASKHRFIAAQFVALFGDGLWL
Mvan_1179|M.vanbaalenii_PYR-1       RPA---HFDGIHFVQKQIG--------HLASKHRFVAAQFAGLFEGGLWL
MSMEG_4454|M.smegmatis_MC2_155      RPE---LFEGIHFAQKQIG--------HLSSKQRFIAAQFEAMLRDDLWL
MUL_1927|M.ulcerans_Agy99           VPL---LHGGGQERDIRSGTPDVASAVGIAAAARIAVDGLEANSARLQTL
MMAR_0208|M.marinum_M               KKINSAVFPGQQGGPLEHVIAAKATAFKMAAQPEFVQRQQRCLDGARILA
                                           . * :    .           :::  .:               

Mflv_5153|M.gilvum_PYR-GCK          RNAEHANAMARRLSAGLQSLGYQLASPAESNEVFVQIDGDCARAPDAGLS
Mvan_1179|M.vanbaalenii_PYR-1       RNAAHANAMARRLSTGLEALGLQLASPTESNEVFVKLDGEAHRR------
MSMEG_4454|M.smegmatis_MC2_155      RNAAHANAMAARLSSGMTERGLTLASPTDANEVFVNLPAATFAA------
MUL_1927|M.ulcerans_Agy99           RDRLVAGVLAEIDDVRLNGARDPLRLPGNAHFTFRGCEGDALLMLLDANG
MMAR_0208|M.marinum_M               DRLNQPDVAERGITVLTGGTDVHLVLVDLRNADLDGQQAEDRLAAVDITV
                                         ...               *      :  :    .           

Mflv_5153|M.gilvum_PYR-GCK          GPPARPQPACGAVRDVLGHHGGRGRRRPGRVDNVARVGAPRARVSARPSP
Mvan_1179|M.vanbaalenii_PYR-1       -----------LAERYLVHQPDPGQP-------VVRF------VCSWSTT
MSMEG_4454|M.smegmatis_MC2_155      -----------VSERYAVHRLDPRHP-------AVRF------VCSWATT
MUL_1927|M.ulcerans_Agy99           -------IECSTGSACTAGVAQPSHVLIAMGADPASARGSLRLSLGHTTV
MMAR_0208|M.marinum_M               N---RNAVPFDPRPPMVTSGLRIGTPALASRGFSHDDFGAVADIVAAALT
                                                                                 . .  

Mflv_5153|M.gilvum_PYR-GCK          ACHADSPHARRGTTAPIVTP----------
Mvan_1179|M.vanbaalenii_PYR-1       ETEVDDALAALRSAGN--------------
MSMEG_4454|M.smegmatis_MC2_155      DQEVDDVLALLGQL----------------
MUL_1927|M.ulcerans_Agy99           EADVDAALQVLPAAVARARSAAVAAAGAAW
MMAR_0208|M.marinum_M               AADDDQLGELRKQVQELAARYPLYPELHKP
                                      . *