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TLEPLDIDTDAKAYVALHALLDEPASDAALTERELAVRTQTRDVVAREIAPRAAELDRTHTFAHEGVQAL AAEGLCGLIFPTHLGGTGDTNVAYAVAMEEITAGCASTSLVFMTQMHCAYPIMLAGSDELQHRYIPGLLD GSRYGSLGITEPDAGSDVSSLTTTATRTADGWSVNGQKTFITTGDRADIIICFATIDRAAGRNGITAFVV DGRWDGVGHGTPFEKMGMHGSSTAELFFDSVAVPRDHLLGEEGRGWSVVMSSVVKSRISAAAQGVGLARA AYARTLAALTRMHGKRLPDEDTFELAELRGRILQGRMLLHAVARQVDTNPDVTPGQIGIMKQCCTDLGFD AAVQATRILGPYGDLAVLGVERCLRDAKVTQIYDGTNEIQRLLVGREIIRATGELA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4118 | - | - | 100% (407) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0108 | - | 8e-54 | 33.89% (360) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1821 | - | 1e-53 | 32.18% (376) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3302c | fadE25 | 1e-51 | 32.36% (377) | acyl-CoA dehydrogenase FADE25 |
| M. gilvum PYR-GCK | Mflv_4743 | - | 2e-54 | 32.18% (376) | butyryl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv3274c | fadE25 | 1e-51 | 32.36% (377) | acyl-CoA dehydrogenase FADE25 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-53 | 32.10% (377) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3618c | - | 6e-53 | 31.47% (375) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_1262 | fadE25 | 7e-55 | 32.45% (376) | acyl-CoA dehydrogenase FadE25 |
| M. avium 104 | MAV_4243 | - | 3e-55 | 32.18% (376) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3846 | - | 8e-55 | 32.18% (376) | PUTATIVE acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2626 | fadE25 | 5e-56 | 33.24% (376) | acyl-CoA dehydrogenase FadE25 |
| M. vanbaalenii PYR-1 | Mvan_1719 | - | 4e-53 | 31.38% (376) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3302c|M.bovis_AF2122/97 ----------------------------MVGWAGNPSFDLFKLPEEHDEM
Rv3274c|M.tuberculosis_H37Rv ----------------------------MVGWAGNPSFDLFKLPEEHDEM
MLBr_00737|M.leprae_Br4923 ----------------------------MVGWSGNPLFDLFKLPEEHNEL
TH_3846|M.thermoresistible__bu ----------------------------MAAWSGNPSFELFQLPEEHIAL
Mflv_4743|M.gilvum_PYR-GCK MQAEKSVPRNSLPAATALKLPTSSKEMLMASWAGNPSFDLFQLPEEHQEL
Mvan_1719|M.vanbaalenii_PYR-1 ----------------------------MASWAGNPSFDLFQLPEEHQEL
MMAR_1262|M.marinum_M ----------------------------MAGWAGNPSFDLFQLPEEHQEL
MUL_2626|M.ulcerans_Agy99 ----------------------------MAGWAGNPSFDLFQLPEEHQEL
MAV_4243|M.avium_104 ----------------------------MAGWAGNPDFDLFQLPEEHQEL
MAB_3618c|M.abscessus_ATCC_199 -------------------------------MAGNPSFDLFKLGEEHDEL
MSMEG_4118|M.smegmatis_MC2_155 ------------MTLEPLDIDTDAKAYVALHALLDEPASDAALTERELAV
: . * *.. :
Mb3302c|M.bovis_AF2122/97 RSAIRALAEKEIAPHAAEVDEKARFPEEALVALNSSGFNAVHIPEEYGGQ
Rv3274c|M.tuberculosis_H37Rv RSAIRALAEKEIAPHAAEVDEKARFPEEALVALNSSGFNAVHIPEEYGGQ
MLBr_00737|M.leprae_Br4923 RATIRALAEKEIAPHAADVDQRARFPEEALAALNASGFNAIHVPEEYGGQ
TH_3846|M.thermoresistible__bu REAIRALAEKEIAPYAAEVDEKARFPEEALAALNSSGFSAIHVPEEYGGQ
Mflv_4743|M.gilvum_PYR-GCK RAAIRALAEKEIAPHAADVDENARFPQEALDALVANGFNAVHVPEEYGGQ
Mvan_1719|M.vanbaalenii_PYR-1 RAAIRALAEKEIAPHAADVDENSRFPQEALDALNASGFNAVHVPEEFGGQ
MMAR_1262|M.marinum_M RAAIRALAEKEIAPHAADVDENSRFPQEALDALNASGFNAVHVPEEYGGQ
MUL_2626|M.ulcerans_Agy99 RAAIRALAEKEIAPHAADVDENSRFPQEALDALNASGFNALHVPEEYGGQ
MAV_4243|M.avium_104 RAAIRALAEKEIAPHAADVDENSRFPQEALEALNAAGFNAVHVPEEYGGQ
MAB_3618c|M.abscessus_ATCC_199 RAAIRGLAEKEIAPHAKDVDEKARFPQEALDALVASGFNAVHVPEEYDGQ
MSMEG_4118|M.smegmatis_MC2_155 RTQTRDVVAREIAPRAAELDRTHTFAHEGVQALAAEGLCGLIFPTHLGGT
* * :. :**** * ::*. *..*.: ** : *: .: .* . .*
Mb3302c|M.bovis_AF2122/97 GADSVATCIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPA
Rv3274c|M.tuberculosis_H37Rv GADSVATCIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPA
MLBr_00737|M.leprae_Br4923 GADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPS
TH_3846|M.thermoresistible__bu GADSVATCIVIEEVARVDCSASLIPAVNKLGTMGLILRGSEELKKQVLPA
Mflv_4743|M.gilvum_PYR-GCK GADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSDELKQKVLPS
Mvan_1719|M.vanbaalenii_PYR-1 GADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSDELKKKVLPS
MMAR_1262|M.marinum_M GADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSDDLKKQVLPS
MUL_2626|M.ulcerans_Agy99 GADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSDELKKQVLPS
MAV_4243|M.avium_104 GADSVAACIVIEEVARVDTSASLIPAVNKLGTMGLILRGSDELKKQVLPS
MAB_3618c|M.abscessus_ATCC_199 GADSVAACIVIEEVARVCASSSLIPAVNKLGTMGLILNGSDELKKQVLPA
MSMEG_4118|M.smegmatis_MC2_155 GDTNVAYAVAMEEITAGCASTSLVFMTQMHCAYPIMLAGSDELQHRYIPG
* .** .:.:**:: *:**: .: : ::* **::*::: :*.
Mb3302c|M.bovis_AF2122/97 LAAEGAMASYALSEREAGSDAASMRTRAKADGDHWILNGAKCWITNGGKS
Rv3274c|M.tuberculosis_H37Rv LAAEGAMASYALSEREAGSDAASMRTRAKADGDHWILNGAKCWITNGGKS
MLBr_00737|M.leprae_Br4923 LAAEGAMASYALSEREAGSDAASMRTRAKADGDDWILNGFKCWITNGGKS
TH_3846|M.thermoresistible__bu VASGEAMASYALSEREAGSDAASMRTRAVADGDDWILNGSKCWITNGGKS
Mflv_4743|M.gilvum_PYR-GCK LAAGESMASYALSEREAGSDAASMRTRAKADGDDWILNGAKCWITNGGKS
Mvan_1719|M.vanbaalenii_PYR-1 IASGEAMASYALSEREAGSDAAAMRTRAKADGDDWILNGAKCWITNGGKS
MMAR_1262|M.marinum_M LADGAAMASYALSEREAGSDAGAMRTRAKADGDDWILNGTKCWITNGGKS
MUL_2626|M.ulcerans_Agy99 LADGAAMASYALSEREAGSDAGAMRTRAKADGDDWILNGTKCWITNGGKS
MAV_4243|M.avium_104 IADGSAMASYALSEREAGSDAASMRTRARADGDDWILNGAKCWITNGGKS
MAB_3618c|M.abscessus_ATCC_199 IASGEAMASYALSEREAGSDAASMRTRAKADGDDWIINGSKCWITNGGKS
MSMEG_4118|M.smegmatis_MC2_155 LLDGSRYGSLGITEPDAGSDVSSLTTTATRTADGWSVNGQKTFITTGDRA
: .* .::* :****..:: * * .* * :** * :**.*.::
Mb3302c|M.bovis_AF2122/97 TWYTVMAVTDPDRGANGISAFMVHKDDEGFTVGPKERKLGIKGSPTTELY
Rv3274c|M.tuberculosis_H37Rv TWYTVMAVTDPDRGANGISAFMVHKDDEGFTVGPKERKLGIKGSPTTELY
MLBr_00737|M.leprae_Br4923 TWYTVMAVTDPDKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELY
TH_3846|M.thermoresistible__bu TWYTVMAVTDPDKGANGISAFMVHKDDEGFTVGPKERKLGIKGSPTTELY
Mflv_4743|M.gilvum_PYR-GCK DWYTVMAVNDPDKGANGISAFMVHVDDEGFSIGPKERKLGIKGSPTTELY
Mvan_1719|M.vanbaalenii_PYR-1 SWYTVMAVTDPDKGANGISAFMVHIDDEGFTIGPKERKLGIKGSPTTELY
MMAR_1262|M.marinum_M SWYTVMAVTDPEKGANGISAFMVHKDDEGFVVGPKERKLGIKGSPTTELY
MUL_2626|M.ulcerans_Agy99 SWYTVMAVTDPENGANGISAFVVHKDDEGFVVGPKERKLGIKGSPTTELY
MAV_4243|M.avium_104 SWYTVMAVTDPDKGANGISSFMVHKDDEGFTVGPKEKKLGIKGSPTTELY
MAB_3618c|M.abscessus_ATCC_199 SWYTVMAVTDPEKKANGISAFMVHKDDEGFTVGPLEHKLGIKGSPTAELY
MSMEG_4118|M.smegmatis_MC2_155 DIIICFATIDRAAGRNGITAFVVDGRWDGVGHGTPFEKMGMHGSSTAELF
:*. * ***::*:*. :*. *. .*:*::**.*:**:
Mb3302c|M.bovis_AF2122/97 FENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIA
Rv3274c|M.tuberculosis_H37Rv FENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIA
MLBr_00737|M.leprae_Br4923 FDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIV
TH_3846|M.thermoresistible__bu FENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIA
Mflv_4743|M.gilvum_PYR-GCK FENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIE
Mvan_1719|M.vanbaalenii_PYR-1 FENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDASLE
MMAR_1262|M.marinum_M FENCRVPGDRMIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIA
MUL_2626|M.ulcerans_Agy99 FENCRVPGDRMIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIA
MAV_4243|M.avium_104 FENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIA
MAB_3618c|M.abscessus_ATCC_199 FENCRIPGDRIIGEPGTGFKTALQTLDHTRPTIGAQALGIAQGALDQAIA
MSMEG_4118|M.smegmatis_MC2_155 FDSVAVPRDHLLGEEGRGWSVVMSSVVKSRISAAAQGVGLARAAYARTLA
*:. :* *:::** * *:...: :: ::* : .**.:*:*:.* ::
Mb3302c|M.bovis_AF2122/97 YTKDRKQFGESISTFQAVQFMLADMAMKVEAARLMVYSAAARAERGEPDL
Rv3274c|M.tuberculosis_H37Rv YTKDRKQFGESISTFQAVQFMLADMAMKVEAARLMVYSAAARAERGEPDL
MLBr_00737|M.leprae_Br4923 YTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDL
TH_3846|M.thermoresistible__bu YTKERKQFGRPVSDNQGVQFMLADMAMKIEAARLMVYSAAARAERGEGDL
Mflv_4743|M.gilvum_PYR-GCK YTKDRKQFGKSISDFQAVQFMLADMAMKVEAARLMVYSAAARAERGEGNL
Mvan_1719|M.vanbaalenii_PYR-1 YVKDRKQFGKSISEFQAVQFMLADMAMKVEAARLMVYSAAARAERGEGNL
MMAR_1262|M.marinum_M YTKDRKQFGKSISDFQAVQFMLADMAMKVESARLMVYSAAARAERGESNL
MUL_2626|M.ulcerans_Agy99 YTKDRKQFGKSISDFQAVQFMLADMAMKVESARLMVYSAAARAERGESNL
MAV_4243|M.avium_104 YTKERKQFGRPVSDNQGVQFMLADMAMKVESARLMVYHAAARAERGESHL
MAB_3618c|M.abscessus_ATCC_199 YTKDRKQFGKSISDFQGVQFMLADMAMKVEAARLMVYTAAARAERGEKNL
MSMEG_4118|M.smegmatis_MC2_155 ALT--RMHGKRLPDED--TFELAELRGRILQGRMLLHAVARQVDTNPDVT
. : .*. :. : * **:: :: .*:::: .* :.: .
Mb3302c|M.bovis_AF2122/97 GFISAASKCFASDVAMEVTTDAVQLFGGAGYTTDFPVERFMRDAKITQIY
Rv3274c|M.tuberculosis_H37Rv GFISAASKCFASDVAMEVTTDAVQLFGGAGYTTDFPVERFMRDAKITQIY
MLBr_00737|M.leprae_Br4923 GFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIY
TH_3846|M.thermoresistible__bu GFISAASKCFASDVAMEVTTDAVQLFGGYGYTQDFPVERMMRDAKITQIY
Mflv_4743|M.gilvum_PYR-GCK GFISAASKCLASDVAMEVTTDAVQLFGGAGYTVDFPVERMMRDAKITQIY
Mvan_1719|M.vanbaalenii_PYR-1 GFISAASKCLASDVAMEVTTDAVQLFGGAGYTVDFPVERMMRDAKITQIY
MMAR_1262|M.marinum_M GFISAASKCLASDVAMEVTTDAVQLFGGAGYTVDFPVERMMRDAKITQIY
MUL_2626|M.ulcerans_Agy99 GFISAASKCLASDVAMEVTTDAVQLFGGAGYTVDFPVERMMRDAKITQIY
MAV_4243|M.avium_104 GFISAASKCLASDVAMEVTTDAVQLFGGYGYTQDFPVERMMRDAKITQIY
MAB_3618c|M.abscessus_ATCC_199 GFISSASKCFASDVAMEVTTDAVQLFGGAGYTTDFPVERMMRDAKITQIY
MSMEG_4118|M.smegmatis_MC2_155 PGQIGIMKQCCTDLGFDAAVQATRILGPYGDLAVLGVERCLRDAKVTQIY
. * .:*:.::.:.:*.:::* * : *** :****:****
Mb3302c|M.bovis_AF2122/97 EGTNQIQRVVMSRALLR------
Rv3274c|M.tuberculosis_H37Rv EGTNQIQRVVMSRALLR------
MLBr_00737|M.leprae_Br4923 EGTNQIQRVVMSRALLR------
TH_3846|M.thermoresistible__bu EGTNQIQRVVMSRALLR------
Mflv_4743|M.gilvum_PYR-GCK EGTNQIQRVVMSRALLK------
Mvan_1719|M.vanbaalenii_PYR-1 EGTNQIQRVVMSRALLK------
MMAR_1262|M.marinum_M EGTNQIQRVVMSRALLR------
MUL_2626|M.ulcerans_Agy99 EGTNQIQRVVMSRALLR------
MAV_4243|M.avium_104 EGTNQIQRVVMSRALLR------
MAB_3618c|M.abscessus_ATCC_199 EGTNQIQRVVMSRALLTS-----
MSMEG_4118|M.smegmatis_MC2_155 DGTNEIQRLLVGREIIRATGELA
:***:***:::.* ::