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MIRHSPPIRLLLADVDGTLVTHDKVLTHRTLAAVAKLREAGILFAVTSGRPPRGMSKLIEPLGLTTPLAA FNGGLFVRPDLSVIERRMISDDVTAAVIEQLDTDGLTVWVYRGADWLVPDPHGPHVAREARTVGFGPTPI ESYPPISRGVSKIVGVSDDHDAVRKAAARLRERFADHVSAATSQPYYVDVTHPDANKGAVVSFLSAAYDI ATESIATIGDMANDVAMFRKSGLSIAMGNAGDEVRRAARCVTASNADDGFADAVERFVLP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4434 | - | - | 100% (270) | Cof protein |
| M. smegmatis MC2 155 | MSMEG_6407 | - | 1e-21 | 29.67% (273) | Cof-like hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3843c | - | 2e-17 | 28.73% (275) | hypothetical protein Mb3843c |
| M. gilvum PYR-GCK | Mflv_1155 | - | 2e-22 | 29.67% (273) | Cof-like hydrolase |
| M. tuberculosis H37Rv | Rv3813c | - | 1e-17 | 28.73% (275) | hypothetical protein Rv3813c |
| M. leprae Br4923 | MLBr_00089 | - | 1e-20 | 28.68% (272) | hypothetical protein MLBr_00089 |
| M. abscessus ATCC 19977 | MAB_0167 | - | 8e-22 | 29.50% (278) | putative hydrolase |
| M. marinum M | MMAR_5376 | - | 2e-15 | 27.92% (265) | hypothetical protein MMAR_5376 |
| M. avium 104 | MAV_0205 | - | 2e-21 | 30.80% (276) | hypothetical protein MAV_0205 |
| M. thermoresistible (build 8) | TH_0897 | - | 3e-21 | 29.41% (272) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4996 | - | 9e-16 | 27.55% (265) | hypothetical protein MUL_4996 |
| M. vanbaalenii PYR-1 | Mvan_5654 | - | 4e-20 | 29.09% (275) | Cof-like hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00089|M.leprae_Br4923 MTDTTRPAPTPTQPTLIACDVDGTLLDENETVTARTRAAVRSAVAGGAYF
MAV_0205|M.avium_104 ----------MTLPRLIACDVDGTLFDDDERITPRTRAAVRAAVAGGARF
Mb3843c|M.bovis_AF2122/97 --------MKPTVPALVACDVDGTLLDDGETVTKRTRDAVHAAVDAGTHF
Rv3813c|M.tuberculosis_H37Rv --------MKPTVPALVACDVDGTLLDDGETVTKRTRDAVHAAVDAGTHF
MMAR_5376|M.marinum_M ------------------------MLNDDEHVSGRTRDAVRAAVAGGATF
MUL_4996|M.ulcerans_Agy99 ------------------------MLNDDEHVSGRTRDAVRAAVAGGATF
Mflv_1155|M.gilvum_PYR-GCK -----------MTPLMIATDVDGTLLDNDENVTARTRSAVRAAVDAGVRF
Mvan_5654|M.vanbaalenii_PYR-1 --------------MLVATDVDGTLLDDDENVSPRTRSVVRAVVDAGAQF
TH_0897|M.thermoresistible__bu ----------VTLPSLIASDVDGTLLDDQERLTPRTRDAIYAARDAGAHF
MAB_0167|M.abscessus_ATCC_1997 ----------MTHPALIASDVDGTLIDSAEILSARTRAVITAAVESGSAF
MSMEG_4434|M.smegmatis_MC2_155 ------MIRHSPPIRLLLADVDGTLVTHDKVLTHRTLAAVAKLREAGILF
:. : :: ** .: .* *
MLBr_00089|M.leprae_Br4923 VLATGRPPRWVRPVVDALGFPPMAVCANGAVIYDPATDRVVSARTLAVDI
MAV_0205|M.avium_104 VVATGRPPRWIRPVVDALGFAPIAVCANGAVIYDPANDRVLSARTLDVDT
Mb3843c|M.bovis_AF2122/97 ILATGRPPRWVRPIVDALGFAPMAVCANGAVIYDPGTDRVTSVRTLPVDA
Rv3813c|M.tuberculosis_H37Rv ILATGRPPRWVRPIVDALGFAPMAVCANGAVIYDPGTDRVMSVRTLPVDA
MMAR_5376|M.marinum_M ILATGRPPRWVRPVVEELGFTPMAVCANGAVIYDPATDRVVSAHTLSVEA
MUL_4996|M.ulcerans_Agy99 ILATGRPPRWVRPVVEELGFTPMAVCANGAVIYDPATDRVVSAHTLSVEA
Mflv_1155|M.gilvum_PYR-GCK VLATGRPPRWVGPVVDQLGFAPMAVCANGAVIYDPSTDRIVSARTLSTDV
Mvan_5654|M.vanbaalenii_PYR-1 VLATGRPPRWVPPIVDQLGFAPMAVCANGAVIYDPSTDRIISARTLSADA
TH_0897|M.thermoresistible__bu VLATGRPPRWIAPVVDALGFAPMAVCANGAVIYDPDTDRIVSARTLSAAT
MAB_0167|M.abscessus_ATCC_1997 VLATGRPPRWITPIVDALGFAPISVCANGSVLYDAENDRIISAATLSPSE
MSMEG_4434|M.smegmatis_MC2_155 AVTSGRPPRGMSKLIEPLGLTTPLAAFNGGLFVRPDLSVIERRMISDDVT
:::***** : ::: **:.. .. **.:: . . :
MLBr_00089|M.leprae_Br4923 LGELVEIATR-VIPGAGLAVERVGDRAHDSATPQFVSSVGYEHAWLHPDN
MAV_0205|M.avium_104 LAELAELATR-VIPGAGLAVERIGERAHDTATPQFISSPGYEHAWLNPDN
Mb3843c|M.bovis_AF2122/97 LATLAEVATR-VIPGAGLAVERIGERAHDTATPQFVSSPGYEHAWLNPDN
Rv3813c|M.tuberculosis_H37Rv LATLAEVATR-VIPGAGLAVERIGERAHDTATPQFVSSPGYEHAWLNPDN
MMAR_5376|M.marinum_M LATLAEVSSR-VIPGSGLAVERIGERAHDTATPQFVSSPGYEHAWLNPDN
MUL_4996|M.ulcerans_Agy99 LATLAEVSSR-VIPGSGLAVERIGERAHDTAAPQFVSSPGYEHAWLNPDN
Mflv_1155|M.gilvum_PYR-GCK LAMLAEIATR-TIPGAGLAVERVGSSAHDAATPQFVSSPGYEHAWLNPDN
Mvan_5654|M.vanbaalenii_PYR-1 LGQLAEIATR-VVPGAGLAVERVGSSAHDAATPQFVSSPGYEHAWLNPDN
TH_0897|M.thermoresistible__bu LQKLSDLVSR-LLPGAGLAVERVGEQAHDAATPQFVSSPGYEHAWLNPDN
MAB_0167|M.abscessus_ATCC_1997 LAVLAEVAQA-AIPGVGLAVERVGRSAHDAATPQFVSSPGYEHAWLNPDN
MSMEG_4434|M.smegmatis_MC2_155 AAVIEQLDTDGLTVWVYRGADWLVPDPHGPHVAREARTVGFGPTPIESYP
: :: ..: : .*.. ..: : *: : :..
MLBr_00089|M.leprae_Br4923 -TEVSIEDLLSVPAIKLLIRKSGARSADMAAELAKHVGIAG-DITYSTNN
MAV_0205|M.avium_104 -TEVSIEDLLSAPAIKLLIRRAGARSSDIAAELAKHVGLEG-DITYSTDN
Mb3843c|M.bovis_AF2122/97 -TEVSIDHLLSAPAIKLLIRKAGAASADMAAELAKHVGFEG-DITYSTNN
Rv3813c|M.tuberculosis_H37Rv -TEVSIDHLLSAPAIKLLIRKAGAASADMAAELAKHVGFEG-DITYSTNN
MMAR_5376|M.marinum_M -TEVSIEDLLSAPAIKLLIRKAGAASADMAAELAKHVGIEG-DITYSTNN
MUL_4996|M.ulcerans_Agy99 -TEVSIEDLLSAPAIKLLIRKAGAASADMAAELAKHVGIEG-DITYSTNN
Mflv_1155|M.gilvum_PYR-GCK -TEVSIEDLLSAPAVKLLVRKAGARSADMAEVLAQHIGTEG-DITYSTNN
Mvan_5654|M.vanbaalenii_PYR-1 -TEVSMEDLLSAPAVKLLIRKAGARSADMAAVLARHIGIEG-DITYSTNN
TH_0897|M.thermoresistible__bu -TEVSLEDLLSAPAIKLLIRKPGATSSEMAELLGEHIRPYG-EITFSTDN
MAB_0167|M.abscessus_ATCC_1997 -TEVSLEDLLSFPAVKLLVRKAGARSSEMAEVLAPLVTEAGAAITYSTDN
MSMEG_4434|M.smegmatis_MC2_155 PISRGVSKIVGVSDDHDAVRKAAAR---LRERFADHVSAAT------SQP
. .:..::. . : :*:..* : :. : ::
MLBr_00089|M.leprae_Br4923 GLVEILPLGISKATGVEEVGRPLGIADGNAAAFGDMPNDVPMLLRAGHGV
MAV_0205|M.avium_104 GLVEIVPLGISKATGIEEIARPLEIAREEVVAFGDMPNDLPMLRWAGHGV
Mb3843c|M.bovis_AF2122/97 GLVEIVPLGISKATGVDEIARPLGISDAEVVAFGDMPNDVPMLLRAGLGV
Rv3813c|M.tuberculosis_H37Rv GLVEIVPLGISKATGVDEIARPLGISDAEVVAFGDMPNDVPMLLRAGLGV
MMAR_5376|M.marinum_M GLVEIVPLGISKATGVRDVAAPLGIADTDVVAFGDMPNDVPMLLRAGLGV
MUL_4996|M.ulcerans_Agy99 GLVEIVPLGISKATGVRDVAAPLGIADTDVVAFGDMPNDVPMLLRAGLGV
Mflv_1155|M.gilvum_PYR-GCK GLIEIMPLGISKATGIEELARPLGVDAADIVTFGDMPNDVPMLGWAGLGV
Mvan_5654|M.vanbaalenii_PYR-1 GLIEIVPLGVSKATGIEELARPLGIEPADVVTFGDMPNDVPMLGWAGLGV
TH_0897|M.thermoresistible__bu GLLEVVSPGITKATGVEELARPLGLTAADVVAFGDMPNDIPMLRWAGLGV
MAB_0167|M.abscessus_ATCC_1997 GLIEVMPTGISKASGIAIVAKQAGVQPESIIAFGDMPNDVAMLRWAGHGV
MSMEG_4434|M.smegmatis_MC2_155 YYVDVTHPDANKGAVVSFLSAAYDIATESIATIGDMANDVAMFRKSGLSI
::: . .*.: : :. : . ::***.**:.*: :* .:
MLBr_00089|M.leprae_Br4923 AMGNAHPAVLAAADEITAPNTDDGVARVLERWWS-
MAV_0205|M.avium_104 AMGNAHPEVQAAADEITAANNDDGVGRVLERWWL-
Mb3843c|M.bovis_AF2122/97 AMGNAHPDALAVADEVTAPNSEDGVARVLERWWS-
Rv3813c|M.tuberculosis_H37Rv AMGNAHPDALAVADEVTAPNSEDGVARVLERWWS-
MMAR_5376|M.marinum_M AMGNAHPDALAAANEVTAPNSEDGVAKVLERWWF-
MUL_4996|M.ulcerans_Agy99 AMGNAHPDALAAANEVTAPNSEDGVAKVLERWWF-
Mflv_1155|M.gilvum_PYR-GCK AMGNAHPDALAAADEVTGTNAEDGVARVLERWWR-
Mvan_5654|M.vanbaalenii_PYR-1 AMGNAHPDAVAAADEVTATNAEDGVARVLERWWL-
TH_0897|M.thermoresistible__bu AMGNAHPKAIEAADEVTAPNTDDGLARVLERWWM-
MAB_0167|M.abscessus_ATCC_1997 AMGNAHPEARAAANEVTATNNDDGVAKVLERWWG-
MSMEG_4434|M.smegmatis_MC2_155 AMGNAGDEVRRAARCVTASNADDGFADAVERFVLP
***** . .* :*..* :**.. .:**: